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  • 1
    Book
    Book
    Therapeutic antibodies / (2008)
    Berlin [u.a.] :Springer,
    Details
    UID:
    almafu_BV023088282
    Format: XI, 380 S. : , Ill., graph. Darst. ; , 24 cm.
    ISBN: 3-540-73258-6 , 978-3-540-73258-7
    Series Statement: Handbook of experimental pharmacology 181
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-540-73259-4
    Language: English
    Subjects: Medicine
    RVK:
    XD 3115
    RVK:
    XI 1701
    Keywords: Monoklonaler Antikörper ; Therapie ; Aufsatzsammlung
    Author information: Chatenoud, Lucienne 1956-
    Author information: Chernajovsky, Yuti
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  • 2
    Book
    Book
    Gene therapy for autoimmune and inflammatory diseases (2010)
    Basel : Birkhäuser
    Details
    UID:
    kobvindex_ZLB15172694
    Format: XI, 239 Seiten , Ill., graph. Darst. , 24 cm
    Edition: 1. Aufl.
    ISBN: 9783034601641
    Series Statement: Milestones in drug therapy [30]
    Note: Literaturangaben
    Language: English
    Keywords: Autoaggressionskrankheit ; Entzündung ; Gentherapie ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung
    URL: http://d-nb.info/998955817/04
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  • 3
    Online Resource
    Online Resource
    Gene Therapy for Autoimmune and Inflammatory Diseases (2010)
    Basel :Springer Basel :
    Details
    UID:
    almahu_9949419407702882
    Format: XI, 239 p. , online resource.
    Edition: 1st ed. 2010.
    ISBN: 9783034601658
    Series Statement: Milestones in Drug Therapy,
    Content: In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
    Note: Gene therapy for arthritis -- Gene therapy for the treatment of inflammatory bowel disease -- Gene therapy for diabetes -- Gene therapy for cystic fibrosis lung disease -- Gene therapy of multiple sclerosis -- Gene therapy for myositis -- Gene therapy for osteoarthritis -- Gene therapy: Sjögren's syndrome -- Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease -- Regulated promoters -- Development of AAV vectors for the therapy of autoimmune and inflammatory diseases -- Delivery and application of plasmid DNA in arthritis gene therapy -- Helper-dependent adenoviral vectors -- Cells as carriers of gene therapy -- Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783034601665
    Additional Edition: Printed edition: ISBN 9783034601641
    Additional Edition: Printed edition: ISBN 9783034803069
    Language: English
    DOI: 10.1007/978-3-0346-0165-8
    URL: https://doi.org/10.1007/978-3-0346-0165-8
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  • 4
    Book
    Book
    Gene therapy for autoimmune and inflammatory diseases / (2010)
    Basel :Birkhäuser,
    Details
    UID:
    almahu_BV037309963
    Format: XI, 239 S. : , Ill., graph. Darst.
    Edition: 1. Aufl.
    ISBN: 978-3-0346-0164-1
    Series Statement: Milestones in drug therapy
    Note: Literaturangaben
    Language: English
    Subjects: Biology
    RVK:
    WG 7400
    Keywords: Autoaggressionskrankheit ; Entzündung ; Gentherapie ; Aufsatzsammlung
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022464412&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    Author information: Chernajovsky, Yuti
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  • 5
    Online Resource
    Online Resource
    Therapeutic Antibodies (2008)
    Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg
    Details
    UID:
    gbv_1647124867
    Format: Online-Ressource (digital)
    ISBN: 9783540732594
    Series Statement: Handbook of Experimental Pharmacology 181
    Content: This essential work, edited by two researchers at London's famous Queen Mary's medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.
    Content: Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers
    Note: Includes bibliographical references and index , Front Matter; Historical Development of Monoclonal Antibody Therapeutics; Preclinical Safety Evaluation of Monoclonal Antibodies; Engineering Antibodies for Stability and Efficient Folding; Human Monoclonal Antibodies from Transgenic Mice; Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future; Therapeutic Anti-VEGF Antibodies; Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab; Anti-CD20Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus; Herceptin , The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Toward the Induction of Immune Tolerance in the ClinicMonoclonal Antibody Therapy for Prostate Cancer; Anti-IgE and Other Antibody Targets in Asthma; Cytokine, Chemokine, and Co-Stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors; The T-Body Approach: Redirecting T Cells with Antibody Specificity; Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential; Back Matter
    Additional Edition: ISBN 9783540732587
    Additional Edition: Buchausg. u.d.T. Handbook of experimental pharmacology ; 181: Therapeutic antibodies Berlin : Springer, 2008 ISBN 9783540732587
    Additional Edition: ISBN 3540732586
    Additional Edition: ISBN 9783540732594
    Language: English
    Subjects: Medicine
    RVK:
    XD 3115
    Keywords: Monoklonaler Antikörper ; Therapie ; Monoklonaler Antikörper ; Therapie ; Aufsatzsammlung
    DOI: 10.1007/978-3-540-73259-4
    URL: Volltext
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
    URL: Inhaltsverzeichnis
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    UB Potsdam
  • 6
    Online Resource
    Online Resource
    Gene Therapy for Autoimmune and Inflammatory Diseases (2010)
    Basel : Birkhäuser Basel
    Details
    UID:
    gbv_644978104
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
    ISBN: 9783034601658
    Series Statement: Milestones in Drug Therapy
    Content: This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.
    Note: Includes bibliographical references and index , Title Page; Copyright Page; Table of Contents; List of Contributors; Preface; Gene therapy for arthritis; Gene therapy for the treatment of inflammatory bowel disease; Gene therapy for diabetes; Gene therapy for cystic fibrosis lung disease; Gene therapy of multiple sclerosis; Gene therapy for myositis; Gene therapy for osteoarthritis; Gene therapy: Sjögren's syndrome; Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease; Regulated promoters; Development of AAV vectors for the therapy of autoimmune and inflammatory diseases , Delivery and application of plasmid DNA in arthritis gene therapyHelper-dependent adenoviral vectors; Cells as carriers of gene therapy; Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy; Index , CoverTable of Contents -- List of Contributors -- Preface -- Gene Therapy for Arthritis -- Why Gene Therapy in Arthritis? -- Ex Vivo Strategy -- In Vivo Strategy -- Vectors for Gene Transfer in Arthritis -- The Target Genes -- Different Promoter to Provide Safe and Targeted Gene Expression -- What Have We Learnt From Preclinical Studies? -- Clinical Experience of Gene Therapy in Ra -- Conclusion -- References -- Gene Therapy for the Treatment of Inflammatory Bowel Disease -- Inflammatory Bowel Disease -- Pathogenesis of Ibd -- Treatment of Ibd 8211; Current Clinical Standards -- Pharmacologic Therapy -- Surgical Therapy -- New Approaches to the Treatment of Ibd -- Blocking Pro-Inflammatory Cytokine Activity -- Anti-Inflammatory Cytokine Treatment -- T Cell Inhibition -- Promoting Intestinal Repair -- Modifying the Enteric Microbiota -- Applications of Nucleic Acid-Based Therapies in Ibd Treatment -- Concluding Remarks -- References -- Gene Therapy for Diabetes -- Introduction -- Approaches for Treating Type 1 Diabetes By Gene Transfer -- Prevention of Autoimmunity By Gene Therapy -- Islet Transplantation With Immunoregulatory Gene Transfection -- Induction of Insulin-Producing Cells From Stem/Progenitor Cells By Gene Transfection -- Reversible Immortalization of Pancreatic 946; Cells By Gene Transfer and Site Specific Recombination -- Conclusions -- References -- Gene Therapy for Cystic Fibrosis Lung Disease -- Introduction -- Cftr Mutations -- Pathophysiology of Cf Lung Disease -- The Low Volume Hypothesis to Explain Cf Lung Disease -- Pharmacological Approaches to Treat Cf Lung Disease -- Drugs That Increase Cftr Protein Levels -- Cftr Correctors, Drugs to Increase Trafficking of Cftr -- Cftr Potentiators, Drugs That Increase Conductance At the Apical Membrane -- Modulation of Other Ion Channels -- Gene Therapy Clinical Trials -- Adenovirus and Adeno-Associated Virus -- Negative Strand Rna Viruses -- Lentiviruses -- Non-Viral Vectors for Cf Gene Therapy -- Cationic Polymers As Mediators for Cf Plasmid Dna Gene Therapy -- Modifier Genes and Future Directions -- Conclusion -- References -- Gene Therapy of Multiple Sclerosis -- Introduction -- Modulation of T Cells By Cytokines -- Interferon-946; -- Interleukin-4 -- Interleukin-10 -- Th17-Treg Cytokines Family -- Decoy Receptors -- Immunotoxins -- Induction of Tolerance -- Innate Immune System -- Angiogenesis -- Antioxidative Therapy -- Stem Cell Mediated Gene Therapy -- Conclusions -- References -- Gene Therapy for Myositis -- Introduction -- Diagnosis -- Immunopathogenesis -- Conventional Therapies -- Gene Therapy -- Gene Therapy in Inflammatory Muscle Disorders -- Targets for Gene Therapy -- Conclusion and Outlook -- References -- Gene Therapy for Osteoarthritis -- Introduction: Osteoarthritis a Disease of Eroding Cartilage -- Current Approaches to Treatment -- Articular Cartilage Matrix Composition and Oa -- Mediator. , Electronic reproduction; Available via World Wide Web
    Additional Edition: ISBN 9783034601641
    Language: English
    DOI: 10.1007/978-3-0346-0165-8
    URL: Volltext  (lizenzpflichtig)
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  • 7
    Book
    Book
    Therapeutic antibodies (2008)
    Berlin [u.a.] : Springer
    Details
    UID:
    gbv_533187478
    Format: XI, 380 S. , Ill., graph. Darst. , 24 cm
    ISBN: 3540732586 , 9783540732587
    Series Statement: Handbook of experimental pharmacology 181
    Note: Literaturangaben
    Additional Edition: ISBN 9783540732594
    Language: English
    Subjects: Medicine
    RVK:
    XD 3115
    Keywords: Monoklonaler Antikörper ; Therapie ; Monoklonaler Antikörper ; Pharmakotherapie ; Aufsatzsammlung
    URL: Inhaltsverzeichnis
    Author information: Chatenoud, Lucienne 1956-
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  • 8
    Book
    Book
    Therapeutic antibodies (2008)
    Berlin [u.a.] : Springer-Verlag
    Details
    UID:
    kobvindex_ZLB14267397
    Format: XI, 380 Seiten , Ill., graph. Darst.
    ISBN: 9783540732587
    Series Statement: Handbook of experimental pharmacology 181
    Note: Literaturangaben , Text engl.
    Language: English
    Keywords: Monoklonaler Antikörper ; Therapie ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung
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  • 9
    Online Resource
    Online Resource
    Therapeutic Antibodies (2008)
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Details
    UID:
    almahu_9949419404002882
    Format: XI, 380 p. , online resource.
    Edition: 1st ed. 2008.
    ISBN: 9783540732594
    Series Statement: Handbook of Experimental Pharmacology, 181
    Content: Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers.
    Note: Historical Development of Monoclonal Antibody Therapeutics -- Preclinical Safety Evaluation of Monoclonal Antibodies -- Molecular Developments in Antibody Production -- Engineering Antibodies for Stability and Efficient Folding -- Human Monoclonal Antibodies from Transgenic Mice -- Antibodies to Cytokines -- Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future -- Therapeutic Anti-VEGF Antibodies -- Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab -- Antibodies to Cell Markers -- Anti-CD20Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus -- Herceptin -- The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Toward the Induction of Immune Tolerance in the Clinic -- Monoclonal Antibody Therapy for Prostate Cancer -- Anti-IgE and Other Antibody Targets in Asthma -- Development of Antibody-Based Cellular and Molecular Therapies -- Cytokine, Chemokine, and Co-Stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors -- The T-Body Approach: Redirecting T Cells with Antibody Specificity -- Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783540839941
    Additional Edition: Printed edition: ISBN 9783642092305
    Additional Edition: Printed edition: ISBN 9783540732587
    Language: English
    DOI: 10.1007/978-3-540-73259-4
    URL: https://doi.org/10.1007/978-3-540-73259-4
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Open Access Request
    HU Berlin
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