UID:
almafu_9959327759202883
Format:
1 online resource (xv, 557 pages) :
,
illustrations
ISBN:
9780471758044
,
0471758043
Content:
Ecogenetics can be defined as the study of genetic determinants that dictate susceptibility to environmentally-influenced adverse health effects.
Content:
The explosion in new, high throughput techniques for identifying genetic variants, coupled with the realization that the majority of human diseases arise through a complex interplay of genetics and environment has led to remarkable growth and interest in the field of ecogenetics.
Content:
The first section of this book covers fundamental aspects of ecogenetic, such as history of the discipline, a discussion of the molecular tools currently available to assess genotypes and their pros and cons, the use of such measurements in molecular epidemiology studies, and considerations on how knowledge acquired in pharmacogenetics can be applied to ecogenetics.
Content:
The second section discusses key genetic polymorphisms relevant for ecogenetics.
Content:
The third section presents a disease-based approach, to address the question of how genetic polymorphisms can influence gene-environment interactions relevant to determining susceptibility to the disease.
Content:
These core chapterss address various types of cancers, neurodegenerative diseases, cardiovascular disease, diabetes and obesity.
Note:
Ecogenetics : historical perspectives /
,
Tools of ecogenetics /
,
Epidemiologic approaches /
,
Statistical issues in ecogenetic studies /
,
Polymorphisms in cytochrome P450 and flavin-containing monooxygenase genes /
,
Polymorphisms in xenobiotic conjugation /
,
Paraoxonase, butyrylcholinesterase, and epoxide hydrolase /
,
DNA repair enzymes /
,
Receptors and ion channels /
,
Lung cancer /
,
Gastrointestinal cancers /
,
Neurodegenerative diseases /
,
Cardiovascular disease /
,
Type 2 diabetes /
,
Infectious disease ecogenetics /
,
Genetic variation, diet, and disease susceptibility /
,
Genetic determinants of addiction to alcohol, tobacco, and drugs of abuse /
,
Ethical issues in ecogenetics /
,
Social and psychological aspects of ecogenetics /
,
Legal issues /
,
Risk assessment and the impact of ecogenetics /
Additional Edition:
Print version: Costa, Lucio G., 1954- Gene-environment interactions. Hoboken, N.J. : Wiley-Liss, 2006 ISBN 9780471467816
Additional Edition:
ISBN 0471467812
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0471758043
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0471758043
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0471758043
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