Format:
Online-Ressource (XI, 636p. 80 illus., 30 illus. in color, digital)
ISBN:
9783642278594
Series Statement:
Current Topics in Behavioral Neurosciences 12
Content:
Andreas Reif
Content:
This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
Note:
Description based upon print version of record
,
13…Social Behavior14…Concluding Remarks; Acknowledgments; References; 189 Forward Genetic Approaches to Understanding Complex Behaviors; Abstract; 1…The Importance of Phenotype; 2…Forward Genetics and Inbred Strains: The QTL Approach; 3…QTL Mapping: The Basics; 4…Initial QTL Identification: Standard Mapping Populations; 4.1 Recombinant Inbred Lines; 4.2 Intercross and Backcross Mapping Populations; 4.3 Consomic Lines or Chromosome Substitution Strains; 5…QTL Fine Mapping; 5.1 Congenic Strains; 5.2 Advanced Intercross Lines; 5.3 Heterogeneous Stocks; 5.4 Outbred Mice
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5.5 The Collaborative Cross6…Haplotype Association Mapping; 7…Mutagenesis; 8…Beyond QTL Analysis: Finding the Quantitative Trait Gene; 9…The Future of Forward Genetics; References; 190 Mouse Models of the 5-HTTLPR x Stress Risk Factor for Depression; Abstract; 1…Challenges of Designing Mouse Models of the 5-HTTLPR x Stress Risk Factor; 2…Mouse Models of the 5-HTTLPR x Early Stress Risk Factor for Depression; 3…Mouse Models of the 5-HTTLPR x Adult Stress Risk Factor for Depression; 4…Physiological and Molecular Substrates of the 5-HTT x Stress Risk Factor in Mice
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7…Modulation of Serotonergic Activity by Other Systems7.1 Excitatory and Inhibitory Amino acids; 7.1.1 gamma -Aminobutyric Acid; 7.1.2 Glutamate; 7.2 Neuropeptides; 7.2.1 Corticotropin-Releasing Factor; 7.2.2 Neuropeptide Y; 7.2.3 Arginine Vasopressin; 7.2.4 Oxytocin; 7.3 Other Molecules that Directly or Indirectly Affect 5-HT Pathways and Aggression; 7.3.1 Tryptophan Hydroxylase; 7.3.2 Pet-1; 7.3.3 Brain-Derived Neurotrophic Factor; 7.3.4 Neuronal Nitric Oxide; 7.3.5 alpha -Calcium-Calmodulin Kinase II; 8…Concluding Remarks; References
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192 Selectively Bred Rodents as Models of Depression and Anxiety
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Behavioral Neurogenetics; Preface; Contents; Part IPreclinical Behavioral Genetics; 180 Using Zebrafish to Unravel the Genetics of Complex Brain Disorders; Abstract; 1…Zebrafish, a Novel Research Tool with Some Advantages; 2…Zebrafish, the Favorite of Geneticists; 3…Reverse Genetic Tools; 4…Forward Genetic Tools; 5…Parkinson's Disease; 6…Tauopathy and Alzheimer's Disease; 7…The Anxiety ''Cluster''; 8…Autism Spectrum Disorders; 9…Schizophrenia; 10…Expanding Our Horizon: The Need for Sophisticated Behavioral Test Paradigms in Zebrafish Research; 11…Learning and Memory; 12…Fear and Anxiety
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5…Promises of Mouse Models of Gene x Environment Risk Factors for Clinical ResearchReferences; 191 Behavioral and Pharmacogenetics of Aggressive Behavior; Abstract; 1…Introduction; 2…Definition and Measurement of Aggression; 3…Aggressive ''Trait'' Versus ''States''; 4…5-HT Receptors; 4.1 5-HT1 Family; 4.1.1 Pharmacological Approach; 4.1.2 Genetic Approach; 4.2 5-HT2 Family; 4.2.1 Pharmacological Approach; 4.2.2 Genetic Approach; 5…Serotonin Transporter (5-HTT); 5.1 Pharmacological Approach; 5.2 Genetic Approach; 6…Monoamine Oxidase A; 6.1 Pharmacological Approach; 6.2 Genetic Approach
Additional Edition:
ISBN 9783642278587
Additional Edition:
Buchausg. u.d.T. Behavioral neurogenetics Berlin : Springer, 2012 ISBN 3642278582
Additional Edition:
ISBN 9783642278587
Language:
English
Subjects:
Biology
Keywords:
Neurogenetik
;
Neuropsychiatrie
;
Neuropsychologie
;
Verhaltensgenetik
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-27859-4
Author information:
Reif, Andreas 1971-
Author information:
Cryan, J. F.
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