Format:
Online-Ressource (VII, 262 p. 23 illus., 22 illus. in color, digital)
ISBN:
9783642377655
Series Statement:
Current Topics in Microbiology and Immunology 371
Content:
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Note:
Includes bibliographical references and index
,
Preface; Contents; The APOBEC3 Family of Retroelement Restriction Factors; Abstract; 1 DNA Deaminase Evolution; 2 Biochemical and Structural Insights; 3 Biological Functions; 3.1 APOBEC3 Proteins in HIV Restriction; 3.2 APOBEC3 Proteins in General Innate Immune Defense; 4 Pathological Consequences of DNA Deamination; 5 Possible Avenues to APOBEC3-Based Therapeutics; 5.1 Therapy by Hypermutation; 5.2 Therapy by Hypomutation; References; Inhibition of Retroviral Replication by Members of the TRIM Protein Family; Abstract; 1 Introduction
,
2 TRIM5α and TRIMCyp Bind Retroviral Capsids to Accelerate Their Degradation and Stimulate Innate Signaling2.1 Combining Two Activities; 2.2 The C-Terminal PRYSPRY has Surface Variable Loops that Determine Restriction Specificity; 2.3 TRIM5α Recognizes Multiple Capsid Epitopes to Maintain Broad Specificity; 2.4 TRIMCyp is Also a Versatile Capsid Recognition Domain; 2.5 TRIM5α Causes Structural Damage to Capsids; 2.6 TRIM5α Ubiquitination; 2.6.1 The Role of the RING; 2.6.2 TRIM5 Signaling; 2.7 TRIM5α Cytoplasmic Bodies as Components of Restriction
,
3 TRIM28 is a Transcriptional Corepressor of Endogenous and Exogenous Retroviruses3.1 TRIM28 is a Molecular Scaffold for Heterochromatin-Inducing Enzymes; 3.2 TRIM28 Mediates Repression of Endogenous Retroviruses in Embryonic Stem Cells; 3.3 TRIM28 is Responsible for the Stem Cell-Specific Restriction of Murine Leukemia Viruses; 3.4 TRIM28-Mediated Restriction of Complex Retroviruses; 3.5 TRIM28 Restricts HIV-1 Integration by Facilitating Integrase Deacetylation; 3.6 TRIM28-Related Protein TRIM24 Represses ERV Transcription in Hepatocytes
,
4 TRIM22 Represses HIV-1 LTR Transcription and is a Correlate of Viral Control in HIV-1-Infected Patients5 Do Other TRIM Family Proteins Inhibit Retroviral Replication?; 6 Concluding Remarks; References; The Antiviral Activities of Tetherin; Abstract; 1 Introduction; 2 Tetherin; 2.1 Structure and Subcellular Localization; 2.2 Mechanism of Tetherin's Antiviral Activity; 2.3 Genetic Diversity in Mammalian Tetherins; 2.4 Tissue expression and Transcriptional Regulation of Tetherin; 3 Viral Countermeasures of Tetherin; 3.1 Overview; 3.2 HIV-1 and SIV Vpu; 3.2.1 TetherinVpu Interactions
,
3.2.2 Vpu-Mediated Subversion of Tetherin Trafficking3.2.3 Ubiquitination of Tetherin Induced by Vpu; 3.2.4 Degradation of Tetherin in Response to Vpu; 3.2.5 Impaired or Absent Tetherin Counteraction in SIVcpz and HIV-1 Non-group M Vpu Proteins: A Determinant of Pandemic Spread?; 3.3 SIV Nef; 3.4 HIV-2 and Other Lentiviral Envelope Proteins; 3.5 HHV8 K5; 3.6 Ebola Virus GP; 3.7 Other Viruses and Tetherin; 4 Tetherin and Cell-to-Cell Transmission of Retroviruses; 5 Tetherin and Viral Pathogenesis In vivo; 6 Tetherin as a Viral Sensor and Regulator of Antiviral Immune Responses
,
7 Concluding Remarks
Additional Edition:
ISBN 9783642377648
Additional Edition:
Erscheint auch als Druck-Ausgabe Intrinsic immunity Berlin : Springer, 2013 ISBN 9783642377648
Language:
English
Subjects:
Biology
Keywords:
Virusinfektion
;
Immunität
;
Viren
;
Replikation
;
Inhibition
DOI:
10.1007/978-3-642-37765-5
URL:
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