Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9781441902979
Series Statement:
Advances in Experimental Medicine and Biology 649
Content:
It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize this growing knowledge and present all the current studies concerning the basic research of SpA. Over the last decade, enormous progress has been made in the understanding of the molecular and cellular processes that lead to disease pathology. Recognition of the pathways involved in the pathogenic mechanisms of disease and the potential to target specific immune effector functions have opened the door to a wide range of innovative treatment opportunities for the SpA. Thus, we believe that the understanding of the specific molecular mechanisms involved would help to design highly specific drugs in the future. The contributors are among the best in their field and reflect the state of the art of research and current opinion of rheumatologists and immunologists.
Note:
Includes bibliographical references and index
,
Title Page; Copyright Page; PREFACE; ABOUT THE EDITORS ...; PARTICIPANTS; TABLE OF CONTENTS; ACKNOWLEDGEMENTS; CHAPTER 1 Clinical Assessment in the Spondyloarthropathies; Abstract; Introduction; Ankylosing Spondylitis; Symptoms and Disease Activity; Axial Pain; Stiffness; Peripheral Disease Manifestations; Fatigue; Mobility; Cervical Rotation; Lateral Flexion of the Neck; Chin to Chest; Occiput to WallDistance (OW D); Tragus to Wall Distance (TWD); Schober's Test; Finger to Floor Distance; Lateral Lumbar Flexion; Chest Expansion; Intermalleolar Distance
,
BASMI (Bath Ankylosing Spondylitis Metrology Index)EDASMI (Edmonton AS Metrology Index); Functioning; Physical Function; Quality of Life; Structural Damage; Composite Index; Response to Treatment; Psoriatic Arthritis; Symptoms and Disease Activity; Skin Psoriasis; Peripheral Disease/Enthesitis/Dactylitis; Nail Involvement; Fatigue; Spine Assessments; Functioning; Physical Function; Quality of Life; Structural Damage; References; CHAPTER 2 Imaging in Spondyloarthritis; Abstract; Introduction; Plain Radiography; Computed Tomography; Isotopic Imaging; Ultrasound; Magnetic Resonance Imaging
,
Sacroiliac JointSpine; Conclusions; References; CHAPTER 3 Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis(DISH) and Chondrocalcinosis; Abstract; Introduction; Spondyloarthritis; Diffuse Idiopathic Skeletal Hyperostosis (DISH); Chondrocalcinosis/Crystal Deposition Disease (CPPD CDD); Molecular Genetics; Conclusions; References; CHAPTER 4 The Enthesis Organ Concept and Its Relevance to the Spondyloarthropathies; Abstract; Introduction; Enthesis Organ Structure; The Archetypal Enthesis Organ; Other Enthesis Organs; The Blood Supply of En thesis Organs
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Mechanisms for Reducing Stress Concentration at the Enthesis ItselfRelated Concepts; The Synovio-Entheseal Complex (SEC); Functional Entheses; Conclusions; References; CHAPTER 5 Synovial and Mucosal Immunopathology in Spondyloarthritis; Abstract; Introduction; The Immunopathology of Axial Spondyloarthritis; The Immunopathology of Peripheral Spondyloarthritis; Axial Versus Peripheral Spondyloarthritis; Skeletal Remodeling in Spondyoarthritis; Synovial Biomarkers in Spondyoarthritis; Gut Inflammation in Spondyloarthritis; The Pathogenesis ofSpondyloarthritis: The Mucosa Hypothesis
,
Innate Immunity and Mucosal InflammationAdaptive Immunity and Mucosal Inflammation; The Pathogenesis of Joint Inflammation; Conclusions; References; CHAPTER 6 Bone Loss in the Spondyloarthropathies:Role of Osteoclast, RANKL, RANK and OPGin the Spondyloarthropathies; Abstract; Introduction; Pathogenesis of Bone Loss; Osteoclast; RANK/RANKL/OPG System; RANKL; RANK; OPG; Other Important Cytokines Involved in Bone Remodeling; Bone Loss in the Spondyloarthritis; Bone Loss in Ankylosing Spondylitis; Generalized Bone Loss in AS; Bone Loss in PsA; Bone Loss in Enteropathic Arthritis
,
Bone Loss in Reactive Arthritis
,
Biomarkers in spondyloarthropathies
,
Clinical assessment in the spondyloarthropathies
,
HLA-B27 misfolding and spondyloarthropathies
,
Therapy of spondyloarthritides
,
Genomewide screens in ankylosing spondylitis
,
Subtypes of HLA-B27 : history and implications in the pathogenesis of ankylosing spondylitis
,
Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis
,
HLA-B27-bound peptide repertoires : their nature, origin and pathogenetic relevance
,
Biochemical features of HLA-B27 and antigen processing
,
Imaging in spondyloarthritis
,
Spondyloarthritis, diffuse idiopathic skeletal hyperostosis (DISH) and chondrocalcinosis
,
The enthesis organ concept and its relevance to the spondyloarthropathies
,
Synovial and mucosal immunopathology in spondyloarthritis
,
Bone loss in the spondyloarthropathies : role of osteoclast, RANKL, RANK, and OPG in the spondyloarthropathies
,
RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies
,
Bone formation versus bone resorption in ankylosing spondylitis
,
HLA-B27 and host-pathogen interaction
,
Animal models of spondyloarthritis
,
T-cell responses against viral and self-epitopes and HLA-B27 subtypes differentially associated with ankylosing spondylitis
,
Dendritic cell : T-cell interactions in spondyloarthritis
,
The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis
,
KIR genes and their role in spondyloarthropathies
,
Innate immunity of spondyloarthritis : the role of toll-like receptors
,
Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9781441902986
Additional Edition:
ISBN 9781441902979
Language:
English
DOI:
10.1007/978-1-4419-0298-6
URL:
Volltext
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