Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (466 pages)

Edition: 1st ed.

ISBN: 0-323-90106-9

Content: The field of Assisted Reproductive Technology (ART) is rapidly evolving and stimulation protocols, fertility strategies and aspects of infertility treatments are constantly being updated as advances and new discoveries are made. Handbook of Current and Novel Protocols for the Treatment of Infertility is a valuable resource of well-organized, comprehensive scientific data with practical guides and step-by-step protocols for infertility management. Written by world-wide experts, this book discusses different practice patterns and approaches used internationally and presents innovative topics including preimplantation genetic testing, time lapse imaging and the role of artificial intelligence in ART. This book provides up-to-date, evidence-based guidance on daily practice and is an important resource for infertility providers, including trainees or experienced clinicians, embryologist, and is geared for both specialist in reproductive medicine and gynecologists interested in increasing their knowledge in the field of reproductive endocrinology and intertility.

Note: Front Cover -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- Copyright -- Dedication -- Contents -- List of contributors -- Preface -- 1 - The evaluation of the female infertility patient -- History assessment -- Physical exam -- Height and weight measurements, BMI calculation, and appearance -- Thyroid and breast -- Pelvic exam -- Pelvic ultrasound -- Evaluation of ovarian reserve -- Ovulation assessment -- Tubal patency evaluation -- Other investigations -- Conclusion -- References -- 2 - The fertility evaluation of the male partner -- Overview -- Clinical history -- Physical examination -- Semen analysis -- Hormonal evaluation -- Genetic studies -- Histopathology -- Conditions with special considerations -- Congenital bilateral absence of the vas deferens -- Ejaculatory duct obstruction -- Globozoospermia -- Recurrent pregnancy loss -- Surgical sperm extraction techniques -- Infertility and general health -- Summary -- References -- 3 - Sperm DNA fragmentation and male infertility: a comprehensive review for the clinicians -- Sperm genetics -- Sperm chromatin and DNA packaging -- Sperm contribution to the developing embryo -- Sperm DNA repair by oocyte: what we know and what we don't? -- How do sperm genetics become dysfunctional? -- Defective sperm chromatin packaging -- Abortive apoptosis -- Oxidative damage -- Single- or double-strand breaks: does it really matter? -- Which test to assess sperm chromatin integrity and SDF? -- Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling (TUNEL) assay -- Sperm chromatin structure assay (SCSA) -- Sperm chromatin dispersion (SCD) test -- In situ nick translation (NT) assay -- Comet assay -- Acridine orange test -- High-performance liquid chromatography. , Less commonly used tests for SDF assessment -- Etiologies and risk factors for SDF -- Varicocele -- Genital tract infection -- Aging -- Smoking and alcohol -- Obesity and overweight -- Occupational and environmental exposures -- The impact of SDF on male reproductive outcomes -- Implications of SDF on natural pregnancy -- Implications of SDF on ART outcomes -- Impact of SDF on offspring -- How to manage patients with high SDF? -- Addressing patient risk factors -- Use of antioxidants -- Use of ART -- Clinical practice guidelines and recommendations on SDF testing -- Limitations of sperm SDF testing in clinical practice? -- Updates in the recent research on SDF (2019-21) -- Clinical scenarios on SDF management -- Case 1 -- Case 2 -- Case 3 -- Conclusion -- References -- 4 - The evaluation and management of recurrent pregnancy loss -- Introduction -- Incidence and prevalence -- Etiology and risk factors -- Genetic causes -- Anatomic causes -- Congenital uterine anomalies -- Acquired uterine abnormalities -- Endocrine causes -- Thyroid dysfunction -- Hyperprolactinemia -- Polycystic ovary syndrome -- Insulin resistance -- Luteal phase deficiency -- Immune causes -- Autoimmune causes -- Alloimmune causes -- Inherited thrombophilia -- Infection -- Obesity/overweight/underweight -- Male factor -- Psychological factors -- Lifestyle and environmental factors -- Dietary factors -- Unexplained recurrent miscarriage -- Evaluation of RPL -- Genetic evaluation of RPL -- Parental karyotyping -- Cytogenetic testing of products of conception -- Anatomical evaluation -- Endocrinological evaluation -- Thyroid evaluation -- Insulin resistance evaluation -- Hyperprolactinemia evaluation -- Luteal phase deficiency evaluation -- Polycystic ovary syndrome evaluation -- Immunological testing -- Antiphospholipid antibody testing -- Alloimmunity testing. , Inherited thrombophilias evaluation -- Infections testing -- Male factor assessment -- Prevention -- Treatment -- Couples with structural chromosomal abnormalities -- Anatomical factor correction -- Congenital anatomical factors -- Acquired anatomical factors -- Uterine fibroids -- Intrauterine adhesions -- Uterine polyp -- Cervical insufficiency -- Management of endocrine factors -- Treatment of thyroid dysfunction associated with RPL -- Treatment of luteal phase deficiency and RPL -- Treatment of polycystic ovary syndrome and insulin resistance in women with RPL -- Treatment of hyperprolactinemia and RPL -- Treatment of immunological disorders with RPL -- Treatment of antiphospholipid antibody syndrome with RPL -- Treatment of inherited thrombophilia in women with RPL -- Treatment of infections with RPL -- Treatment of male factor in RPL couples -- Psychological support in RPL patients -- Couples with unexplained recurrent pregnancy loss -- Role of progesterone in unexplained recurrent miscarriage -- Role of immunotherapy in unexplained recurrent miscarriage -- ASA and low-molecular weight heparin in unexplained recurrent pregnancy loss -- Preimplantation genetic testing for aneuploidy in patients with unexplained RPL -- Endometrial scratch in women with RPL -- Future directions -- Conclusion -- References -- 5 - The role of surgery in infertility, an evidence-based approach -- Introduction -- Congenital uterine abnormalities -- Uterine septum -- Dysmorphic uterus -- Acquired uterine pathology -- Endometrial polyps -- Intrauterine adhesions -- Fibroids -- Isthmocele -- Tubal pathology -- Distal tubal obstruction -- Proximal tubal obstruction -- References -- 6 - Ovarian stimulation and intrauterine insemination -- Introduction -- Definition and indications -- Ovarian stimulation protocols -- Natural cycle IUI -- Stimulated cycle IUI. , Combined protocols -- The use of a GnRH-antagonist in the last days of ovarian stimulation -- Efficacy and safety of the different protocols -- Cancellation criteria during stimulated IUI -- Final oocyte maturation and ovulation triggering and timing of insemination -- Bed rest -- Number of inseminations during treatment -- Luteal phase support -- Final remarks -- References -- 7 - Infertility care of the PCOS patient -- Introduction -- Preconception risk factors -- Weight loss and obesity -- Pharmacologic treatment strategies -- Metformin -- Letrozole -- Selective estrogen receptor modulators -- Gonadotropins -- Considerations for administration of ovulation induction agents -- In vitro fertilization/Intracytoplasmic sperm injection -- In vitro maturation -- Inositol -- Laparoscopic ovarian drilling -- Acupuncture, herbal remedies, and traditional Chinese medicine -- Conclusion -- References -- 8 - The GnRH antagonist protocol -- Introduction -- GnRH antagonist protocols -- Cetrorelix versus ganirelix -- GnRH antagonist fixed protocol -- GnRH antagonist flexible protocol -- Fixed versus flexible GnRH antagonist protocol -- Pretreatment with oral contraceptive pill in a GnRH antagonist cycle -- Elevated progesterone at initiation of stimulation in a GnRH antagonist cycle -- FSH dose in GnRH antagonist protocols -- Initiation of FSH dose in GnRH antagonist protocols -- Administration of antagonist in the early follicular phase -- Delayed start GnRH antagonist protocol -- Luteal GnRH antagonist administration -- Criteria for triggering final oocyte maturation -- GnRH antagonists and OHSS -- The modified natural cycle -- Use of GnRH antagonists in ovarian stimulation for intrauterine insemination -- Luteal phase support in antagonist cycles -- Alternative to GnRH antagonists LH suppression regimens -- References. , 9 - The long gonadotropin releasing hormone agonist IVF protocol -- Introduction -- A brief history of IVF attempts -- Natural cycle IVF -- IVF with exogeneous pharmacologic agents -- Shortcomings of early IVF protocols -- Gonadotropin-releasing hormone agonists -- Physiology, structure, and early studies -- GnRH-a and early IVF outcomes -- Current GnRH-a protocols -- Shortcomings of GnRH-a protocols -- Conclusions -- References -- 10 - Double stimulation in the same ovarian cycle (DuoStim) and luteal phase start IVF protocols -- Introduction -- Theories of folliculogenesis -- Definition of poor prognosis patients -- An unconventional ovarian stimulation protocol: luteal phase stimulation -- DuoStim for poor prognosis patients: the evidence up to date -- Framework of a DuoStim protocol -- Clinical indications for DuoStim -- DuoStim: is the second stimulation in the same ovarian cycle conducted in the luteal phase pf the cell cycle? -- Conclusions -- References -- 11 - The mild stimulation in vitro fertilization protocol -- Mild ovarian stimulation for IVF -- Background -- Concepts behind the mild ovarian stimulation protocol -- Oocyte competency -- Embryo quality and ploidy status -- Stimulation versus response -- Endometrial receptivity -- The protocol -- Antagonist vs Agonist -- What type of gonadotropin -- Gonadotropin dose -- Oral agents -- Why mild? -- Clinical effectiveness -- Perinatal outcomes -- Safety -- Patient's experience -- Cost -- Limitations -- Cumulative pregnancy outcome -- Goal of "completing family" -- Cycle cancellation -- Future prospects -- Disclosure of interests -- References -- 12 - The use of progestins to prevent the LH surge in IVF cycles -- Alternative protocols for ovarian stimulation -- Mechanism of pituitary suppression by progestins -- Progestins -- PPOS protocols: outcomes and schemes of treatment. , Advantages and limits.

Additional Edition: Print version: Dahan, Michael H. Handbook of Current and Novel Protocols for the Treatment of Infertility San Diego : Elsevier Science & Technology,c2023 ISBN 9780323856874

Language: English

UID:

Format: 1 online resource (466 pages)

Edition: 1st ed.

ISBN: 0-323-90106-9

Content: The field of Assisted Reproductive Technology (ART) is rapidly evolving and stimulation protocols, fertility strategies and aspects of infertility treatments are constantly being updated as advances and new discoveries are made. Handbook of Current and Novel Protocols for the Treatment of Infertility is a valuable resource of well-organized, comprehensive scientific data with practical guides and step-by-step protocols for infertility management. Written by world-wide experts, this book discusses different practice patterns and approaches used internationally and presents innovative topics including preimplantation genetic testing, time lapse imaging and the role of artificial intelligence in ART. This book provides up-to-date, evidence-based guidance on daily practice and is an important resource for infertility providers, including trainees or experienced clinicians, embryologist, and is geared for both specialist in reproductive medicine and gynecologists interested in increasing their knowledge in the field of reproductive endocrinology and intertility.

Note: Front Cover -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- Copyright -- Dedication -- Contents -- List of contributors -- Preface -- 1 - The evaluation of the female infertility patient -- History assessment -- Physical exam -- Height and weight measurements, BMI calculation, and appearance -- Thyroid and breast -- Pelvic exam -- Pelvic ultrasound -- Evaluation of ovarian reserve -- Ovulation assessment -- Tubal patency evaluation -- Other investigations -- Conclusion -- References -- 2 - The fertility evaluation of the male partner -- Overview -- Clinical history -- Physical examination -- Semen analysis -- Hormonal evaluation -- Genetic studies -- Histopathology -- Conditions with special considerations -- Congenital bilateral absence of the vas deferens -- Ejaculatory duct obstruction -- Globozoospermia -- Recurrent pregnancy loss -- Surgical sperm extraction techniques -- Infertility and general health -- Summary -- References -- 3 - Sperm DNA fragmentation and male infertility: a comprehensive review for the clinicians -- Sperm genetics -- Sperm chromatin and DNA packaging -- Sperm contribution to the developing embryo -- Sperm DNA repair by oocyte: what we know and what we don't? -- How do sperm genetics become dysfunctional? -- Defective sperm chromatin packaging -- Abortive apoptosis -- Oxidative damage -- Single- or double-strand breaks: does it really matter? -- Which test to assess sperm chromatin integrity and SDF? -- Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling (TUNEL) assay -- Sperm chromatin structure assay (SCSA) -- Sperm chromatin dispersion (SCD) test -- In situ nick translation (NT) assay -- Comet assay -- Acridine orange test -- High-performance liquid chromatography. , Less commonly used tests for SDF assessment -- Etiologies and risk factors for SDF -- Varicocele -- Genital tract infection -- Aging -- Smoking and alcohol -- Obesity and overweight -- Occupational and environmental exposures -- The impact of SDF on male reproductive outcomes -- Implications of SDF on natural pregnancy -- Implications of SDF on ART outcomes -- Impact of SDF on offspring -- How to manage patients with high SDF? -- Addressing patient risk factors -- Use of antioxidants -- Use of ART -- Clinical practice guidelines and recommendations on SDF testing -- Limitations of sperm SDF testing in clinical practice? -- Updates in the recent research on SDF (2019-21) -- Clinical scenarios on SDF management -- Case 1 -- Case 2 -- Case 3 -- Conclusion -- References -- 4 - The evaluation and management of recurrent pregnancy loss -- Introduction -- Incidence and prevalence -- Etiology and risk factors -- Genetic causes -- Anatomic causes -- Congenital uterine anomalies -- Acquired uterine abnormalities -- Endocrine causes -- Thyroid dysfunction -- Hyperprolactinemia -- Polycystic ovary syndrome -- Insulin resistance -- Luteal phase deficiency -- Immune causes -- Autoimmune causes -- Alloimmune causes -- Inherited thrombophilia -- Infection -- Obesity/overweight/underweight -- Male factor -- Psychological factors -- Lifestyle and environmental factors -- Dietary factors -- Unexplained recurrent miscarriage -- Evaluation of RPL -- Genetic evaluation of RPL -- Parental karyotyping -- Cytogenetic testing of products of conception -- Anatomical evaluation -- Endocrinological evaluation -- Thyroid evaluation -- Insulin resistance evaluation -- Hyperprolactinemia evaluation -- Luteal phase deficiency evaluation -- Polycystic ovary syndrome evaluation -- Immunological testing -- Antiphospholipid antibody testing -- Alloimmunity testing. , Inherited thrombophilias evaluation -- Infections testing -- Male factor assessment -- Prevention -- Treatment -- Couples with structural chromosomal abnormalities -- Anatomical factor correction -- Congenital anatomical factors -- Acquired anatomical factors -- Uterine fibroids -- Intrauterine adhesions -- Uterine polyp -- Cervical insufficiency -- Management of endocrine factors -- Treatment of thyroid dysfunction associated with RPL -- Treatment of luteal phase deficiency and RPL -- Treatment of polycystic ovary syndrome and insulin resistance in women with RPL -- Treatment of hyperprolactinemia and RPL -- Treatment of immunological disorders with RPL -- Treatment of antiphospholipid antibody syndrome with RPL -- Treatment of inherited thrombophilia in women with RPL -- Treatment of infections with RPL -- Treatment of male factor in RPL couples -- Psychological support in RPL patients -- Couples with unexplained recurrent pregnancy loss -- Role of progesterone in unexplained recurrent miscarriage -- Role of immunotherapy in unexplained recurrent miscarriage -- ASA and low-molecular weight heparin in unexplained recurrent pregnancy loss -- Preimplantation genetic testing for aneuploidy in patients with unexplained RPL -- Endometrial scratch in women with RPL -- Future directions -- Conclusion -- References -- 5 - The role of surgery in infertility, an evidence-based approach -- Introduction -- Congenital uterine abnormalities -- Uterine septum -- Dysmorphic uterus -- Acquired uterine pathology -- Endometrial polyps -- Intrauterine adhesions -- Fibroids -- Isthmocele -- Tubal pathology -- Distal tubal obstruction -- Proximal tubal obstruction -- References -- 6 - Ovarian stimulation and intrauterine insemination -- Introduction -- Definition and indications -- Ovarian stimulation protocols -- Natural cycle IUI -- Stimulated cycle IUI. , Combined protocols -- The use of a GnRH-antagonist in the last days of ovarian stimulation -- Efficacy and safety of the different protocols -- Cancellation criteria during stimulated IUI -- Final oocyte maturation and ovulation triggering and timing of insemination -- Bed rest -- Number of inseminations during treatment -- Luteal phase support -- Final remarks -- References -- 7 - Infertility care of the PCOS patient -- Introduction -- Preconception risk factors -- Weight loss and obesity -- Pharmacologic treatment strategies -- Metformin -- Letrozole -- Selective estrogen receptor modulators -- Gonadotropins -- Considerations for administration of ovulation induction agents -- In vitro fertilization/Intracytoplasmic sperm injection -- In vitro maturation -- Inositol -- Laparoscopic ovarian drilling -- Acupuncture, herbal remedies, and traditional Chinese medicine -- Conclusion -- References -- 8 - The GnRH antagonist protocol -- Introduction -- GnRH antagonist protocols -- Cetrorelix versus ganirelix -- GnRH antagonist fixed protocol -- GnRH antagonist flexible protocol -- Fixed versus flexible GnRH antagonist protocol -- Pretreatment with oral contraceptive pill in a GnRH antagonist cycle -- Elevated progesterone at initiation of stimulation in a GnRH antagonist cycle -- FSH dose in GnRH antagonist protocols -- Initiation of FSH dose in GnRH antagonist protocols -- Administration of antagonist in the early follicular phase -- Delayed start GnRH antagonist protocol -- Luteal GnRH antagonist administration -- Criteria for triggering final oocyte maturation -- GnRH antagonists and OHSS -- The modified natural cycle -- Use of GnRH antagonists in ovarian stimulation for intrauterine insemination -- Luteal phase support in antagonist cycles -- Alternative to GnRH antagonists LH suppression regimens -- References. , 9 - The long gonadotropin releasing hormone agonist IVF protocol -- Introduction -- A brief history of IVF attempts -- Natural cycle IVF -- IVF with exogeneous pharmacologic agents -- Shortcomings of early IVF protocols -- Gonadotropin-releasing hormone agonists -- Physiology, structure, and early studies -- GnRH-a and early IVF outcomes -- Current GnRH-a protocols -- Shortcomings of GnRH-a protocols -- Conclusions -- References -- 10 - Double stimulation in the same ovarian cycle (DuoStim) and luteal phase start IVF protocols -- Introduction -- Theories of folliculogenesis -- Definition of poor prognosis patients -- An unconventional ovarian stimulation protocol: luteal phase stimulation -- DuoStim for poor prognosis patients: the evidence up to date -- Framework of a DuoStim protocol -- Clinical indications for DuoStim -- DuoStim: is the second stimulation in the same ovarian cycle conducted in the luteal phase pf the cell cycle? -- Conclusions -- References -- 11 - The mild stimulation in vitro fertilization protocol -- Mild ovarian stimulation for IVF -- Background -- Concepts behind the mild ovarian stimulation protocol -- Oocyte competency -- Embryo quality and ploidy status -- Stimulation versus response -- Endometrial receptivity -- The protocol -- Antagonist vs Agonist -- What type of gonadotropin -- Gonadotropin dose -- Oral agents -- Why mild? -- Clinical effectiveness -- Perinatal outcomes -- Safety -- Patient's experience -- Cost -- Limitations -- Cumulative pregnancy outcome -- Goal of "completing family" -- Cycle cancellation -- Future prospects -- Disclosure of interests -- References -- 12 - The use of progestins to prevent the LH surge in IVF cycles -- Alternative protocols for ovarian stimulation -- Mechanism of pituitary suppression by progestins -- Progestins -- PPOS protocols: outcomes and schemes of treatment. , Advantages and limits.

Additional Edition: Print version: Dahan, Michael H. Handbook of Current and Novel Protocols for the Treatment of Infertility San Diego : Elsevier Science & Technology,c2023 ISBN 9780323856874

Language: English

UID:

Format: 1 online resource (466 pages)

Edition: 1st ed.

ISBN: 0-323-90106-9

Content: The field of Assisted Reproductive Technology (ART) is rapidly evolving and stimulation protocols, fertility strategies and aspects of infertility treatments are constantly being updated as advances and new discoveries are made. Handbook of Current and Novel Protocols for the Treatment of Infertility is a valuable resource of well-organized, comprehensive scientific data with practical guides and step-by-step protocols for infertility management. Written by world-wide experts, this book discusses different practice patterns and approaches used internationally and presents innovative topics including preimplantation genetic testing, time lapse imaging and the role of artificial intelligence in ART. This book provides up-to-date, evidence-based guidance on daily practice and is an important resource for infertility providers, including trainees or experienced clinicians, embryologist, and is geared for both specialist in reproductive medicine and gynecologists interested in increasing their knowledge in the field of reproductive endocrinology and intertility.

Note: Front Cover -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- HANDBOOK OF CURRENT AND NOVEL PROTOCOLS FOR THE TREATMENT OF INFERTILITY -- Copyright -- Dedication -- Contents -- List of contributors -- Preface -- 1 - The evaluation of the female infertility patient -- History assessment -- Physical exam -- Height and weight measurements, BMI calculation, and appearance -- Thyroid and breast -- Pelvic exam -- Pelvic ultrasound -- Evaluation of ovarian reserve -- Ovulation assessment -- Tubal patency evaluation -- Other investigations -- Conclusion -- References -- 2 - The fertility evaluation of the male partner -- Overview -- Clinical history -- Physical examination -- Semen analysis -- Hormonal evaluation -- Genetic studies -- Histopathology -- Conditions with special considerations -- Congenital bilateral absence of the vas deferens -- Ejaculatory duct obstruction -- Globozoospermia -- Recurrent pregnancy loss -- Surgical sperm extraction techniques -- Infertility and general health -- Summary -- References -- 3 - Sperm DNA fragmentation and male infertility: a comprehensive review for the clinicians -- Sperm genetics -- Sperm chromatin and DNA packaging -- Sperm contribution to the developing embryo -- Sperm DNA repair by oocyte: what we know and what we don't? -- How do sperm genetics become dysfunctional? -- Defective sperm chromatin packaging -- Abortive apoptosis -- Oxidative damage -- Single- or double-strand breaks: does it really matter? -- Which test to assess sperm chromatin integrity and SDF? -- Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling (TUNEL) assay -- Sperm chromatin structure assay (SCSA) -- Sperm chromatin dispersion (SCD) test -- In situ nick translation (NT) assay -- Comet assay -- Acridine orange test -- High-performance liquid chromatography. , Less commonly used tests for SDF assessment -- Etiologies and risk factors for SDF -- Varicocele -- Genital tract infection -- Aging -- Smoking and alcohol -- Obesity and overweight -- Occupational and environmental exposures -- The impact of SDF on male reproductive outcomes -- Implications of SDF on natural pregnancy -- Implications of SDF on ART outcomes -- Impact of SDF on offspring -- How to manage patients with high SDF? -- Addressing patient risk factors -- Use of antioxidants -- Use of ART -- Clinical practice guidelines and recommendations on SDF testing -- Limitations of sperm SDF testing in clinical practice? -- Updates in the recent research on SDF (2019-21) -- Clinical scenarios on SDF management -- Case 1 -- Case 2 -- Case 3 -- Conclusion -- References -- 4 - The evaluation and management of recurrent pregnancy loss -- Introduction -- Incidence and prevalence -- Etiology and risk factors -- Genetic causes -- Anatomic causes -- Congenital uterine anomalies -- Acquired uterine abnormalities -- Endocrine causes -- Thyroid dysfunction -- Hyperprolactinemia -- Polycystic ovary syndrome -- Insulin resistance -- Luteal phase deficiency -- Immune causes -- Autoimmune causes -- Alloimmune causes -- Inherited thrombophilia -- Infection -- Obesity/overweight/underweight -- Male factor -- Psychological factors -- Lifestyle and environmental factors -- Dietary factors -- Unexplained recurrent miscarriage -- Evaluation of RPL -- Genetic evaluation of RPL -- Parental karyotyping -- Cytogenetic testing of products of conception -- Anatomical evaluation -- Endocrinological evaluation -- Thyroid evaluation -- Insulin resistance evaluation -- Hyperprolactinemia evaluation -- Luteal phase deficiency evaluation -- Polycystic ovary syndrome evaluation -- Immunological testing -- Antiphospholipid antibody testing -- Alloimmunity testing. , Inherited thrombophilias evaluation -- Infections testing -- Male factor assessment -- Prevention -- Treatment -- Couples with structural chromosomal abnormalities -- Anatomical factor correction -- Congenital anatomical factors -- Acquired anatomical factors -- Uterine fibroids -- Intrauterine adhesions -- Uterine polyp -- Cervical insufficiency -- Management of endocrine factors -- Treatment of thyroid dysfunction associated with RPL -- Treatment of luteal phase deficiency and RPL -- Treatment of polycystic ovary syndrome and insulin resistance in women with RPL -- Treatment of hyperprolactinemia and RPL -- Treatment of immunological disorders with RPL -- Treatment of antiphospholipid antibody syndrome with RPL -- Treatment of inherited thrombophilia in women with RPL -- Treatment of infections with RPL -- Treatment of male factor in RPL couples -- Psychological support in RPL patients -- Couples with unexplained recurrent pregnancy loss -- Role of progesterone in unexplained recurrent miscarriage -- Role of immunotherapy in unexplained recurrent miscarriage -- ASA and low-molecular weight heparin in unexplained recurrent pregnancy loss -- Preimplantation genetic testing for aneuploidy in patients with unexplained RPL -- Endometrial scratch in women with RPL -- Future directions -- Conclusion -- References -- 5 - The role of surgery in infertility, an evidence-based approach -- Introduction -- Congenital uterine abnormalities -- Uterine septum -- Dysmorphic uterus -- Acquired uterine pathology -- Endometrial polyps -- Intrauterine adhesions -- Fibroids -- Isthmocele -- Tubal pathology -- Distal tubal obstruction -- Proximal tubal obstruction -- References -- 6 - Ovarian stimulation and intrauterine insemination -- Introduction -- Definition and indications -- Ovarian stimulation protocols -- Natural cycle IUI -- Stimulated cycle IUI. , Combined protocols -- The use of a GnRH-antagonist in the last days of ovarian stimulation -- Efficacy and safety of the different protocols -- Cancellation criteria during stimulated IUI -- Final oocyte maturation and ovulation triggering and timing of insemination -- Bed rest -- Number of inseminations during treatment -- Luteal phase support -- Final remarks -- References -- 7 - Infertility care of the PCOS patient -- Introduction -- Preconception risk factors -- Weight loss and obesity -- Pharmacologic treatment strategies -- Metformin -- Letrozole -- Selective estrogen receptor modulators -- Gonadotropins -- Considerations for administration of ovulation induction agents -- In vitro fertilization/Intracytoplasmic sperm injection -- In vitro maturation -- Inositol -- Laparoscopic ovarian drilling -- Acupuncture, herbal remedies, and traditional Chinese medicine -- Conclusion -- References -- 8 - The GnRH antagonist protocol -- Introduction -- GnRH antagonist protocols -- Cetrorelix versus ganirelix -- GnRH antagonist fixed protocol -- GnRH antagonist flexible protocol -- Fixed versus flexible GnRH antagonist protocol -- Pretreatment with oral contraceptive pill in a GnRH antagonist cycle -- Elevated progesterone at initiation of stimulation in a GnRH antagonist cycle -- FSH dose in GnRH antagonist protocols -- Initiation of FSH dose in GnRH antagonist protocols -- Administration of antagonist in the early follicular phase -- Delayed start GnRH antagonist protocol -- Luteal GnRH antagonist administration -- Criteria for triggering final oocyte maturation -- GnRH antagonists and OHSS -- The modified natural cycle -- Use of GnRH antagonists in ovarian stimulation for intrauterine insemination -- Luteal phase support in antagonist cycles -- Alternative to GnRH antagonists LH suppression regimens -- References. , 9 - The long gonadotropin releasing hormone agonist IVF protocol -- Introduction -- A brief history of IVF attempts -- Natural cycle IVF -- IVF with exogeneous pharmacologic agents -- Shortcomings of early IVF protocols -- Gonadotropin-releasing hormone agonists -- Physiology, structure, and early studies -- GnRH-a and early IVF outcomes -- Current GnRH-a protocols -- Shortcomings of GnRH-a protocols -- Conclusions -- References -- 10 - Double stimulation in the same ovarian cycle (DuoStim) and luteal phase start IVF protocols -- Introduction -- Theories of folliculogenesis -- Definition of poor prognosis patients -- An unconventional ovarian stimulation protocol: luteal phase stimulation -- DuoStim for poor prognosis patients: the evidence up to date -- Framework of a DuoStim protocol -- Clinical indications for DuoStim -- DuoStim: is the second stimulation in the same ovarian cycle conducted in the luteal phase pf the cell cycle? -- Conclusions -- References -- 11 - The mild stimulation in vitro fertilization protocol -- Mild ovarian stimulation for IVF -- Background -- Concepts behind the mild ovarian stimulation protocol -- Oocyte competency -- Embryo quality and ploidy status -- Stimulation versus response -- Endometrial receptivity -- The protocol -- Antagonist vs Agonist -- What type of gonadotropin -- Gonadotropin dose -- Oral agents -- Why mild? -- Clinical effectiveness -- Perinatal outcomes -- Safety -- Patient's experience -- Cost -- Limitations -- Cumulative pregnancy outcome -- Goal of "completing family" -- Cycle cancellation -- Future prospects -- Disclosure of interests -- References -- 12 - The use of progestins to prevent the LH surge in IVF cycles -- Alternative protocols for ovarian stimulation -- Mechanism of pituitary suppression by progestins -- Progestins -- PPOS protocols: outcomes and schemes of treatment. , Advantages and limits.

Additional Edition: Print version: Dahan, Michael H. Handbook of Current and Novel Protocols for the Treatment of Infertility San Diego : Elsevier Science & Technology,c2023 ISBN 9780323856874

Language: English