UID:
almafu_9959632688202883
Format:
1 online resource (xiv, 453 pages) :
,
illustrations.
ISBN:
9781683671749
,
1683671740
Content:
"This work examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the experimental rabbit model. Tuberculosis in the rabbit model most closely resembles that found in humans, including caseous necrosis, liquefaction, and cavity formation with bronchial spread of the disease. Other animal models-mouse, guinea pig, and monkey-are compared with the rabbit and human models." "Authored by an experienced and noted expert in the field, Pathogenesis of Human Pulmonary Tuberculosis reviews the interplay of delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses. The pathology and structure of tuberculous lesions are thoroughly investigated. Other significant topics discussed include the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development. The final chapter describes many areas in which future research could contribute to our knowledge, treatment, and control of this disease. The text is complemented by high-quality illustrations of both human and rabbit disease. Pathogenesis of Human Pulmonary Tuberculosis updates and revises the ground-breaking work of Max B. Lurie, summarizing the combined 80 years of research by Drs. Lurie and Dannenberg. The book offers a comprehensive resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology. Book jacket."--BOOK JACKET.
Note:
Stages in the pathogenesis of human and rabbit tuberculosis -- Types of human pulmonary tuberculosis -- Liquefaction of caseous foci and cavity formation -- Delayed-type hypersensitivity, cell-mediated immunity, and antibodies in tuberculosis -- Macrophages and other cells in tuberculous lesions -- Structural components of tuberculous lesions -- Microvascular density in tuberculous lesions -- Early pulmonary lesions in rabbits -- Macrophage turnover, division, and activation in tuberculous lesions -- Lurie's pulmonary Tubercle-count method -- Natural airborne infection -- Response of rabbits to inhaled tubercle bacilli including BCG-- Characteristics of resistance and susceptibility to tuberculosis in Lurie's inbred rabbits -- Comparisons of tuberculosis in rabbits, mice, and guinea pigs -- Effects of cortisone and adrenocorticotropic hormone on tuberculosis -- Effects of estrogen, chorionic gonadotropin, and thyroid hormone on tuberculosis -- Effects of whole-body X-irradiation on tuberculosis -- Cytokine production in primary BCG lesions -- Cytokine production in reinfection bcg lesions and in tuberculin reactions -- Vascular adhesion molecules in tuberculous lesions -- Principles and guidelines for developing better tuberculosis vaccines -- Characteristics of rabbit BCG lesions and efficacies of BCG and mycobacterium microti vaccines.
Additional Edition:
Print version: Dannenberg, Arthur M. Pathogenesis of human pulmonary tuberculosis. Washington, D.C. : ASM Press, ©2006 ISBN 1555813739
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1128/9781555815684
URL:
https://onlinelibrary.wiley.com/doi/book/10.1128/9781555815684
URL:
https://onlinelibrary.wiley.com/doi/book/10.1128/9781555815684
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