UID:
almafu_9961426817702883
Format:
1 video recording (51 min., 32 sec.) :
,
sound, color
,
005132
Note:
Retrieved April 8, 2024, from https://hstalks.com/bs/2077/.
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Introduction -- In search of novel drugs against new targets -- The HIV replication cycle -- Cellular cofactors as novel antiviral targets -- Algorithm to identify and validate new cofactors (1) -- Algorithm to identify and validate new cofactors (2) -- Two novel integrase cofactors -- Identification of LEDGF: binding partner of integrase -- LEDGF/p75 identified by co-immunoprecipitation -- Lens epithelium-derived growth factor -- LEDGF properties -- Characterization of the interaction (1) -- Integrase and LEDGF co-localize in the nucleus -- LEDGF/p75 stimulates in vitro integrase activity -- LEDGF/p75 tethers HIV-1 IN to the chromatin -- Characterization of the interaction (2) -- Co-crystal structure.
Language:
English
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