Format:
1 online resource (848 pages).
ISBN:
978-0-12-812033-0
Content:
Front Cover -- SECOND GENERATION CELL AND GENE-BASED THERAPIES -- SECOND GENERATION CELL AND GENE-BASED THERAPIES -- Copyright -- Contents -- List of Contributors -- Foreword -- Preface -- 1 - Science -- 1 - Innovation S-Curves in Living Drugs Development and Their Commercialisation -- INTRODUCTION -- S-CURVE PATTERNS IN INDUSTRIAL PRODUCT EMERGENCE -- THE BOTTOM-LINE IMPACT OF THE SUCCESSFUL ADOPTION OF A RADICAL INNOVATION -- BLACK SWAN RISK: THE CONSEQUENCES OF NONADOPTION OF A RADICAL INNOVATION -- THE BIG PHARMAS AND RADICAL INNOVATION ADOPTION -- POLICIES AND REGULATORY FRAMEWORKS AS ACCELERATORS OF TECHNOLOGY ADOPTION AND DEPLOYMENT -- PREDICTING TECHNOLOGICAL PROGRESS: CRITICAL INNOVATION CHUNKS OF THE CAR-T S-ŁCURVE -- PERSPECTIVES -- REFERENCES -- 2 - Development and Deployment of Gene Therapies: An ADA- SCID Case Study -- INTRODUCTION -- HISTORY -- Early Development -- Vector Development -- Early ADA-SCID Gene Therapy -- Early Gene Therapy Failures -- First Approvals -- STRIMVELIS DEVELOPMENT -- Strategic Alliance -- Strimvelis Efficacy -- Strimvelis Registry -- Success of Strimvelis -- Vector Improvement -- Collaboration and Division of Expertise -- Treatment Manufacturing -- BUSINESS -- PAYMENT AND REIMBURSEMENT FOR CURATIVE TREATMENTS -- PERSPECTIVES -- Limited Patient Population -- Future Research Funding -- Technology -- ABBREVIATIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- 3 - Therapeutic Potential of Cells of the Immune System -- INTRODUCTION -- γδ T CELLS AND THE RECOGNITION OF MALIGNANT DISEASE - MULTIPLE WEAPONS, MULTIPLE TARGETS -- Vδ2+ T Cells -- Vδ1+ T Cells -- Regulatory γδ T Cells -- Potential for γδ T Cells as Primary Effectors in Immunotherapy of Cancer -- In vivo Activation and Expansion of γδ T Cells -- Autologous γδ T cell Therapy
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
ISBN 9780128120347
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9780128120347
Language:
English
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