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  • 1
    Online Resource
    Online Resource
    Economic benefit of Tuberculosis control / (2007)
    Washington, D.C., : The World Bank,
    Details
    UID:
    almafu_9958062371302883
    Format: 1 online resource (59 pages)
    Series Statement: Policy research working papers.
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV.
    Language: English
    DOI: 10.1596/1813-9450-4295
    URL: Volltext
    URL: Volltext  (Deutschlandweit zugänglich)
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    HWR Berlin
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    EUV Frankfurt
    TH Brandenburg
    HTW Berlin
    Charité
    MPI Bildungsforschung
  • 2
    Online Resource
    Online Resource
    Economic benefit of Tuberculosis control (2007)
    Washington, D.C : The World Bank
    Details
    UID:
    b3kat_BV049074328
    Format: 1 Online-Ressource (59 Seiten))
    Edition: Online-Ausg
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV
    Additional Edition: Adeyi, Olusoji Economic benefit of Tuberculosis control
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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    Online Access
    EUV Frankfurt
    HTW Berlin
  • 3
    Book
    Book
    After 2015 : infectious diseases in a new era of health and development ; papers of a Theme Issue (2014)
    London : The Royal Society
    Details
    UID:
    gbv_786140429
    Format: getr. Pag. , Ill., graph. Darst. , 30 cm
    ISBN: 9781782520702
    Series Statement: Philosophical transactions 369.2014, Nr. 1645
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Book
    Akademie d. Wiss. get availability status
  • 4
    Online Resource
    Online Resource
    Economic Benefit of Tuberculosis Control (2012)
    Washington, DC : World Bank
    Details
    UID:
    gbv_797535772
    Format: Online-Ressource
    Series Statement: Policy Research Working Paper 4295
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV.
    Note: English
    Language: English
    URL: Volltext  (kostenfrei)
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Fulltext
    Stabi Berlin
  • 5
    Online Resource
    Online Resource
    Economic benefit of Tuberculosis control / (2007)
    Washington, D.C., : The World Bank,
    Details
    UID:
    edocfu_9958062371302883
    Format: 1 online resource (59 pages)
    Series Statement: Policy research working papers.
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV.
    Language: English
    DOI: 10.1596/1813-9450-4295
    Library Location Call Number Volume/Issue/Year Availability
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    Open Access Request
    FU Berlin
  • 6
    Online Resource
    Online Resource
    Economic benefit of Tuberculosis control / (2007)
    Washington, D.C., : The World Bank,
    Details
    UID:
    edoccha_9958062371302883
    Format: 1 online resource (59 pages)
    Series Statement: Policy research working papers.
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV.
    Language: English
    DOI: 10.1596/1813-9450-4295
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Open Access Request
    Charité
  • 7
    Online Resource
    Online Resource
    Drug resistant tuberculosis : biology, epidemiology and control (2015)
    London :Henry Stewart Talks Ltd,
    Details
    UID:
    almafu_9961426823302883
    Format: 1 videorecording (32 min., 27 sec.) : , sound, color. , 003325
    Series Statement: Henry Stewart talks
    Note: Introduction -- Why TB patients are treated with drugs -- Natural history and control of TB -- Streptomycin in TB treatment -- Combination therapy of TB -- DOTS strategy (1) -- DOTS strategy (2) -- Reduction in TB death rate -- How drug resistance arises -- Resistance genes -- Mechanism of resistance -- Evolution of resistance by natural selection -- Resistance causes treatment failure -- Initial resistance assists resistance to other drugs -- Risk of acquiring resistance after treatment failure -- Duration and regimen effect on MDR-TB cure rates -- Rifampin-resistant mutants of TB (1) -- Rifampin-resistant mutants of TB (2) -- Isoniazid resistant TB and MDR-TB: fitness -- Geographical distribution of drug resistant TB -- Treatment success reaches 85 percent target -- Reasons for treatment failure under DOTS -- Retreatment proportion: China vs. India -- Cure rates are lower for MDR-TB patients -- 510,000 people developed MDR-TB in 2007 -- MDR-TB among previously treated TB patients -- Countries reporting at least one XDR-TB case -- TB drug resistance and HIV -- XDR-TB outbreak in SA and HIV (1) -- XDR-TB outbreak in SA and HIV (2) -- Drug resistant TB is linked to HIV coinfection -- Reversing the spread of drug resistant TB -- TB rates in Europe and Africa -- Benign epidemic -- Severe epidemic -- TB strain prevalence: the USA -- TB strain prevalence: Hong Kong -- TB strain prevalence: Estonia -- TB strain prevalence: Russia -- Reproduction numbers world wide -- Reversing the spread of MDR-TB -- Spread of Beijing TB strains in Cape Town -- Summary -- References.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Charité
  • 8
    Online Resource
    Online Resource
    The Population Biology of Tuberculosis / (2015)
    Princeton, NJ :Princeton University Press,
    Details
    UID:
    almafu_9961326490502883
    Format: 1 online resource (296 p.) : , 85 halftones. 7 tables.
    Edition: Course Book
    ISBN: 9781400866571
    Series Statement: Monographs in Population Biology ; 54
    Content: Despite decades of developments in immunization and drug therapy, tuberculosis remains among the leading causes of human mortality, and no country has successfully eradicated the disease. Reenvisioning tuberculosis from the perspective of population biology, this book examines why the disease is so persistent and what must be done to fight it. Treating tuberculosis and its human hosts as dynamic, interacting populations, Christopher Dye seeks new answers to key questions by drawing on demography, ecology, epidemiology, evolution, and population genetics. Dye uses simple mathematical models to investigate how cases and deaths could be reduced, and how interventions could lead to TB elimination.Dye's analysis reveals a striking gap between the actual and potential impact of current interventions, especially drug treatment, and he suggests placing more emphasis on early case detection and the treatment of active or incipient tuberculosis. He argues that the response to disappointingly slow rates of disease decline is not to abandon long-established principles of chemotherapy, but to implement them with greater vigor. Summarizing epidemiological insights from population biology, Dye stresses the need to take a more inclusive view of the factors that affect disease, including characteristics of the pathogen, individuals and populations, health care systems, and physical and social environments.In broadening the horizons of TB research, The Population Biology of Tuberculosis demonstrates what must be done to prevent, control, and defeat this global threat in the twenty-first century.
    Note: Frontmatter -- , Contents -- , Preface -- , CHAPTER 1. Tuberculosis Undefeated -- , CHAPTER 2. Concepts and Models -- , CHAPTER 3. Risk and Variation -- , CHAPTER 4. Interventions and Control -- , CHAPTER 5. Strains and Drug Resistance -- , CHAPTER 6. TB and HIV/AIDS -- , CHAPTER 7. Elimination and Eradication -- , CHAPTER 8. Populations and Social Diseases -- , APPENDIX 1. Derivation of the Basic Case Reproduction Number and Epidemic Doubling Time -- , APPENDIX 2. Formal Description of the Standard Model -- , References -- , Index -- , Backmatter , Issued also in print. , In English.
    Additional Edition: ISBN 9780691154626
    Language: English
    DOI: 10.1515/9781400866571
    URL: https://doi.org/10.1515/9781400866571?locatt=mode:legacy
    URL: https://www.degruyter.com/isbn/9781400866571
    URL: https://doi.org/10.1515/9781400866571?locatt=mode:legacy
    URL: https://www.degruyter.com/isbn/9781400866571
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    FU Berlin
  • 9
    Online Resource
    Online Resource
    The TB and HIV/AIDS Epidemics in the Russian Federation (2013)
    Washington, DC : World Bank
    Details
    UID:
    gbv_79785469X
    Format: Online-Ressource
    ISBN: 0821349643
    Series Statement: World Bank Technical Paper 510
    Content: The Russian Federation has been confronting a major epidemiological crisis, which will have considerable human and economic costs if it is not swiftly addressed. Between 1999 and 2000, the country experienced the world's biggest increase in new cases of HIV/AIDS infection. The TB epidemic is at risk of becoming uncontrollable if the country experiences a moderate epidemic of HIV/AIDS. This report represents the analysis and recommendations of a group of experts from the World Health Organization and the World Bank, and focuses on the current epidemiological situation in the Russian Federation and the existing institutional arrangements available to tackle both epidemics. It encompasses projections for the TB epidemic, the interaction with the HIV/AIDS epidemic, and the impact of a spiraling duel epidemic. The report has four sections. The first briefly describes socioeconomic conditions. The second section discusses the impact on the population of the epidemic, incidence and prevalence in the general and prison populations, diagnosis and treatment processes, and current TB management and control structures. The third section profiles the HIV/AIDS epidemic and its impact, and the role of STIs in fostering the disease. Finally, the fourth section describes a mathematical model of health improvements possible under various TB control strategies with implications for HIV/aids as well.
    Note: English , en_US
    Language: English
    URL: Volltext  (kostenfrei)
    URL: kostenfrei
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    Fulltext
    Stabi Berlin
  • 10
    Online Resource
    Online Resource
    The great health dilemma : is prevention better than cure? (2021)
    Oxford :Oxford University Press,
    Details
    UID:
    almahu_9949102706502882
    Format: 1 online resource (224 pages) : , illustrations (black and white).
    Edition: First edition.
    ISBN: 9780191888205 (ebook) :
    Series Statement: Oxford scholarship online
    Content: The proverbial benefits of prevention over cure are self-evident and yet we are reluctant to invest in staying healthy. Resolution of this age-old dilemma begins with a timeless truth: the benefits of good health come at a cost; prevention is not better than cure at any price. That logic leads to the testable hypothesis that prevention should be favoured when an imminent, high-risk, high-impact hazard can be averted at relatively low cost. Much more money and effort are invested in health promotion and prevention today than is commonly thought, but the enormous avoidable burden of illness is reason to seek ways of investing further. This book provides a framework for investigating prevention and illustrates the application of principles with practical examples.
    Note: This edition also issued in print: 2021.
    Additional Edition: Print version : ISBN 9780198853824
    Language: English
    URL: Oxford scholarship online
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    HU Berlin
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