Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (401 pages)

ISBN: 0-12-813361-9

Note: Front Cover -- Coronary Microvascular Obstruction in Acute Myocardial Infarction -- Copyright Page -- Contents -- List of Contributors -- Preface -- 1 Pathogenesis of ST-Elevation Myocardial Infarction -- Introduction -- Development of Coronary Atherosclerosis and Plaque De-Stabilization -- Endothelium and Vascular Function -- Progression of Vascular Damage: Smooth Muscle Cells and Extracellular Matrix -- Complication by Inflammation: Innate and Acquired Immunity -- High-Risk Plaques and Atherothrombosis -- Characteristics of Acute Intracoronary Thrombosis -- Platelets in Coronary Thrombosis -- Activation of the Coagulation Cascade -- Platelet Released Microvesicles -- Characteristics of Myocardial Ischemia and Cardiomyocyte Necrosis -- Biochemical Markers for Detecting Myocardial Necrosis -- Tissue Infarction and Myocardial Damage -- References -- Further Reading -- 2 Reperfusion Therapy in ST-Elevation Myocardial Infarction -- Fibrinolytic Therapy in ST-Segment-Elevation Myocardial Infarction -- "Rescue" and Early Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction Following Thrombolysis -- "Primary" Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction -- Primary Percutaneous Coronary Intervention Versus Thrombolysis -- Primary Percutaneous Coronary Intervention With or Without "Stenting" for the Treatment of ST-Segment-Elevation Myocardial ... -- Early Thrombolysis With Delayed Percutaneous Coronary Intervention: The "Pharmaco-Invasive" Strategy -- Multivessel Coronary Artery Disease in ST-Segment-Elevation Myocardial Infarction -- Cardiogenic Shock and Resuscitated Cardiac Arrest -- Adjunctive Interventions and Pharmacotherapy to Improve Outcomes in ST-Segment-Elevation Myocardial Infarction -- Dual Antiplatelet Therapy -- Glycoprotein IIb/IIIa Platelet Receptor Inhibitors. , Manual Thrombus Aspiration -- Radial Versus Femoral Arterial Primary Percutaneous Coronary Intervention Access -- New-Generation Drug-Eluting Stents -- Future Advances to Optimize Clinical Outcomes in ST-Segment-Elevation Myocardial Infarction -- References -- 3 Epidemiology of Coronary Microvascular Obstruction -- Introduction -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Primary Percutaneous Coronary Intervention Accordi... -- Angiographic Indexes -- Cardiac Magnetic Resonance -- Myocardial Contrast Echocardiography -- Electrocardiographic ST-Resolution -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Thrombolysis -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Rescue Primary Percutaneous Coronary Intervention -- Incidence of Coronary Microvascular Obstruction in Specific Subset of Patients -- Diabetes -- Women -- Chronic Kidney Disease -- Saphenous Vein Graft -- Latecomers -- Conclusions -- References -- 4 Individual Predisposition to Coronary Microvascular Obstruction -- Introduction -- Coronary Microvascular Physiology -- Risk Factors for Coronary Microvascular Disease -- Contributions of Coronary Microvascular Function to Subsequent Microvascular Obstruction -- Prevention Strategies to Improve Microvascular Function -- Lifestyle Modification-Diet and Exercise -- Nitrates -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Beta-Blockers -- Calcium Channel Antagonists -- Statins -- Ranolazine -- Phosphodiesterase Inhibition -- L-Arginine -- Conclusions -- References -- 5 Coronary Microembolization and Microvascular Dysfunction -- Highlights -- Morphology -- Pathophysiology -- Coronary Microembolization in Cardiac Imaging -- Coronary Microembolization Versus Cardioprotection -- In Vitro Characterization of Coronary Aspirate From Patients Undergoing PCI. , Coronary Microembolization Versus Coronary Microvascular Dysfunction-A Perspective -- References -- 6 Role of Ischemia-Reperfusion Injury in Coronary MVO -- Oxygen Free Radicals -- Microvascular Dysfunction -- Microvascular Compression -- Neutrophil Plugging -- Microthrombi Formation -- Soluble Vasoconstrictors and Thrombogenic Factors -- Postreperfusion Hemorrhage -- References -- 7 Angiography and Electrocardiography (ECG) for the Assessment of Coronary Microvascular Obstruction -- Coronary Angiography -- Thrombolysis in Myocardial Infarction Flow Score -- Thrombolysis in Myocardial Infarction (TIMI) Frame Count -- Other Angiographic Parameters to Describe the Effectiveness of Myocardial Reperfusion -- Myocardial Blush Grades -- TIMI Myocardial Perfusion Grade -- Electrocardiogram -- ST Resolution Quantification -- ST-Segment Elevation Resolution and Diagnosis of Microvascular Obstruction -- Correlation of STR with Other Imaging Techniques of MVO -- Postprocedural Residual Cumulative ST-Segment Deviation and ST Depression Resolution -- Q Waves and QRS for Prediction of Poor Microvascular Reperfusion -- References -- 8 Invasive Assessment of Coronary Microvascular Obstruction -- Introduction -- Invasive Techniques for Assessment of Microvascular Obstruction -- Angiography-Based Techniques -- TIMI Flow Grade -- Corrected TIMI Frame Count -- Myocardial Blush Grade and TIMI Myocardial Perfusion Grade -- Quantitative Blush Evaluator -- Intracoronary Doppler-Based Techniques -- Diastolic Flow Deceleration and Systolic Flow Reversal -- Coronary Flow Velocity Reserve -- Hyperemic Microvascular Resistance -- Zero-Flow Pressure -- Wave Intensity Analysis -- Thermodilution-Derived Techniques -- Thermodilution-Derived Coronary Flow Reserve -- Index of Microcirculatory Resistance -- Absolute Coronary Blood Flow Assessment -- Conclusion -- References. , 9 Imaging Modalities for the Assessment of CMVO -- Imaging Modalities for the Assessment of CMVO -- Myocardial Scintigraphy and PET -- Computed Tomography -- Myocardial Contrast Echocardiography -- CMR Imaging -- Conclusions -- References -- 10 Intracoronary Imaging for Assessing the Risk of Coronary Microvascular Obstruction -- Introduction -- Intravascular Ultrasound -- Optical Coherence Tomography -- Other Imaging Modalities -- Conclusions -- References -- 11 A Comprehensive Prognostic Assessment of ST-Elevation Myocardial Infarction by Cardiac MRI -- Introduction -- Myocardial Function -- Left Ventricular Ejection Fraction -- Other Parameters of Left Myocardial Function -- Right Myocardial Function -- Infarct Size -- Microvascular Injury -- Microvascular Obstruction -- Intramyocardial Hemorrhage -- Myocardial Salvage -- Remote Myocardium -- References -- 12 Prognosis of Coronary Microvascular Obstruction -- Introduction -- ST-Segment Resolution -- Coronary Angiography -- Invasive Assessment -- Cardiac Magnetic Resonance -- References -- 13 Prevention of Coronary Microvascular Obstruction by Addressing the Individual Susceptibility -- Introduction -- Pre-Existent Microvascular Dysfunction -- Major Cardiovascular Risk Factors -- Hyperglycemia -- Hypercolesterolemia -- Arterial Hypertension -- Smoking -- Aging -- Gender -- Minor Cardiovascular Risk Factors -- Inflammation -- Hyperhomocystinemia -- Renal Dysfunction -- Genetic Factors -- Ischemic Pre-Conditioning and Its Modulation -- Therapies for the Improvement of Individual Susceptibility -- Conclusions -- References -- 14 Prevention of Coronary Microvascular Obstruction by Addressing Distal Embolization -- Pathophysiology of Microvascular Obstruction and Distal Embolization -- Thrombus Aspiration Catheters -- Evidence for Manual Thrombus Aspiration. , Thrombus Aspiration in Patients with High Thrombus Burden -- Distal Embolic Protection Devices -- Mesh Covered Stents -- Direct Stenting -- Deferred Stenting -- Intra Coronary Thrombolysis -- Potential for Therapy to Cause Harm -- Conclusion -- Acknowledgements -- References -- 15A Prevention of Coronary Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part A: Antiplatelets, Stati... -- Introduction -- Scientific Evidence -- Antiplatelets -- Glycoprotein IIb/IIIa Inhibitors -- P2Y12 Receptor Antagonists -- Statins -- Vasodilators -- Adenosine -- Nitroprusside -- Nicorandil -- Calcium Channel Blockers -- Natriuretic Peptides -- Other Vasodilators -- Summary of Evidence and Guideline Recommendations -- Conclusions and Future Perspective -- References -- 15B Prevention of Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part B: Cardioprotective Therapies -- Pharmacological Therapies -- Agents Targeting Mitochondrial Integrity -- Cyclosporine A -- Bendavia -- Translocator Protein 18kDa Antagonist, TRO40303 (MITOCARE) -- Protein Kinase C Inhibitors: Delcasertib, KAI-9803 -- Glucose Modulators -- Glucose-Insulin-Potassium -- Antidiabetic Drugs -- Beta-Blockers -- Metoprolol -- Carvedilol and Nebivolol -- Short Half-Life Beta-Blockers: Esmolol and Landiolol -- Atrial Natriuretic Peptide -- Inhaled Oxygen -- N-Acetylcysteine -- Erythropoietin -- Mechanical Therapies -- Ischemic Conditioning -- Ischemic Pre-Conditioning -- Ischemic Post-Conditioning -- Remote Ischemic Conditioning -- Hypothermia -- Other Mechanical Therapies -- References -- 16 Why Did All Treatments of Reperfusion Injury Failed in Humans? -- Reperfusion Injury: A Brief Historical Overview -- Experimental Demonstration of Protection Against Reperfusion Injury -- First Clinical Evidence of Reperfusion Injury in Acute Myocardial Infarction Patients. , Questioning the Clinical Benefit of Preventing Lethal Myocardial Reperfusion Injury.

Additional Edition: ISBN 0-12-812528-4

Language: English

UID:

Format: 1 online resource (401 pages)

ISBN: 0-12-813361-9

Note: Front Cover -- Coronary Microvascular Obstruction in Acute Myocardial Infarction -- Copyright Page -- Contents -- List of Contributors -- Preface -- 1 Pathogenesis of ST-Elevation Myocardial Infarction -- Introduction -- Development of Coronary Atherosclerosis and Plaque De-Stabilization -- Endothelium and Vascular Function -- Progression of Vascular Damage: Smooth Muscle Cells and Extracellular Matrix -- Complication by Inflammation: Innate and Acquired Immunity -- High-Risk Plaques and Atherothrombosis -- Characteristics of Acute Intracoronary Thrombosis -- Platelets in Coronary Thrombosis -- Activation of the Coagulation Cascade -- Platelet Released Microvesicles -- Characteristics of Myocardial Ischemia and Cardiomyocyte Necrosis -- Biochemical Markers for Detecting Myocardial Necrosis -- Tissue Infarction and Myocardial Damage -- References -- Further Reading -- 2 Reperfusion Therapy in ST-Elevation Myocardial Infarction -- Fibrinolytic Therapy in ST-Segment-Elevation Myocardial Infarction -- "Rescue" and Early Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction Following Thrombolysis -- "Primary" Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction -- Primary Percutaneous Coronary Intervention Versus Thrombolysis -- Primary Percutaneous Coronary Intervention With or Without "Stenting" for the Treatment of ST-Segment-Elevation Myocardial ... -- Early Thrombolysis With Delayed Percutaneous Coronary Intervention: The "Pharmaco-Invasive" Strategy -- Multivessel Coronary Artery Disease in ST-Segment-Elevation Myocardial Infarction -- Cardiogenic Shock and Resuscitated Cardiac Arrest -- Adjunctive Interventions and Pharmacotherapy to Improve Outcomes in ST-Segment-Elevation Myocardial Infarction -- Dual Antiplatelet Therapy -- Glycoprotein IIb/IIIa Platelet Receptor Inhibitors. , Manual Thrombus Aspiration -- Radial Versus Femoral Arterial Primary Percutaneous Coronary Intervention Access -- New-Generation Drug-Eluting Stents -- Future Advances to Optimize Clinical Outcomes in ST-Segment-Elevation Myocardial Infarction -- References -- 3 Epidemiology of Coronary Microvascular Obstruction -- Introduction -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Primary Percutaneous Coronary Intervention Accordi... -- Angiographic Indexes -- Cardiac Magnetic Resonance -- Myocardial Contrast Echocardiography -- Electrocardiographic ST-Resolution -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Thrombolysis -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Rescue Primary Percutaneous Coronary Intervention -- Incidence of Coronary Microvascular Obstruction in Specific Subset of Patients -- Diabetes -- Women -- Chronic Kidney Disease -- Saphenous Vein Graft -- Latecomers -- Conclusions -- References -- 4 Individual Predisposition to Coronary Microvascular Obstruction -- Introduction -- Coronary Microvascular Physiology -- Risk Factors for Coronary Microvascular Disease -- Contributions of Coronary Microvascular Function to Subsequent Microvascular Obstruction -- Prevention Strategies to Improve Microvascular Function -- Lifestyle Modification-Diet and Exercise -- Nitrates -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Beta-Blockers -- Calcium Channel Antagonists -- Statins -- Ranolazine -- Phosphodiesterase Inhibition -- L-Arginine -- Conclusions -- References -- 5 Coronary Microembolization and Microvascular Dysfunction -- Highlights -- Morphology -- Pathophysiology -- Coronary Microembolization in Cardiac Imaging -- Coronary Microembolization Versus Cardioprotection -- In Vitro Characterization of Coronary Aspirate From Patients Undergoing PCI. , Coronary Microembolization Versus Coronary Microvascular Dysfunction-A Perspective -- References -- 6 Role of Ischemia-Reperfusion Injury in Coronary MVO -- Oxygen Free Radicals -- Microvascular Dysfunction -- Microvascular Compression -- Neutrophil Plugging -- Microthrombi Formation -- Soluble Vasoconstrictors and Thrombogenic Factors -- Postreperfusion Hemorrhage -- References -- 7 Angiography and Electrocardiography (ECG) for the Assessment of Coronary Microvascular Obstruction -- Coronary Angiography -- Thrombolysis in Myocardial Infarction Flow Score -- Thrombolysis in Myocardial Infarction (TIMI) Frame Count -- Other Angiographic Parameters to Describe the Effectiveness of Myocardial Reperfusion -- Myocardial Blush Grades -- TIMI Myocardial Perfusion Grade -- Electrocardiogram -- ST Resolution Quantification -- ST-Segment Elevation Resolution and Diagnosis of Microvascular Obstruction -- Correlation of STR with Other Imaging Techniques of MVO -- Postprocedural Residual Cumulative ST-Segment Deviation and ST Depression Resolution -- Q Waves and QRS for Prediction of Poor Microvascular Reperfusion -- References -- 8 Invasive Assessment of Coronary Microvascular Obstruction -- Introduction -- Invasive Techniques for Assessment of Microvascular Obstruction -- Angiography-Based Techniques -- TIMI Flow Grade -- Corrected TIMI Frame Count -- Myocardial Blush Grade and TIMI Myocardial Perfusion Grade -- Quantitative Blush Evaluator -- Intracoronary Doppler-Based Techniques -- Diastolic Flow Deceleration and Systolic Flow Reversal -- Coronary Flow Velocity Reserve -- Hyperemic Microvascular Resistance -- Zero-Flow Pressure -- Wave Intensity Analysis -- Thermodilution-Derived Techniques -- Thermodilution-Derived Coronary Flow Reserve -- Index of Microcirculatory Resistance -- Absolute Coronary Blood Flow Assessment -- Conclusion -- References. , 9 Imaging Modalities for the Assessment of CMVO -- Imaging Modalities for the Assessment of CMVO -- Myocardial Scintigraphy and PET -- Computed Tomography -- Myocardial Contrast Echocardiography -- CMR Imaging -- Conclusions -- References -- 10 Intracoronary Imaging for Assessing the Risk of Coronary Microvascular Obstruction -- Introduction -- Intravascular Ultrasound -- Optical Coherence Tomography -- Other Imaging Modalities -- Conclusions -- References -- 11 A Comprehensive Prognostic Assessment of ST-Elevation Myocardial Infarction by Cardiac MRI -- Introduction -- Myocardial Function -- Left Ventricular Ejection Fraction -- Other Parameters of Left Myocardial Function -- Right Myocardial Function -- Infarct Size -- Microvascular Injury -- Microvascular Obstruction -- Intramyocardial Hemorrhage -- Myocardial Salvage -- Remote Myocardium -- References -- 12 Prognosis of Coronary Microvascular Obstruction -- Introduction -- ST-Segment Resolution -- Coronary Angiography -- Invasive Assessment -- Cardiac Magnetic Resonance -- References -- 13 Prevention of Coronary Microvascular Obstruction by Addressing the Individual Susceptibility -- Introduction -- Pre-Existent Microvascular Dysfunction -- Major Cardiovascular Risk Factors -- Hyperglycemia -- Hypercolesterolemia -- Arterial Hypertension -- Smoking -- Aging -- Gender -- Minor Cardiovascular Risk Factors -- Inflammation -- Hyperhomocystinemia -- Renal Dysfunction -- Genetic Factors -- Ischemic Pre-Conditioning and Its Modulation -- Therapies for the Improvement of Individual Susceptibility -- Conclusions -- References -- 14 Prevention of Coronary Microvascular Obstruction by Addressing Distal Embolization -- Pathophysiology of Microvascular Obstruction and Distal Embolization -- Thrombus Aspiration Catheters -- Evidence for Manual Thrombus Aspiration. , Thrombus Aspiration in Patients with High Thrombus Burden -- Distal Embolic Protection Devices -- Mesh Covered Stents -- Direct Stenting -- Deferred Stenting -- Intra Coronary Thrombolysis -- Potential for Therapy to Cause Harm -- Conclusion -- Acknowledgements -- References -- 15A Prevention of Coronary Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part A: Antiplatelets, Stati... -- Introduction -- Scientific Evidence -- Antiplatelets -- Glycoprotein IIb/IIIa Inhibitors -- P2Y12 Receptor Antagonists -- Statins -- Vasodilators -- Adenosine -- Nitroprusside -- Nicorandil -- Calcium Channel Blockers -- Natriuretic Peptides -- Other Vasodilators -- Summary of Evidence and Guideline Recommendations -- Conclusions and Future Perspective -- References -- 15B Prevention of Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part B: Cardioprotective Therapies -- Pharmacological Therapies -- Agents Targeting Mitochondrial Integrity -- Cyclosporine A -- Bendavia -- Translocator Protein 18kDa Antagonist, TRO40303 (MITOCARE) -- Protein Kinase C Inhibitors: Delcasertib, KAI-9803 -- Glucose Modulators -- Glucose-Insulin-Potassium -- Antidiabetic Drugs -- Beta-Blockers -- Metoprolol -- Carvedilol and Nebivolol -- Short Half-Life Beta-Blockers: Esmolol and Landiolol -- Atrial Natriuretic Peptide -- Inhaled Oxygen -- N-Acetylcysteine -- Erythropoietin -- Mechanical Therapies -- Ischemic Conditioning -- Ischemic Pre-Conditioning -- Ischemic Post-Conditioning -- Remote Ischemic Conditioning -- Hypothermia -- Other Mechanical Therapies -- References -- 16 Why Did All Treatments of Reperfusion Injury Failed in Humans? -- Reperfusion Injury: A Brief Historical Overview -- Experimental Demonstration of Protection Against Reperfusion Injury -- First Clinical Evidence of Reperfusion Injury in Acute Myocardial Infarction Patients. , Questioning the Clinical Benefit of Preventing Lethal Myocardial Reperfusion Injury.

Additional Edition: ISBN 0-12-812528-4

Language: English

UID:

Format: 1 online resource (401 pages)

ISBN: 0-12-813361-9

Note: Front Cover -- Coronary Microvascular Obstruction in Acute Myocardial Infarction -- Copyright Page -- Contents -- List of Contributors -- Preface -- 1 Pathogenesis of ST-Elevation Myocardial Infarction -- Introduction -- Development of Coronary Atherosclerosis and Plaque De-Stabilization -- Endothelium and Vascular Function -- Progression of Vascular Damage: Smooth Muscle Cells and Extracellular Matrix -- Complication by Inflammation: Innate and Acquired Immunity -- High-Risk Plaques and Atherothrombosis -- Characteristics of Acute Intracoronary Thrombosis -- Platelets in Coronary Thrombosis -- Activation of the Coagulation Cascade -- Platelet Released Microvesicles -- Characteristics of Myocardial Ischemia and Cardiomyocyte Necrosis -- Biochemical Markers for Detecting Myocardial Necrosis -- Tissue Infarction and Myocardial Damage -- References -- Further Reading -- 2 Reperfusion Therapy in ST-Elevation Myocardial Infarction -- Fibrinolytic Therapy in ST-Segment-Elevation Myocardial Infarction -- "Rescue" and Early Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction Following Thrombolysis -- "Primary" Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction -- Primary Percutaneous Coronary Intervention Versus Thrombolysis -- Primary Percutaneous Coronary Intervention With or Without "Stenting" for the Treatment of ST-Segment-Elevation Myocardial ... -- Early Thrombolysis With Delayed Percutaneous Coronary Intervention: The "Pharmaco-Invasive" Strategy -- Multivessel Coronary Artery Disease in ST-Segment-Elevation Myocardial Infarction -- Cardiogenic Shock and Resuscitated Cardiac Arrest -- Adjunctive Interventions and Pharmacotherapy to Improve Outcomes in ST-Segment-Elevation Myocardial Infarction -- Dual Antiplatelet Therapy -- Glycoprotein IIb/IIIa Platelet Receptor Inhibitors. , Manual Thrombus Aspiration -- Radial Versus Femoral Arterial Primary Percutaneous Coronary Intervention Access -- New-Generation Drug-Eluting Stents -- Future Advances to Optimize Clinical Outcomes in ST-Segment-Elevation Myocardial Infarction -- References -- 3 Epidemiology of Coronary Microvascular Obstruction -- Introduction -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Primary Percutaneous Coronary Intervention Accordi... -- Angiographic Indexes -- Cardiac Magnetic Resonance -- Myocardial Contrast Echocardiography -- Electrocardiographic ST-Resolution -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Thrombolysis -- Incidence of Coronary Microvascular Obstruction in Patients Treated With Rescue Primary Percutaneous Coronary Intervention -- Incidence of Coronary Microvascular Obstruction in Specific Subset of Patients -- Diabetes -- Women -- Chronic Kidney Disease -- Saphenous Vein Graft -- Latecomers -- Conclusions -- References -- 4 Individual Predisposition to Coronary Microvascular Obstruction -- Introduction -- Coronary Microvascular Physiology -- Risk Factors for Coronary Microvascular Disease -- Contributions of Coronary Microvascular Function to Subsequent Microvascular Obstruction -- Prevention Strategies to Improve Microvascular Function -- Lifestyle Modification-Diet and Exercise -- Nitrates -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Beta-Blockers -- Calcium Channel Antagonists -- Statins -- Ranolazine -- Phosphodiesterase Inhibition -- L-Arginine -- Conclusions -- References -- 5 Coronary Microembolization and Microvascular Dysfunction -- Highlights -- Morphology -- Pathophysiology -- Coronary Microembolization in Cardiac Imaging -- Coronary Microembolization Versus Cardioprotection -- In Vitro Characterization of Coronary Aspirate From Patients Undergoing PCI. , Coronary Microembolization Versus Coronary Microvascular Dysfunction-A Perspective -- References -- 6 Role of Ischemia-Reperfusion Injury in Coronary MVO -- Oxygen Free Radicals -- Microvascular Dysfunction -- Microvascular Compression -- Neutrophil Plugging -- Microthrombi Formation -- Soluble Vasoconstrictors and Thrombogenic Factors -- Postreperfusion Hemorrhage -- References -- 7 Angiography and Electrocardiography (ECG) for the Assessment of Coronary Microvascular Obstruction -- Coronary Angiography -- Thrombolysis in Myocardial Infarction Flow Score -- Thrombolysis in Myocardial Infarction (TIMI) Frame Count -- Other Angiographic Parameters to Describe the Effectiveness of Myocardial Reperfusion -- Myocardial Blush Grades -- TIMI Myocardial Perfusion Grade -- Electrocardiogram -- ST Resolution Quantification -- ST-Segment Elevation Resolution and Diagnosis of Microvascular Obstruction -- Correlation of STR with Other Imaging Techniques of MVO -- Postprocedural Residual Cumulative ST-Segment Deviation and ST Depression Resolution -- Q Waves and QRS for Prediction of Poor Microvascular Reperfusion -- References -- 8 Invasive Assessment of Coronary Microvascular Obstruction -- Introduction -- Invasive Techniques for Assessment of Microvascular Obstruction -- Angiography-Based Techniques -- TIMI Flow Grade -- Corrected TIMI Frame Count -- Myocardial Blush Grade and TIMI Myocardial Perfusion Grade -- Quantitative Blush Evaluator -- Intracoronary Doppler-Based Techniques -- Diastolic Flow Deceleration and Systolic Flow Reversal -- Coronary Flow Velocity Reserve -- Hyperemic Microvascular Resistance -- Zero-Flow Pressure -- Wave Intensity Analysis -- Thermodilution-Derived Techniques -- Thermodilution-Derived Coronary Flow Reserve -- Index of Microcirculatory Resistance -- Absolute Coronary Blood Flow Assessment -- Conclusion -- References. , 9 Imaging Modalities for the Assessment of CMVO -- Imaging Modalities for the Assessment of CMVO -- Myocardial Scintigraphy and PET -- Computed Tomography -- Myocardial Contrast Echocardiography -- CMR Imaging -- Conclusions -- References -- 10 Intracoronary Imaging for Assessing the Risk of Coronary Microvascular Obstruction -- Introduction -- Intravascular Ultrasound -- Optical Coherence Tomography -- Other Imaging Modalities -- Conclusions -- References -- 11 A Comprehensive Prognostic Assessment of ST-Elevation Myocardial Infarction by Cardiac MRI -- Introduction -- Myocardial Function -- Left Ventricular Ejection Fraction -- Other Parameters of Left Myocardial Function -- Right Myocardial Function -- Infarct Size -- Microvascular Injury -- Microvascular Obstruction -- Intramyocardial Hemorrhage -- Myocardial Salvage -- Remote Myocardium -- References -- 12 Prognosis of Coronary Microvascular Obstruction -- Introduction -- ST-Segment Resolution -- Coronary Angiography -- Invasive Assessment -- Cardiac Magnetic Resonance -- References -- 13 Prevention of Coronary Microvascular Obstruction by Addressing the Individual Susceptibility -- Introduction -- Pre-Existent Microvascular Dysfunction -- Major Cardiovascular Risk Factors -- Hyperglycemia -- Hypercolesterolemia -- Arterial Hypertension -- Smoking -- Aging -- Gender -- Minor Cardiovascular Risk Factors -- Inflammation -- Hyperhomocystinemia -- Renal Dysfunction -- Genetic Factors -- Ischemic Pre-Conditioning and Its Modulation -- Therapies for the Improvement of Individual Susceptibility -- Conclusions -- References -- 14 Prevention of Coronary Microvascular Obstruction by Addressing Distal Embolization -- Pathophysiology of Microvascular Obstruction and Distal Embolization -- Thrombus Aspiration Catheters -- Evidence for Manual Thrombus Aspiration. , Thrombus Aspiration in Patients with High Thrombus Burden -- Distal Embolic Protection Devices -- Mesh Covered Stents -- Direct Stenting -- Deferred Stenting -- Intra Coronary Thrombolysis -- Potential for Therapy to Cause Harm -- Conclusion -- Acknowledgements -- References -- 15A Prevention of Coronary Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part A: Antiplatelets, Stati... -- Introduction -- Scientific Evidence -- Antiplatelets -- Glycoprotein IIb/IIIa Inhibitors -- P2Y12 Receptor Antagonists -- Statins -- Vasodilators -- Adenosine -- Nitroprusside -- Nicorandil -- Calcium Channel Blockers -- Natriuretic Peptides -- Other Vasodilators -- Summary of Evidence and Guideline Recommendations -- Conclusions and Future Perspective -- References -- 15B Prevention of Microvascular Obstruction by Addressing Ischemia Reperfusion Injury-Part B: Cardioprotective Therapies -- Pharmacological Therapies -- Agents Targeting Mitochondrial Integrity -- Cyclosporine A -- Bendavia -- Translocator Protein 18kDa Antagonist, TRO40303 (MITOCARE) -- Protein Kinase C Inhibitors: Delcasertib, KAI-9803 -- Glucose Modulators -- Glucose-Insulin-Potassium -- Antidiabetic Drugs -- Beta-Blockers -- Metoprolol -- Carvedilol and Nebivolol -- Short Half-Life Beta-Blockers: Esmolol and Landiolol -- Atrial Natriuretic Peptide -- Inhaled Oxygen -- N-Acetylcysteine -- Erythropoietin -- Mechanical Therapies -- Ischemic Conditioning -- Ischemic Pre-Conditioning -- Ischemic Post-Conditioning -- Remote Ischemic Conditioning -- Hypothermia -- Other Mechanical Therapies -- References -- 16 Why Did All Treatments of Reperfusion Injury Failed in Humans? -- Reperfusion Injury: A Brief Historical Overview -- Experimental Demonstration of Protection Against Reperfusion Injury -- First Clinical Evidence of Reperfusion Injury in Acute Myocardial Infarction Patients. , Questioning the Clinical Benefit of Preventing Lethal Myocardial Reperfusion Injury.

Additional Edition: ISBN 0-12-812528-4

Language: English

UID:

ISSN: 1468-201X

In: Heart, [London] : BMJ Publ. Group, 1996, 103(2017), 15, Seite 1177-1184, 1468-201X

In: volume:103

In: year:2017

In: number:15

In: pages:1177-1184

Language: English

DOI: 10.1136/heartjnl-2016-310403

URL: Volltext

URL: Volltext

Author information: Ledwoch, Jakob 1985-

Author information: Werdan, Karl 1947-

Author information: Waha-Thiele, Suzanne de 1982-

Author information: Schuler, Gerhard 1946-

Author information: Eitel, Ingo 1977-

Author information: Thiele, Holger 1969-

UID:

ISSN: 0002-8703

In: American heart journal, St. Louis, Mo. : Mosby, 1925, 163(2012), 6, Seite 938-945, 0002-8703

In: volume:163

In: year:2012

In: number:6

In: pages:938-945

Language: English

URL: http://dx.doi.org/10.1016/j.ahj.2012.03.012

Author information: Neumann, Franz-Josef 1955-

Author information: Ebelt, Henning 1974-

Author information: Schuler, Gerhard 1946-

Author information: Eitel, Ingo 1977-

Author information: Thiele, Holger 1969-

Author information: Möllmann, Helge 1975-

UID:

ISSN: 1438-9010

In: RöFo, Stuttgart [u.a.] : Thieme, 1975, 189(2017), 3, Seite 204-217, 1438-9010

In: volume:189

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In: number:3

In: pages:204-217

Language: English

DOI: 10.1055/s-0043-102029

URL: Volltext

Author information: Bauer, Wolfgang 1971-

Author information: Fischbach, Katharina

Author information: Barkhausen, Jörg Johannes 1966-

Author information: Quick, Harald H. 1969-

Author information: Eitel, Ingo 1977-

Author information: Gutberlet, Matthias

Author information: Bänsch, Dietmar 1962-

Author information: Thiele, Holger 1969-

UID:

Format: Diagramme

ISSN: 1861-0692

Content: Acute myocardial infarction; Atrial fibrillation; Cardiogenic shock; Prognosis

In: Clinical research in cardiology, Berlin : Springer, 2006, 107(2018), 3, Seite 233-240, 1861-0692

In: volume:107

In: year:2018

In: number:3

In: pages:233-240

Language: English

DOI: 10.1007/s00392-017-1175-1

URL: Volltext

Author information: Werdan, Karl 1947-

Author information: Waha-Thiele, Suzanne de 1982-

Author information: Schuler, Gerhard 1946-

Author information: Pöss, Janine 1981-

Author information: Eitel, Ingo 1977-

Author information: Eitel, Charlotte 1980-

Author information: Thiele, Holger 1969-

UID:

Format: Diagramme

ISSN: 1474-547X

In: The lancet, London [u.a.] : Elsevier, 1823, 382(2013), 9905, Seite 1638-45, 1474-547X

In: volume:382

In: year:2013

In: number:9905

In: pages:1638-45

Language: English

DOI: 10.1016/S0140-6736(13)61783-3

URL: Volltext

Author information: Werdan, Karl 1947-

UID:

Format: Diagramme, graphische Darstellungen

ISSN: 1874-1754

Content: Acute kidney injury, biomarkers, cardiogenic shock, myocardial infarction

In: International journal of cardiology, Amsterdam [u.a.] : Elsevier Science, 1981, 191(2015), Seite 150-66, 1874-1754

In: volume:191

In: year:2015

In: pages:150-66

Language: English

DOI: 10.1016/j.ijcard.2015.04.242

URL: Volltext

Author information: Werdan, Karl 1947-

UID:

ISSN: 1097-6744

In: American heart journal, Amsterdam [u.a.] : Elsevier, 1925, Bd. 169.2015, 4, S. e7-8, 1097-6744

In: volume:169

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Language: English

DOI: 10.1016/j.ahj.2015.01.009

URL: Volltext

Author information: Ebelt, Henning 1974-

Author information: Werdan, Karl 1947-