Format:
1 Online-Ressource (22 Seiten)
Content:
Several biogerontology databases exist
that focus on genetic or gene expression data linked
to health as well as survival, subsequent to compound
treatments or genetic manipulations in animal models.
However, none of these has yet collected experimental
results of compound-related health changes. Since
quality of life is often regarded as more valuable than
length of life, we aim to fill this gap with the ‘‘Healthy
Worm Database’’ (http://healthy-worm-database.eu).
Literature describing health-related compound studies
in the aging model Caenorhabditis elegans was
screened, and data for 440 compounds collected. The
database considers 189 publications describing 89
different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for
promising compounds for further investigations, this
database also offers insights into the research field of
studies on healthy aging based on a frequently used
model organism. Some weaknesses of C. elegansbased aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as
well as the convenience-based use of young worms as
the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the
database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential
shortcomings in current aging research.
Content:
Peer Reviewed
In:
Dordrecht u.a. : Springer Science + Business Media B.V, 22,2, Seiten 215-236
Language:
English
DOI:
10.1007/s10522-021-09913-2
URN:
urn:nbn:de:kobv:11-110-18452/26230-1
URL:
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