Kooperativer Bibliotheksverbund

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Format: 1 online resource (386 pages)

ISBN: 0-12-813929-3

Content: Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions.

Note: Front Cover -- Nanomaterials for Magnetic and Optical Hyperthermia Applications -- Copyright -- Contents -- Contributors -- Introduction to Hyperthermia -- 1. Hyperthermia as Therapeutic Approach -- 1.1. Short History of Hyperthermia -- 1.2. The Cellular and Molecular Foundation of Hyperthermia -- 1.2.1. The Effect of Hyperthermia at Cellular Level -- 1.2.2. Heat Shock Proteins -- 1.3. Hyperthermia Modalities -- 2. Hyperthermia at the Nanoscale-Why Nanomaterials? -- 2.1. Introduction -- 2.2. Magnetic Nanoparticles -- 2.3. Plasmonic Nanomaterials -- 2.4. Carbon-Based Nanomaterials -- 2.5. Fundamentals of Nanomaterial-Based Magnetic and Optical Hyperthermia -- 2.5.1. Heat Generation in Magnetic Nanoparticle Hyperthermia -- 2.5.2. Heat Generation in Optical Hyperthermia -- 3. About This book -- References -- Section A: Principles of Hyperthermia -- Chapter 1: Design Criteria of Thermal Seeds for Magnetic Fluid Hyperthermia - From Magnetic Physics Point of View -- 1.1. Introduction -- 1.2. Mechanism of Heat Generation -- 1.2.1. Heat Generation in a Magnetic Conductor -- 1.2.2. Hysteresis Loss -- 1.2.3. Relaxation Loss -- 1.2.4. Friction Loss -- 1.2.5. Eddy Current Loss -- 1.2.6. Maximization of the Heating Power Based on the Origin of Heat Generating Mechanism -- 1.3. Operational Limits of Magnetic Field and Frequency Conditions -- 1.3.1. Safety Criteria for Exposure of the Human Body to Electromagnetic Waves -- 1.3.2. The Moderate Solution Within the Framework of Safety Criterion -- 1.3.3. Alternative Solution Within the Framework of Safety Criterion -- 1.4. Novel Responses of Individual Magnetic Nanoparticles to AC Magnetic Fields -- 1.4.1. Néel Relaxation in Magnetic Fields -- 1.4.2. Brownian Relaxation in Magnetic Fields -- 1.4.3. Easy Axes Oriented Toward Directions Parallel, or Perpendicular to the AC Field. , 1.4.4. Magnetic Hysteresis of Superparamagnetic States -- 1.4.5. Intermediate State Between Ferromagnetic and Superparamagnetic Nanoparticles -- 1.4.6. Efficient Heat Generation in Magnetic Nanoparticles -- 1.5. Potential of Interacting Magnetic Nanoparticles -- 1.5.1. Effects of Magnetic Interaction Between Nanoparticles -- 1.5.2. Evaluation of Assembled Structures -- 1.6. Summary and Perspectives -- References -- Chapter 2: Design of Anisotropic Iron-Oxide-Based Nanoparticles for Magnetic Hyperthermia -- 2.1. Key Parameters Controlling the Generated Heat -- 2.1.1. Extrinsic Parameters -- 2.1.2. Intrinsic Parameters -- 2.1.3. Design of IONPs for MH -- 2.2. Optimization of MH Properties of IONPs by Doping or Shape-Controlled Synthesis -- 2.2.1. Wet Chemical Synthesis Methods -- 2.2.2. The TD Method -- 2.2.2.1. Understanding NPs Formation With TD -- General Principle -- LaMer's Theory -- 2.2.2.2. Controlled Synthesis of NP With TD -- Size and Size Distribution Control -- Size Control -- Size Distribution Control -- Composition Control -- Shape Control -- Theory -- Shape of the Nucleus -- The Example of the Nanocube Synthesis -- 2.3. Conclusion -- References -- Chapter 3: Synthesis and Characterization of Magnetic-Plasmonic Hybrid Nanoparticles -- 3.1. Introduction -- 3.1.1. Magnetic Nanoparticles for Hyperthermia -- 3.1.2. Plasmonic Nanoparticles for Photothermal Therapy -- 3.1.3. Magnetic-Plasmonic Hybrid Nanoparticles for Hyperthermia -- 3.2. Synthesis and Characterization -- 3.2.1. Synthesis of MPNPs -- 3.2.1.1. Aqueous Reduction Method -- 3.2.1.2. Heat-up Method -- 3.2.1.3. Hot Injection Method -- 3.2.1.4. Reverse Micelle Method -- 3.2.1.5. Solvothermal Method -- 3.2.2. Characterization of MPNPs -- 3.2.2.1. Influence on the LSPR Properties -- 3.2.2.2. Enhancement of the Faraday Effects -- 3.2.2.3. Phase Transition Investigated by SERS. , 3.2.2.4. Induced Magnetic Moment in Plasmonic Component -- 3.2.2.5. Electron Transfer Phenomenon -- 3.3. Conclusion -- References -- Chapter 4: Noble Metal-Based Plasmonic Nanoparticles for SERS Imaging and Photothermal Therapy -- 4.1. Introduction -- 4.2. Plasmonic Properties of Metallic Nanoparticles -- 4.2.1. Surface-Enhanced Raman Scattering -- 4.2.2. Raman Scattering: A Molecular Vibration ``Fingerprint´´ -- 4.2.3. Enhancement Mechanisms of SERS: Ultrasensitivity -- 4.3. Optical Hyperthermia -- 4.3.1. Mechanism of Heat Generation -- 4.3.2. Noble Metal Nanoparticles -- 4.4. Synthesis Methods -- 4.4.1. Spherical Nanoparticles -- 4.4.2. Anisotropic Nanoparticles -- 4.4.2.1. Nanorods -- 4.4.2.2. Nanocubes and Nanocages -- 4.4.2.3. Nanoprisms -- 4.4.2.4. Branched Nanoparticles -- 4.4.2.5. Hybrid Nanoparticles -- 4.5. Functionalization -- 4.6. Theragnostics (SERS+PTT) -- 4.7. Conclusion -- References -- Further Reading -- Chapter 5: Instrumentation for Magnetic Hyperthermia -- 5.1. Introduction -- 5.2. Fundamental Aspects of Coil Design for MH -- 5.2.1. Preliminary Considerations -- 5.2.1.1. Coil Cooling -- 5.2.1.2. Solenoid Coil Construction -- 5.2.2. Solenoid Coil Design Specifications -- 5.2.2.1. Coil Dimensions -- 5.2.2.2. Field Intensity -- 5.2.3. Coil Electrical Connections and Other Electrical Considerations -- 5.2.4. Magnetic Field Generated by the Coil -- 5.2.4.1. Coil Field Simulations and Measurement -- 5.2.5. Exploitation of Magnetic Field Inside Solenoid Coils: Limitations for Large Animals and Human Bodies -- 5.2.6. Exploitation of Magnetic Field Outside Coils -- 5.2.7. Considerations on the Use of Industrial Induction Heaters for MH Research -- 5.3. Temperature Measurement in MH -- 5.3.1. Overview of Thermometry Literature -- 5.3.2. Harmonic Phase vs. Temperature -- 5.4. Commercial and Noncommercial Instrumentation to Measure SAR. , 5.4.1. AC Magnetometry -- 5.4.2. Magneto-Thermal Calorimetry -- 5.4.3. Adiabatic Systems -- 5.4.4. Nonadiabatic Systems -- 5.5. Conclusions and Perspectives -- Acknowledgments -- References -- Chapter 6: Nanoscale Thermometry for Hyperthermia Applications -- 6.1. Introduction -- 6.2. High Spatial Resolution Thermometry -- 6.3. Luminescence Thermometry -- 6.3.1. Advantages and Challenges of Luminescent Nanoprobes -- 6.3.2. The Peculiar Example of Trivalent Lanthanide Ions (Ln3+) -- 6.3.3. Downshifting Versus Upconversion in Ln3+: Benefits and Challenges -- 6.3.4. Quantifying the Thermometer's Performance -- 6.3.4.1. Relative Thermal Sensitivity -- 6.3.4.2. Temperature Uncertainty -- 6.3.4.3. Spatial and Temporal Resolution -- 6.3.4.4. Repeatability -- 6.3.5. Trends in Luminescence Thermometry -- 6.4. Intracellular Thermometry -- 6.4.1. Molecular Cell Thermometers -- 6.4.2. Polymer Cell Thermometers -- 6.4.3. Inorganic Nanoparticle Cell Thermometers -- 6.4.4. Organic-Inorganic Hybrids Cell Thermometry -- 6.4.5. Endogenous Fluorescence Cell Thermometers -- 6.4.6. Cellular Contact Thermometry -- 6.5. Intracellular Thermometry for Hyperthermia Studies -- 6.5.1. Intracellular Thermometry in Optical Hyperthermia -- 6.5.1.1. Dual-Particle Systems -- 6.5.1.2. Single-Particle Systems -- 6.5.2. Intracellular Thermometers in Magnetic Hyperthermia -- 6.6. Conclusions and Perspectives -- Acknowledgments -- References -- Further Reading -- Chapter 7: High-Frequency Magnetic Response and Hyperthermia From Nanoparticles in Cellular Environments -- 7.1. Introduction -- 7.1.1. AC Magnetization and Magnetic Hyperthermia in Nanoparticles -- 7.1.2. Magnetization Relaxation Phenomena -- 7.2. Measuring the High-Frequency Magnetic Response of Nanoparticles -- 7.2.1. AC Susceptibility -- 7.2.2. AC Magnetometry -- 7.3. Magnetic Nanoparticles in Cellular Environments. , 7.3.1. Biodistribution of Nanoparticles In Vitro and In Vivo -- 7.3.2. Factors Influencing AC Magnetic Response and Heating -- 7.4. Summary and Future Perspectives -- References -- Section B: Cellular Response to Heat -- Chapter 8: Mechanisms of Cell Death Induced by Optical Hyperthermia -- 8.1. Introduction -- 8.2. Types of Cell Death -- 8.2.1. Regulated Cell Death -- 8.2.1.1. Apoptosis -- 8.2.1.2. Autophagy -- 8.2.2. Accidental Cell Death -- 8.2.2.1. Necrosis -- 8.3. Techniques to Determine the Type of Cell Death -- 8.3.1. Methods Commonly Used to Analyze Cell Viability in PTT -- 8.3.1.1. MTT Assay -- 8.3.1.2. Exclusion Dyes for DNA Staining -- 8.3.1.3. Calcein Retention -- 8.3.2. Analysis of Apoptosis -- 8.3.2.1. Activation of Caspases -- 8.3.2.2. Phosphatidylserine Exposure -- 8.3.2.3. Loss of Mitochondrial Potential -- 8.3.2.4. Immunohistochemistry -- 8.3.3. Analysis of Autophagy -- 8.3.3.1. Electron Microscopy -- 8.3.3.2. LC3 -- LC3 by Western Blot -- LC3 by Confocal Microscopy -- LC3-II by Flow Cytometry -- LC3 by Immunohistochemistry -- 8.4. Cell Death Induced by PTT -- 8.4.1. PTT and Apoptosis/Necrosis -- 8.4.2. PTT and Autophagy -- 8.4.3. PTT and Heat Shock Proteins -- 8.4.4. PTT and Immune Activity -- 8.4.5. PTT Against Stem Cells and Metastasis -- 8.4.6. PTT in Tumor Microenvironment -- 8.4.7. PTT in Combination With Other Therapeutic Approaches -- 8.5. Conclusion -- References -- Chapter 9: Invertebrate Models for Hyperthermia: What We Learned From Caenorhabditis elegans and Hydra vulgaris -- 9.1. Introduction to Animal Models in Nanoscience -- 9.1.1. The Freshwater Polyp H. vulgaris -- 9.1.2. The Roundworm C. elegans -- 9.2. NP Fate and Status In Vivo -- 9.2.1. Hydra -- 9.2.1. Caernohabditis elegans -- 9.3. Biological Effects of Heat -- 9.3.1. Hyperthermia -- 9.3.1.1. Photothermal Cell Ablation Using H. vulgaris. , 9.3.1.2. Photothermal Approach Using C. elegans.

Additional Edition: ISBN 0-12-813928-5

Language: English

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Format: 1 online resource (128 pages) : , illustrations (chiefly colour); digital file(s).

ISBN: 9782889197767

Series Statement: Frontiers in Chemistry

Content: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells... Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

Note: Also available in print form. , In English.

Additional Edition: Print version: Cancer nanotheranostics: what have we learned so far? [Lausanne, Switzerland]: Frontiers Media SA, 2015 ISBN 288919776X

Language: English

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Format: 1 Online-Ressource (185 p.)

ISBN: 9782889632374

Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Note: English

Language: English

URL: kostenfrei

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Format: 1 Online-Ressource (XIX, 520 S.).

ISBN: 978-0-12-415769-9 , 0-12-415769-6 , 978-0-12-398304-6 , 0-12-398304-5

Series Statement: Frontiers of nanoscience 4

Note: Includes index. - Nanotechnology is considered the next big revolution in medicine and biology. For the past 20 years, research groups have been involved in the development of new applications of novel nanomaterials for biotechnological applications. Nanomaterials are also becoming increasingly important in medical applications, with new drugs and diagnostic tools based on nanotechnology. Every year, hundreds of new ideas using nanomaterials are applied in the development of biosensors. An increasing number of new enterprises are also searching for market opportunities using these technologies. Nanomaterials for biotechnological applications is a very complex field. Thousands of different nanoparticles could potentially be used for these purposes. Some of them are very different; their synthesis, characterization and potentiality are very diverse. This book aims to establish a route guide for non-erudite researchers in the field, showing the advantages and disadvantages of the different kind of nanomaterials. Particular attention is given to the differences, advantages and disadvantages of inorganic nanoparticles versus organic nanoparticles when used for biotechnological applications. A tutorial introduction provides the basis for understanding the subsequent specialized chapters. Provides an overview of the main advantages and disadvantages of the use of organic and inorganic nanoparticles for use in biotechnology and nanomedicine Provides an excellent starting point for research groups looking for solutions in nanotechnology who do not know which kind of materials will best suit their needsIncludes a tutorial introduction that provides a basis for understanding the subsequent specialized chapters. - Includes bibliographical references and index

Language: English

URL: Volltext

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Format: 1 electronic resource (185 p.)

Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Note: English

Additional Edition: ISBN 2-88963-237-7

Language: English

UID:

Format: 1 electronic resource (185 p.)

Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Note: English

Additional Edition: ISBN 2-88963-237-7

Language: English

UID:

Format: 1 electronic resource (185 p.)

Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Note: English

Additional Edition: ISBN 2-88963-237-7

Language: English

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Format: 240 pages , illustrations, portraits , 25 cm

Edition: Primera edición

ISBN: 9786077152354 , 6077152358

Series Statement: Biblioteca básica de agricultura 59

Content: Historia de la investigación en México -- Entrevistas con Jesús Moncada de la Fuente

Note: Errata , Includes bibliographical references

Language: Spanish

URL: Cover

URL: Inhaltsverzeichnis

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Format: 382 S , 1 Bilds., 1 Kt., 2 Pl., 16 Abb. auf 8 Bl., 16 Abb., 1 Faks., 1 Tab

Series Statement: Serie científica del Museo Nacional de Antropología 1

Language: Spanish

UID:

Format: 2 CDs in Album , stereo, DDD , Beih. (271 S.) , 12 cm

Series Statement: Raices & memoria Vol. 4

Note: Super-Audio-CDs , Aufn.: 2005 , Enth. u.a. Werke von Bailly, Narvaez, Milan, Mudarra, Cabezon, Pisador, Vasquez, Cervantes und Salinas , Span. gesungen. - Text des Beih. span., franz., engl., katalan., dt., ital. und japan.

Language: Spanish

Subjects: Musicology

Keywords: Cervantes Saavedra, Miguel de 1547-1616 Don Quijote ; Romanze ; CD

Author information: Cervantes Saavedra, Miguel de 1547-1616