UID:
almafu_9961427411702883
Format:
1 videorecording (1 hr., 05 min., 04 sec.)
,
010504
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/505/.
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Introduction -- Some lessons from the biases of recent past -- In the early 1980s the biases were shattered -- Human viruses that cause malignancies -- The discovery of human retroviruses: background -- Characteristics of HTLV-I, II (1) -- Characteristics of HTLV-I, II (2) -- Circa 1970-80 -- Factors encouraging human retroviruses search -- Interspecies transmission of retroviruses -- Fibrosarcoma of a woolly-monkey -- Gibbon ape leukemia virus -- Generation of SSV -- New human viruses/viral diseases -- Electron micrograph of HTLV-I -- The first proven human retrovirus carrier -- The first Caucasian with diagnosed HTLV -- Adult T cell leukemia caused by HTLV-I -- Example of nodular skin lesions of ATL -- Example of skin lesions in ATL -- Smaller skin lessions in ATL -- Lytic lesions of the bone -- Early description of ATL in Japan -- CD4 T-cells with typical lobulated nuclei -- HTLV-I associated diseases -- Childhood manifestations of HTLV-I infection -- Origin and dissemination of HTLV-I -- Prevalence of HTLV-I in Japan -- HTLV in the Carribean and South America -- HTLV in the South Pacific -- HTLV variants worldwide -- Dendrogram of STLVs, HTLV - Is and HTLV-II -- Transmission of HTLV-I from primates to humans -- Discovery of HTLV-II -- How HTLVs cause disease -- Genomic structure of human retroviruses -- Life cycle of HTLV-I, II -- Expression and function of retroviral gene products -- Common features of HTLV-I Rex and HIV-1 Rev -- Human vs. "classical" animal retroviruses -- Survival of HTLV-I -- The HTLV-I Tax and T-cells -- What are the pathogenic mechanisms of HTLV-I? -- Reasons for late isolation of human retroviruses -- A contraversial human retrovirus discovery paper -- The discovery of HIV and its linkage to AIDS -- At the beginning -- Some notable theories of the cause of AIDS -- Why HTLV-I was thought to cause AIDS in 1982 -- Some similarities of HTLVs and HIVs -- Periods of AIDS history -- Unique challenges of presenting the cause of AIDS -- Problems in confirming HIV as the cause of AIDS -- Importance and characteristics of HIV blood test -- HIV-1 morphology -- The discovery of HIV as the cause of AIDS -- How does HIV cause disease? -- Human retroviruses avoid/impair immune response -- Survival mechanisms of HIV-1 lead to AIDS -- Cellular targets of HIV -- Other cell targets of HIV -- Some major features of HIV pathogenesis -- Different effects of HIV on infected cells -- Uninfected T-cells are also impaired in AIDS -- Attachment and entry -- Riddle: how is HIV like a diamond? -- The provirus hypothesis -- Integration is the key property of all retroviruses -- HIV provirus integration into host DNA is the key -- Reverse transcription and integration -- HIV in cancer (as a "co-carcinogen") -- Are there co-factors in the cause of AIDS? -- Prospects.
Language:
English
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