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  • 1
    Online Resource
    Online Resource
    Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function (2020)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    UID:
    gbv_1794544097
    Format: 1 Online-Ressource (132 p.)
    ISBN: 9782889635689
    Content: Testicular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as infertility, hypogonadism, metabolic syndrome, osteoporosis, sexual disorders, depressed mood, and in general impaired quality of life. This aspect is the most serious and potentially life threatening effect in TGCT survivors. Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life. The objective of this Research Topic is to group a collection of articles focused on new and more recent insights about TGCT
    Note: English
    Language: English
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Stabi Berlin
    UB Potsdam
  • 2
    Online Resource
    Online Resource
    Klinefelter's Syndrome : From a Disabling Condition to a Variant of Normalcy (2020)
    Cham :Springer International Publishing, | Cham :Springer.
    Details
    UID:
    almafu_BV046878434
    Format: 1 Online-Ressource (XI, 232 p. 10 illus., 6 illus. in color).
    Edition: 1st ed. 2020
    ISBN: 978-3-030-51410-5
    Series Statement: Trends in Andrology and Sexual Medicine
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51409-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51411-2
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51412-9
    Language: English
    DOI: 10.1007/978-3-030-51410-5
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032288485&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032288485&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Online Access
    Open Access Request
    FU Berlin
    Charité
  • 3
    Online Resource
    Online Resource
    Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function (2020)
    Frontiers Media SA
    Details
    UID:
    edocfu_9960411702202883
    Format: 1 electronic resource (132 p.)
    Content: Testicular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as infertility, hypogonadism, metabolic syndrome, osteoporosis, sexual disorders, depressed mood, and in general impaired quality of life. This aspect is the most serious and potentially life threatening effect in TGCT survivors. Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life. The objective of this Research Topic is to group a collection of articles focused on new and more recent insights about TGCT.
    Note: English
    Additional Edition: ISBN 2-88963-568-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    FU Berlin
  • 4
    Online Resource
    Online Resource
    Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function (2020)
    Frontiers Media SA
    Details
    UID:
    almahu_9949281914402882
    Format: 1 electronic resource (132 p.)
    Content: Testicular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as infertility, hypogonadism, metabolic syndrome, osteoporosis, sexual disorders, depressed mood, and in general impaired quality of life. This aspect is the most serious and potentially life threatening effect in TGCT survivors. Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life. The objective of this Research Topic is to group a collection of articles focused on new and more recent insights about TGCT.
    Note: English
    Additional Edition: ISBN 2-88963-568-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    HU Berlin
  • 5
    Online Resource
    Online Resource
    Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function (2020)
    Frontiers Media SA
    Details
    UID:
    edoccha_9960411702202883
    Format: 1 electronic resource (132 p.)
    Content: Testicular cancer (TC) is the most frequent solid malignancy in young men aged between 15 and 40 years. The worldwide incidence is about 7.5 per 100,000 subjects, but the rates vary considerably between countries and ethnic groups. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It has been reported that about 18,000 European subjects over reproductive age develop a TGCT every year and its incidence is increasing in several countries over the past 50 years. Early diagnosis and modern treatment have resulted in over 95% survival rate and improved quality of life in testicular cancer survivors. However, the benefits of cancer treatments may hide some risks. In fact, possible side effects can be developed during the treatment itself or later from months to years after the completion of therapy, persisting during the whole life. Therefore, TGCT survivors frequently complain a number of healthy problems such as infertility, hypogonadism, metabolic syndrome, osteoporosis, sexual disorders, depressed mood, and in general impaired quality of life. This aspect is the most serious and potentially life threatening effect in TGCT survivors. Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life. The objective of this Research Topic is to group a collection of articles focused on new and more recent insights about TGCT.
    Note: English
    Additional Edition: ISBN 2-88963-568-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Charité
  • 6
    Online Resource
    Online Resource
    Klinefelter’s Syndrome : From a Disabling Condition to a Variant of Normalcy (2020)
    Cham :Springer International Publishing :
    Details
    UID:
    almahu_9948691268202882
    Format: XI, 232 p. 10 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030514105
    Series Statement: Trends in Andrology and Sexual Medicine,
    Content: This book presents the latest insights into all the critical aspects of Klinefelter’s Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more “evidence-based” support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.
    Note: Poetry -- Preface -- 1. Introduction - From a disabling condition to a variant of normalcy -- 2. Epidemiology of an underdiagnosed syndrome -- 3. Causes of the extra chromosome/s -- 4. Different karyotypes, same disease? -- 5. Genetic and epigenetic aspects of the supernumerary X chromosome -- 6. Prenatal Counselling and management in the early neonatal period -- 7. Early developmental pathways and communication good practices -- 8. The diagnosis at prepubertal age -- 9. What to do and when from infancy to puberty -- 10. Neuropsychiatric aspects -- 11. Testicular development -- 12. The Klinefelter puberty -- 13. Genetic of Gametes -- 14. Phenotype of the adulthood -- 15. Hypothalamic-Pituitary Axis Function -- 16. The altered bone -- 17. Obesity, the rule or not -- 18. Lipids and glucose metabolism -- 19. Cardiovascular characteristics -- 20. The Thyroid Function -- 21. Oncological problems -- 22. Fertility preservation -- 23. Fertility vs Infertility -- 24. Psychological features -- 25. Sexual function -- 26. Testosterone treatment in male patients with Klinefelter’s syndrome.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783030514099
    Additional Edition: Printed edition: ISBN 9783030514112
    Additional Edition: Printed edition: ISBN 9783030514129
    Language: English
    DOI: 10.1007/978-3-030-51410-5
    URL: https://doi.org/10.1007/978-3-030-51410-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    HU Berlin
  • 7
    Online Resource
    Online Resource
    Klinefelter's Syndrome : From a Disabling Condition to a Variant of Normalcy (2020)
    Cham :Springer International Publishing, | Cham :Springer.
    Details
    UID:
    edocfu_BV046878434
    Format: 1 Online-Ressource (XI, 232 p. 10 illus., 6 illus. in color).
    Edition: 1st ed. 2020
    ISBN: 978-3-030-51410-5
    Series Statement: Trends in Andrology and Sexual Medicine
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51409-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51411-2
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-51412-9
    Language: English
    DOI: 10.1007/978-3-030-51410-5
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032288485&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Online Access
    Open Access Request
    FU Berlin
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