Format:
1 Online-Ressource (XI, 442 p. 135 illus., 37 illus. in color)
ISBN:
9783642325632
Series Statement:
Studies in mechanobiology, tissue engineering and biomaterials 10
Content:
〈p〉One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: 〈/p〉〈p〉 (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population;〈/p〉〈p〉(ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and 〈/p〉〈p〉(iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g.
Note:
〈p〉In vivo, in vitro, in silico: computational tools for product and process design in tissue engineering -- Protein modeling and surface folding by limiting the degrees of freedom -- Adaptive Quasi-linear Viscoelastic Modeling -- Computational modeling of mass transport and its relation to cell behavior in tissue engineering constructs -- Computational Methods in the Modeling of Scaffolds for Tissue Engineering -- Computational Modeling of Tissue Engineering Scaffolds as Delivery Devices for Mechanical and Mechanically Modulated Signals -- Modeling the cryopreservation process of a suspension of cells: the effect of a sizedistributed cell population -- Mesenchymal Stem Cell Heterogeneity and Ageing in vitro - a Model Approach.- Image-based cell quality assessment: Modeling of cell morphology and quality for clinical cell therapy -- Continuum modelling of in vitro tissue engineering: a review -- Multiphysics Computational Modeling in Cartilage Tissue Engineering -- Oxygen Transport in Bioreactors for Engineered Vascular Tissues -- Multi-scale Modelling of Vascular Disease: Abdominal Aortic Aneurysm Evolution -- Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissue Structure -- Mechanobiological modelling of angiogenesis impact on tissue engineering and bone regeneration -- Mathematical modeling of regeneration of a tissue-engineered trachea.〈/p〉
Additional Edition:
Erscheint auch als Druckausgabe ISBN 978-3-642-32562-5
Language:
English
Subjects:
Biology
DOI:
10.1007/978-3-642-32563-2
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