Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource (XXVI, 968 S.) , Ill.

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 9781846288548

Additional Edition: Reproduktion von Electrical diseases of the heart 2008

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-84628-853-1

Language: English

DOI: 10.1007/978-1-84628-854-8

URL: Volltext

UID:

Format: Online-Ressource , v.: digital

Edition: Online-Ausg. 2008 Springer eBook Collection. Medicine

ISBN: 9781846288548

Additional Edition: ISBN 9781846288531

Additional Edition: Erscheint auch als Druck-Ausgabe Electrical diseases of the heart London : Springer, 2008 ISBN 9781846288531

Additional Edition: ISBN 1846288533

Additional Edition: ISBN 1846288541

Additional Edition: ISBN 9781846288548

Language: English

DOI: 10.1007/978-1-84628-854-8

URL: Volltext  (lizenzpflichtig)

UID:

Format: 1 Online-Ressource (XXVI, 968 S.) : , Ill.

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 978-1-84628-854-8

Additional Edition: Reproduktion von Electrical diseases of the heart 2008

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-84628-853-1

Language: English

DOI: 10.1007/978-1-84628-854-8

URL: Volltext

URL: Volltext

UID:

Format: XVII, 548 S , Ill., zahlr. graph. Darst

ISBN: 1588290697

Series Statement: Contemporary cardiology

Note: Includes bibliographical references and index

Language: English

Keywords: Elektrokardiografie ; Herzrhythmusstörung ; Repolarisation

URL: Inhaltsverzeichnis

URL: Verlagsangaben

UID:

Format: XII, 362 p. , online resource.

Edition: 1st ed. 2005.

ISBN: 9781592598847

Content: Although it is relatively easy to determine the efficacy of a new drug, it is difficult to establish its safety when administered to millions of patients with multifaceted diseases, co-morbidities, sensitivities, and multiple drug use. In Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development, basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs from their effects on the electrocardiogram (ECG). The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiology in clinical research, demonstrating the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web-based technology in clinical research, and how to follow the new FDA requirements for ECG submissions. Authoritative and up-to-date, Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development offers clinical researchers in industry and academia expert practical advice on establishing their product's cardiac safety, predicting regulatory actions, and getting it successfully to market.

Note: Cardiac Safety of Noncardiac Drugs -- Preclinical and Pharmacogenomic Cardiac Safety Evaluations -- Molecular Physiology of Ion Channels That Control Cardiac Repolarization -- Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis -- hERG Assay, QT Liability, and Sudden Cardiac Death -- Pharmacogenomics in Drug Development -- Clinical Methodologies and Technical Aspects of Assessing Cardiac Safety of Investigational Drugs: Focus on Cardiac Repolarization -- Assessment of Ventricular Repolarization From Body-Surface ECGs in Humans -- ECG Acquisition and Signal Processing -- Digital 12-Lead Holter vs Standard Resting Supine Electrocardiogram for the Assessment of Drug-Induced QTc Prolongation -- Holter Monitoring for QT -- Application of ELectrocardiology in Clinical Research -- Fundamentals of ECG Interpretation in Clinical Research and Cardiac Safety Assessment -- Design and Conduct of the Thorough Phase I ECG Trial for New Bioactive Drugs -- Use of ECGs in Support of Cardiac Safety in Phase II and III Clinical Trials -- Cardiac Arrhythmia Assessment in Phase IV Clinical Studies -- Statistical Analysis Plans for ECG Data -- Interpretation of Clinical ECG Data -- Regulatory COnsiderations -- The FDA's Digital ECG Initiative and Its Impact on Clinical Trials -- Quality Control and Quality Assurance for Core ECG Laboratories -- ECG Digital Communities and Electronic Reporting of Cardiac Safety Data.

In: Springer Nature eBook

Additional Edition: Printed edition: ISBN 9781603276641

Additional Edition: Printed edition: ISBN 9781617376122

Additional Edition: Printed edition: ISBN 9781588295156

Language: English

DOI: 10.1007/978-1-59259-884-7

URL: https://doi.org/10.1007/978-1-59259-884-7

UID:

Format: 1 Online-Ressource (XXVI, 968 S.) : , Ill.

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 978-1-84628-854-8

Additional Edition: Reproduktion von Electrical diseases of the heart 2008

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-84628-853-1

Language: English

DOI: 10.1007/978-1-84628-854-8

URL: Volltext

UID:

Format: 1 Online-Ressource (XXVI, 968 S.) : , Ill.

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 978-1-84628-854-8

Additional Edition: Reproduktion von Electrical diseases of the heart 2008

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-84628-853-1

Language: English

DOI: 10.1007/978-1-84628-854-8

URL: Volltext

UID:

Format: 1 online resource (1 PDF (xiv, 430 pages) :) , illustrations

ISBN: 0-8135-8642-9 , 0-8135-8643-7

Content: Iatrogenesis is the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one's expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors. This is a huge public health issue: tens to hundreds of thousands of deaths are attributed to iatrogenic causes each year in the U.S., and vulnerable populations such as the elderly and minorities are particularly susceptible. Edited by two renowned cardiology experts, Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine addresses both the iatrogenicity that arises with cardiovascular interventions, as well as non-cardiovascular interventions that result in adverse consequences on the cardiovascular system. The book aims to achieve three things: to summarize the available information on this topic in a single high-yield volume; to highlight the human and financial cost of iatrogenesis; and to describe and propose potential interventions to ameliorate the effects of iatrogenesis. This accessible book is a practical reference for any practicing physician who sees patients with cardiovascular issues. .

Note: Frontmatter -- , Contents -- , Contributors -- , The Concept of Iatrogenicity / , PART I. Medical Harm -- , CHAPTER 1. Iatrogenicity: Definition, History, and Modern Context / , CHAPTER 2. Epidemiology and Public Health Aspects and Implications of Iatrogenicity: Regulatory, Legal and Ethical Dimensions / , CHAPTER 3. Risk Management: The Medical Center Administration Perspective / , CHAPTER 4. Iatrogenicity from the Patient's Perspective / , CHAPTER 5. A Naturopathic Perspective on Iatrogenesis / , PART II. Iatrogenicity of Cardiovascular Drugs and Cardiovascular Toxicity of Noncardiac Drugs -- , CHAPTER 6. Clinical Manifestations of Acute and Chronic Drug-Induced Iatrogenic Cardiovascular Diseases and Syndromes / , CHAPTER 7. Drug-Induced Cardiac Arrhythmias and Sudden Cardiac Death / , CHAPTER 8. Chemotherapy-Induced Cardiomyopathy / , CHAPTER 9. Iatrogenicity of Blood Pressure Measurement in the Diagnosis of Hypertension / , CHAPTER 10. Antihypertensive Drug-Induced Iatrogenic Cardiovascular Syndromes / , CHAPTER 11. Iatrogenicity of Cardiovascular Drugs Associated With Cardiac and Noncardiac Toxicities: Antihypertensive Agents and Biologics / , CHAPTER 12. Iatrogenic Aspects of Hypertension in Pregnancy: Focus on Preeclampsia / , CHAPTER 13 Women and Iatrogenic Cardiovascular Disease: Menopausal Estrogen as the Prime Suspect / , CHAPTER 14. Iatrogenic Aspects of Lipid-Lowering, Antiplatelet, and Anticoagulant Agents / , CHAPTER 15. Iatrogenic Effects of Urologic Drugs on the Cardiovascular System / , CHAPTER 16. Iatrogenicity and Antianginal Drugs / , CHAPTER 17. Antidiabetic Drugs and Cardiovascular Risk: Where Do We Stand? / , CHAPTER 18. Cardiovascular Iatrogenicity in Older Adults / , PART III. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Noninvasive Cardiovascular Interventions, Devices, and Surgeries -- , CHAPTER 19. Iatrogenic Aspects of Noninvasive and Invasive Diagnostic Methods in Interventional Cardiology / , CHAPTER 20. Iatrogenicity Associated With Interventional Treatment Modalities in Cardiology / , CHAPTER 21. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Noninvasive Cardiovascular Interventions, Devices, and Surgeries / , CHAPTER 22. Iatrogenic Aspects of Cardiac Electrophysiology / , CHAPTER 23. Iatrogenic Aspects in Cardiac Device / , CHAPTER 24. Cardiovascular Iatrogenicity of Respiratory Therapeutic Modalities / , PART IV. Iatrogenic Aspects of Sport Cardiology and Lifestyle Modifications -- , CHAPTER 25. Trained Athletes / , CHAPTER 26. Sports Cardiology / , CHAPTER 27. Dangers of Lifestyle Modification Advice / , PART V. Iatrogenicity of Dietary Supplements, Herbal Products, and Other Nontraditional Therapies in Cardiovascular Medicine -- , CHAPTER 28. Safety of Dietary and Herbal Supplements: Side Effects and Contraindications / , CHAPTER 29. Interactions Between Supplements and Medications / , Index , Issued also in print. , In English.

Additional Edition: ISBN 0-8135-9040-X

Additional Edition: ISBN 0-8135-8641-0

Language: English

Keywords: Electronic books. ; Electronic books.

DOI: 10.36019/9780813586434

UID:

Format: 1 online resource (987 p.)

Edition: 1st ed. 2008.

ISBN: 1-281-77388-3 , 9786611773885 , 1-84628-854-1

Content: The past decade has witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis. Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. Residents, fellows, and physicians in cardiology and electrophysiology will gain valuable insight into cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes, and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.

Note: Description based upon print version of record. , Basic Foundations of Normal and Abnormal Cardiac Electrical Activity -- The Past and Promise of Basic Cardiac Electrophysiology -- Basic Physiology of Ion Channel Function -- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form -- Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heart -- Neural Regulation of the Heart in Health and Disease -- Mechanisms of Cardiac Arrhythmia -- Mechanisms of Action of Antiarrhythmic Drugs -- Mechanoelectrical Interactions and Their Role in Electrical Function of the Heart -- The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribution of the Late Sodium Current -- Sodium Ion Channelopathies -- L-type Calcium Channel Disease -- K+ Channelopathies (I Ks and I Kr) -- Channelopathies of Cardiac Inwardly Rectifying Potassium Channels -- Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesis -- Caveolae and Arrhythmogenesis -- Senescence and Arrhythmogenesis -- Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation -- Single Nucleotide Polymorphisms in Health and Cardiac Disease -- Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure -- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy -- Physiological and Other Biological Pacemakers -- Clinical Rhythmology: Diagnostic Methods and Tools -- Diagnostic Electrocardiography -- Ambulatory Monitoring (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology) -- Signal Averaged Electrocardiogram -- Heart Rate Variability: Measurements and Risk Stratification -- Surface Mapping and Magnetoelectrocardiography -- Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death -- Invasive Electrophysiologic Testing: Role in Sudden Death Prediction -- Provocative Testing in Inherited Arrhythmias -- Novel Predictors of Sudden Cardiac Death -- Genetic Testing -- Heritable Cardiac Channelopathies, Primary Electrical Diseases, and Clinical Syndromes -- Celebrating the Challenge of Cardiac Arrhythmias -- Congenital Long QT Syndrome -- Brugada Syndrome: Clinical and Genetic Aspects -- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy -- Catecholaminergic Polymorphic Ventricular Tachycardia -- Andersen-Tawil and Timothy Syndromes -- Short QT Syndrome -- Progressive Cardiac Conduction Disease -- Familial Atrial Fibrillation and Standstill -- Idiopathic Ventricular Fibrillation -- Secondary Hereditary Electrical Diseases and Clinical Syndromes -- Cardiac Remodeling -- Arrhythmogenic Malignancies in Hypertrophic Cardiomyopathy -- Sudden Death in Dilated Cardiomyopathy and Skeletal Myopathies -- Ventricular Arrhythmias in Right Ventricular Dysplasia/Cardiomyopathy -- The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death -- Iatrogenic (Drug-Induced) Cardiac Channelopathies and Sudden Cardiac Death -- Drug-Induced Enhanced Risk for Sudden Cardiac Death in Clinical Practice, Clinical Research, and Drug Development -- Pharmacogenomics in Drug Development and Clinical Research -- Mechanisms of Drug-Induced Cardiac Toxicity -- Acquired (Drug-Induced) Long QT Syndrome -- Acquired Form of Brugada Syndrome -- Treatment Modalities -- Treatment Modalities -- Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death -- Nonantiarrhythmic Drugs in Sudden Death Prevention -- The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations -- Beyond Sudden Death Prevention: Minimizing Implantable Cardioverter Defibrillator Shocks and Morbidity and Optimizing Efficacy -- Pacing and Cardiac Resynchronization -- Device Therapy for Remote Patient Management -- Catheter Ablation of Ventricular Tachycardia and Fibrillation -- Surgical Treatment of Atrial Fibrillation -- Risk Stratification and Prevention of Sudden Cardiac Death in Acquired Clinical Conditions -- Screening for Risk of Sudden Cardiac Death -- Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints -- Risk Stratification forSsudden Death in Patients with Coronary Artery Disease -- Heart Failure and Sudden Death -- Neurological Conditions and Sudden Death -- Obstructive Sleep Apnea and Sudden Death -- Sudden Cardiac Death in Athletes -- Sudden Cardiac Death in Infancy: Focus on Prolonged Repolarization -- Sudden Cardiac Death in Kidney Diseases. , English

Additional Edition: ISBN 1-84628-853-3

Language: English

DOI: 10.1007/978-1-84628-854-8

UID:

Format: 1 online resource (448 p.) : , 32 line drawings

ISBN: 9780813586434

Content: Iatrogenesis is the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one’s expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors. This is a huge public health issue: tens to hundreds of thousands of deaths are attributed to iatrogenic causes each year in the U.S., and vulnerable populations such as the elderly and minorities are particularly susceptible. Edited by two renowned cardiology experts, Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine addresses both the iatrogenicity that arises with cardiovascular interventions, as well as non-cardiovascular interventions that result in adverse consequences on the cardiovascular system. The book aims to achieve three things: to summarize the available information on this topic in a single high-yield volume; to highlight the human and financial cost of iatrogenesis; and to describe and propose potential interventions to ameliorate the effects of iatrogenesis. This accessible book is a practical reference for any practicing physician who sees patients with cardiovascular issues. .

Note: Frontmatter -- , Contents -- , Contributors -- , The Concept of Iatrogenicity / , PART I. Medical Harm -- , CHAPTER 1. Iatrogenicity: Definition, History, and Modern Context / , CHAPTER 2. Epidemiology and Public Health Aspects and Implications of Iatrogenicity: Regulatory, Legal and Ethical Dimensions / , CHAPTER 3. Risk Management: The Medical Center Administration Perspective / , CHAPTER 4. Iatrogenicity from the Patient’s Perspective / , CHAPTER 5. A Naturopathic Perspective on Iatrogenesis / , PART II. Iatrogenicity of Cardiovascular Drugs and Cardiovascular Toxicity of Noncardiac Drugs -- , CHAPTER 6. Clinical Manifestations of Acute and Chronic Drug-Induced Iatrogenic Cardiovascular Diseases and Syndromes / , CHAPTER 7. Drug-Induced Cardiac Arrhythmias and Sudden Cardiac Death / , CHAPTER 8. Chemotherapy-Induced Cardiomyopathy / , CHAPTER 9. Iatrogenicity of Blood Pressure Measurement in the Diagnosis of Hypertension / , CHAPTER 10. Antihypertensive Drug–Induced Iatrogenic Cardiovascular Syndromes / , CHAPTER 11. Iatrogenicity of Cardiovascular Drugs Associated With Cardiac and Noncardiac Toxicities: Antihypertensive Agents and Biologics / , CHAPTER 12. Iatrogenic Aspects of Hypertension in Pregnancy: Focus on Preeclampsia / , CHAPTER 13 Women and Iatrogenic Cardiovascular Disease: Menopausal Estrogen as the Prime Suspect / , CHAPTER 14. Iatrogenic Aspects of Lipid-Lowering, Antiplatelet, and Anticoagulant Agents / , CHAPTER 15. Iatrogenic Effects of Urologic Drugs on the Cardiovascular System / , CHAPTER 16. Iatrogenicity and Antianginal Drugs / , CHAPTER 17. Antidiabetic Drugs and Cardiovascular Risk: Where Do We Stand? / , CHAPTER 18. Cardiovascular Iatrogenicity in Older Adults / , PART III. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Noninvasive Cardiovascular Interventions, Devices, and Surgeries -- , CHAPTER 19. Iatrogenic Aspects of Noninvasive and Invasive Diagnostic Methods in Interventional Cardiology / , CHAPTER 20. Iatrogenicity Associated With Interventional Treatment Modalities in Cardiology / , CHAPTER 21. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Noninvasive Cardiovascular Interventions, Devices, and Surgeries / , CHAPTER 22. Iatrogenic Aspects of Cardiac Electrophysiology / , CHAPTER 23. Iatrogenic Aspects in Cardiac Device / , CHAPTER 24. Cardiovascular Iatrogenicity of Respiratory Therapeutic Modalities / , PART IV. Iatrogenic Aspects of Sport Cardiology and Lifestyle Modifications -- , CHAPTER 25. Trained Athletes / , CHAPTER 26. Sports Cardiology / , CHAPTER 27. Dangers of Lifestyle Modification Advice / , PART V. Iatrogenicity of Dietary Supplements, Herbal Products, and Other Nontraditional Therapies in Cardiovascular Medicine -- , CHAPTER 28. Safety of Dietary and Herbal Supplements: Side Effects and Contraindications / , CHAPTER 29. Interactions Between Supplements and Medications / , Index , In English.

Language: English

DOI: 10.36019/9780813586434

URL: https://www.degruyter.com/isbn/9780813586434

URL: https://www.degruyter.com/isbn/9780813586434