Kooperativer Bibliotheksverbund

UID:

Format: xxxii, 855 Seiten : , Illustrationen (teilweise farbig).

ISBN: 978-3-642-03650-7

Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-642-03651-4

Language: English

Subjects: Chemistry/Pharmacy

Keywords: Organische Chemie ; Reaktionsmechanismus ; Lehrbuch ; Lehrbuch ; Lehrbuch ; Lehrbuch

URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018980723&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA

URL: http://d-nb.info/995947813/04

URL: Inhaltsverzeichnis

Author information: Brückner, Reinhard, 1955-

UID:

Format: 1 online resource (537 p.)

Edition: 1st ed.

ISBN: 1-281-09619-9 , 9786611096199 , 0-08-055602-7

Series Statement: Strategies and Tactics in Organic Synthesis

Content: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to

Note: Description based upon print version of record. , Cover; Dedication; Contents; Contributors; Preface; Foreword; Chapter 1. Total Synthesis of RK-397; I. Introduction and Background; II. Retrosynthetic Analysis; III. Synthesis of RK-397; IV. Completion of the Synthesis; V. Summary; Acknowledgements; References and Footnotes; Chapter 2. A Formal Total Synthesis of the Marine Diterpenoid, Diisocyanoadociane; I. Introduction and Background; II. Synthesis Plan; III. Foundations and Proof of Concept; IV. Elaboration of the D-Ring; V. Elaboration of the B-ring and Exploration of the Michael Reaction , VI. Improved Synthesis of an Advanced Tetracyclic IntermediateVII. Deoxygenation, Curtius Rearrangement, and Completion of the Synthesis; IX. Epilogue; Acknowledgments; References and Footnotes; Chapter 3. Total Syntheses of Zoapatanol; I. Introduction; II. Nicolaou's Synthesis; III. Chen's Synthesis; IV. Cookson's Synthesis; V. Kocienski's Synthesis; VI. Kane's Synthesis; VII. Trost's Synthesis; VIII. Our Approaches for the Total Synthesis of (+)-Zoapatanol; IX. Conclusion; References and Footnotes , Chapter 4. Synthesis of Molecular Tweezers and Clips by the use of a Molecular Lego Set and Their Supramolecular FunctionsI. Introduction and Background; II. Retrosynthetic Analysis; III. Preparation of the Molecular Building Blocks; IV. Synthesis of Molecular Tweezers and Clips; V. Thermodynamic Parameters of Host-Guest Complex Formation with Molecular Tweezers and Clips; VI. Host-Guest Structures and Dynamics; VII. Synthesis of Water-Soluble Molecular Tweezers and Clips; VIII. Binding of Biologically Interesting Substrates such as Enzyme Cofactors and Nucleosides in Aqueous Solution , IX. ConclusionAcknowledgments; References and Footnotes; Chapter 5. Application of C-Glycosides in the Total Synthesis of (Š)-Gambierol; I. Introduction and Background; II. Preliminary Studies; III. Synthetic Strategies; IV. Total Synthesis of (Š)-Gambierol; V. Summary; Acknowledgements; References and Footnotes; Chapter 6. A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones; I. Introduction and Background; II. Synthetic Strategies: A Biomimetic Approach via Photogeneration of Oxidopyryliums , III. Synthesis of (Š)-Methyl Rocaglate and Related Natural ProductsIV. Enantioselective Synthesis of Rocaglamide Using Chiral Brønsted Acid; V. Summary; Acknowledgments; References and Footnotes; Chapter 7. Synthesis Studies of Dolabellanes and Transannular Processes Leading to Related Diterpenes; I. Introduction and Background; II. Biosynthesis; III. Preliminary Studies; IV. Synthesis of a Dolastane via a Dolabellane Precursor; V. Fusicoccane Synthesis via a Dolabellane Progenitor: Total Synthesis of (+)-Fusicoauritone; VI. Summary; Acknowledgments; References and Footnotes , Chapter 8. Diphenyloxazinones: Versatile Templates for the Asymmetric Synthesis of a-Amino Acids, Peptide Isosteres, and Natural Products , English

Additional Edition: ISBN 0-12-373903-9

Language: English

UID:

Format: 1 online resource (455 p.)

ISBN: 1-283-54848-8 , 9786613860934 , 0-12-386539-5

Series Statement: Strategies and Tactics in Organic Synthesis

Content: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts how synthesis is really done and how by discovering new reactions, creating new designs and building molecules with atom and step economies, the advancement of the science of organic synthesis is providing solutions through function to create a better world. 〈b

Note: Description based upon print version of record. , Front Cover; Strategies and Tactics in Organic Synthesis; Copyright; Dedication; Contents; Chapter 1: Total Syntheses of Solandelactones E and F; 1. Introductions and Background; 1.1. Solandelactone and Related Natural Products; 1.2. Previous Syntheses; 1.3. Aggarwal Methodology for the Synthesis of 2-ene-1,4-diols; 2. Retrosynthetic Analysis; 3. Synthesis of Solandelactone E; 3.1. Preparation of Aldehyde 3; 3.2. Preparation of Enantioenriched Lithiated Carbamate; 3.3. Completion of Solandelactone E; 4. Synthesis of Solandelactone F; 5. Conclusions; References , Chapter 2: The Marine Alkaloid Halichlorine: Its Defenses and Its Defeat1. Introduction; 2. The First Approach; 3. The First Surprise; 4. The Second Approach; 5. Saved by Selenium; 6. A Stereochemical Disaster-But a Blessing in Disguise; 7. The Ring A Problem and the Development of a General Annulation Method; 8. The Continuing Saga of Ring A; 9. Formation of the Macrolactone; 10. The Optical Purity Problem; 11. Conclusion; Acknowledgments; References; Chapter 3: An Adventure in Synthesis Inspired by the Pseudolaric Acids; 1. How this Chemist Came to Be; 2. Pseudolaric Acids , 3. The First Strategy4. Development of the Copper Hydride-Induced Reductive Aldol Cyclization; 5. The Second Strategy to Pseudolaric Acid A; 6. Case 1: When Model Reactions Fail; 7. Case 2: When Model Reactions Fail; 8. Too Happy too Quickly, and the Importance of IR Spectroscopy; 9. But it was not Time to Give Up; 10. Other Natural Products; 11. Epilogue; Acknowledgments; References; Chapter 4: Total Synthesis of Papulacandin D; 1. Introduction and Background; 2. Retrosynthetic Analysis; 3. Preparation of the Spirocyclic Aryl Glycoside; 3.1. Development of Cross-Coupling Conditions , 3.2. Optimization of Protecting Groups for the Glucal Silanol3.3. Optimization of Protecting Groups for the Aromatic Iodide; 3.4. Implementation of the Key Cross-Coupling Sequence; 3.5. Oxidative Spiroketalization and C(2)-Hydroxyl Group Protection; 3.6. Completion of the Synthesis of the Spirocyclic Aryl Glyco-Pyranoside; 4. Synthesis of Fatty Acid Side Chain 26 and Acylation; 4.1. Preparation of the Dienylaldehyde 28; 4.2. Model Study of Lewis-Base-Catalyzed Asymmetric Aldol Addition Reactions; 4.2.1. Doubly Vinylogous Aldol Addition; 4.2.2. Vinylogous Aldol Addition , 4.2.3. Simple Aldol Addition: Is the α-Methyl Group of the Aldehyde Problematic?4.3. Model Study of an Asymmetric Allylation Reaction; 4.4. Asymmetric Allylation of Aldehyde 28 and Proof of Configuration; 4.5. Acylation of tris-SEM Protected Aryl Glycoside; 4.5.1. Model Acylation with Sorbic Acid; 5. Studies on the Global Deprotection to Synthesize Papulacandin D; 5.1. Model Study of SEM Deprotection; 6. New Protecting Group Strategy; 6.1. Introduction of TEOC Protecting Groups; 6.2. Studies on the Removal of TEOC Groups; 7. Global Deprotection; 8. Conclusion; Acknowledgments; References , Chapter 5. Asymmetric Total Synthesis of the Antitumor Sesquiterpenoid (+)-Eremantholide A , English

Additional Edition: ISBN 0-12-386540-9

Language: English

UID:

Format: 1 online resource (xx, 402 pages) : , illustrations

ISBN: 0470597518 , 9780470597514 , 1282772902 , 9781282772908

Content: "The book will provide a resource for people wishing to do chemistry with silver cations, an area that stands in the shadow of gold chemistry but is quite powerful and ultimately less expensive"--

Note: Frontmatter -- Silver Alkyls, Alkenyls, Aryls, and Alkynyls in Organic Synthesis / Rebecca H Pouwer, Craig M Williams -- Cycloaddition Reactions / Alex M Szpilman, Erick M Carreira -- Sigmatropic Rearrangements and Related Processes Promoted by Silver / Jean-Marc Weibel, Auřlien Blanc, Patrick Pale -- Silver(I)-Mediated Electrocyclic Processes / Tina N Grant, Frederick G West -- Silver-Catalyzed Cycloisomerization Reactions / Philippe Belmont -- Silver-Catalyzed Nitrene Transfer Reactions / Zigang Li, David A Capretto, Chuan He -- Silver-Catalyzed Silylene Transfer / Tom G Driver -- Silver Carbenoids / Carl J Lovely -- Aldol and Related Processes / Masanori Kawasaki, Hisashi Yamamoto -- Coupling Reactions Promoted by Silver / Jean-Marc Weibel, Auřlien Blanc, Patrick Pale -- Supramolecular Chemistry of Silver / Wei-Yin Sun, Zheng-Shuai Bai, Jin-Quan Yu -- A Critical Comparison: Copper, Silver, and Gold / A Stephen K Hashmi -- Index.

Additional Edition: Print version: Silver in organic chemistry. Hoboken, N.J. : John Wiley & Sons, ©2010 ISBN 9780470466117

Language: English

Keywords: Electronic books. ; Electronic books. ; Electronic books.

DOI: 10.1002/9780470597521

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470597521

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470597521

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470597521

UID:

Format: 1 online resource (xxii, 322 pages) : , illustrations (some color).

ISBN: 0-12-405855-8

Series Statement: Strategies and Tactics in Organic Synthesis

Content: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune

Note: "ISSN: 1874-6004." , Front Cover; Strategies and Tactics in Organic Synthesis; Copyright; Dedication; Contents; Contributors; Foreword; Preface; Chapter 1: Total Synthesis of Strychnos Alkaloids Akuammicine, Strychnine, and Leuconicines A and B; 1. Introduction and Overview; 2. Background on the Synthesis of Strychnine and Our Retrosynthesis; 3. Selected Strategies for Preparing the ABCE Tetracyclic Framework of Strychnos and Aspidosperma Alkaloids; 3.1. Ziegler ́s 1,2-Dibromoethane Linchpin Approach; 3.2. Potier-Wenkert 2-Haloacetyl-Gramine Approach; 3.3. Magnus ́ Pummerer Approach , 3.4. Natsume ́s 2-Chloroethylgramine Approach3.5. Bosch ́s Thionium Approach; 3.6. Rubiralta ́s 2-Hydroxyethyl Gramine Approach; 3.7. Heathcock ́s 2-Iodoacetylgramine Approach; 3.8. Rawal ́s 2-Chloroethylgramine Approach; 3.9. Martin ́s 2-Hydroxyethyl Gramine Approach; 4. Selected Bis-Cyclization Approaches; 4.1. Harley-Mason ́s Approach; 4.2. Büchi ́s Approach; 4.3. Wenkert ́s Approach; 4.4. Kuehne ́s Approach; 4.5. Padwa ́s Approach; 4.6. Vanderwal ́s Approach; 5. Our Approach to the ABCE Tetracycle; 6. Racemic Syntheses of Akuammicine and Strychnine; 7. Asymmetric Preparation of the ABCE Tetracycle , 8. Asymmetric Syntheses of Leuconicines A and BAcknowledgments; References; Chapter 2: Total Synthesis of the Unusual Peptide Celogentin C; 1. Introduction; 2. First Synthetic Plan and Initial Studies; 2.1. First-Generation Retrosynthesis; 2.2. Catalytic Asymmetric Synthesis of Functionalized Tryptophan Derivative; 2.3. Radical Conjugate Addition Model Studies; 2.4. Attempted Metal-Catalyzed Aryl Aminations; 3. Synthesis of the Right-Hand Ring via Oxidative Coupling; 3.1. Model Studies; 3.2. Synthesis of Functionalized Right-Hand Ring; 4. Early Attempts to Form the Left-Hand Ring , 4.1. Intramolecular Knoevenagel Condensation and Alkylation Strategies4.2. Intermolecular Knoevenagel Condensation and Change in Overall Strategy; 5. Construction of the Left-Hand Ring; 5.1. Radical Conjugate Addition and Nitro Reduction; 5.2. Macrolactamization and Determination of Stereochemistry; 6. Oxidative Coupling Is Enabled by an Unexpected Additive; 6.1. The Serendipitous Discovery; 6.2. Mechanistic Studies; 7. Right-Hand Macrolactamization and One Final Surprise; 8. Anticancer Screening; 9. Conclusion; Acknowledgments; References , Chapter 3: The Upside of Panic: Developing a Synthesis of Englerin A1. Introduction: Carbonyls and Target Selection; 1.1. Working with Carbonyl Chemistry; 1.2. Englerin A, Englerin B, and Englerin B Acetate; 1.2.1. Structure and Biological Activity of the Natural Product; 1.2.2. Proposed Biosynthesis of the Natural Product; 1.2.3. The Big Idea: Putting Together the Natural Product; 2. Putting the Pieces Together: Developing a Carbonyl-Based Synthesis of Englerin A; 2.1. Synthesis of the Building Blocks and Liabilities of Their Union; 2.2. A Diastereoselective Michael Addition , 2.3. Umpolung Chemistry to Close the Core Structure , English

Additional Edition: ISBN 0-08-099362-1

Additional Edition: ISBN 1-299-77448-2

Language: English

UID:

Format: 1 online resource (xxii, 322 pages) : , illustrations (some color).

ISBN: 0-12-405855-8

Series Statement: Strategies and Tactics in Organic Synthesis

Content: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune

Note: "ISSN: 1874-6004." , Front Cover; Strategies and Tactics in Organic Synthesis; Copyright; Dedication; Contents; Contributors; Foreword; Preface; Chapter 1: Total Synthesis of Strychnos Alkaloids Akuammicine, Strychnine, and Leuconicines A and B; 1. Introduction and Overview; 2. Background on the Synthesis of Strychnine and Our Retrosynthesis; 3. Selected Strategies for Preparing the ABCE Tetracyclic Framework of Strychnos and Aspidosperma Alkaloids; 3.1. Ziegler ́s 1,2-Dibromoethane Linchpin Approach; 3.2. Potier-Wenkert 2-Haloacetyl-Gramine Approach; 3.3. Magnus ́ Pummerer Approach , 3.4. Natsume ́s 2-Chloroethylgramine Approach3.5. Bosch ́s Thionium Approach; 3.6. Rubiralta ́s 2-Hydroxyethyl Gramine Approach; 3.7. Heathcock ́s 2-Iodoacetylgramine Approach; 3.8. Rawal ́s 2-Chloroethylgramine Approach; 3.9. Martin ́s 2-Hydroxyethyl Gramine Approach; 4. Selected Bis-Cyclization Approaches; 4.1. Harley-Mason ́s Approach; 4.2. Büchi ́s Approach; 4.3. Wenkert ́s Approach; 4.4. Kuehne ́s Approach; 4.5. Padwa ́s Approach; 4.6. Vanderwal ́s Approach; 5. Our Approach to the ABCE Tetracycle; 6. Racemic Syntheses of Akuammicine and Strychnine; 7. Asymmetric Preparation of the ABCE Tetracycle , 8. Asymmetric Syntheses of Leuconicines A and BAcknowledgments; References; Chapter 2: Total Synthesis of the Unusual Peptide Celogentin C; 1. Introduction; 2. First Synthetic Plan and Initial Studies; 2.1. First-Generation Retrosynthesis; 2.2. Catalytic Asymmetric Synthesis of Functionalized Tryptophan Derivative; 2.3. Radical Conjugate Addition Model Studies; 2.4. Attempted Metal-Catalyzed Aryl Aminations; 3. Synthesis of the Right-Hand Ring via Oxidative Coupling; 3.1. Model Studies; 3.2. Synthesis of Functionalized Right-Hand Ring; 4. Early Attempts to Form the Left-Hand Ring , 4.1. Intramolecular Knoevenagel Condensation and Alkylation Strategies4.2. Intermolecular Knoevenagel Condensation and Change in Overall Strategy; 5. Construction of the Left-Hand Ring; 5.1. Radical Conjugate Addition and Nitro Reduction; 5.2. Macrolactamization and Determination of Stereochemistry; 6. Oxidative Coupling Is Enabled by an Unexpected Additive; 6.1. The Serendipitous Discovery; 6.2. Mechanistic Studies; 7. Right-Hand Macrolactamization and One Final Surprise; 8. Anticancer Screening; 9. Conclusion; Acknowledgments; References , Chapter 3: The Upside of Panic: Developing a Synthesis of Englerin A1. Introduction: Carbonyls and Target Selection; 1.1. Working with Carbonyl Chemistry; 1.2. Englerin A, Englerin B, and Englerin B Acetate; 1.2.1. Structure and Biological Activity of the Natural Product; 1.2.2. Proposed Biosynthesis of the Natural Product; 1.2.3. The Big Idea: Putting Together the Natural Product; 2. Putting the Pieces Together: Developing a Carbonyl-Based Synthesis of Englerin A; 2.1. Synthesis of the Building Blocks and Liabilities of Their Union; 2.2. A Diastereoselective Michael Addition , 2.3. Umpolung Chemistry to Close the Core Structure , English

Additional Edition: ISBN 0-08-099362-1

Additional Edition: ISBN 1-299-77448-2

Language: English

UID:

Format: 1 online resource (xxii, 322 pages) : , illustrations (some color).

ISBN: 0-12-405855-8

Series Statement: Strategies and Tactics in Organic Synthesis

Content: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune

Note: "ISSN: 1874-6004." , Front Cover; Strategies and Tactics in Organic Synthesis; Copyright; Dedication; Contents; Contributors; Foreword; Preface; Chapter 1: Total Synthesis of Strychnos Alkaloids Akuammicine, Strychnine, and Leuconicines A and B; 1. Introduction and Overview; 2. Background on the Synthesis of Strychnine and Our Retrosynthesis; 3. Selected Strategies for Preparing the ABCE Tetracyclic Framework of Strychnos and Aspidosperma Alkaloids; 3.1. Ziegler ́s 1,2-Dibromoethane Linchpin Approach; 3.2. Potier-Wenkert 2-Haloacetyl-Gramine Approach; 3.3. Magnus ́ Pummerer Approach , 3.4. Natsume ́s 2-Chloroethylgramine Approach3.5. Bosch ́s Thionium Approach; 3.6. Rubiralta ́s 2-Hydroxyethyl Gramine Approach; 3.7. Heathcock ́s 2-Iodoacetylgramine Approach; 3.8. Rawal ́s 2-Chloroethylgramine Approach; 3.9. Martin ́s 2-Hydroxyethyl Gramine Approach; 4. Selected Bis-Cyclization Approaches; 4.1. Harley-Mason ́s Approach; 4.2. Büchi ́s Approach; 4.3. Wenkert ́s Approach; 4.4. Kuehne ́s Approach; 4.5. Padwa ́s Approach; 4.6. Vanderwal ́s Approach; 5. Our Approach to the ABCE Tetracycle; 6. Racemic Syntheses of Akuammicine and Strychnine; 7. Asymmetric Preparation of the ABCE Tetracycle , 8. Asymmetric Syntheses of Leuconicines A and BAcknowledgments; References; Chapter 2: Total Synthesis of the Unusual Peptide Celogentin C; 1. Introduction; 2. First Synthetic Plan and Initial Studies; 2.1. First-Generation Retrosynthesis; 2.2. Catalytic Asymmetric Synthesis of Functionalized Tryptophan Derivative; 2.3. Radical Conjugate Addition Model Studies; 2.4. Attempted Metal-Catalyzed Aryl Aminations; 3. Synthesis of the Right-Hand Ring via Oxidative Coupling; 3.1. Model Studies; 3.2. Synthesis of Functionalized Right-Hand Ring; 4. Early Attempts to Form the Left-Hand Ring , 4.1. Intramolecular Knoevenagel Condensation and Alkylation Strategies4.2. Intermolecular Knoevenagel Condensation and Change in Overall Strategy; 5. Construction of the Left-Hand Ring; 5.1. Radical Conjugate Addition and Nitro Reduction; 5.2. Macrolactamization and Determination of Stereochemistry; 6. Oxidative Coupling Is Enabled by an Unexpected Additive; 6.1. The Serendipitous Discovery; 6.2. Mechanistic Studies; 7. Right-Hand Macrolactamization and One Final Surprise; 8. Anticancer Screening; 9. Conclusion; Acknowledgments; References , Chapter 3: The Upside of Panic: Developing a Synthesis of Englerin A1. Introduction: Carbonyls and Target Selection; 1.1. Working with Carbonyl Chemistry; 1.2. Englerin A, Englerin B, and Englerin B Acetate; 1.2.1. Structure and Biological Activity of the Natural Product; 1.2.2. Proposed Biosynthesis of the Natural Product; 1.2.3. The Big Idea: Putting Together the Natural Product; 2. Putting the Pieces Together: Developing a Carbonyl-Based Synthesis of Englerin A; 2.1. Synthesis of the Building Blocks and Liabilities of Their Union; 2.2. A Diastereoselective Michael Addition , 2.3. Umpolung Chemistry to Close the Core Structure , English

Additional Edition: ISBN 0-08-099362-1

Additional Edition: ISBN 1-299-77448-2

Language: English

UID:

Format: xvii, 332 Seiten : , Illustrationen.

ISBN: 978-0-12-814805-1

Language: English

Subjects: Chemistry/Pharmacy

UID:

Format: 1 online resource (352 pages)

ISBN: 0-12-814806-3 , 0-12-814805-5

Language: English

UID:

Format: 1 online resource (352 pages)

ISBN: 0-12-814806-3 , 0-12-814805-5

Language: English