Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource.

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 978-1-4020-8441-6

Additional Edition: Reproduktion von General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma 2008

Language: English

DOI: 10.1007/978-1-4020-8442-3

URL: Volltext

URL: Volltext

UID:

Format: 1 Online-Ressource

Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008

ISBN: 9781402083693

In: 1

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-4020-8368-6

Language: English

DOI: 10.1007/978-1-4020-8369-3

URL: Volltext

UID:

Format: XVII, 455 S. : Ill.

ISBN: 0-306-44294-9

Language: English

Subjects: Biology

Keywords: Elektronenmikroskopie ; Färben ; Cytochemie ; Färben ; Färben ; Biologie

URL: Inhaltsverzeichnis

URL: http://www.loc.gov/catdir/enhancements/fy0819/92040617-d.html

URL: http://www.loc.gov/catdir/enhancements/fy0819/92040617-t.html

URL: Inhaltsverzeichnis

UID:

Format: 1 online resource (lvii, 733 pages) : , illustrations

ISBN: 0-12-374212-9

Note: Bibliographic Level Mode of Issuance: Monograph , English

Language: English

UID:

Format: XVIII, 323 S. : Ill., graph. Darst.

ISBN: 0-8391-1173-8

Language: English

URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008566567&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA

URL: Inhaltsverzeichnis

URL: Inhaltsverzeichnis

UID:

Format: 1 Online-Ressource (XXXVI, 602 Seiten)

ISBN: 9781402084423

Series Statement: Methods of cancer diagnosis, therapy, and prognosis volume 2

Content: This is the first book that discusses the subjects of diagnosis, therapy, therapy assessment, and prognosis of lung and prostate cancer in one single volume. Cancer killed 6.7 million people around the world in 2002, and this figure is expected to rise to 10.1 million in 2020. Lung cancer has been the most common cancer in the world since 1985, and by 2002 there were 1.35 million new cases, representing 12.5% of all new cancers. It was also the most common cause of death from cancer, with 1.18 million deaths (17.6% of the world total). Lung cancer remains a highly lethal disease. After diagnosis, survival at 5 years in the United States is 15%. This second volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis presents a comprehensive treatise on all aspects of Lung and Prostate cancer, including diagnosis, treatments and prognosis. Scientists and Clinicians have contributed state of the art chapters on their respective areas of expertise providing the reader a whole field view of lung and prostate cancer management. This fully illustrated volume * Discusses diagnosis using molecular genetics, various imaging modalities, tumor markers and tumor gene therapy * Discusses treatments such as chemotherapy, radiation, chemoradiation, hormonal therapy, immunotherapy, and surgery, and prognosis * Highlights both primary and secondary cancers, and explains the risk of cancer survivors developing other cancers. * Attempts to translate molecular genetics into clinical practice. Evidence-based therapy is included. * Discusses the role of histology and immunohistochemistry in differentiating between pleuropulmonary desmoid tumors and solid fibroustumors. * Discusses cancer stem cells, mutations, cancer vaccines, and personalized cancer medicine. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editinga must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Note: Description based upon print version of record , Metabolic Transformations of Malignant Cells: An Overview; Detection of Recurrent Cancer by Radiological Imaging; Tumor Gene Therapy: Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy; Assessment of Gene Transfer: Magnetic Resonance Imaging and Nuclear Medicine Techniques; Role of TP53 Mutations in Cancer (An Overview); Personalized Medicine for Cancer; Radiation Doses to Patients Using Computed Radiography, Direct Digital Radiography, and Screen-Film Radiography; Cancer Vaccines and Immune Monitoring (An Overview) , New Insights into the Role of Infection,Immunity and Apoptosis in the Genesis of the Cancer Stem CellSuccessful Cancer Treatment: Eradication of Cancer Stem Cells; Overexposure of Patients to Ionizing Radiation: An Overview; Lung Carcinoma; Extra-Pulmonary Small Cell Cancer: Diagnosis, Treatment, and Prognosis; Magnetic Resonance Imaging of the Lung: Automated Segmentation Methods; Peripheral Lung Lesions: Diagnosis Using Transcutaneous Contrast-Enhanced Sonography; Small Pulmonary Nodules: Detection Using Multidetector-Row Computed Tomography , Secondary Primary Cancer Following Chemoradiation for Non-Small-Cell Lung CancerAdvanced Non-Small Cell Lung Cancer: Second-Line Treatment with Docetaxel; Non-Small Cell Lung Cancer with Brain Metastases: Platinum-Based Chemotherapy; Non-Small Cell Lung Carcinoma: EGFR Gene Mutations and Response to Gefitinib; Advanced Non-Small Cell Lung Carcinoma: Acquired Resistance to Gefitinib; Prognostic Significance of [18F]-Fluorodeoxyglucose Uptake on Positron Emission Tomography in Patients with Pathological Stage I Lung Adenocarcinoma , Non-Small Cell Lung Cancer: Prognosis Using the TNM Staging SystemDifferentiation Between Malignant and Benign Pleural Effusions: Methylation Specific Polymerase Chain Reaction Analysis; Pathological Distinction of Pulmonary Large Cell Neuroendocrine Carcinoma from Small-Cell Lung Carcinoma Using Immunohistochemistry; Differentiation Between Pleuropulmonary Desmoid Tumors and Solitary Fibrous Tumors: Role of Histology and Immunohistochemistry; Non-Small Cell Lung Cancer with Brain Metastasis: Role of Epidermal Growth Factor Receptor Gene Mutation; Prostate Carcinoma , The Role of Intermediary Metabolism and Molecular Genetics in Prostate CancerArray-Based Comparative Genomic Hybridization in Prostate Cancer: Research and Clinical Applications; Prostate Cancer: Role of Vav3 Overexpression in Development and Progression; Prostate Cancer: Detection and Monitoring Using Mitochondrial Mutations as a Biomarker; Prognostic Markers in Prostatic Carcinoma; Prostate Cancer: Detection of Free Tumor-Specific DNA in Blood and Bone Marrow; Prostate Carcinoma: Evaluation Using Transrectal Sonography , Prostate Cancer: 16ß-[18F] Fluoro-5a-Dihydrotesterone (FDHT) Whole-Body Positron Emission Tomography

Additional Edition: ISBN 9781402084416

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-4020-8441-6

Language: English

DOI: 10.1007/978-1-4020-8442-3

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: 1 Online-Ressource (XLVIII, 728 Seiten) , Illustrationen

ISBN: 9781402083693

Series Statement: Methods of cancer diagnosis, therapy and prognosis volume 1

Content: Discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer. Part of the series "Methods of Cancer Diagnosis, Therapy and Prognosis", this title presents a constructive evaluation of commonly used methods for elucidating primary and secondary cancer initiation, progression, relapse, and metastasis

Note: Includes bibliographical references and index , Breast Cancer: An Introduction; Breast Cancer: Computer-Aided Detection; Sebaceous Carcinoma of the Breast: Clinicopathologic Features; Breast Cancer: Detection by In-Vivo Imaging of Angiogenesis; Breast and Prostate Biopsies: Use of Optimized High-Throughput MicroRNA Expression for Diagnosis (Methodology); Familial Breast Cancer: Detection of Prevalent High-Risk Epithelial Lesions; Differentiation Between Benign and Malignant Papillary Lesions of Breast: Excisional Biopsy or Stereotactic Vacuum-Assisted Biopsy (Methodology) , Multicentric Breast Cancer: Sentinel Node Biopsy as a Diagnostic ToolBreast Cancer Recurrence: Role of Serum Tumor Markers CEA and CA 15-3; Breast Cancer Patients Before, During or After Treatment: Circulating Tumor Cells in Peripheral Blood Detected by Multigene Real-Time Reverse Transcriptase-Polymerase Chain Reaction; Breast Cancer Patients: Diagnostic Epigenetic Markers in Blood; Breast Cancer Patients: Detection of Circulating Cancer Cell-Related mRNA Markers with Membrane Array Method , Prediction of Metastasis and Recurrence of Breast Carcinoma: Detection of Survivin-Expressing Circulating Cancer CellsNode-Negative Breast Cancer: Predictive and Prognostic Value of Peripheral Blood Cytokeratin-19 mRNA-Positive Cells; Breast and Colon Carcinomas: Detection with Plasma CRIPTO-1; Breast Cancer Risk in Women with Abnormal Cytology in Nipple Aspirate Fluid; Tissue Microarrays: Construction and Utilization for Biomarker Studies; Systematic Validation of Breast Cancer Biomarkers Using Tissue Microarrays: From Construction to Image Analysis , Phyllodes Tumors of the Breast: The Role of Immunohistochemistry in DiagnosisPhyllodes Tumor of the Breast: Prognostic Assessment Using Immunohistochemistry; Metaplastic Breast Carcinoma: Detection Using Histology and Immunohistochemistry; Invasive Breast Cancer: Overexpression of HER-2 Determined by Immunohistochemistry and Multiplex Ligation-Dependent Probe Amplification; Operable Breast Cancer: Neoadjuvant Treatment (Methodology); Chemotherapy for Breast Cancer; Locally Advanced Breast Cancer: Role of Chemotherapy in Improving Prognosis , Relevance of Dose-Intensity for Adjuvant Treatment of Breast CancerAdvanced Breast Cancer: Treatment with Docetaxel/Epirubicin; Systemic Therapy for Breast Cancer: Using Toxicity Data to Inform Decisions; Chemotherapy for Metastatic Breast Cancer Patients Who Received Adjuvant Anthracyclines (An Overview); Estrogen Receptor-Negative and HER-2/neu-Positive Locally Advanced Breast Carcinoma: Therapy with Paclitaxel and Granulocyte-Colony Stimulating Factor; Breast Cancer: Side Effects of Tamoxifen and Anastrozole , Breast Cancer: Expression of HER-2 and Epidermal Growth Factor Receptor as Clinical Markers for Response to Targeted Therapy

Additional Edition: ISBN 9781402083686

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-4020-8368-6

Language: English

DOI: 10.1007/978-1-4020-8369-3

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: 1 online resource (261 p.)

ISBN: 1-280-62844-8 , 9786610628445 , 0-08-045625-1

Series Statement: Handbook of immunohistochemistry and in situ hybridization of human carcinomas ; 3

Content: Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides ste

Note: Description based upon print version of record. , Front Cover; Genetic Recombination in Cancer; Copyright Page; Contents; Preface; Abbreviations; Chapter 1. Introduction; Chapter 2. Genetic integrity, DNA repair and recombination; Base excision and nucleotide excision repair system; RAD genes and their operation in DNA replication checkpoint; DNA recombination repair pathway; VDJ recombination, the immune system and haematological malignancy; SET domain proteins in genetic transcription, growth regulation and myeloma; Ku protein in cell function; Chapter 3. Replication error (RER) and genetic instability , Microsatellite instability and cancer progressionEffects of microsatellite instability on p53 and growth factor gene expression; Influence of microsatellite instability on invasive behaviour of tumours; Microsatellite instability and metastasis suppressor nm23 gene abnormalities; Chromosomal fragile sites and the RER phenotype; Sister chromatid recombination and fragile sites; Microsatellite instability and sister chromatid recombination; Genomic stability and chromosome structural dynamics; Chapter 4. DNA repeats, genetic recombination and the pathogenesis of genetic disorders , CAG repeat expansion and genetic instabilityMicrosatellite dinucleotide repeats in insulin-dependent diabetes mellitus and autoimmune thyroid disease; Alu repeats in genetic recombination; LINE repeats in genetic rearrangement; Cognate elements associated with recombination; Chapter 5. Chromosomal recombination in cancer; Karyotypic abnormalities in cancer; DNA aneuploidy and cancer progression; DNA ploidy, cell proliferation and growth factor expression; Association of DNA ploidy with p53 abnormalities; Chapter 6. Chromosomal translocation and its phenotypic effects , Chromosomal translocation and signal transductionChromosomal translocation and the dynamics of cell population expansion in cancer; The PI-3 kinase/Akt pathway of signal transduction in cell proliferation, apoptosis and differentiation; Chromosomal translocation and genetic transcription; Chromosomal translocation, fusion proteins and tumour vascularisation; Chromosomal translocations, fusion proteins and immunity; The association of chromosomal translocation with fragile sites; Chromosomal fragility, genetic loss and tumour suppressor genes , Gene amplification and its relationship to genetic instabilityChromosomal fragility and micronuclei; Chapter 7. DNA methylation and genetic instability; DNA methylation in normal and neoplastic development; Abnormal DNA methylation in ICF and Rett syndromes; DNA methylation and genetic instability; The CpG Island Methylator Phenotype (CIMP); Influence of DNA methylation on recombination; Methylation-associated chromosomal recombination and genetic transcription in childhood leukaemias; The dynamics of histone acetylation in cell differentiation, cell proliferation and neoplasia , The effects of p53 methylation on chromosome stability , English

Additional Edition: ISBN 0-12-372546-1

Additional Edition: ISBN 0-12-088404-6

Language: English

UID:

Format: 1 online resource (lxxix, 349 pages) : , illustrations

ISBN: 0-12-809427-3 , 0-12-805420-4

Note: Includes index. , Front Cover -- Autophagy -- Copyright Page -- Dedication -- Knowing Autophagy -- 10 Lines of Autophagy for Volume 10 -- Mitophagy and Biogenesis -- Autophagy and Cancer -- Some Thoughts on Autophagy and Immunity -- Autophagy: Friend or Foe? -- Autophagy: If and When -- What Happened When Autophagy Didn't -- Sugar Isn't Always Sweet -- Mitochondrial Mysteries -- A Photo Is Static, An Instant in Time -- Autophagy Subversion -- Contents -- Foreword by Roberta A. Gottlieb -- Foreword by Eeva-Liisa Eskelinen -- Preface -- Contributors -- Autophagy: Volume 1-Contributions -- Autophagy: Volume 2-Contributions -- Autophagy: Volume 3-Contributions -- Autophagy: Volume 4-Contributions -- Autophagy: Volume 5-Contributions -- Autophagy: Volume 6-Contributions -- Autophagy:Volume 7-Contributions -- Autophagy: Volume 8-Contributions -- Autophagy: Volume 9-Contributions -- Autophagy: Volume 10-Contributions -- I. Molecular Mechanisms -- 1 Overview of Autophagy -- Specific Functions of Autophagy (A Summary) -- Autophagy Process -- Autophagy in Normal Mammalian Cells -- Endoplasmic Reticulum -- ER Stress -- Major Types of Autophagies -- Macroautophagy (Autophagy) -- Microautophagy -- Chaperone-Mediated Autophagy -- Autophagosome Formation -- Autophagic Flux -- Autophagic Lysosome Reformation -- Autophagy as a Double-Edged Sword -- Protein Synthesis -- Methods -- Abnormal Proteins -- Molecular Chaperones -- The ER -- ER and Apoptosis -- Autophagic Proteins -- Protein Degradation Systems -- Beclin 1 -- Nonautophagic Functions of Autophagy-Related Proteins -- Microtubule-Associated Protein Light Chain 3 -- Aggrephagy -- Aggresome, Ubiquitin Proteasome, and Autophagic Systems -- Monitoring Autophagy -- Reactive Oxygen Species -- Mammalian Target of Rapamycin -- Role of Autophagy in Tumorigenesis and Cancer -- Autophagy and Immune System -- Autophagy and Senescence. , Role of Autophagy and Cellular Senescence in Aging -- Role of mTOR -- Response by mTOR and Autophagy to Dietary Restriction -- Role of Sirtuins -- Role of Stem Cells -- Role of Cellular Senescence -- Effect of Aging on Skeletal Muscle -- Role of Autophagy in Heart Disease -- Role of Autophagy in Huntington's Disease -- Role of Autophagy in Alzheimer's Disease -- Role of Autophagy in Macular Degeneration -- Role of Autophagy in Viral Defense and Replication -- Role of Autophagy in Intracellular Bacterial Infection -- Role of Autophagy in Heart Disease -- Role of Autophagy in Neurodegenerative Diseases -- Cross Talk Between Autophagy and Apoptosis -- Autophagy and Ubiquitination -- Autophagy and Necroptosis -- Mitochondrial Fusion and Fission -- Selective Autophagy -- Allophagy -- Axonophagy (Neuronal Autophagy) -- Chromatophagy -- Ciliophagy -- Crinophagy -- Exophagy -- Glycophagy -- Lipophagy -- Lysophagy -- Mitophagy -- Nucleophagy -- Pexophagy -- Role of Pexophagy in Yeast -- Reticulophagy -- Ribophagy -- Xenophagy -- Zymophagy -- References -- 2 Methods for Measuring Autophagosome Flux-Impact and Relevance -- Introduction -- Measuring Autophagic Flux-A Slope Rather Than a Column -- Quantifying the Autophagic Flux Deviation With Precision -- Modeling the Autophagy System-Key Determinants Characterized by Rates -- Summary, Conclusion, and Future Outlook -- Acknowledgments -- References -- 3 Loss of Pigment Epithelial Cells Is Prevented by Autophagy -- Introduction -- Anatomy and Histology -- General Morphology -- Morphological Polarity -- Regional Heterogeneity -- Functional Polarity and Heterogeneity -- Cellular Junctions -- Cytoskeletons -- Function of the RPE -- Bruch Membrane and IPM Synthesis -- Absorption of Light -- Role in Visual Cycle -- Phagocytosis of Photoreceptor OS and Photoreceptor Renewal. , Transepithelial Transport of Molecules and Ions, Water -- Secretion -- Function in Immune Privilege -- Exposure to Potential Damage -- Exposure to Potential Damage -- Protection From the Light and Oxidative Stress -- Age-Related Macular Degeneration -- Autophagy in the RPEs -- Overview on Autophagy -- Autophagy in Retinal Homeostasis -- Autophagy in RPECs Homeostasis -- Aging and Autophagy in RPECs -- Autophagy of Iron-Binding Proteins in RPECs -- Retinal Pathologic Conditions and Autophagy of RPECs -- Autophagy of RPECs in Experimental Systems -- Involvement of Autophagy in RPECs Demise -- αB-Crystallin and Autophagy -- αB-Crystallin and Autophagy in RPECs -- Conclusions -- Acknowledgment -- References -- 4 Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator RE ... -- Introduction -- Proteasome Links Autophage and Lipid Metabolism-Molecular Mechanisms -- REGγ and Ub-Independent Proteasome Systems -- REGγ Regulates Hepatic Lipid Metabolism Through Inhibition of Autophagy -- Molecular Switch: REGγ-Sirt1 Cross Talk Modulates Autophage Activity in Lipid Metabolism -- SirT1 (Yeast Sir2) as a Nutrient/Metabolic Sensor -- REGγ-SirT1 Regulates Lipid Metabolism by Modulating Autophagy -- Discussion -- Acknowledgments -- References -- 5 Role of Autophagy in Regulating Cyclin A2 Degradation: Live-Cell Imaging -- Introduction -- Autophagy Regulates Protein Turnover -- Mitotic Autophagy, a Failsafe Mechanism -- Monitoring a Nonclassical Substrate of Autophagy, Cyclin A2 -- Discussion -- References -- 6 Roles of Rab-GAPs in Regulating Autophagy -- Introduction -- Roles of Rab-Type Small GTPases in Membrane Trafficking -- Membrane Remodeling in Autophagy -- RAB-GAPs Involved in Autophagy -- TBC1D2/Armus -- TBC1D5 -- TBC1D14 -- TBC1D15 and TBC1D17 -- TBC1D25/OATL1 -- Rab3GAP1 and Rab3GAP2. , Other Rab-GAPs Possibly Involved in Autophagy -- Discussion -- Acknowledgments -- References -- 7 The Role of Histone Deacetylase Inhibition in the Accumulation and Stability of Disease-Related Proteins -- Introduction -- Histones and HDAC Enzymes -- Class I HDACs -- Class II HDACs -- Class III and IV HDACs -- HDAC Inhibitors -- Cancer Versus Neurodegenerative Disorders -- Ubiquitin Proteasomal and Autophagy Pathways -- Protein Folding Disorders/Proteopathies -- Huntington's Disease -- Alzheimer's Disease -- Parkinson's Disease -- A Role for HDAC Inhibitors in Proteopathies -- HDAC Inhibitors and HD -- Autophagy and Htt clearance -- Altered Ubiquitination-Related Gene Expression in Response to HDAC Inhibitors -- HDAC Inhibitors in AD -- HDAC Inhibitors and PD Models -- Conclusions/Future Perspectives -- References -- 8 The Role of Atg9 in Yeast Autophagy -- Introduction -- Structure and Role of Atg9 in Autophagy -- Atg9 Trafficking via ER and Golgi Compartments -- Atg9 Vesicles/Reservoirs Contribute to the Formation of the Preautophagosomal Structure -- Atg9 Roles at the Preautophagosomal Structure -- Atg9 Recycling From Autophagosomal Membranes -- Concluding Remarks -- Acknowledgments -- References -- II. Role in Disease -- 9 Methods for Measuring Autophagy Levels in Disease -- Introduction -- Methods of Measuring Autophagy in Disease -- In Vitro Methods -- Transmission Electron Microscopy -- Immunoblots for LC3 and SQSTM1/p62 -- LC3 and p62 Immunohistochemistry -- LC3 Fluorescence Microscopy -- Tandem GFP-RFP-LC3 to Assess Autophagic Flux -- Flow Cytometry-Based Methods -- Nanoparticles -- In Vivo Methods -- Diseases -- Cancer -- Neurodegeneration -- Infectious Diseases -- Metabolic Diseases and Myopathies -- Autoimmune Disorders -- Emerging Trends -- References -- 10 Regulation of the DNA Damage Response by Autophagy -- Introduction. , The DNA Damage Response (DDR) in Higher Eukaryotes -- Types of DNA Damage -- DNA Damage Checkpoint -- DNA Damage Checkpoint Signaling -- The DDR in Budding Yeast -- Repair of DNA Damage -- Double Strand Break (DSB) Repair -- Nonhomologous End Joining -- Homologous Recombination -- The Autophagy Pathway in Higher Eukaryotes -- The Autophagy Pathway -- Regulation of Autophagy in Yeast and Mammals -- Selective Autophagy -- Mitophagy -- Pexophagy -- Chaperone-Mediated Autophagy -- Autophagy and DNA Damage-A Complex Cross Talk -- A DNA Damage-Induced Autophagy Pathway -- ATM-A Diverse Kinase With Roles Outside of the Nucleus -- Autophagy and Senescence -- Autophagy Regulation of the DDR -- Conclusions and Perspectives -- Acknowledgments -- References -- 11 Autophagy and Cancer -- Introduction -- Cancer-Promoting Action of Autophagy -- Cancer-Suppressing Action of Autophagy -- Autophagy-Suppressing Drug -- Autophagy-Suppressing Drug and Acute Kidney Injury -- Conclusion -- References -- 12 ULK1 Can Suppress or Promote Tumor Growth Under Different Conditions -- Introduction -- The Serine/Threonine Protein Kinase: ULK1 -- The Structure of ULK1 -- The ULK1-mAtg13-FIP200-Atg101 Complex -- Expression, Transcriptional Regulation, and Posttranscriptional Modification of ULK1 -- The Expression of ULK1 in Different Cancers -- ULK1 Promote Tumor Growth -- ULK1 Suppress Tumor Growth -- Therapeutic Strategy for Targeting ULK1 in Cancers -- Discussion -- Acknowledgments -- References -- 13 X-Box-Binding Protein 1 Splicing Induces an Autophagic Response in Endothelial Cells: Molecular Mechanisms in ECs and A ... -- Introduction -- Atherosclerosis -- Autophagy -- Autophagy and Atherosclerosis -- X-Box Binding Protein 1 -- XBP1 and ER Stress Response -- Discussion -- XBP1 Role in ECs, Atherosclerosis, and Autophagy -- BECLIN-1 -- XBP1 mRNA Splicing and BECLIN-1. , XBP1 Mechanism Is Cell-Type Dependent.

Language: English

UID:

Format: 1 online resource (609 p.)

ISBN: 1-280-64138-X , 9786610641383 , 0-08-045787-8

Series Statement: Handbook of immunohistochemistry and in situ hybridization of human carcinomas ; 4

Content: Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods

Note: Description based upon print version of record. , v.1 Molecular genetics: lung and breast carcinomas -- v.2 Molecular pathology: colorectal carcinoma and prostate carcinoma -- v.3 Molecular genetics: liver and pancreatic carcinomas -- v.4 Molecular genetics: gastrointestinal carcinoma and ovarian carcinoma. , English

Additional Edition: ISBN 0-12-369402-7

Language: English