UID:
almafu_9958068624002883
Format:
1 online resource (117 p.)
ISBN:
1-281-26851-8
,
9786611268510
,
3-8055-7969-1
Series Statement:
Key issues in mental health, v. 174
Content:
The prevention, diagnosis and treatment of stress-related disorders are major challenges across medical disciplines. Reasons include a missing covariance between the psychological and physiological stress response and a tremendous intra-individual complexity of disease-related factors, resulting in a broad inter-individual heterogeneity of pathogenetic mechanisms. This book introduces ‘Neuropattern’, a new concept that attempts to assess the activity of neuroendocrine interfaces participating in the communication between the brain and the body during stress. This approach allows close examination of the causal mechanisms behind stress-related disturbances and diseases, thus enabling individualized preventive and therapeutic interventions. This publication provides clinicians, researchers and students from the fields of psychiatry, psychology, neurobiology and psychoendocrinology with an excellent overview of how knowledge from basic psychobiological research can be translated for the benefit of their patients.
Note:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Foreword""; ""1. Neurobehavioral Medicine and Stress-Related Disorders""; ""1 .1. Strategies to Bridge the Gap between Bench and Bedside""; ""1.1.1. Translational Research""; ""1.1.2. Early Adversity""; ""1. 1.3. Genetics and Epigenetics""; ""1.1.4. Behavioral Neurobiology""; ""1. 1.5. Individualized Interventions""; ""1.2. Neurobehavioral Medicine""; ""1.3. Conclusions""; ""1.4. Summary""; ""References""; ""2. Neuropattern � A Step towards Neurobehavioral Medicine""; ""2 .1. Criteria for Clinical Translational Diagnostics""
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""2.1.1. Complexity and Heterogeneity""""2.1.2. Missing Covariance""; ""2.1.3. Translational Concepts""; ""2 .1.4. Accessibility to Clinical Routine""; ""2 .1.5. Exchange and Update of Data""; ""2 .1.6. Therapeutic Advantages and Cost-Effectiveness""; ""2.2. Neuropattern""; ""2.3. Conclusions""; ""2.4. Summary""; ""References""; ""3. Principles of the Crosstalk between Brain and Body � Glandotropy, Ergotropy, and Trophotropy""; ""3.1. Glandotropic Interfaces""; ""3.1.1. Paraventricular Nucleus""; ""3.1.2. Anterior Pituitary""; ""3.1.3. Adrenals""; ""3.1.4. Glucocorticoid Receptors""
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""3.2. Ergotropy""""3.2.1. Locus coeruleus""; ""3.2.2. Sympathetic Nervous System""; ""3.3. Trophotropy""; ""3.3.1. Parasympathetic Nervous System""; ""3.4. Summary""; ""References""; ""4 . Hypercortisolemic Disorders""; ""4 .1. Conditions Facilitating Persistent HPAA Hyperactivity""; ""4 .1.1. Genetically Determined HPAA Hyperactivity""; ""4.1.2. Epigenetically Determined HPAA Hyperactivity""; ""4 .1.3. Acquired HPAA Hyperactivity""; ""4 .1.4. Interaction of All Three Factors""; ""4 .2. Chronic Stress Exposure, HPA Sensitization and Stress Disorders""; ""4.2.1. Shut-Down of HPA Activity""
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""4.2.2. Sensitization""""4.2.3. Compensation""; ""4.3. Endophenotypes""; ""4 .3.1. CRF Hyperactivity""; ""4.3.1.1. Loss of Appetite""; ""4.3.1.2. Inhibition of Reproductive Functions""; ""4.3.1.3. Anxiety""; ""4.3.1.4. Irritable Stomach and Irritable Bowel Syndrome""; ""4.3.1.5. Melancholic Depression""; ""4.3.2. CRF Hyperreactivity""; ""4.3.3. Cortisol Hyperactivity""; ""4.3.3.1. Increased Adrenal Capacity""; ""4.3.3.2. Adrenal Sensitivity""; ""4.3.3.3. Downregulation of Glucocorticoid Receptors on Lymphocytes""; ""4.3.3.4. Sequelae of Cortisol Hypersecretion""; ""4.3.3.5. Metabolism""
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""4.3.3.6. Depression""""4.3.3.7. Memory Impairment""; ""4.4. Summary""; ""References""; ""5. Hypocortisolemic Disorders""; ""5.1. The Hypothalamic-Pituitary-Adrenal Axis in Hypocortisolemic Disorders""; ""5.2. Endophenotypes""; ""5.2.1. CRF and ACTH Hypoactivity and Hyporeactivity""; ""5.2.2. Cortisol Hypoactivity""; ""5. 3. Conceptualization of Hypocortisolism""; ""5. 4. Protective Effects of Hypocortisolism""; ""5.5. Conclusions""; ""5.6. Summary""; ""References""; ""6. Noradrenergic and Sympathetic Disorders""; ""6.1. Determinants of Ergotropy""; ""6.2. Ergotropic Endophenotypes""
,
""6.2.1. Ergotropic Hyperactivity and Hyperreactivity""
,
English
Additional Edition:
ISBN 3-8055-8295-1
Language:
English
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