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  • 1
    Online Resource
    Online Resource
    Basel :Karger,
    UID:
    edoccha_BV036069255
    Format: 1 Online-Ressource (X, 360 Seiten) : , Diagramme.
    ISBN: 978-3-318-00715-2
    Series Statement: Current directions in autoimmunity Vol. 4
    Content: Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity
    Note: an authoritative and up-to-date overview
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7240-8
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Diabetes mellitus Typ 1 ; Molekulare Medizin
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Basel :Karger,
    UID:
    almahu_BV036069255
    Format: 1 Online-Ressource (X, 360 Seiten) : , Diagramme.
    ISBN: 978-3-318-00715-2
    Series Statement: Current directions in autoimmunity Vol. 4
    Content: Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity
    Note: an authoritative and up-to-date overview
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7240-8
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Diabetes mellitus Typ 1 ; Molekulare Medizin
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Basel : Karger
    UID:
    b3kat_BV036069255
    Format: 1 Online-Ressource (X, 360 Seiten) , Diagramme
    ISBN: 9783318007152
    Series Statement: Current directions in autoimmunity Vol. 4
    Content: Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity
    Note: an authoritative and up-to-date overview
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7240-8
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Diabetes mellitus Typ 1 ; Molekulare Medizin
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    UID:
    gbv_526106026
    Format: XII, 220 S. , Ill., graph. Darst. , 23cm
    ISBN: 1573316784 , 9781573316781
    Series Statement: Annals of the New York Academy of Sciences 1103
    Note: Includes bibliographical references , Are insights gained from NOD mice sufficient to guide clinical translation? another inconvenient truth / by Bart O. RoepBuilding different mouse models for human MS / by Estelle Bettelli -- Autoimmunity and [beta] cell regeneration in mouse and human type 1 diabetes: the peace is not enough / by Vitaly Ablamunits ... [et al.] -- Diabetes research in jeopardy: the extinction of clinical diabetes researchers / by Aldo A. Rossini and Dale L. Greiner -- The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes / by Yanan Zheng ... [et al.] -- Dosing and timing effects of anti-CD40L therapy: predictions from a mathematical model of type 1 diabetes / by Kapil G. Gadkar ... [et al.] -- Autoreactive T cells in a partially humanized murine model of T1D / by John A Gebe ... [et al.] -- Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research / by Leonard D. Shultz ... [et al.] -- Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity / by Marie King ... [et al.] -- Resistance to the induction of mixed chimerism in spontaneously diabetic NOD mice depends on the CD40/CD154 pathway and donor MHC disparity / by Bin Luo ... [et al.] -- "Humanized" HLA transgenic NOD mice to identify pancreatic [beta] cell autoantigens of potential clinical relevance to type 1 diabetes / by David V. Serreze, Michele P. Marron, and Teresa P. DiLorenzo -- A new humanized HLA transgenic mouse model of multiple sclerosis expressing class II on mouse CD4 T cells / by Ashutosh Mangalam, Moses Rodriguez, and Chella David , The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen / by Emma E. Hamilton-Williams ... [et al.]Refinement of the Iddm4 diabetes susceptibility locus reveals TCRV[beta]4 as a candidate gene / by Elizabeth P. Blankenhorn... [et al.] -- Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity / by Klaus Pechhold, Sagarika Chakrabarty, and David M. Harlan -- Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes / by Steven Tracy and Kristen M. Drescher -- Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions / by Kristen M. Drescher and Steven Tracy -- Experimental autoimmune encephalomyelitis mediated by CD8+ T cells / by Qingyong Ji and Joan Goverman -- Impaired T cell receptor signaling in Foxp3+ CD4 T cells / by Bryan D. Carson and Steven F. Ziegler -- Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis / by Stephen D. Miller... [et al.] -- Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men / by W.W.J. Unger ... [et al.] -- Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: implications in diabetic retinopathy / by Ru Yang ... [et al.] -- Mouse models for cardiovascular complications of type 1 diabetes / by Xia Shen and Karen E. Bornfeldt.
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Diabetes mellitus ; Multiple Sklerose ; Tiermodell ; Konferenzschrift
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Online Resource
    Online Resource
    Basel :Karger,
    UID:
    almafu_BV036069255
    Format: 1 Online-Ressource (X, 360 Seiten) : , Diagramme.
    ISBN: 978-3-318-00715-2
    Series Statement: Current directions in autoimmunity Vol. 4
    Content: Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity
    Note: an authoritative and up-to-date overview
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7240-8
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Diabetes mellitus Typ 1 ; Molekulare Medizin
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
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