UID:
almahu_9949244031302882
Format:
1 online resource (648 p.)
ISBN:
9783110308426
,
9783110238570
Content:
This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures. Numerous chapters discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.
Note:
Mode of access: Internet via World Wide Web.
,
In English.
In:
DGBA Backlist Complete English Language 2000-2014 PART1, De Gruyter, 9783110238570
In:
DGBA Backlist Physical Sciences 2000-2014 (EN), De Gruyter, 9783110238518
In:
DGBA Physical Sciences 2000 - 2014, De Gruyter, 9783110637212
In:
EBOOK PACKAGE Chemistry, Materials Sc, Biol, Geosc 2014, De Gruyter, 9783110369601
In:
EBOOK PACKAGE Complete Package 2014, De Gruyter, 9783110369526
Additional Edition:
ISBN 9783110308327
Language:
English
Subjects:
Biology
Keywords:
Aufsatzsammlung
;
Aufsatzsammlung
DOI:
10.1515/9783110308426
URL:
https://doi.org/10.1515/9783110308426
URL:
https://www.degruyter.com/isbn/9783110308426
URL:
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