UID:
almahu_9947368229902882
Format:
1 online resource (1040 p.)
Edition:
4th ed.
ISBN:
0-323-26196-5
Content:
Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology.
Note:
Description based upon print version of record.
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Front Cover; IFC; The Molecular Basis of Cancer; Copyright; Dedication; Contributors; Preface; Contents; I Carcinogenesis and cancer Genetics; Chapter 1 - Cancer: A Genetic Disorder; The Discovery of Cellular Oncogenes; Multistep Tumorigenesis; The Discovery of Tumor Suppressor Genes; Guardians of the Genome; Epigenetic Mechanisms Leading to Loss of Gene Function; Immortalized Proliferation; Non-genetic Mechanisms Accelerating Multistep Tumor Progression; Invasive and Metastatic Behaviors; Other Phenotypes of Neoplasia; References; Chapter 2 - Oncogenes and Signal Transduction
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Signaling: An Overview; Oncogenes; Signal Transduction by Protein Tyrosine Kinase Receptors; Signaling Pathways of Tyrosine Kinase Receptors; Oncogenes and Survival Signaling; Cytokine Receptor Signaling; Neurotransmitters; Wnt Signaling; Hedgehog/Patched Signaling; Implications for Cancer Therapy; References; Chapter 3 - Tumor Suppressor Genes; Introduction; Complications of Tumor Suppression; Interconnecting the pRB, p53, and mTORC1 Pathways; Epigenetic Modifications and Tumor Suppression; Conclusions; References; Chapter 4 - DNA Repair Pathways and Human Cancer; Introduction
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The Spectrum of DNA Damage; The Systematic Study of DNA Repair; DNA Repair and the DNA Damage Response; Prognostic and Predictive DNA Repair Biomarkers in Cancer Treatment; The Development of New DNA Repair Biomarkers; Multiple Mechanisms of Cisplatin Resistance; Conclusion; References; Chapter 5 - Epigenetics and Cancer; The Molecular Basis for Epigenetic Control of Gene Expression; Abnormalities of DNA Methylation and Chromatin Organization in Cancer: The Cancer "Epigenome"; Translational Implications of Epigenetic Changes in Cancer; References; Chapter 6 - Infectious Agents and Cancer
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Overview of Cancer and Infectious Agents; Viruses and Cancer; Bacteria and Cancer; Parasites and Cancer; Perspectives; References; Chapter 7 - Environmental Carcinogenesis; Introduction to Cancer and the Environment; Causes of Cancer; Classes and Types of Carcinogens; Mechanisms of Chemical Carcinogenesis; Endogenous Defense Systems against Chemical Carcinogenesis; Cancer Prevention; Summary and Conclusions; References; Chapter 8 - Animal Models: Flies, Fish, and Yeast; Why Use a Simple Model Organism?; Genetic Conservation and Synteny; Forward Genetics, Reverse Genetics, and Transgenesis
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Drug Screens; Conditional Models; Yeast; Flies; Fish; Conclusion; References; Chapter 9 - Genetic Mouse Models of Cancer; Basis for Mouse Models of Cancer; Mouse Models of Cancer; Applications of Mouse Models to Cancer Biology; Future Directions of Cancer Models; Conclusions; References; IICancer biology; Chapter 10 - Cancer Stem Cells and the Microenvironment; Identification of Cancer Stem Cells; Cytokine Networks Can Promote Cancer Stem Cell Self-Renewal; Summary; References; CHAPTER 11 - Regulation of the Cell Cycle; Basic Principles of Cell Cycle Progression; The Cyclin-Dependent Kinases
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Posttranslational Regulation of CDKs
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English
Additional Edition:
ISBN 1-336-24968-4
Additional Edition:
ISBN 1-4557-4066-7
Language:
English
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