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  • 1
    Book
    Book
    New York [u.a.] :Oxford Univ. Press,
    UID:
    almahu_BV013260304
    Format: IX, 270 S. : Ill., graph. Darst.
    ISBN: 0-19-511626-7
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    RVK:
    Keywords: Evolution ; Genetik
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    New York, New York ; : Oxford University Press,
    UID:
    almafu_9959240891202883
    Format: 1 online resource (175 p.)
    Edition: 1st ed.
    ISBN: 1-280-44021-X , 0-19-534533-9 , 1-60256-591-0
    Content: A theoretical approach to human social behaviour that is rooted in evolutionary biology and sociobiology, applying the principles of kin selection theory.
    Note: Description based upon print version of record. , Contents; 1. Philosophical Background; 2. The Theory of Kin Selection; 3. Cooperation and Sharing among Kin; 4. The Structure of Relatedness; 5. Kin Group Subdivision and Conflict; 6. Kinship and Leadership; 7. The Structure of Kinship Terminologies; 8. Prospects for a Biologically Based Social Science; Appendix A; Appendix B; Bibliography; Author Index; Subject Index , English
    Additional Edition: ISBN 0-19-505234-X
    Language: English
    Keywords: Electronic books.
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  • 3
    Book
    Book
    New York [u.a.] :Oxford Univ. Press,
    UID:
    almafu_BV000869729
    Format: VIII, 162 S. : graph. Darst.
    ISBN: 0-19-505234-X
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Verwandtschaft
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  • 4
    Online Resource
    Online Resource
    London :Henry Stewart Talks,
    UID:
    almafu_9961427213802883
    Format: 1 videorecording (33 min., 45 sec.) : , sound, color , 003345
    Content: Audio-visual presentation : Inferring selection from patterns of nucleotide substitution ; The Major Histocompatibility Complex as an example of positive selection ; Immunodeficiency virus escapes from immune recognition ; Purifying selection on Single Nucleotide Polymorphisms.
    Note: Retrieved April 13, 2024, from https://hstalks.com/bs/312/. , Introduction -- Deoxyribonucleic acid (DNA) structure -- The genetic code -- Given 4 nucleotides and 20 amino acids -- Codon chart -- Nucleotide substitutions in coding regions -- Synonymous and nonsynonymous sites -- DNA code redundancy and natural selection -- Natural selection - Darwin and Wallace 1859 -- Natural selection: the basic idea -- Two kinds of natural selection -- Purifying selection -- Positive (Darwinian) selection -- Two forms of positive selection -- A relationship described by Motoo Kimura -- The total mutation rate variation -- Synonymous vs. nonsynonymous sites -- Nucleotide substitutions per site -- Comparing dS and dN: dS greater than dN -- Computing dS and dN -- Comparison of orthologous loci: human vs. mouse -- Ratio mean dS: mean dN = 6.5:1 -- Comparing dS and dN: dN greater than dS -- Example of positive selection at the DNA level -- The major histocompatibility complex (MHC) -- Two main subfamilies of MHC genes -- Class I MHC -- HLA-A, -B, and -C are highly polymorphic -- Two MHC mysteries -- Zinkernagel and Doherty (1974) -- Schematic view of MHC class I function -- MHC class I structure -- Peptide-binding region (PBR) -- Doherty and Zinkernagel's (1975) hypothesis -- Predictions about nucleotide substitutions -- dN and dS in PBR -- dN and dS in non-PBR -- Nucleotide substitution at MHC loci -- Class I MHC apply selective pressure on viruses -- CTL escape mutation -- Experiments with SIV in rhesus monkeys -- CTL epitope in the tat protein of SIV -- Genome map of SIV -- dS and dN: tat and vpr genes -- Amino acid replacements in tat epitope -- Convergent evolution -- Rhesus monkey/SIV model system -- Importance of purifying selection -- Complex disease -- Single nucleotide polymorphisms (SNPs) -- Frequency data for 1442 SNPs -- Silent versus nonsynonymous SNPs -- Gene diversity for different SNPs categories -- Evidence for purifying selection on common SNPs -- Nonsynonymous SNPs cause less radical changes -- Comparison with mouse model (1) -- Comparison with mouse model (2) -- Candidate SNPs for complex diseases association -- Slightly deleterious SNPs in the human genome -- Effect of bottleneck on allele frequency -- Natural selection - brief history of an idea -- Natural selection at the DNA level -- Two kinds of natural selection: conclusions.
    Language: English
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