UID:
almafu_9959328523102883
Format:
1 online resource (viii, 578 pages) :
,
illustrations
Edition:
Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010.
ISBN:
0470851988
,
9780470851982
,
0470846305
,
9780470846308
,
0471894664
,
9780471894667
,
128065435X
,
9781280654350
Series Statement:
Current toxicology series
Content:
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:*enzyme function in the metabolism and bioactivation of xenobiotics*substrate specificity*tissue distribution*species distribution (to include laboratory animals and humans)*hormonal regulation*sex differences*modulation by prior exposure to other chemicals*age-dependent expression*pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
Note:
Cover -- Contents -- Contributors -- Foreword -- 1 Xenobiotic Metabolism58; An Overview -- 2 Cytochrome P450 -- 3 Flavin Monooxygenases -- 4 Amine Oxidases and the Metabolism of Xenobiotics -- 5 Molybdenum Hydroxylases -- 6 Prostaglandin Synthases -- 7 Lipoxygenases -- 8 UDP45;Glucuronosyltransferases -- 9 Glutathione S45;transferases -- 10 Sulphotransferases -- 11 Arylamine Acetyltransferases -- 12 Mammalian Xenobiotic Epoxide Hydrolases -- 13 Methyltransferases -- 14 The Amino Acid Conjugations -- 15 Deconjugating Enzymes58; Sulphatases and Glucuronidases -- 16 Nitroreductases and Azoreductases -- Index -- Last Page.
,
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Additional Edition:
Print version: Enzyme systems that metabolise drugs and other xenobiotics. Chichester ; New York : J. Wiley, ©2002 ISBN 0471894664
Language:
English
Subjects:
Chemistry/Pharmacy
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0470846305
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0470846305
URL:
http://purl.oclc.org/DLF/benchrepro0212
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/0470846305
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