UID:
almahu_9948026251702882
Format:
1 online resource (679 p.)
ISBN:
1-281-00592-4
,
9786611005924
,
0-08-048994-X
Series Statement:
Comprehensive biochemistry ; 42
Content:
This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of lea
Note:
Description based upon print version of record.
,
Front Cover; Comprehensive Biochemistry; Copyright Page; CONTENTS; Preface to Volume 42; Contributors to this Volume; Chapter 1. Fifty Years in the World of Proteins; Origins; Cohn and Edsall; My First Project in Protein Science; The Invention of Polymer Science?; Macromolecules:Theoretical Research with J.G. Kirkwood; Antibodies; Genetic Basis forAntibody Diversity; Subunits and Allosterism; Micelles and Membranes; Membrane Proteins; Philip Handler and the Einstein Statue; Eastman Professor at Oxford; Popular Writing: Travel Books; Historical Perspective; References
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Chapter 2. Proteins, Life and EvolutionAbstract; Introduction; CV of the Guide Through the Text; Early Days, Scientific Fathers; Cambridge, the Mecca at the Start; Development of Protein Sequence Analysis; SeparationTechniques and Continued Progress; Amino Acid Analysis, Complementary Approaches, and Further Development; Correlationwith 3-D Structures; Developments in Molecular Genetics; Molecular Evolution: Development from Early "Diagonals," over the Atlas Issues, to Bioinformatics; Mass Spectrometry; Present Situation, Including Comments on Karolinska, Nobel, and Funding
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Summary of RevolutionsPerspectives; Acknowledgments; References; Chapter 3. Pehr Victor Edman:The Solitary Genius; Nature is the Guide; Science Takes Hold; Birth of an Idea; Idea Becomes True; Automation Must Come; End of Journey; Edman,The Person; Acknowledgments; References; Selected References from Pehr Edman's Biography; Chapter 4. A Privileged Life; Introduction; Family Background; The Karolinska Institute; Establishing a Research Career; Permanent Position; The Royal Swedish Academy of Sciences; The Wenner-Gren Foundations; Concluding Thoughts; References
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Chapter 5. RNA Enzymology and BeyondGrowing Up; Weizmann Institute of Science; St. Louis: Polynucleotide Phosphorylase; Isolation of High Molecular Weight Ribosomal RNA; The Single-Stranded Nature of rRNA; Early Studies on the Secondary Structure of RNA; tRNA Regulation; PNPase Research Applications; Differentiation of Artemia salina Cysts; Establishment of the Department of Neurobiology; Microtubule Proteins; Promoting International Links; References; Chapter 6. Some Selected Recollections from a Life with Biochemistry; Introduction; StudentYears at the University of Copenhagen
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Experiments with PenicillinPupil of Herman Kalckar and Experiments with Xanthine Oxidase; Excursion to Two European Strongholds in Biochemistry; Ribose 1,5-Diphosphate; National Institutes of Health 1952-1953; Back in Copenhagen; Cancer Research; Experiments with 2' -Deoxyadenosine; Experiments with 3' -Deoxyadenosine; Back to the University of Copenhagen; Experiments with other Congeners of Adenosine; Experiments with DNA Polymerase from E. coli; Ribonucleotides Again; Regulation of Cellular Content of Nucleoside Triphosphates; Conclusion; References
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Chapter 7. A Risky Job: In Search of Noncanonical Pathways
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English
Additional Edition:
ISBN 0-444-50924-0
Language:
English
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