Format:
Online-Ressource
ISBN:
9781461412229
Series Statement:
Advances in Experimental Medicine and Biology 729
Content:
Michael P. Lisanti
Content:
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm. Jean-François Jasmin, PhD, obtained his degree at the University of Montreal (Montreal, Canada) in 2004. From 2004 to 2007, he was a Post-Doctoral Fellow at both the Albert Einstein College of Medicine (Bronx, NY; Department of Molecular Pharmacology) and the Thomas Jefferson University (Philadelphia, PA; Department of Cancer Biology). Currently, he is an Assistant Professor (Tenure-Track) in the Department of Stem Cell Biology and Regenerative Medicine at the Thomas Jefferson University (Philadelphia, PA). The current focus of his laboratory is on the role of caveolin proteins in the development of cardiovascular and pulmonary diseases. Philippe G. Frank, PhD, obtained his degree in 1998 at the University of Ottawa (Ottawa, Canada), under mentor Professor Yves L. Marcel, a pioneer in lipoprotein studies. Dr. Frank's doctoral dissertation examined the role and function of apolipoprotein A-I in the reverse cholesterol transport pathway. Also in 1998, he continued his career with a post-doctoral fellowship at the Albert Einstein College of Medicine (Bronx, NY). There, his project focused on the role of caveolin proteins in cancer and atherosclerosis, in addition to lipoprotein and cholesterol metabolism. In 2006, he joined the Kimmel Cancer Center as an Assistant Professor at Thomas Jefferson University in Philadelphia, Pennsylvania, where he focuses on the role of lipoproteins in cancer and vascular diseases. Michael P. Lisanti, MD, PhD, obtained his degrees at Cornell University Medical College (New York, NY) in 1992. From 1992-97, he was a Fellow at the Whitehead Institute at MIT (Cambridge, MA), affiliated with Dr. Harvey Lodish's laboratory. Currently, he is Chairman of the Stem Cell Biology and Regenerative Medicine Department, Leader/ Director of the Program in Molecular Biology and Genetics of Cancer, and Director of the Stem Cell Biology and Regenerative Medicine Center at the Thomas Jefferson University (Philadelphia, PA) as well as Editor-in-Chief of the American Journal of Pathology. The current focus of his laboratory is on the role of caveolin-1 in cancer pathogenesis.
Note:
Description based upon print version of record
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Title Page; Copyright Page; PREFACE; ABOUT THE EDITORS...; ABOUT THE EDITORS...; ABOUT THE EDITORS...; PARTICIPANTS; Table of Contents; SECTION I IDENTIFICATION AND CELLULAR FUNCTIONS OF CAVEOLAE AND CAVEOLINS; CHAPTER 1 LIPID RAFTS, CAVEOLAE AND GPI-LINKED PROTEINS; INTRODUCTION: LIPID RAFTS; CAVEOLAE; CHOLESTEROL; CAVEOLIN-1 ROLE AND FUNCTION; CAVEOLIN-2 ROLE AND FUNCTION; CAVEOLIN-3 ROLE AND FUNCTION; PTRF; CONCLUSION; REFERENCES; CHAPTER 2 CAVEOLAE AND THE REGULATION OF ENDOCYTOSIS; INTRODUCTION; CAVEOLAE AT THE PLASMA MEMBRANE; INTERNALIZATION OF CAVEOLAE
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Are Caveolae Stable and Highly Immobile Invaginations at the Plasma Membrane?Caveolar Budding and Pinching Off from the Plasma Membrane; INTRACELLULAR ROUTE OF CAVEOLAE; REGULATION OF CAVEOLAR TRAFFICKING; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 3 CAVEOLIN-1: Role in Cell Signaling; INTRODUCTION: COMPLEXITY OF CAVEOLIN MEMBRANE DOMAINS; Structure of Cav1; Cav1-Associated Membrane Domains: Rafts, Caveolae and Cav1 Scaffolds; Cav1: Up and Down Regulation in Cancer; SCAFFOLDING DOMAIN AND TYROSINE KINASE RECEPTOR REGULATION; Complexity of Tyrosine Kinase Receptor Regulation by Cav1
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Regulation of EGF Receptor Signaling by Cav1CAV1 REGULATION OF CELL PROLIFERATION, SURVIVAL AND DIFFERENTIATION; Cav1 is an Antiproliferative Factor that Down-Regulates Cyclin D1 Expression; Cav1 Prevents MAP Kinase and PI3 Kinase Signaling Pathways; Cav1 Down-Regulates the -Catenin-TCF/LEF Signaling Pathway; Cell Survival and Drug Resistance to Cell Death; Cav1 as Pro-Apoptotic Factor; Cav1 as a Pro-Survival Factor; Regulation of Cell Phenotype and Differentiation; CAV1 REGULATION OF SIGNALING PATHWAYS IN CELL MIGRATION; Regulation of Cell Migration
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Cav1 Participates to Polarity of Endothelial Migrating CellsPhosphorylated Cav1 Regulates Focal Adhesion Signaling and Structure; Central Role of Cav1 in Outside-In and Inside-Out Integrin Signaling: The Cav1-Src-Rho Loop; Cav1 in Mechanotransduction; CONCLUSION: Cav1 OR THE YIN AND THE YANG OF SIGNALING REGULATION; ACKNOWLEDGEMENT; REFERENCES; CHAPTER 4 REGULATION OF eNOS IN CAVEOLAE; INTRODUCTION; eNOS LOCALIZATION IN ENDOTHELIAL CELL CAVEOLAE; CAVEOLIN AND THE REGULATION OF eNOS; HDL ACTIVATION OF eNOS; ESTROGEN MODULATION OF eNOS; CRP MODULATION OF eNOS; CONCLUSION; ACKNOWLEDGEMENTS
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REFERENCESSECTION II CAVEOLAE AND CAVEOLINS IN HUMAN DISEASES; CHAPTER 5 RECENT DEVELOPMENTS IN THE INTERACTIONS BETWEEN CAVEOLIN AND PATHOGENS; INTRODUCTION; VIRUSES; BACTERIA; PROTOZOAN PARASITES; Leishmania; Trypanosoma cruzi; Toxoplasma gondii; FUNGI; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 6 CAVEOLIN-1 AND BREAST CANCER :A New Clinical Perspective; INTRODUCTION; CAVEOLIN-1, A POTENT SUPPRESSOR OF GROWTH IN BREAST CANCER CELLS; INSIGHTS FROM THE CAVEOLIN-1 KNOCKOUT MOUSE MODEL; CAVEOLIN-1 MUTATIONS FOUND IN BREAST CANCER PATIENTS
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CAVEOLIN-1, A REGULATOR OF ESTROGEN-DEPENDENT SIGNALING AND PROLIFERATION
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Lipid rafts, caveolae, and GPI linked proteins / Valerie L. Reeves, Candice M. Thomas, and Eric J. Smart -- Caveolae and the regulation of endocytosis / Anna L. Kiss -- Caveolin : role in cell signaling / Cecile Boscher and Ivan Robert Nabi -- Regulation of ENOS in caveolae / Chieko Mineo and Philip W. Shaul -- Recent developments in the interactions between caveolin and pathogens / Fabiana S. Machado ... [et al.] -- Caveolin and breast cancer : a new clinical perspective / Isabelle Mercier and Michael P. Lisanti -- Caveolin and prostate cancer progression / Michael R. Freeman, Wei Yang, and Dolores Di Vizio -- Caveolins and caveolae, roles in insulin signalling, and diabetes / Peter Strolfors -- Atherosclerosis, caveolae, and caveolin / Stephanos Pavlides ... [et al.] -- Caveolins and heart diseases / Mathivadhani Panneerselvam, Hemal H. Patel, and David M. Roth -- Caveolins and lung function / Nikolaos A. Maniatis ... [et al.].
Additional Edition:
ISBN 9781461412212
Additional Edition:
Buchausg. u.d.T. Caveolins and caveolae New York, NY : Springer Science + Business Media, LLC, 2012 ISBN 9781461412212
Language:
English
Subjects:
Biology
DOI:
10.1007/978-1-4614-1222-9
URL:
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