Kooperativer Bibliotheksverbund

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Format: 1 Online Ressource (xvi, 511 Seiten)

ISBN: 9783319218137

Series Statement: Biosystems & Biorobotics volume 9 (2016)

Additional Edition: Erscheint auch als Druckausgabe ISBN 978-3-319-21812-0

Language: English

Subjects: Medicine

Keywords: Biomedizinische Technik ; Biomedizin ; Biotechnologie ; Aufsatzsammlung

DOI: 10.1007/978-3-319-21813-7

URL: Volltext  (URL des Erstveröffentlichers)

URL: Inhaltsverzeichnis

URL: Abstract

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Format: XVI, 509 Seiten , Illustrationen, Diagramme

ISBN: 9783319218120

Series Statement: Biosystems & biorobotics volume 9

Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-319-21813-7

Language: English

Subjects: Medicine

Keywords: Biomedizinische Technik ; Biomedizin ; Biotechnologie ; Aufsatzsammlung

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Format: viii, 370 p. : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

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Format: 1 online resource (x, 249 pages)

ISBN: 1000021262 , 9780429294839 , 0429294832 , 9781000021264 , 9781000020922 , 1000020924 , 9781000021097 , 1000021092 , 1000020924 , 1000021092

Content: Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology

Additional Edition: Print version: ISBN 9781000021264

Additional Edition: Print version: ISBN 9789814800587

Additional Edition: ISBN 9814800589

Language: English

Keywords: Electronic books.

DOI: 10.1201/9780429294839

URL: https://www.taylorfrancis.com/books/9780429294839

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Format: 1 online resource (380 p.)

Edition: 1st ed.

ISBN: 1-283-14379-8 , 9786613143792 , 981-4280-42-9

Content: The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of tissue engineering, nanotechnology and stem cell research. This is the first textbook to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.

Note: Description based upon print version of record. , PREFACE; CONTENTS; Chapter 1 FLOW AND ATHEROSCLEROSIS; 1. Overview and Clinical Significance; 1.1. Composition and Progression of Atherosclerotic Plaques; 1.1.1. Early Lesions; 1.1.2. Advanced Lesions; 1.1.3. Outward Remodeling and Plaque Stenosis; 2. Methods for Studying the Role of Flow in the Pathogenesis of Atherosclerosis; 2.1. Tools for Studying Biological Responses to Mechanical Stimuli in Vitro; 2.2. Animal Models of Atherosclerosis and Relation to Flow; 2.2.1. Genetically-manipulated Mouse Models; 2.2.2. Mechanical Induction of Stenosis in Animals , 2.2.3. Larger Animal Models of Atherosclerosis2.3. Flow in Humans and Its Role in Atherosclerosis; 2.4. Computational Fluid Dynamics; 2.4.1. Imaging Data for Lesion-specific Geometry; 2.4.2. Modeling Assumptions; 3. Wall Shear Stress is a Potent Modulator of Plaque Formation and Localization; 3.1. Low and Oscillatory Wall Shear Stress Promote Atherosclerotic Plaque Formation; 3.2. High Wall Shear Stress Protects Arteries from Atherosclerosis; 3.3. Hemodynamic Parameters Related to Plaque Formation; 3.4. Wall Shear Stress and Plaque Rupture , 4. Flow is Not the Only Biomechanical Determinant of Plaque Formation and Disruption4.1. Solid Wall Mechanics and Atherosclerotic Responses to Stretch; 4.2. Plaque Composition Influences Solid Wall Mechanics and Risk for Rupture; 4.3. Fluid-solid Interaction Provides Additional Biomechanical Insight into Atherosclerosis; 5. Current Dilemmas and Future Directions for Atherosclerotic Research; 5.1. Need for Better Understanding of Plaque Disruption Events; 5.2. How Do Flow-mediated Mechanisms of Atherogenesis Occur on Human Timescales? , 5.3. How Much Does Directionality of Flow Contribute to Atherosclerosis?6. Conclusion; References; Chapter 2 SHEAR STRESS-MEDIATED SIGNAL TRANSDUCTION; 1. Introduction; 2. Mechanosignal Transduction: From Molecular Sensors to Cellular Responses; 3. The Role of Mechanotransduction in Cardiovascular Health and Disease; 4. The Unique Role of PECAM-1 in Mechanosensing; 4.1. Forced-induced PECAM-1 Phosphorylation and Mechano-signaling; 4.2. PECAM-1 as a Mechanosensor; 4.3. PECAM-1 Kinase in Mechanotransduction; 5. S-flow-mediated Redox Regulation and Inflammation , 5.1. TRX and TRX-interacting Protein (TXNIP)5.2. Thiol Regulation and Glutaredoxin; 6. S-flow Inhibits TNF-α Signaling by Multiple Mechanisms; 6.1. MAP Kinases in Response to s-flow and TNF-α; 6.2. S-flow Inhibits PKCζ Signaling in ECs; 6.3. S-flow Inhibits TNF-α-mediated SHP-2 Phosphatase Activity and MEKK3 Signaling; 6.4. ERK5 Inhibits TNF-α-mediated JNK Activation; 7. ERK5 and Shear Stress; 7.1. s-flow Mediated ERK5 Activation; 7.2. ERK5 in Diabetes: ERK5-SUMOylation; 7.2.1. SUMOylation; 7.2.2. ERK5-SUMOylation; Acknowledgments; References , Chapter 3 ENDOTHELIAL GLYCOCALYX STRUCTURE AND ROLE IN MECHANOTRANSDUCTION , English

Additional Edition: ISBN 981-4280-41-0

Language: English