Format:
Online-Ressource (XIV, 339p. 71 illus., 48 illus. in color, digital)
ISBN:
9789400730274
,
1280787368
,
9781280787362
Series Statement:
SpringerLink
Content:
Renu Wadhwa
Content:
The phrase 'Life, stress and death' connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume 'Mortalin Biology: Life, Stress and Death' is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.
Note:
Description based upon print version of record
,
Foreword; Preface; Contents; Contributors; Part I Structure and Function of Mortalin; Chapter 1Birth of Mortalin: Multiple Names, Nichesand Functions Connecting Stress,Senescence and Cancer; 1.1 Mortalin as a Member of Hsp70 Family of Proteins; 1.2 Mortalin-Multiple Births; 1.2.1 Cell Fusion Studies for Markers of Mortality and Immortality; 1.2.2 Mortalin as CSA (C3H Strain Specific Antigen); 1.2.3 Mortalin as PBP74 (Peptide-Binding Protein) in Immune Regulation; 1.2.4 Mortalin as Grp75 (Glucose Regulated Protein 75) in Stress Response; 1.2.5 Mortalin as mtHsp70, a Mitochondrial Chaperone
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1.2.6 Mortalin as Tumor Necrosis Factor Receptor-Associated Protein 11.3 Mortalin: Inside and Outside the Mitochondria; 1.4 Mortalin: Stress, Aging and Cancer; 1.5 Mortalin: Therapeutic Target; 1.6 Summary; References; Chapter2 Mortalin's Machinery; 2.1 Introduction; 2.2 N-terminal Nucleotide Binding Domain (NBD); 2.3 C-terminal Substrate Binding Domain (SBD); 2.4 Mortalin-1 Versus Mortalin-2: A Case of a Substrate Lid ``Overbite''; References; Chapter3 The Role of Mortalin in Iron Homeostasis; 3.1 Iron-Sulfur (Fe--S) Cluster Biogenesis; 3.1.1 Fe--S Cluster Biosynthesis and Iron Homeostasis
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3.1.2 Overview of Fe--S Cluster Biosynthesis Machinery3.1.3 Iron-Sulfur Cluster (ISC) Machinery; 3.1.3.1 Iron Donors and Cysteine Desulfurases; 3.1.3.2 Scaffold Proteins; 3.1.3.3 Other Components; 3.2 Hsp70 Chaperones in the ISC Machinery; 3.2.1 Hsp70 Chaperones in the Bacterial and Yeast ISC Machinery; 3.2.2 Role of Hsp70 Chaperones in the ISC Machinery; 3.3 Mortalin in the ISC Machinery; 3.3.1 Mortalin in the Human ISC Machinery; 3.3.2 Structural and Functional Relationships Between Mortalin and Scaffold Proteins; 3.4 Concluding Remarks; References
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Chapter4 Functional Characteristics of Mortalin4.1 Introduction; 4.2 Mortalin Overview; 4.3 Functional Roles of Mortalin; 4.3.1 Mortalin-Mitochondrial Functions; 4.3.1.1 Mitochondrial Protein Import; 4.3.1.2 Mitochondrial Protein Folding; 4.3.1.3 Mitochondrial Protein Degradation; 4.3.2 Mortalin-Extramitochondrial Functions; 4.3.2.1 Mortalin and Protein 53 (p53); 4.3.2.2 Mortalin and Centrosomes; 4.3.2.3 Mortalin and Fibroblast Growth Factor-1 (FGF-1); 4.3.2.4 Mortalin and the Immune System; 4.3.2.5 Mortalin and the Endoplasmic Reticulum
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4.3.2.6 Mortalin and Mevalonate Pyrophosphate Decarboxylase (MPD)4.4 Mortalin Proteomics in Pathology; 4.4.1 Mortalin and Cancer; 4.4.2 Mortalin and Neurological Disease; 4.4.3 Mortalin and Cardiovascular Disease; 4.4.4 Mortalin and Diabetes Mellitus; References; Part II Mortalin in Evolution; Chapter 5Mortalin and Drosophila DmHsp22:Two Mitochondrial Chaperones RegulatingAging and Carcinogenesis; 5.1 Introduction; 5.2 Both Mortalin and DmHsp22 are Mitochondrial Chaperones; 5.2.1 mtHsp70/Mortalin: A Major Mitochondrial Hsp; 5.2.2 DmHsp22: A Unique sHsp in Drosophila melanogaster
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5.3 Both DmHsp22 and Mortalin Interact with Hsp60
Additional Edition:
ISBN 9789400730267
Additional Edition:
Buchausg. u.d.T. ISBN 978-94-007-3026-7
Language:
English
DOI:
10.1007/978-94-007-3027-4
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