UID:
almafu_9961427219002883
Format:
1 streaming video file (48 min.) :
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digital, mono, SWF file, sound, color
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004746
Content:
Audio-visual presentation : Ways of assessing heritability in humans: twin and adoption designs ; The evolutionary paradox of common, heritable mental disorders ; Possible resolutions to the paradox: balancing selection, neutral mutation and polygenic mutation-selection balance.
Note:
Retrieved April 6, 2024, from https://hstalks.com/bs/160/.
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Introduction -- Mental disorders (MDs) -- Example: schizophrenia -- Paradox of common, harmful, heritable MDs -- Outline -- Mental disorders run in families -- Classical twin design -- Twin designs -- Twin design example: schizophrenia -- Adoption designs (1) -- Adoption designs (2) -- Adoption design example: schizophrenia -- Genetic effects on mental disorder risk -- Heritability -- Two types of heritability -- Meaning of low heritability -- Meaning of high heritability -- The evolutionary paradox of heritable MDs -- Heritability and prevalence of mental disorders (1) -- Heritability and prevalence of mental disorders (2) -- Deleterious mutations -- Heritability and prevalence of mental disorders (3) -- Prevalence of MDs vs. other genetic disorders -- Possible explanations to the paradox -- Four non-resolutions to the paradox -- Three better resolutions to the paradox -- Neutral hypothesis of MD alleles -- Gene-environment interaction and depression -- Problems with neutral explanation -- Balancing selection hypothesis of MD alleles -- Frequency dependent selection (1) -- Frequency dependent selection (2) -- Heterozygote advantage -- Heterozygotes cannot 'breed true' -- Byproducts of heterozygous advantage -- Predictions of heterozygote advantage -- Problems with balancing selection hypothesis -- Polygenic mutation-selection hypothesis (1) -- Polygenic mutation-selection hypothesis (2) -- Deleterious mutations in the brain -- The individually effect of these mutations -- The cumulative effect of these mutations -- Perception of these underlying dimensions -- Different distribution of behaviours -- Mental disorders vs. single gene disorders -- Importance of mutation-selection in MDs -- Inbreeding reveals full recessive genetic effects -- Brain damage increases risk to common MDs -- MDs are probably highly polygenic -- Problems with mutation-selection hypothesis -- Conclusions (1) -- Conclusions (2) -- Thanks.
Language:
English
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