Format:
Online-Ressource (digital)
ISBN:
9783540728436
Series Statement:
Handbook of Experimental Pharmacology 186
Content:
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Note:
Description based upon print version of record
,
A-Kinase Anchoring Proteins as the Basis for cAMP Signaling; Arrestins as Multi-Functional Signaling Adaptors; Role of Ena/VASP Proteins in Homeostasis and Disease; Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy; Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?; PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases; G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains
,
Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug DesignCompartmentalised MAPK Pathways; Dynamic Protein Complexes Regulate NF-.B Signaling; An Oncogenic Hub: ß-Catenin as a Molecular Target for Cancer Therapeutics; A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling; Scaffolding Proteins in Cardiac Myocytes; Molecular Architecture of Signal Complexes Regulating Immune Cell Function; Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework
,
Domains Mediate Protein-Protein Interactions and Nucleate Protein AssembliesProline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition; Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors; Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs; Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets;
Additional Edition:
ISBN 9783540728429
Additional Edition:
Buchausg. u.d.T. Handbook of experimental pharmacology ; 186: Protein-Protein interactions as new drug targets Berlin : Springer, 2008 ISBN 9783540728429
Additional Edition:
ISBN 3540728422
Language:
English
Subjects:
Biology
Keywords:
Targeted drug delivery
;
Protein-Protein-Wechselwirkung
;
Aufsatzsammlung
DOI:
10.1007/978-3-540-72843-6
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