Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English

UID:

Format: 1 online resource (xiv, 629 pages) : , illustrations (some color)

ISBN: 9781444344080 , 1444344080 , 9781444351132 , 1444351133 , 6613274178 , 9786613274175

Content: "The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field -- Summarizes the most recent developments in the fields of Alzheimer's disease and dementia -- Brings together articles from a prominent and international group of contributors -- Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences."--Provided by publisher.

Note: Alzheimer's disease / by Alan M. Mandell and Robert C. Green -- Vascular dementia / by Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon -- Dementia with Lewy bodies / by Tamara G. Fong and Daniel Press -- Frontotemporal dementia / by Adam L. Boxer -- Other causes of dementia / by Peter Morin -- Genetic risk factors for dementia / by Paul Hollingworth and Julie Williams -- The neuropathology of the dementing disorders / by Ann C McKee and Brandon E. Gavett -- Amyloid beta peptide and the amyloid cascade hypothesis / by Carmela R. Abraham -- Other mechanisms of neurodegeneration / by Marina Boziki, Vassilis Papaliagkas, and MagdaTsolaki -- Rational therapeutics in dementia / by Neil W. Kowall -- Memory systems in dementia / by Andrew E. Budson -- Language processing in dementia / by Jamie Reilly, Joshua Troche, and Murray Grossman -- Executive functioning in dementia / by Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett -- Emotion and behavior in Alzheimer's disease and other dementias / by Christopher I. Wright -- Visuospatial function in Alzheimer's disease and related disorders / by Alice Cronin-Golomb -- Sleep and circadian rhythms in dementia / by David G. Harper -- Glimpses of the living brain with Alzheimer's disease / by Ronald J. Killiany -- Functional MRI in Alzheimer's disease and other dementias / by Maija Pihlajamäki & Reisa A. Sperling -- Molecular neuroimaging of the dementias: from scientific insights to clinical applications / by Bradford C. Dickerson -- Using EEG and MEG to understand brain physiology in Alzheimer's disease and related dementias / by Brandon A. Ally.

Additional Edition: Print version: Handbook of Alzheimer's disease and other dementias. Chichester, West Sussex, UK: Wiley-Blackwell, 2011 ISBN 9781405168281

Language: English

Keywords: Electronic books. ; Handboeken (vorm) ; Elektronische boeken. ; Electronic books. ; Handboeken (vorm) ; Elektronische boeken. ; Electronic books. ; Handboeken (vorm) ; Elektronische boeken.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

UID:

Format: Tab.; Lit.

ISSN: 0022-1422

Note: Band: 49; Heft: 5; Seiten: M223-226

In: The journals of gerontology, Washington, DC [u.a.] : Soc., 1946, 49(1994), 5, Seite 223-226, 0022-1422

In: volume:49

In: year:1994

In: number:5

In: pages:223-226

Language: English

UID:

Format: xiv, 629p. : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Series Statement: Wiley-Blackwell handbooks of behavioral neuroscience

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English