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  • 1
    UID:
    gbv_1794588639
    Format: 1 Online-Ressource (185 p.)
    ISBN: 9782889634705
    Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Note: English
    Language: English
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  • 2
    Book
    Book
    Berlin [u.a.] :Springer,
    UID:
    almafu_BV002493535
    Format: 251 S. : , Ill.
    ISBN: 3-540-51513-5 , 0-387-51513-5
    Series Statement: Current topics in microbiology and immunology 153
    Note: Literaturangaben
    Language: English
    Keywords: Komplement C3 ; Komplement C3a ; Aufsatzsammlung
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  • 3
    Book
    Book
    New York, Ny [u.a.] : Springer-Verlag
    UID:
    kobvindex_ZLB15406662
    Format: XVII, 351 , Ill.
    ISBN: 9781461401056
    Series Statement: Advances in experimental medicine and biology 946
    Language: English
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  • 4
    Book
    Book
    New York, NY [u.a.] : Springer-Verlag
    UID:
    kobvindex_ZLB15253034
    Format: XIII, 167 Seiten , Ill., graph. Darst. , 235 mm x 155 mm
    Edition: 1st ed.
    ISBN: 9781441956347
    Series Statement: Advances in experimental medicine and biology 703
    Note: Text engl.
    Language: English
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  • 5
    UID:
    almahu_BV042697934
    Format: XII, 242 S. : , Ill., graph. Darst.
    ISBN: 978-3-319-18602-3
    Series Statement: Advances in experimental medicine and biology 865
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-319-18603-0
    Language: English
    Subjects: Biology
    RVK:
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  • 6
    Online Resource
    Online Resource
    New York, NY :Springer,
    UID:
    almahu_BV039901125
    Format: 1 Online-Ressource (xviii, 354 Seiten) : , Illustrationen.
    ISBN: 978-1-4614-0106-3
    Series Statement: Advances in experimental medicine and biology 946
    Note: Papers of the 7th Internat. Aegean Conference on Innate Immunity in Rhodes, Greece (July 4 - 9, 2010)
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-4614-0105-6
    Additional Edition: Erscheint auch als Druck-Ausgabe, Paperback ISBN 978-1-4614-2952-4
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Angeborene Immunität ; Konferenzschrift
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  • 7
    Online Resource
    Online Resource
    New York, NY : Springer Science+Business Media, LLC
    UID:
    gbv_1651286175
    Format: Online-Ressource (XVII, 354p. 61 illus., 45 illus. in color, digital)
    Edition: 1
    ISBN: 9781461401063 , 1283351838 , 9781283351836
    Series Statement: Advances in Experimental Medicine and Biology 946
    Content: Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists
    Note: Includes bibliographical references and index , Preface; Contents; List of Contributors; Pentraxins in Humoral Innate Immunity; 1 Introduction; 2 The Pentraxin Superfamily; 3 The Short Pentraxins in Innate Immunity; 4 The Long Pentraxin PTX3; 4.1 Gene Organization and Expression; 4.2 Protein Structure; 4.3 Interaction with Complement and Fc? Receptors; 4.4 PTX3 in Pathogen Recognition and Inflammation; 4.5 Self versus Modified Self-Discrimination; 4.6 PTX3 Role in Tissue Remodelling; 4.7 Diagnostic and Prognostic Potential of PTX3 in Infectious Disorders; 5 Concluding Remarks; References , Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution1 Introduction; 2 Structure and Biochemical Properties of Galectins; 3 Biological Roles of Galectins in Development and Regulation of Immune Homeostasis; 4 Galectins as Pattern Recognition Receptors; 5 Some Microbial Pathogens and Parasites Subvert the Role of Galectins as PRRs; 6 Conclusions; References; The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells-An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids; 1 Introduction , 2 Stem Cell Mobilization2.1 Stem Cell Mobilization as Part of Stress Response; 2.2 Activation of Complement Cascade (CC); 2.3 Involvement of Granulocytes in Mobilization; 2.4 Role of Sphingosine 1-Phosphate (S1P); 3 Stem Cell Homing; 3.1 Conditioning for Transplantation Induces Proteolytic Microenvironment in BM; 3.2 Conditioning for Transplantation Activates Complement Cascade (CC) in BM; 4 Implications of "Priming Phenomenon" that Enhances Responsiveness of CXCR4 Receptor to SDF-1 Gradient; 5 Conclusions; References , Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds1 Introduction; 2 The Burden of Chronic Wounds; 3 Surveying the Microbial Diversity of Chronic Wounds; 4 The Skin is the First Line of Defense; 5 The Innate Immune Response During Normal Wound Healing; 6 An Aberrant Innate Immune Response in Chronic Wounds; 7 Conclusions and Perspectives; References; Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity; 1 Introduction; 2 Keystone Pathogens in the Periodontal Biofilm , 3 Porphyromonas gingivalis: Interfering with Host Immunity for the Microbial "Common Good"?3.1 The LPS as a Tool to Antagonize TLR4; 3.2 The Gingipains as a Means to Manipulate Complement and Leukocytes; 3.3 Fimbriae: Multitasking Beyond Colonization; 4 Is the Presence of P. gingivalis Benefiting Other Periodontal Bacteria?; 5 Perspectives and Conclusions; References; A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects; 1 Immunoglobulins; 2 A Conserved Binding Site at the Junction of Two Constant Domains , 3 Functional Consequences of Host Proteins Binding to the Conserved Site on Immunoglobulins
    Additional Edition: ISBN 9781461401056
    Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-40105-6
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Angeborene Immunität
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 8
    Online Resource
    Online Resource
    New York, NY : Springer US
    UID:
    gbv_1649892470
    Format: Online-Ressource (digital)
    ISBN: 9780387789521
    Series Statement: Advances in Experimental Medicine and Biology 632
    Content: Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the ““novel”” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.
    Additional Edition: ISBN 9780387789514
    Additional Edition: Buchausg. u.d.T. ISBN 978-0-387-78951-4
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 9
    UID:
    gbv_1647688019
    Format: Online-Ressource (digital)
    ISBN: 9780387782614
    Series Statement: Advances in Experimental Medicine and Biology 628
    Note: Includes bibliographical references and index
    Additional Edition: ISBN 9780387782607
    Additional Edition: Buchausg. u.d.T. Brain development in Drosophila melanogaster New York, NY : Springer Scence+Business Media, LLC, 2008 ISBN 9780387782607
    Additional Edition: ISBN 0387782605
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    Keywords: Taufliege ; Gehirn ; Entwicklung ; Taufliege ; Gehirn ; Entwicklung
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 10
    Online Resource
    Online Resource
    New York, NY : Springer Science + Business Media | Austin, Tex. : Landes Bioscience
    UID:
    gbv_1647687969
    Format: Online-Ressource (digital)
    ISBN: 9780387775746
    Series Statement: Advances in Experimental Medicine and Biology 624
    Content: The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment
    Note: Includes bibliographical references and index , CONTENTS; 1. SUNLIGHT, UV-RADIATION, VITAMIN D AND SKIN CANCER: HOW MUCH SUNLIGHT DO WE NEED?; Abstract; Prehistorical and Historic Perspectives; Photoproduction of Vitamin D3; Factors Controlling Cutaneous Vitamin D Synthesis; Sources and Metabolism of Vitamin D; Role of Vitamin D in the Prevention of Chronic Diseases; Vitamin D Deficiency Pandemic; Sunlight, Vitamin D and the Skin Cancer Conundrum; Conclusion; 2. SOLAR ULTRAVIOLET IRRADIANCE AND CANCER INCIDENCE AND MORTALITY; Introduction; Cancer; Other Diseases for Which Solar UVB and Vitamin D Are Beneficial/Protective , Summary and Conclusion3. VITAMIN D STATUS AND CANCER INCIDENCE AND MORTALITY; Introduction; Ecologic Studies of Sun Exposure; Case-Control and Cohort Studies of Sun Exposure; Prospective Studies of Circulating 25(OH)vitamin D and Cancer Risk; Studies of Vitamin D Intake; Randomized Trial of Vitamin D Intake and Colorectal Cancer; Solar Radiation, Vitamin D and Survival Rate of Colon Cancer; Vitamin D and Cancer Rates in United States Black Men; Synthesis of Evidence Regarding Sun Exposure, Vitamin D and Cancer Incidence and Mortality; Implications for Future Research , 4. SUN EXPOSURE AND CANCER SURVIVAL IN NORWAY: CHANGES IN THE RISK OF DEATH WITH SEASON OF DIAGNOSIS AND LATITUDEAbstract; Introduction; Materials and Methods; Dependency of Survival on Season of Diagnosis; Dependency of Survival on Residential Region; Discussion; Conclusions; 5. OPTIMAL SERUM 25-HYDROXYVITAMIN D LEVELS FOR MULTIPLE HEALTH OUTCOMES; Abstract; Introduction; 25(OH)D Levels and Bone Health; 25(OH)D and Lower Extremity Function; 25(OH)D and Dental Health; 25(OH)D and Cancer Incidence and Mortality; Vitamin D Intake Needed to Achieve Optimal 25(OH)D Levels , Adding Calcium to Vitamin DDiscussion; 6. ULTRAVIOLET EXPOSURE SCENARIOS: RISKS OF ERYTHEMA FROM RECOMMENDATIONS ON CUTANEOUS VITAMIN D SYNTHESIS; Abstract; Introduction; Differences between Vitamin D Synthesis and Erythema; Implications for UV Exposure; Assessing the Erythema Risks of Exposures for Vitamin D Synthesis; Public Health and Personal Choice; 7. AT WHAT TIME SHOULD ONE GO OUT IN THE SUN?; Abstract; Introduction; Methods; Results and Discussion; 8. EPIDEMIOLOGY OF MELANOMA AND NONMELANOMA SKIN CANCER-THE ROLE OF SUNLIGHT; Abstract; Introduction; Nonmelanoma Skin Cancer , Sun Exposure and Nonmelanoma Skin CancerMelanoma; Sun Exposure and Melanoma; 9. ULTRAVIOLET RADIATION AND MALIGNANT MELANOMA; Abstract; Introduction; Does UV Radiation Induce CMM?; Materials and Methods; Results and Discussion; 10. SOLAR UV EXPOSURE AND MORTALITY FROM SKIN TUMORS; Abstract; Introduction; Observed Relationships for Nonmelanoma Skin Cancer; Observed Relationships for Cutaneous Melanoma; Potential Mechanisms; Conclusions; 11. HEALTH INITIATIVES FOR THE PREVENTION OF SKIN CANCER; Introduction; Prevention of Skin Cancer; Balanced Messages (Concerning Vitamin D); Conclusion , 12. SUNSCREENS
    Additional Edition: ISBN 9780387775739
    Additional Edition: Erscheint auch als Druck-Ausgabe Sunlight, vitamin D, and skin cancer New York, NY : Springer Science+Business Media [u.a.], 2008 ISBN 9780387775739
    Additional Edition: ISBN 0387775730
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Hautkrebs ; Vitamin D3 ; Sonnenstrahlung ; Aufsatzsammlung
    URL: Cover
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