Format:
Online-Ressource (XXIV, 923 p. 162 illus., 107 illus. in color, digital)
ISBN:
9781441995308
Series Statement:
Springer Series in Translational Stroke Research
Content:
John H Zhang
Content:
This book presents a foundation for effective translational research. It emphasizes target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design
Note:
Description based upon print version of record
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Translational Stroke Research; Stroke Progress and Promises: Going Forward (Preface); Contents; Contributors; Part I: Theoretical Overview; Chapter 1: Vascular Targets for Ischemic Stroke Treatment; 1 Introduction to Vascular Protection; 2 Hemodynamics of Focal Ischemia; 2.1 Collateral Vessels During Focal Ischemia; 2.2 Hemodynamic Reserve Capacity and Regulation of CBF During Ischemia and Reperfusion; 3 The Penumbra as a Target in Stroke Protection; 4 Parenchymal Arterioles as Targets for Vascular Protection During Stroke; 5 Microcirculation as a Target for Vascular Protection During Stroke
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6 Middle Cerebral Arteries as Targets for Vascular Protection During Stroke6.1 Myogenic Mechanisms; 6.2 Threshold Duration of Ischemia and Reperfusion for Myogenic Responses; 6.3 Effect of tPA on Myogenic Responses and Vascular Function; 6.4 Mechanism of I/R-Induced Loss of Myogenic Tone; 7 The Cerebral Endothelium as a Therapeutic Target During Focal Ischemia; 7.1 eNOS; 7.2 EDHF; 7.3 Calcium; 7.4 Endothelin; 8 Hyperglycemia as a Therapeutic Target During Stroke; 9 Inflammation and Circulating Immune Factors as a Target for Vascular Protection During Stroke; 10 Conclusions; References
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Chapter 2: Identifying Vascular Targets to Treat Hemorrhagic Stroke1 Hemorrhage: Incidence and Pathophysiology; 2 Inflammatory Pathways and Vascular Damage; 2.1 Coagulation Factors and Pathway; 2.2 Thrombin and Coagulation; 2.3 Inflammation and Cytokines; 2.4 Other Anti-inflammatory Drug Approaches; 3 Free Radicals and Vascular Damage; 3.1 Free Radical Scavengers; 4 Regulation of MMPs in Hemorrhage; 4.1 TNF and MMPs Are Useful Drug Targets; 5 New Treatment Options; 5.1 Hydrogen Gas (HG); 5.2 Hyperbaric Oxygen (HBO); 5.3 Normobaric Oxygen (NBO); 5.4 Brain Hypothermia (BH); 6 Conclusion
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ReferencesChapter 3: Experimental Platforms for Assessing White Matter Pathophysiology in Stroke; 1 Introduction; 2 White Matter Damage in Stroke; 3 Experimental Platforms for Assessing White Matter Pathophysiology in Stroke; 3.1 Cell Culture and Tissue Platforms; 3.2 In Vivo Rodent White Matter Ischemia Models; 4 Cell-Cell Trophic Coupling in White Matter; 5 White Matter Recovery in Rodent Stroke Models; 6 Potential Therapeutic Targets for White Matter Ischemia; 7 Conclusions; References; Chapter 4: Neuroprotection in Stroke; 1 Cerebral Ischemia: Modes of Cell Injury and the Ischemic Cascade
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2 Neuroprotection Strategies: Translation of Available Research3 Challenges: Why Previous Translational Clinical Trials Have Failed; 3.1 Preclinical Development; 3.2 Evolving Understanding of the Ischemic Cascade; 3.3 Trial Design; 3.4 Measuring Outcomes; 4 Recommendations for Future Trials; 5 Specific Agents and Therapeutic Targets; 6 Conclusion; References; Part II: Mechanisms and Targets; Chapter 5: Protein Aggregation and Multiple Organelle Damage After Brain Ischemia; 1 Introduction; 2 Historical Review of Protein Aggregation; 3 Mechanisms of Protein Aggregation After Brain Ischemia
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4 Concluding Remark
Additional Edition:
ISBN 9781441995292
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-441-99529-2
Language:
English
DOI:
10.1007/978-1-4419-9530-8
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