UID:
almahu_9948025687202882
Format:
1 online resource (297 p.)
ISBN:
1-281-02722-7
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9786611027223
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0-08-053240-3
Series Statement:
Neuroscience perspectives
Content:
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In ad
Note:
Description based upon print version of record.
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Front Cover; Genetic Manipulation of the Nervous System; Copyright Page; Contents; Contributors; Series Preface; Preface; Chapter 1. Genetic manipulation of the nervous system: an overview; 1.1 Introduction; 1.2 Applications of in vivo gene delivery to the nervous system; 1.3 Methods of in vivo gene delivery to the nervous system; 1.4 Conclusions; References; Chapter 2. Non-neurotropic adenovirus: a vector for gene transfer to the brain and possible gene therapy of neurological disorders; 2.1 Introduction; 2.2 The vector system
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2.3 Developments in the use of adenovirus recombinants as vectors2.4 Adenoviral recombinant vectors: applications to basic neuroscience; 2.5 Adenoviral recombinant vectors: applications to neurological gene therapy; 2.6 Summary: targeting the brain with adenovirus recombinants; Acknowledgements; References; Chapter 3. Adenovirus: a new tool to transfer genes into the central nervous system for treatment o f neurodegenerative disorders; 3.1 Introduction; 3.2 The adenovirus as a tool to express genes in the brain; 3.3 Ex vivo gene therapy; 3.4 In vivo gene therapy
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3.5 Immunological aspects and improvement of the recombinant adenoviral tool3.6 Conclusions; References; Chapter 4. Adenovirus-mediated gene therapy of tumors in the central nervous system; 4.1 Introduction; 4.2 Viral-mediated gene therapy for CNS tumors; 4.3 Experimental models of ADV/RSV-tk and ganciclovir therapy for CNS tumors; 4.4 Discussion; Acknowledgements; References; Chapter 5. Gene delivery using adeno-associated virus; 5.1 Introduction; 5.2 The virion; 5.3 Genome organization; 5.4 Adeno-associated virus life cycle; 5.5 Host range; 5.6 Adeno-associated virus as a transducing vector
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AcknowledgementReferences; Chapter 6. Herpes simplex virus-based vectors; 6.1 Introduction; 6.2 The potential of herpes simplex virus as a vector for the nervous system; 6.3 Herpes simplex virus and other viral vectors compared; 6.4 Types of herpes simplex virus vector; 6.5 Disabled herpes viruses; 6.6 Promoters for transgene expression using disabled viruses; 6.7 Defective herpes viruses (amplicons); 6.8 Conclusions; References; Chapter 7. Gene delivery using herpes simplex virus type 1 plasmid vectors; 7.1 Introduction; 7.2 Packaging of defective HSV1 vectors
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7.3 Modification of neuronal physiology using HSV-1 vectors7.4 Cell type-specific gene expression using defective HSV-1 vectors; 7.5 The use of HSV-1 vectors in gene therapy paradigms; 7.6 A genetic intervention strategy. using HSV-1 vectors, to analyze neuronal physiology in vivo; 7.7 Concluding remarks; Acknowledgements; References; Chapter 8. Problems in the use of herpes simplex virus as a vector; 8.1 Introduction; 8.2 Cytopathic effects; 8.3 The problem of long-term expression; 8.4 Targeted expression; 8.5 Neural tracing studies; 8.6 Expression in non-neuronal cells; Acknowledgements
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References
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English
Additional Edition:
ISBN 0-12-437165-5
Language:
English
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