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  • 1
    UID:
    almafu_9958062371302883
    Format: 1 online resource (59 pages)
    Series Statement: Policy research working papers.
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV.
    Language: English
    URL: Volltext  (Deutschlandweit zugänglich)
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  • 2
    UID:
    almahu_9949191304602882
    Format: 1 online resource (426 pages)
    ISBN: 9781464805288
    Series Statement: Disease Control Priorities
    Content: As the culminating volume in the DCP3 series, volume 9 will provide an overview of DCP3 findings and methods, a summary of messages and substantive lessons to be taken from DCP3, and a further discussion of cross-cutting and synthesizing topics across the first eight volumes. The introductory chapters (1-3) in this volume take as their starting point the elements of the Essential Packages presented in the overview chapters of each volume. First, the chapter on intersectoral policy priorities for health includes fiscal and intersectoral policies and assembles a subset of the population policies and applies strict criteria for a low-income setting in order to propose a "highest-priority" essential package. Second, the chapter on packages of care and delivery platforms for universal health coverage (UHC) includes health sector interventions, primarily clinical and public health services, and uses the same approach to propose a highest priority package of interventions and policies that meet similar criteria, provides cost estimates, and describes a pathway to UHC.
    Additional Edition: Print Version: ISBN 9781464805271
    Language: English
    URL: Volltext  (kostenfrei)
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  • 3
    UID:
    b3kat_BV049074954
    Format: 1 Online-Ressource
    Edition: Online-Ausg Also available in print
    Series Statement: Policy research working paper 3670
    Content: "Artemisinin-based combination treatments (ACTs) are seen as an important tool in the global effort to roll back malaria. With rapidly increasing parasite resistance to chloroquine in many parts of the world, there is greater international recognition of the need for both a different antimalarial and a coordinated malaria treatment strategy to ensure that resistance does not needlessly cut short the useful therapeutic life of any successor drug to chloroquine. The effectiveness of antimalarial drugs is a global public good, of particular value in malarious regions that also are among the most economically impoverished parts of the world. Inappropriate drug use in neighboring countries reduces the incentive of any given country to deploy drug regimens that may be rapidly undermined by resistance originating outside their borders. Therefore, a case can be made for globally coordinated action to protect the effectiveness of these valuable drugs.
    Content: Translating this case to one for a global subsidy is not straightforward. On the one hand, in the absence of such a subsidy to ensure that ACTs are comparably priced to monotherapies, increasing monotherapy of artemisinin and other antimalarials that would be used along with artemisinin in ACT will hasten the demise of this drug. On the other hand, a global subsidy would greatly increase the use and potential misuse of ACTs and could result in resistance emerging at a more rapid rate. This study finds that a subsidy to ACTs is likely to slow the rate of emergence of resistance to artemisinin and partner drugs, even if such a subsidy were to increase the use of ACTs significantly. This conclusion is robust to alternative assumptions regarding the responsiveness of demand to the lower price for ACTs and a wide range of epidemiological and economic parameters.
    Content: However, the simulation results show that a subsidy for two or more ACT combinations is likely to be much more cost-effective than a subsidy to a single ACT. The only consideration is that the drugs used as partners to artemisinin be unrelated to each other and to artemisinin in mechanism of action and in genetic bases of resistance, so that a single mutation cannot encode resistance to both components. Such a subsidy program for ACTs, administered globally, that reduces reliance on any single combination, and discourages monotherapy, not only of artemisinin but of any effective antimalarial that could potentially be used as partner drug with artemisinin, is likely to be effective (and cost-effective) both in buying time for ACTs and in saving lives "--World Bank web site
    Note: Includes bibliographical references , Title from PDF file as viewed on 8/16/2005
    Additional Edition: Laxminarayan, Ramanan Will a global subsidy of artemisinin-based combination treatment (act) for malaria delay the emergence of resistance and save lives?
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 4
    UID:
    almahu_9949191371202882
    Format: 1 online resource (pages) ; , cm.
    ISBN: 9781464803475 (hc : alk. paper) , 9781464803482 (alk. paper)
    Series Statement: Disease control priorities ; volume 2
    Note: Reproductive, maternal, newborn, and child health : an overview / Robert Black, Marleen Temmerman, and Neff Walker -- The burden of reproductive ill health / Alex Ezeh, Abdhalah K. Ziraba, John Cleland, Akinrinota Bankole, anmd Claudia Garcia Moreno Esteva -- Levels and causes of maternal mortality and morbidity / Veronique Filippi, Doris Chou, Carine Ronsmans, Wendy Graham, and Lale Say -- Levels and causes of mortality under age five years / Li Liu, Kenneth Hill, Shefali Oza, Dan Hogan, Simon Cousens, Colin Mathers, Cynthia Stanton, Joy Lawn, Robert E. Black -- Levels and trends in low height-for-age / Gretchen Stevens, Mariel Finucane, and Christopher Paciorek -- Interventions to improve reproductive health / John Stover, Karen Hardee, Bella Ganatra, Claudia Garcia Moreno, and Susan E. Horton -- Interventions to reduce maternal and newborn morbidity and mortality / A. Metin Guilmezoglu, Theresa A. Lawrie, Natasha Hezelgrave, Olufemi T. Oladapo, Joao Paulo Souza, Marijke Gielen, Joy E. Lawn, Rajiv Bahl, Fernando Althabe, Daniela Colaci, and G. Justus Hofmey -- Diagnosis and treatment of the febrile child / Julie M. Herlihy, Valerie D'acremont, Deborah C. Hay Burgess, and Davidson H. Hamer -- Diarrheal diseases / Gerald T. Keusch, Christa Fischer-Walker, Jai K. Das, Susan Horton, and Demissie Habte -- Vaccines for children in low- and middle-income countries / Daniel R. Feikin, Brendan Flannery, Mary J. Hamel, Meghan Stack, Peter Hansen -- Management of severe and moderate acute malnutrition in children / Lindsey Lenters, Kerri Wazny, and Zulfiqar A. Bhutta -- Infant and young child growth / Jai K. Das, Rehana A. Salam, Aamer Imdad, and Zulfiqar A. Bhutta -- Very early childhood development / Frances E. Aboud and Aisha K. Yousafzai -- Community based care to improve maternal, newborn and child health / Zohra S. Lassi, Rohail Kumar, and Zulfiqar A. Bhutta -- Innovations to expand access and improve quality of health services / Lori A. Bollinger and Margaret E. Kruk -- Returns on investment in the continuum of care for reproductive, maternal, newborn, and child health / Karin Stenberg, Kim Sweeny, Henrik Axelson, and Peter Sheehan -- Cost-effectiveness of interventions for reproductive, maternal, neonatal, and child health / Susan Horton and Carol Levin -- The benefits of a universal home-based neonatal care package in rural india : an extended cost-effectiveness analysis / Ashvin Ashok, Arindam Nandi, and Ramanan Laxminarayan -- Health gains and financial risk protection afforded by treatment and prevention of diarrhea and pneumonia in ethiopia : an extended cost-effectiveness analysis / Stephane Verguet, Clint Pecenka, Kjell Arne Johansson, Solomon Tessea Memirie, Ingrid K. Friberg, Julia R. Driessen, and Dean T. Jamison.
    Additional Edition: Print Version: ISBN 9781464803482
    Language: English
    URL: Volltext  (kostenfrei)
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  • 5
    UID:
    b3kat_BV040523560
    Format: 1 Online-Ressource
    ISBN: 9789400748385 , 9789400748392
    Language: English
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  • 6
    UID:
    gbv_1657051315
    Format: Online-Ressource (1 online resource (p.)) , cm
    Edition: Online-Ausg.
    ISBN: 9781464803475 , 9781464803482
    Series Statement: Disease control priorities volume 2
    Content: Reproductive, maternal, newborn, and child health : an overview / Robert Black, Marleen Temmerman, and Neff Walker -- The burden of reproductive ill health / Alex Ezeh, Abdhalah K. Ziraba, John Cleland, Akinrinota Bankole, anmd Claudia Garcia Moreno Esteva -- Levels and causes of maternal mortality and morbidity / Veronique Filippi, Doris Chou, Carine Ronsmans, Wendy Graham, and Lale Say -- Levels and causes of mortality under age five years / Li Liu, Kenneth Hill, Shefali Oza, Dan Hogan, Simon Cousens, Colin Mathers, Cynthia Stanton, Joy Lawn, Robert E. Black -- Levels and trends in low height-for-age / Gretchen Stevens, Mariel Finucane, and Christopher Paciorek -- Interventions to improve reproductive health / John Stover, Karen Hardee, Bella Ganatra, Claudia Garcia Moreno, and Susan E. Horton -- Interventions to reduce maternal and newborn morbidity and mortality / A. Metin Guilmezoglu, Theresa A. Lawrie, Natasha Hezelgrave, Olufemi T. Oladapo, Joao Paulo Souza, Marijke Gielen, Joy E. Lawn, Rajiv Bahl, Fernando Althabe, Daniela Colaci, and G. Justus Hofmey -- Diagnosis and treatment of the febrile child / Julie M. Herlihy, Valerie D'acremont, Deborah C. Hay Burgess, and Davidson H. Hamer -- Diarrheal diseases / Gerald T. Keusch, Christa Fischer-Walker, Jai K. Das, Susan Horton, and Demissie Habte -- Vaccines for children in low- and middle-income countries / Daniel R. Feikin, Brendan Flannery, Mary J. Hamel, Meghan Stack, Peter Hansen -- Management of severe and moderate acute malnutrition in children / Lindsey Lenters, Kerri Wazny, and Zulfiqar A. Bhutta -- Infant and young child growth / Jai K. Das, Rehana A. Salam, Aamer Imdad, and Zulfiqar A. Bhutta -- Very early childhood development / Frances E. Aboud and Aisha K. Yousafzai -- Community based care to improve maternal, newborn and child health / Zohra S. Lassi, Rohail Kumar, and Zulfiqar A. Bhutta -- Innovations to expand access and improve quality of health services / Lori A. Bollinger and Margaret E. Kruk
    Note: Includes bibliographical references and index. - Description based on print version record
    Additional Edition: ISBN 9781464803482
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-4648-0348-2
    Language: English
    URL: Volltext  (Deutschlandweit zugänglich)
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  • 7
    UID:
    gbv_724216731
    Format: Online-Ressource
    Edition: Online-Ausg. World Bank E-Library Archive Also available in print
    Series Statement: Policy research working paper 3670
    Content: "Artemisinin-based combination treatments (ACTs) are seen as an important tool in the global effort to roll back malaria. With rapidly increasing parasite resistance to chloroquine in many parts of the world, there is greater international recognition of the need for both a different antimalarial and a coordinated malaria treatment strategy to ensure that resistance does not needlessly cut short the useful therapeutic life of any successor drug to chloroquine. The effectiveness of antimalarial drugs is a global public good, of particular value in malarious regions that also are among the most economically impoverished parts of the world. Inappropriate drug use in neighboring countries reduces the incentive of any given country to deploy drug regimens that may be rapidly undermined by resistance originating outside their borders. Therefore, a case can be made for globally coordinated action to protect the effectiveness of these valuable drugs. Translating this case to one for a global subsidy is not straightforward. On the one hand, in the absence of such a subsidy to ensure that ACTs are comparably priced to monotherapies, increasing monotherapy of artemisinin and other antimalarials that would be used along with artemisinin in ACT will hasten the demise of this drug. On the other hand, a global subsidy would greatly increase the use and potential misuse of ACTs and could result in resistance emerging at a more rapid rate. This study finds that a subsidy to ACTs is likely to slow the rate of emergence of resistance to artemisinin and partner drugs, even if such a subsidy were to increase the use of ACTs significantly. This conclusion is robust to alternative assumptions regarding the responsiveness of demand to the lower price for ACTs and a wide range of epidemiological and economic parameters. However, the simulation results show that a subsidy for two or more ACT combinations is likely to be much more cost-effective than a subsidy to a single ACT. The only consideration is that the drugs used as partners to artemisinin be unrelated to each other and to artemisinin in mechanism of action and in genetic bases of resistance, so that a single mutation cannot encode resistance to both components. Such a subsidy program for ACTs, administered globally, that reduces reliance on any single combination, and discourages monotherapy, not only of artemisinin but of any effective antimalarial that could potentially be used as partner drug with artemisinin, is likely to be effective (and cost-effective) both in buying time for ACTs and in saving lives "--World Bank web site
    Note: Includes bibliographical references , Title from PDF file as viewed on 8/16/2005 , Also available in print.
    Additional Edition: Laxminarayan, Ramanan Will a global subsidy of artemisinin-based combination treatment (act) for malaria delay the emergence of resistance and save lives?
    Language: English
    URL: Volltext  (Deutschlandweit zugänglich)
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    UID:
    b3kat_BV049074328
    Format: 1 Online-Ressource (59 Seiten))
    Edition: Online-Ausg
    Content: Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that includes directly observed treatment, short course chemotherapy and several other components) as proposed in the Global Plan to Stop TB, 2006-2015. The authors use a model-based approach that combines epidemiological projections of averted mortality and economic benefits measured using value of statistical life for the Sub-Saharan Africa region and the 22 high-burden, tuberculosis-endemic countries in the world. The analysis finds that the economic benefits between 2006 and 2015 of sustaining DOTS at current levels relative to having no DOTS coverage are significantly greater than the costs in the 22 high-burden, tuberculosis-endemic countries and the Africa region. The marginal benefits of implementing the Global Plan to Stop TB relative to a no-DOTS scenario exceed the marginal costs by a factor of 15 in the 22 high-burden endemic countries, a factor of 9 (95% CI, 8-9) in the Africa region, and a factor of 9 (95% CI, 9-10) in the nine high-burden African countries. Uncertainty analysis shows that benefit-cost ratios of the Global Plan strategy relative to sustained DOTS were unambiguously greater than one in all nine high-burden countries in Africa and in Afghanistan, Pakistan, and Russia. Although HIV curtails the effect of the tuberculosis programs by lowering the life expectancy of those receiving treatment, the benefits of the Global Plan are greatest in African countries with high levels of HIV
    Additional Edition: Adeyi, Olusoji Economic benefit of Tuberculosis control
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 9
    Online Resource
    Online Resource
    Washington, DC : International Bank for Reconstruction and Development /The World Bank
    UID:
    b3kat_BV048266712
    Format: 1 Online-Ressource (p)
    ISBN: 9781464804267 , 9781464804274 , 9781464804281
    Series Statement: Disease control priorities volume 4
    Content: Moving toward universal health coverage for mental, neurological, and substance use disorders : an extended cost-effectiveness analysis / Dan Chisholm, Kjell Arne Johansson, Neha Raykar, Itamar Megiddo, Aditi Nigam, Kirsten Bjerkreim Strand, Abigail Colson, Abebaw Fekadu, and Stephane Verguet
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Online-Ausgabe Mental, neurological, and substance use disorders Washington, DC : International Bank for Reconstruction and Development /The World Bank, [2016]
    Language: English
    URL: Volltext  (kostenfrei)
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  • 10
    UID:
    b3kat_BV047935152
    Format: 1 Online-Ressource (41 Seiten) , 21 x 29.7cm
    Series Statement: OECD Food, Agriculture and Fisheries Papers
    Content: Antimicrobials have been used in human medicine and in livestock production for more than 60 years, improving human and animal health but also fostering the emergence and spread of antimicrobial resistant pathogens worldwide. This report focuses on the specific issue of the economic value of antimicrobial growth promoters (AGPs) to producers and consumers. After estimating orders of magnitude of current antimicrobial consumption in livestock globally, the report investigates the potential effects of restricting AGPs on livestock production globally. The growth response to AGPs appears to be small in optimised production systems, suggesting that the economic impacts of a ban on AGPs could be limited in high-income industrialized countries but potentially higher in lower income countries with less developed hygiene and production practices. With no major changes in policy, global consumption of antimicrobials in food-producing animals is projected to rise by two-thirds by 2030, with the majority of that increase occurring in emerging economies where the demand for livestock products, especially poultry, is growing fastest
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Volltext  (URL des Erstveröffentlichers)
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