Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource (xvi, 600 Seiten) : , Illustrationen.

ISBN: 978-3-030-44211-8

Series Statement: Tissue engineering and regeneration

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-030-44210-1

Language: English

DOI: 10.1007/978-3-030-44211-8

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Eberli, Daniel, 1971-

UID:

Format: 1 online resource (460 pages) : , illustrations (some color), tables

ISBN: 0-12-802500-X

Note: Front Cover -- In Situ Tissue Regeneration -- Dedication -- In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design -- Copyright -- Contents -- List of Contributors -- Preface -- 01 - INTRODUCTION -- 1 - FUNDAMENTALS OF IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGY: IN SITU TISSUE REGENERATION -- DESIGN CONSIDERATIONS: BIOMATERIAL SCAFFOLDS -- APPLICATIONS OF IN SITU TISSUE REGENERATION -- CONCLUSION AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 02 - ENDOGENOUS CELL SOURCES -- 2 - STEM CELL HOMING -- INTRODUCTION -- HOMING OF HEMATOPOIETIC STEM CELLS TO BONE MARROW NICHES -- CHANGES IN THE BONE MARROW LEVEL OF CHEMOATTRACTANTS FOR HEMATOPOIETIC STEM CELLS -- HOMING OF NONHEMATOPOIETIC STEM CELLS TO DAMAGED ORGANS -- TO MODULATE HOMING GRADIENTS AS A STRATEGY TO DELIVER THERAPEUTIC STEM CELLS TO THE DAMAGED ORGANS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 3 - IMMUNOLOGY: HOST RESPONSES TO BIOMATERIALS -- INTRODUCTION -- INNATE IMMUNITY -- CELL TYPES -- COMPLEMENT -- ADAPTIVE IMMUNITY -- T CELL DEVELOPMENT -- HELPER T CELLS -- B CELLS -- BIOMATERIALS -- ACUTE RESPONSE TO BIOMATERIALS -- CHRONIC IMMUNE RESPONSE TO BIOMATERIALS -- Adhesion of macrophages -- Foreign body response -- ADAPTIVE IMMUNE RESPONSE TO BIOMATERIALS -- BIOMATERIAL COMPOSITION INFLUENCES THE IMMUNE RESPONSE -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 4 - FOREIGN BODY REACTION AND STEM CELL RESPONSES -- INTRODUCTION -- IMPLANT-MEDIATED INFLAMMATORY RESPONSES AND STEM CELL RECRUITMENT -- FOREIGN BODY REACTIONS VERSUS WOUND HEALING RESPONSES -- IMPLANT-MEDIATED STEM AND PROGENITOR CELL RECRUITMENT -- INFLAMMATION-MEDIATED STEM CELL RECRUITMENT -- INFLAMMATORY CYTOKINES AND STEM CELL RECRUITMENT. , FIBROCYTES-PROGENITOR FIBROTIC CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- FIBROCYTES-FIBROBLAST PROGENITOR CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- INFLUENCE OF INFLAMMATORY RESPONSES ON FIBROCYTES RECRUITMENT -- SOURCE OF FIBROCYTES -- NEW STRATEGIES TO ENGINEER STEM CELL RESPONSES FOR TISSUE REGENERATIONS -- TISSUE ENGINEERING SCAFFOLDS FOR DIRECTING AUTOLOGOUS STEM CELL RESPONSES -- PROGRAMMED STEM CELL DIFFERENTIATION TO ALTER FIBROCYTE REACTIONS -- CYTOKINE-MEDIATED STEM CELL RECRUITMENT AND TISSUE REGENERATION -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 03 - BIOCHEMICAL AND PHYSICAL CUES -- 5 - ROLES OF ENDOGENOUS GROWTH FACTORS AND SMALL PEPTIDES IN IN SITU TISSUE REGENERATION -- INTRODUCTION -- STEM CELL MOBILIZATION AND VASCULOGENESIS -- STROMAL CELL-DERIVED FACTOR 1 ALPHA -- VASCULAR ENDOTHELIAL GROWTH FACTOR -- GRANULOCYTE-COLONY STIMULATING FACTOR -- SUBSTANCE-P -- EXPERIMENTAL STRATEGIES TO IDENTIFY STEM CELL TRAFFICKING AND HOMING USING CANDIDATE MOLECULES -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 - SMALL MOLECULES: CONTROLLING CELL FATE AND FUNCTION -- INTRODUCTION -- TARGET CELLS FOR SMALL MOLECULE REGULATION IN REGENERATIVE MEDICINE -- HUMAN EMBRYONIC STEM CELLS -- HUMAN INDUCED PLURIPOTENT STEM CELLS -- ADULT STEM CELLS -- TERMINALLY DIFFERENTIATED CELLS -- IN VITRO/EX VIVO REGULATION OF HUMAN CELLS BY SMALL MOLECULES -- SMALL MOLECULES FOR HESC/HIPSC CELL PROLIFERATION AND MAINTENANCE -- SMALL MOLECULES FOR GUIDED PLURIPOTENT STEM CELL DIFFERENTIATION -- SMALL MOLECULES FOR HIPSC GENERATION -- SMALL MOLECULES FOR IN VITRO ADULT STEM CELL REGULATION -- SMALL MOLECULES FOR IMPROVING SAFETY OF PLURIPOTENT STEM CELL-DERIVED CELLS -- USING SMALL MOLECULES TO ENHANCE IN VIVO TISSUE REGENERATION. , SMALL MOLECULES FACILITATING THE PROLIFERATION AND DIFFERENTIATION OF ADULT STEM CELLS -- Small molecules promoting neurogenesis -- Small molecules promoting cardiomyocyte regeneration -- Small molecules promoting regeneration of other tissues -- ENHANCING THE PROLIFERATION/FUNCTION OF DIFFERENTIATED CELLS -- INDUCING REPROGRAMMING AND TRANSDIFFERENTIATION OF FIBROBLASTS TO TARGET CELLS -- CURRENT STATUS AND FUTURE DIRECTIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 7 - SMALL RNA DELIVERY FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR SMALL RNAS IN TISSUE REGENERATION -- RNA INTERFERENCE -- SMALL RNAS: SMALL INTERFERING RNAS AND MICRORNAS -- DESIGN CONSIDERATION FOR SMALL RNA DELIVERY -- GENERAL DELIVERY STRATEGY OF SMALL RNAS -- POLYMERIC DELIVERY SYSTEM -- ADVANCED CARRIER MATERIALS FOR SMALL RNA DELIVERY -- SMALL RNAS FOR IN SITU TISSUE REGENERATION -- REGULATION OF STEMNESS -- BONE REGENERATION -- CARTILAGE REGENERATION -- SKELETAL MUSCLE REGENERATION -- NERVE REGENERATION -- CARDIAC TISSUE REGENERATION -- WOUND HEALING -- VASCULARIZATION -- OTHER APPLICATIONS -- SUMMARY AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENT -- REFERENCES -- 8 - MICRO- AND NANOTOPOGRAPHICAL CUES GUIDING BIOMATERIAL HOST RESPONSE -- INTRODUCTION -- EXTRACELLULAR MATRIX TOPOGRAPHY AND ITS EFFECT ON CELLULAR RESPONSE -- CONTROLLED SUBSTRATE TOPOGRAPHY GUIDING IN VIVO HOST RESPONSE -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON WATER INTERACTION -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON PROTEIN ADSORPTION -- DIFFERENT FABRICATION TECHNIQUES USED TO CREATE MICRO-/NANOSURFACE TOPOGRAPHY -- PHOTOLITHOGRAPHY AND ELECTRON BEAM LITHOGRAPHY -- SOFT LITHOGRAPHY -- ELECTROSPINNING -- MICROSTEREOLITHOGRAPHY -- IN VITRO ASSESSMENT OF MICRO- AND NANOTOPOGRAPHIC FEATURES. , THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL MORPHOLOGY AND MIGRATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL PROLIFERATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON STEM CELL DIFFERENTIATION -- The effect of topographic modulation on mesenchymal stem cell differentiation -- The effect of topographic modulation on embryonic stem cells -- The effect of topographic modulation on adipose-derived stem cells -- USE OF TOPOGRAPHICAL MODIFICATIONS TO ENGINEER FUNCTIONAL TISSUE-ENGINEERED CONSTRUCTS -- Tendon tissue engineering -- Vascular tissue engineering -- Cardiac tissue engineering -- MODULATION OF SURFACE TOPOGRAPHY AND ITS EFFECT ON ASSOCIATED IN VIVO RESPONSE -- EFFECTS ON THE BONE IMPLANTS TISSUE INTEGRATION -- SUMMARY -- REFERENCES -- 9 - MECHANOBIOLOGY AND MECHANOTHERAPY IN TISSUE ENGINEERING -- INTRODUCTION -- CELLS AND THE PHYSICAL ENVIRONMENT -- MECHANOSENSITIVITY OF CELLS -- MECHANOSENSORS, MECHANORECEPTORS, AND MECHANOSENSITIVE NOCICEPTORS -- MECHANOSIGNALING PATHWAYS -- MECHANOBIOLOGY AND MECHANOTHERAPY -- MECHANOTHERAPY AT THE MOLECULAR LEVEL -- MECHANOTHERAPY AT A CELLULAR LEVEL -- MECHANOTHERAPY AT THE TISSUE LEVEL -- MECHANOTHERAPY FOR DISEASES -- DEVELOPMENT OF NEW MECHANOTHERAPIES FOR TISSUE ENGINEERING -- CONCLUSION -- REFERENCES -- 04 - SMART BIOMATERIALS DEVELOPMENT -- 10 - A BIOMIMETIC STRATEGY TO DESIGN BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- BIOMIMETIC MATERIALS -- EXTRACELLULAR MATRIX-MIMETIC BIOACTIVE MATERIALS -- Cell-adhesive or enzyme-sensitive peptides -- Growth factor bearing or binding biomaterials -- PHYSICOCHEMICAL SIGNALS FOR CONTROLLING CELL FATES -- Bioactive molecules for controlling stem cell fates -- Substrates with controlled topographical cues -- Substrate elasticity/stiffness and mechanical cues -- Electrical stimuli. , DESIGNED STRUCTURE OF PEPTIDE-BASED MOLECULES -- Growth factor-mimicking peptides -- Peptide amphiphiles -- SUMMARY AND FUTURE PERSPECTIVES -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 11 - IMPACT OF MATRIX DYNAMIC PROPERTIES ON STEM CELL VIABILITY -- INTRODUCTION -- VIABILITY OF HUMAN MESENCHYMAL STEM CELLS IN TWO HYDROGELS -- STIFFNESS AND RELAXATION SPECTRA OF TWO HYDROGELS -- NANOSCALE STRUCTURAL DIFFERENCES DEFINING FIBER DYNAMICS -- CONCLUSIONS -- GLOSSARY -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 12 - FUNCTIONALIZED POLYMERIC BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR THE FUNCTIONALIZED POLYMERIC SCAFFOLD -- BIOMATERIALS FOR FUNCTIONALIZED POLYMERIC SCAFFOLD -- SCAFFOLDING SYSTEM -- CHEMOKINE SIGNALING -- STEM CELL RECRUITING FACTORS -- DESIGN CONSIDERATIONS OF FUNCTIONALIZED POLYMERIC SCAFFOLDS -- IN SITU TISSUE REGENERATION USING THE FUNCTIONALIZED POLYMERIC SCAFFOLDS -- CONCLUSION AND FUTURE TECHNOLOGICAL CHALLENGES -- REFERENCES -- 13 - TISSUE-DERIVED MATRICES -- INTRODUCTION -- COMPOSITION OF THE EXTRACELLULAR MATRIX -- FIBROUS PROTEINS -- PROTEOGLYCANS -- GLYCOPROTEINS -- FUNCTIONS OF NATIVE EXTRACELLULAR MATRIX -- STRUCTURAL FUNCTION OF THE EXTRACELLULAR MATRIX -- REGULATION OF THE ACTIVITY OF OTHER EXTRACELLULAR MOLECULES -- Regulation of growth factor signaling -- Regulation of proteolytic enzymes -- FUNCTIONAL INTERACTIONS OF THE EXTRACELLULAR MATRIX WITH EMBEDDED CELLS -- The ECM interacts with cells via specific receptors -- ECM physical properties can affect stem cell fate -- ECM physical properties regulate branching morphogenesis in development -- TISSUE-DERIVED MATRICES FOR TISSUE ENGINEERING -- METHODS FOR THE REMOVAL OF CELLS FROM TISSUE-DERIVED MATRICES -- Physical protocols to decellularize tissues. , Chemical methods to decellularize tissues.

Additional Edition: ISBN 0-12-802225-6

Language: English

UID:

ISBN: 9783030185121

Series Statement: Tissue Engineering and Regeneration

Language: English

DOI: 10.1007/978-3-030-18512-1

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 Online-Ressource (xvi, 600 Seiten) , Illustrationen

ISBN: 9783030442118

Series Statement: Tissue engineering and regeneration

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-030-44210-1

Language: English

DOI: 10.1007/978-3-030-44211-8

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Eberli, Daniel 1971-

UID:

Format: IV, 245 S. , graph. Darst.

Original writing title: 韓國農樂槪論 : 이론과 기예

Original writing person/organisation: 李, 相鎭

Original writing publisher: 서울 : 민속원

Language: Korean

Subjects: Musicology

UID:

Format: 1 Online-Ressource(61 illus., 55 illus. in color. eReference.)

Edition: 1st ed. 2021.

ISBN: 9783030442118

Series Statement: Tissue Engineering and Regeneration

Content: Brain Central Neural System -- Vison system, retina, cornea -- Olfactory system -- Craniomaxillofacial bone engineering -- Ear, Nose and Throat -- Dental, tooth -- Thymus, Lymphoid -- Oesophagus, Trachea -- Lung -- Gastro Intestinal Tract (Organoids) -- Kidney -- Bladder/Urethra -- Liver (Biomaterial, Cells) -- Endocrine Organs (Pancreas) -- Salivary grand -- Breast Tissue / Fat Tissue -- Ovary -- Penis -- Great Vessels -- Cell sheets for cardiac tissue engineering -- Heart valve Bioengineering -- Ligament -- Meniskus als muskuloskelettaler Abschnitt -- Tendons -- Skeletal system and Muscle.

Content: The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function. In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.

Additional Edition: ISBN 9783030442101

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030442101

Language: English

DOI: 10.1007/978-3-030-44211-8

URL: lizenzpflichtig

UID:

Format: 1 online resource (460 pages) : , illustrations (some color), tables

ISBN: 0-12-802500-X

Note: Front Cover -- In Situ Tissue Regeneration -- Dedication -- In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design -- Copyright -- Contents -- List of Contributors -- Preface -- 01 - INTRODUCTION -- 1 - FUNDAMENTALS OF IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGY: IN SITU TISSUE REGENERATION -- DESIGN CONSIDERATIONS: BIOMATERIAL SCAFFOLDS -- APPLICATIONS OF IN SITU TISSUE REGENERATION -- CONCLUSION AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 02 - ENDOGENOUS CELL SOURCES -- 2 - STEM CELL HOMING -- INTRODUCTION -- HOMING OF HEMATOPOIETIC STEM CELLS TO BONE MARROW NICHES -- CHANGES IN THE BONE MARROW LEVEL OF CHEMOATTRACTANTS FOR HEMATOPOIETIC STEM CELLS -- HOMING OF NONHEMATOPOIETIC STEM CELLS TO DAMAGED ORGANS -- TO MODULATE HOMING GRADIENTS AS A STRATEGY TO DELIVER THERAPEUTIC STEM CELLS TO THE DAMAGED ORGANS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 3 - IMMUNOLOGY: HOST RESPONSES TO BIOMATERIALS -- INTRODUCTION -- INNATE IMMUNITY -- CELL TYPES -- COMPLEMENT -- ADAPTIVE IMMUNITY -- T CELL DEVELOPMENT -- HELPER T CELLS -- B CELLS -- BIOMATERIALS -- ACUTE RESPONSE TO BIOMATERIALS -- CHRONIC IMMUNE RESPONSE TO BIOMATERIALS -- Adhesion of macrophages -- Foreign body response -- ADAPTIVE IMMUNE RESPONSE TO BIOMATERIALS -- BIOMATERIAL COMPOSITION INFLUENCES THE IMMUNE RESPONSE -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 4 - FOREIGN BODY REACTION AND STEM CELL RESPONSES -- INTRODUCTION -- IMPLANT-MEDIATED INFLAMMATORY RESPONSES AND STEM CELL RECRUITMENT -- FOREIGN BODY REACTIONS VERSUS WOUND HEALING RESPONSES -- IMPLANT-MEDIATED STEM AND PROGENITOR CELL RECRUITMENT -- INFLAMMATION-MEDIATED STEM CELL RECRUITMENT -- INFLAMMATORY CYTOKINES AND STEM CELL RECRUITMENT. , FIBROCYTES-PROGENITOR FIBROTIC CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- FIBROCYTES-FIBROBLAST PROGENITOR CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- INFLUENCE OF INFLAMMATORY RESPONSES ON FIBROCYTES RECRUITMENT -- SOURCE OF FIBROCYTES -- NEW STRATEGIES TO ENGINEER STEM CELL RESPONSES FOR TISSUE REGENERATIONS -- TISSUE ENGINEERING SCAFFOLDS FOR DIRECTING AUTOLOGOUS STEM CELL RESPONSES -- PROGRAMMED STEM CELL DIFFERENTIATION TO ALTER FIBROCYTE REACTIONS -- CYTOKINE-MEDIATED STEM CELL RECRUITMENT AND TISSUE REGENERATION -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 03 - BIOCHEMICAL AND PHYSICAL CUES -- 5 - ROLES OF ENDOGENOUS GROWTH FACTORS AND SMALL PEPTIDES IN IN SITU TISSUE REGENERATION -- INTRODUCTION -- STEM CELL MOBILIZATION AND VASCULOGENESIS -- STROMAL CELL-DERIVED FACTOR 1 ALPHA -- VASCULAR ENDOTHELIAL GROWTH FACTOR -- GRANULOCYTE-COLONY STIMULATING FACTOR -- SUBSTANCE-P -- EXPERIMENTAL STRATEGIES TO IDENTIFY STEM CELL TRAFFICKING AND HOMING USING CANDIDATE MOLECULES -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 - SMALL MOLECULES: CONTROLLING CELL FATE AND FUNCTION -- INTRODUCTION -- TARGET CELLS FOR SMALL MOLECULE REGULATION IN REGENERATIVE MEDICINE -- HUMAN EMBRYONIC STEM CELLS -- HUMAN INDUCED PLURIPOTENT STEM CELLS -- ADULT STEM CELLS -- TERMINALLY DIFFERENTIATED CELLS -- IN VITRO/EX VIVO REGULATION OF HUMAN CELLS BY SMALL MOLECULES -- SMALL MOLECULES FOR HESC/HIPSC CELL PROLIFERATION AND MAINTENANCE -- SMALL MOLECULES FOR GUIDED PLURIPOTENT STEM CELL DIFFERENTIATION -- SMALL MOLECULES FOR HIPSC GENERATION -- SMALL MOLECULES FOR IN VITRO ADULT STEM CELL REGULATION -- SMALL MOLECULES FOR IMPROVING SAFETY OF PLURIPOTENT STEM CELL-DERIVED CELLS -- USING SMALL MOLECULES TO ENHANCE IN VIVO TISSUE REGENERATION. , SMALL MOLECULES FACILITATING THE PROLIFERATION AND DIFFERENTIATION OF ADULT STEM CELLS -- Small molecules promoting neurogenesis -- Small molecules promoting cardiomyocyte regeneration -- Small molecules promoting regeneration of other tissues -- ENHANCING THE PROLIFERATION/FUNCTION OF DIFFERENTIATED CELLS -- INDUCING REPROGRAMMING AND TRANSDIFFERENTIATION OF FIBROBLASTS TO TARGET CELLS -- CURRENT STATUS AND FUTURE DIRECTIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 7 - SMALL RNA DELIVERY FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR SMALL RNAS IN TISSUE REGENERATION -- RNA INTERFERENCE -- SMALL RNAS: SMALL INTERFERING RNAS AND MICRORNAS -- DESIGN CONSIDERATION FOR SMALL RNA DELIVERY -- GENERAL DELIVERY STRATEGY OF SMALL RNAS -- POLYMERIC DELIVERY SYSTEM -- ADVANCED CARRIER MATERIALS FOR SMALL RNA DELIVERY -- SMALL RNAS FOR IN SITU TISSUE REGENERATION -- REGULATION OF STEMNESS -- BONE REGENERATION -- CARTILAGE REGENERATION -- SKELETAL MUSCLE REGENERATION -- NERVE REGENERATION -- CARDIAC TISSUE REGENERATION -- WOUND HEALING -- VASCULARIZATION -- OTHER APPLICATIONS -- SUMMARY AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENT -- REFERENCES -- 8 - MICRO- AND NANOTOPOGRAPHICAL CUES GUIDING BIOMATERIAL HOST RESPONSE -- INTRODUCTION -- EXTRACELLULAR MATRIX TOPOGRAPHY AND ITS EFFECT ON CELLULAR RESPONSE -- CONTROLLED SUBSTRATE TOPOGRAPHY GUIDING IN VIVO HOST RESPONSE -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON WATER INTERACTION -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON PROTEIN ADSORPTION -- DIFFERENT FABRICATION TECHNIQUES USED TO CREATE MICRO-/NANOSURFACE TOPOGRAPHY -- PHOTOLITHOGRAPHY AND ELECTRON BEAM LITHOGRAPHY -- SOFT LITHOGRAPHY -- ELECTROSPINNING -- MICROSTEREOLITHOGRAPHY -- IN VITRO ASSESSMENT OF MICRO- AND NANOTOPOGRAPHIC FEATURES. , THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL MORPHOLOGY AND MIGRATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL PROLIFERATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON STEM CELL DIFFERENTIATION -- The effect of topographic modulation on mesenchymal stem cell differentiation -- The effect of topographic modulation on embryonic stem cells -- The effect of topographic modulation on adipose-derived stem cells -- USE OF TOPOGRAPHICAL MODIFICATIONS TO ENGINEER FUNCTIONAL TISSUE-ENGINEERED CONSTRUCTS -- Tendon tissue engineering -- Vascular tissue engineering -- Cardiac tissue engineering -- MODULATION OF SURFACE TOPOGRAPHY AND ITS EFFECT ON ASSOCIATED IN VIVO RESPONSE -- EFFECTS ON THE BONE IMPLANTS TISSUE INTEGRATION -- SUMMARY -- REFERENCES -- 9 - MECHANOBIOLOGY AND MECHANOTHERAPY IN TISSUE ENGINEERING -- INTRODUCTION -- CELLS AND THE PHYSICAL ENVIRONMENT -- MECHANOSENSITIVITY OF CELLS -- MECHANOSENSORS, MECHANORECEPTORS, AND MECHANOSENSITIVE NOCICEPTORS -- MECHANOSIGNALING PATHWAYS -- MECHANOBIOLOGY AND MECHANOTHERAPY -- MECHANOTHERAPY AT THE MOLECULAR LEVEL -- MECHANOTHERAPY AT A CELLULAR LEVEL -- MECHANOTHERAPY AT THE TISSUE LEVEL -- MECHANOTHERAPY FOR DISEASES -- DEVELOPMENT OF NEW MECHANOTHERAPIES FOR TISSUE ENGINEERING -- CONCLUSION -- REFERENCES -- 04 - SMART BIOMATERIALS DEVELOPMENT -- 10 - A BIOMIMETIC STRATEGY TO DESIGN BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- BIOMIMETIC MATERIALS -- EXTRACELLULAR MATRIX-MIMETIC BIOACTIVE MATERIALS -- Cell-adhesive or enzyme-sensitive peptides -- Growth factor bearing or binding biomaterials -- PHYSICOCHEMICAL SIGNALS FOR CONTROLLING CELL FATES -- Bioactive molecules for controlling stem cell fates -- Substrates with controlled topographical cues -- Substrate elasticity/stiffness and mechanical cues -- Electrical stimuli. , DESIGNED STRUCTURE OF PEPTIDE-BASED MOLECULES -- Growth factor-mimicking peptides -- Peptide amphiphiles -- SUMMARY AND FUTURE PERSPECTIVES -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 11 - IMPACT OF MATRIX DYNAMIC PROPERTIES ON STEM CELL VIABILITY -- INTRODUCTION -- VIABILITY OF HUMAN MESENCHYMAL STEM CELLS IN TWO HYDROGELS -- STIFFNESS AND RELAXATION SPECTRA OF TWO HYDROGELS -- NANOSCALE STRUCTURAL DIFFERENCES DEFINING FIBER DYNAMICS -- CONCLUSIONS -- GLOSSARY -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 12 - FUNCTIONALIZED POLYMERIC BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR THE FUNCTIONALIZED POLYMERIC SCAFFOLD -- BIOMATERIALS FOR FUNCTIONALIZED POLYMERIC SCAFFOLD -- SCAFFOLDING SYSTEM -- CHEMOKINE SIGNALING -- STEM CELL RECRUITING FACTORS -- DESIGN CONSIDERATIONS OF FUNCTIONALIZED POLYMERIC SCAFFOLDS -- IN SITU TISSUE REGENERATION USING THE FUNCTIONALIZED POLYMERIC SCAFFOLDS -- CONCLUSION AND FUTURE TECHNOLOGICAL CHALLENGES -- REFERENCES -- 13 - TISSUE-DERIVED MATRICES -- INTRODUCTION -- COMPOSITION OF THE EXTRACELLULAR MATRIX -- FIBROUS PROTEINS -- PROTEOGLYCANS -- GLYCOPROTEINS -- FUNCTIONS OF NATIVE EXTRACELLULAR MATRIX -- STRUCTURAL FUNCTION OF THE EXTRACELLULAR MATRIX -- REGULATION OF THE ACTIVITY OF OTHER EXTRACELLULAR MOLECULES -- Regulation of growth factor signaling -- Regulation of proteolytic enzymes -- FUNCTIONAL INTERACTIONS OF THE EXTRACELLULAR MATRIX WITH EMBEDDED CELLS -- The ECM interacts with cells via specific receptors -- ECM physical properties can affect stem cell fate -- ECM physical properties regulate branching morphogenesis in development -- TISSUE-DERIVED MATRICES FOR TISSUE ENGINEERING -- METHODS FOR THE REMOVAL OF CELLS FROM TISSUE-DERIVED MATRICES -- Physical protocols to decellularize tissues. , Chemical methods to decellularize tissues.

Additional Edition: ISBN 0-12-802225-6

Language: English

UID:

Format: 1 online resource (460 pages) : , illustrations (some color), tables

ISBN: 0-12-802500-X

Note: Front Cover -- In Situ Tissue Regeneration -- Dedication -- In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design -- Copyright -- Contents -- List of Contributors -- Preface -- 01 - INTRODUCTION -- 1 - FUNDAMENTALS OF IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGY: IN SITU TISSUE REGENERATION -- DESIGN CONSIDERATIONS: BIOMATERIAL SCAFFOLDS -- APPLICATIONS OF IN SITU TISSUE REGENERATION -- CONCLUSION AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 02 - ENDOGENOUS CELL SOURCES -- 2 - STEM CELL HOMING -- INTRODUCTION -- HOMING OF HEMATOPOIETIC STEM CELLS TO BONE MARROW NICHES -- CHANGES IN THE BONE MARROW LEVEL OF CHEMOATTRACTANTS FOR HEMATOPOIETIC STEM CELLS -- HOMING OF NONHEMATOPOIETIC STEM CELLS TO DAMAGED ORGANS -- TO MODULATE HOMING GRADIENTS AS A STRATEGY TO DELIVER THERAPEUTIC STEM CELLS TO THE DAMAGED ORGANS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 3 - IMMUNOLOGY: HOST RESPONSES TO BIOMATERIALS -- INTRODUCTION -- INNATE IMMUNITY -- CELL TYPES -- COMPLEMENT -- ADAPTIVE IMMUNITY -- T CELL DEVELOPMENT -- HELPER T CELLS -- B CELLS -- BIOMATERIALS -- ACUTE RESPONSE TO BIOMATERIALS -- CHRONIC IMMUNE RESPONSE TO BIOMATERIALS -- Adhesion of macrophages -- Foreign body response -- ADAPTIVE IMMUNE RESPONSE TO BIOMATERIALS -- BIOMATERIAL COMPOSITION INFLUENCES THE IMMUNE RESPONSE -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 4 - FOREIGN BODY REACTION AND STEM CELL RESPONSES -- INTRODUCTION -- IMPLANT-MEDIATED INFLAMMATORY RESPONSES AND STEM CELL RECRUITMENT -- FOREIGN BODY REACTIONS VERSUS WOUND HEALING RESPONSES -- IMPLANT-MEDIATED STEM AND PROGENITOR CELL RECRUITMENT -- INFLAMMATION-MEDIATED STEM CELL RECRUITMENT -- INFLAMMATORY CYTOKINES AND STEM CELL RECRUITMENT. , FIBROCYTES-PROGENITOR FIBROTIC CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- FIBROCYTES-FIBROBLAST PROGENITOR CELLS-AND THEIR ROLE IN TISSUE REACTIONS TO MATERIALS -- INFLUENCE OF INFLAMMATORY RESPONSES ON FIBROCYTES RECRUITMENT -- SOURCE OF FIBROCYTES -- NEW STRATEGIES TO ENGINEER STEM CELL RESPONSES FOR TISSUE REGENERATIONS -- TISSUE ENGINEERING SCAFFOLDS FOR DIRECTING AUTOLOGOUS STEM CELL RESPONSES -- PROGRAMMED STEM CELL DIFFERENTIATION TO ALTER FIBROCYTE REACTIONS -- CYTOKINE-MEDIATED STEM CELL RECRUITMENT AND TISSUE REGENERATION -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 03 - BIOCHEMICAL AND PHYSICAL CUES -- 5 - ROLES OF ENDOGENOUS GROWTH FACTORS AND SMALL PEPTIDES IN IN SITU TISSUE REGENERATION -- INTRODUCTION -- STEM CELL MOBILIZATION AND VASCULOGENESIS -- STROMAL CELL-DERIVED FACTOR 1 ALPHA -- VASCULAR ENDOTHELIAL GROWTH FACTOR -- GRANULOCYTE-COLONY STIMULATING FACTOR -- SUBSTANCE-P -- EXPERIMENTAL STRATEGIES TO IDENTIFY STEM CELL TRAFFICKING AND HOMING USING CANDIDATE MOLECULES -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 - SMALL MOLECULES: CONTROLLING CELL FATE AND FUNCTION -- INTRODUCTION -- TARGET CELLS FOR SMALL MOLECULE REGULATION IN REGENERATIVE MEDICINE -- HUMAN EMBRYONIC STEM CELLS -- HUMAN INDUCED PLURIPOTENT STEM CELLS -- ADULT STEM CELLS -- TERMINALLY DIFFERENTIATED CELLS -- IN VITRO/EX VIVO REGULATION OF HUMAN CELLS BY SMALL MOLECULES -- SMALL MOLECULES FOR HESC/HIPSC CELL PROLIFERATION AND MAINTENANCE -- SMALL MOLECULES FOR GUIDED PLURIPOTENT STEM CELL DIFFERENTIATION -- SMALL MOLECULES FOR HIPSC GENERATION -- SMALL MOLECULES FOR IN VITRO ADULT STEM CELL REGULATION -- SMALL MOLECULES FOR IMPROVING SAFETY OF PLURIPOTENT STEM CELL-DERIVED CELLS -- USING SMALL MOLECULES TO ENHANCE IN VIVO TISSUE REGENERATION. , SMALL MOLECULES FACILITATING THE PROLIFERATION AND DIFFERENTIATION OF ADULT STEM CELLS -- Small molecules promoting neurogenesis -- Small molecules promoting cardiomyocyte regeneration -- Small molecules promoting regeneration of other tissues -- ENHANCING THE PROLIFERATION/FUNCTION OF DIFFERENTIATED CELLS -- INDUCING REPROGRAMMING AND TRANSDIFFERENTIATION OF FIBROBLASTS TO TARGET CELLS -- CURRENT STATUS AND FUTURE DIRECTIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 7 - SMALL RNA DELIVERY FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR SMALL RNAS IN TISSUE REGENERATION -- RNA INTERFERENCE -- SMALL RNAS: SMALL INTERFERING RNAS AND MICRORNAS -- DESIGN CONSIDERATION FOR SMALL RNA DELIVERY -- GENERAL DELIVERY STRATEGY OF SMALL RNAS -- POLYMERIC DELIVERY SYSTEM -- ADVANCED CARRIER MATERIALS FOR SMALL RNA DELIVERY -- SMALL RNAS FOR IN SITU TISSUE REGENERATION -- REGULATION OF STEMNESS -- BONE REGENERATION -- CARTILAGE REGENERATION -- SKELETAL MUSCLE REGENERATION -- NERVE REGENERATION -- CARDIAC TISSUE REGENERATION -- WOUND HEALING -- VASCULARIZATION -- OTHER APPLICATIONS -- SUMMARY AND FUTURE DIRECTIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENT -- REFERENCES -- 8 - MICRO- AND NANOTOPOGRAPHICAL CUES GUIDING BIOMATERIAL HOST RESPONSE -- INTRODUCTION -- EXTRACELLULAR MATRIX TOPOGRAPHY AND ITS EFFECT ON CELLULAR RESPONSE -- CONTROLLED SUBSTRATE TOPOGRAPHY GUIDING IN VIVO HOST RESPONSE -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON WATER INTERACTION -- MICRO- AND NANOTOPOGRAPHY AND ITS EFFECT ON PROTEIN ADSORPTION -- DIFFERENT FABRICATION TECHNIQUES USED TO CREATE MICRO-/NANOSURFACE TOPOGRAPHY -- PHOTOLITHOGRAPHY AND ELECTRON BEAM LITHOGRAPHY -- SOFT LITHOGRAPHY -- ELECTROSPINNING -- MICROSTEREOLITHOGRAPHY -- IN VITRO ASSESSMENT OF MICRO- AND NANOTOPOGRAPHIC FEATURES. , THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL MORPHOLOGY AND MIGRATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON CELL PROLIFERATION -- THE EFFECTS OF MICRO-/NANOSURFACE TOPOGRAPHY ON STEM CELL DIFFERENTIATION -- The effect of topographic modulation on mesenchymal stem cell differentiation -- The effect of topographic modulation on embryonic stem cells -- The effect of topographic modulation on adipose-derived stem cells -- USE OF TOPOGRAPHICAL MODIFICATIONS TO ENGINEER FUNCTIONAL TISSUE-ENGINEERED CONSTRUCTS -- Tendon tissue engineering -- Vascular tissue engineering -- Cardiac tissue engineering -- MODULATION OF SURFACE TOPOGRAPHY AND ITS EFFECT ON ASSOCIATED IN VIVO RESPONSE -- EFFECTS ON THE BONE IMPLANTS TISSUE INTEGRATION -- SUMMARY -- REFERENCES -- 9 - MECHANOBIOLOGY AND MECHANOTHERAPY IN TISSUE ENGINEERING -- INTRODUCTION -- CELLS AND THE PHYSICAL ENVIRONMENT -- MECHANOSENSITIVITY OF CELLS -- MECHANOSENSORS, MECHANORECEPTORS, AND MECHANOSENSITIVE NOCICEPTORS -- MECHANOSIGNALING PATHWAYS -- MECHANOBIOLOGY AND MECHANOTHERAPY -- MECHANOTHERAPY AT THE MOLECULAR LEVEL -- MECHANOTHERAPY AT A CELLULAR LEVEL -- MECHANOTHERAPY AT THE TISSUE LEVEL -- MECHANOTHERAPY FOR DISEASES -- DEVELOPMENT OF NEW MECHANOTHERAPIES FOR TISSUE ENGINEERING -- CONCLUSION -- REFERENCES -- 04 - SMART BIOMATERIALS DEVELOPMENT -- 10 - A BIOMIMETIC STRATEGY TO DESIGN BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- BIOMIMETIC MATERIALS -- EXTRACELLULAR MATRIX-MIMETIC BIOACTIVE MATERIALS -- Cell-adhesive or enzyme-sensitive peptides -- Growth factor bearing or binding biomaterials -- PHYSICOCHEMICAL SIGNALS FOR CONTROLLING CELL FATES -- Bioactive molecules for controlling stem cell fates -- Substrates with controlled topographical cues -- Substrate elasticity/stiffness and mechanical cues -- Electrical stimuli. , DESIGNED STRUCTURE OF PEPTIDE-BASED MOLECULES -- Growth factor-mimicking peptides -- Peptide amphiphiles -- SUMMARY AND FUTURE PERSPECTIVES -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 11 - IMPACT OF MATRIX DYNAMIC PROPERTIES ON STEM CELL VIABILITY -- INTRODUCTION -- VIABILITY OF HUMAN MESENCHYMAL STEM CELLS IN TWO HYDROGELS -- STIFFNESS AND RELAXATION SPECTRA OF TWO HYDROGELS -- NANOSCALE STRUCTURAL DIFFERENCES DEFINING FIBER DYNAMICS -- CONCLUSIONS -- GLOSSARY -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 12 - FUNCTIONALIZED POLYMERIC BIOMATERIALS FOR IN SITU TISSUE REGENERATION -- INTRODUCTION -- STRATEGIES FOR THE FUNCTIONALIZED POLYMERIC SCAFFOLD -- BIOMATERIALS FOR FUNCTIONALIZED POLYMERIC SCAFFOLD -- SCAFFOLDING SYSTEM -- CHEMOKINE SIGNALING -- STEM CELL RECRUITING FACTORS -- DESIGN CONSIDERATIONS OF FUNCTIONALIZED POLYMERIC SCAFFOLDS -- IN SITU TISSUE REGENERATION USING THE FUNCTIONALIZED POLYMERIC SCAFFOLDS -- CONCLUSION AND FUTURE TECHNOLOGICAL CHALLENGES -- REFERENCES -- 13 - TISSUE-DERIVED MATRICES -- INTRODUCTION -- COMPOSITION OF THE EXTRACELLULAR MATRIX -- FIBROUS PROTEINS -- PROTEOGLYCANS -- GLYCOPROTEINS -- FUNCTIONS OF NATIVE EXTRACELLULAR MATRIX -- STRUCTURAL FUNCTION OF THE EXTRACELLULAR MATRIX -- REGULATION OF THE ACTIVITY OF OTHER EXTRACELLULAR MOLECULES -- Regulation of growth factor signaling -- Regulation of proteolytic enzymes -- FUNCTIONAL INTERACTIONS OF THE EXTRACELLULAR MATRIX WITH EMBEDDED CELLS -- The ECM interacts with cells via specific receptors -- ECM physical properties can affect stem cell fate -- ECM physical properties regulate branching morphogenesis in development -- TISSUE-DERIVED MATRICES FOR TISSUE ENGINEERING -- METHODS FOR THE REMOVAL OF CELLS FROM TISSUE-DERIVED MATRICES -- Physical protocols to decellularize tissues. , Chemical methods to decellularize tissues.

Additional Edition: ISBN 0-12-802225-6

Language: English

UID:

Format: 1 Online-Ressource (xvi, 600 Seiten) : , Illustrationen.

ISBN: 978-3-030-44211-8

Series Statement: Tissue engineering and regeneration

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-030-44210-1

Language: English

DOI: 10.1007/978-3-030-44211-8

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Eberli, Daniel 1971-

UID:

Format: 1 Online-Ressource (xvi, 600 Seiten) : , Illustrationen.

ISBN: 978-3-030-44211-8

Series Statement: Tissue engineering and regeneration

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-030-44210-1

Language: English

DOI: 10.1007/978-3-030-44211-8

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Eberli, Daniel 1971-