Kooperativer Bibliotheksverbund

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Format: VIII, 241 S. : , Ill., graph. Darst.

ISBN: 3-540-57274-0 , 0-387-57274-0

Series Statement: Current topics in microbiology and immunology 188

Content: Interest in the lentivirus subfamily of retroviruses has greatly intensified due to the realization that HIV-1 and HIV-2 are members of this previously obscure group. Related lentiviruses have now been isolated from sheep, goats, horses, cattle, cats, monkeys, and humans

Content: This issue of CTMI is devoted to the lentiviruses of nonhuman primates, referred to as simian immunodeficiency viruses (SIVs). The SIVs provide valuable tools for our quest to understand and control the HIVs, which are obviously important new human pathogens. Included in this volume are discussions of the distribution and molecular phylogeny of the SIVs and their use as animal models for the study of AIDS pathogenesis

Note: Literaturangaben

Language: English

Subjects: Biology , Medicine

Keywords: Affenimmundefizienzvirus ; Immunologie ; Affenimmundefizienzvirus ; Aufsatzsammlung ; Aufsatzsammlung

URL: Inhaltsverzeichnis

URL: Inhaltsverzeichnis

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Format: 1 online resource (546 p.) : , 100 line illus.

ISBN: 9780691228839

Content: The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent. These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients. Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Götte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.

Note: Frontmatter -- , CONTENTS -- , PREFACE -- , CONTRIBUTORS -- , 1 The Structure and Biology of HIV-l: Introduction -- , 2 The Genetics of HIV-1 -- , 3 Nucleoside Inhibitors of HIV Reverse Transcriptase and the Problem of Drug Resistance -- , 4 Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1 -- , 5 HIV-1 Protease Inhibitors -- , 6 The Biology and Biochemistry of Integration as a Target for Chemotherapeutic Intervention -- , 7 Chemokine Receptors in HIV Infection and AIDS -- , 8 Novel HIV-1 Therapeutic Targets: Regulatory Functions -- , 9 Novel HIV-1 Therapeutic Targets: Accessory Functions -- , 10 The Interface between the Pathogenesis and Treatment of HIV Infection -- , 11 HIV Prevention: Implementing Proven Prevention Interventions to Control the Global Epidemic -- , 12 The Immunobiology of HIV-1 Infection -- , 13 HIV Vaccines 2000: Prospects and Challenges -- , INDEX , In English.

Language: English

DOI: 10.1515/9780691228839

URL: https://doi.org/10.1515/9780691228839?locatt=mode:legacy

URL: https://www.degruyter.com/isbn/9780691228839

URL: https://doi.org/10.1515/9780691228839?locatt=mode:legacy

URL: https://www.degruyter.com/isbn/9780691228839

UID:

Format: VIII, 241 S. , Ill., graph. Darst.

ISBN: 3540572740 , 0387572740

Series Statement: Current topics in microbiology and immunology 188

Note: Literaturangaben

Language: English

Subjects: Biology , Medicine

Keywords: Affenimmundefizienzvirus ; Affenimmundefizienzvirus

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Format: 1 videorecording (40 min., 41 sec.) : , sound, color. , 004041

Series Statement: Henry Stewart talks

Content: Audio-visual presentation : HIV molecular biology ; HIV entry into cells ; Immune consequences of HIV infection ; Animal models of HIV infection ; Immune containment of HIV ; HIV vaccine development.

Note: Retrieved April 15, 2024, from https://hstalks.com/bs/367/. , Printable Handouts -- Navigable Slide Index -- Introduction -- World-wide AIDS epidemic -- HIV genomic organization -- HIV virion structure -- Requirements for HIV entry into cells -- HIV life cycle -- Primary HIV infection -- Clinical consequences of HIV infection -- HIV genetic variation: molecular mechanisms -- Genetic diversity - clades -- HIV transmission -- Cell-free versus cell-associated transmission -- Mechanisms of immune containment -- Simian immunodeficiency viruses -- Origin of HIV-1: SIVcpz -- AIDS animal models -- Antibody response to HIV -- CD8+ lymphocytes inhibit HIV replication -- CTL emergence precedes early SIV containment -- High frequency CTL - clinical status association -- Early SIV containment and CD8+ lymphocytes -- Cellular immune response to HIV -- Failure of HIV control by CTL -- Variation in clinical course -- Anti-retroviral therapy -- Failure of traditional vaccine strategies -- Novel vaccine strategies -- CTL-based vaccine in SIV challenge monkeys -- Future.

Language: English