UID:
almafu_9961427398202883
Format:
videorecording (40 min., 31 sec.)
,
004031
Content:
Audio-visual presentation: Functions of the neurovascular unit -- Brain energy substrates -- Pathways across the blood-brain barrier -- Glucose utilization and transport -- Glucose uniporters -- Kinetic transport parameters -- Glucose transport in baseline and during activation -- Neurovascular coupling -- Neurometabolic coupling -- Neurobarrier coupling -- Dynamic changes of glucose concentration -- GLUT-1 stimulation in vitro and in vivo -- Roadmaps for glucose from blood to neurons.
Note:
Retrieved April 16, 2024, from https://hstalks.com/bs/763/.
,
Introduction -- The blood-brain barrier -- The neurovascular unit -- Physiological functions within the NVU -- Pathways across the BBB -- The glucose uniporter family -- GLUTs in the brain -- Glucose transporters in the BBB -- GLUT-1 deficiency syndrome -- Brain energy substrates -- Glucose hurdles in the NVU (1) -- Lower GLUT-1 densities in astrocytes than in BBB -- Glucose hurdles in the NVU (2) -- Properties of BBB glucose transport -- Baseline glucose utilization and transport -- Transporter densities and glucose utilization -- A simple and widely used transport model -- Glucose concentrations -- Kinetic transport parameters -- GLUT-1 topology and kinetic constants -- BBB glucose transport - baseline setpoint -- Glucose transport in baseline and during activation -- Neurovascular coupling (NVC) -- Feeding our thoughts -- Neurometabolic coupling (NMC) (1) -- Astrocyte-neuron lactate shuttle -- Neurometabolic coupling (NMC) (2) -- Coupling in the NVU -- Neurobarrier coupling (NBC) -- Possibilities to stimulate BBB glucose transport -- Analysis of the LMA effect (1) -- Glucose dynamics following brain activation -- Analysis of the LMA effect (2) -- Glycogen in brain astrocytes -- Glucose transport at the next hurdle -- In vitro evidence for G transport modulation -- In vivo evidence for GLUT-1 stimulation -- Mechanisms for GLUT-1 stimulation -- Considerations on G transport -- Two roadmaps for G to arrive at the neurons -- BBB GLUT-1 transporters -- Conclusion.
Language:
English
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