Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (600 pages)

ISBN: 9780128230558

Series Statement: Handbook for Designing and Conducting Clinical and Translational Research Series

Content: Translational Interventional Radiology, a volume in the Handbook for Designing and Conducting Clinical and Translational Research series, covers the principles of evidence-based medicine and applies these principles to the design of translational investigations in Interventional Radiology. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in Interventional Radiology, and know what is needed for successful collaboration. Further, this reference is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps aspiring investigators navigate challenging considerations in study design and implementation. This book provides valuable discussions of the critical appraisal of published studies in Interventional Radiology, elucidating the evaluation of the quality with respect to measuring outcomes and making effective use of all types of evidence in patient care. In short, this practical guide will be of interest to every medical researcher and interventional radiologist who has ever had a good clinical idea but not the knowledge of how to test it. Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within interventional radiology Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation Details discussions of the critical appraisal of published studies in interventional radiology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care.

Note: Front Cover -- Translational Interventional Radiology -- Handbook for designing and conducting clinical and translational research -- Translational Interventional Radiology -- Copyright -- Contents -- List of contributors -- Preface -- I - Introduction -- 1 - Translational process -- Key points -- References -- 2 - Scientific method -- Key points -- Why it matters? -- Observation -- Question -- Hypothesis -- Experiment -- Analysis -- Conclusion -- Get started -- Potential pitfalls -- Real-world examples -- Question -- Hypothesis -- Experiment -- References -- Additional reading -- Further reading -- 3 - Basic science research -- Introduction to basic science research -- The scientific method of inquiry -- Translating basic science research -- Barriers to research -- Conclusion -- References -- II - Pre-clinical: discovery and development -- 4 - Overview of preclinical research -- Key points -- What is preclinical research? -- Why it matters? -- Preclinical research models -- Get started -- Designing in vivo experiments -- Hypothesis and effect size -- Experimental unit and sample size -- Outcome data and measurements -- Reducing biases in preclinical studies -- Real-world examples -- Resources -- References -- Additional reading -- 5 - Defining the problem to solve -- Key points -- Why it matters? -- Step 1 -- Case 1: Prostate artery embolization -- Case 2: Inferior vena cava (IVC) filters -- Case 3: Arterial gene transfer -- Step 2 -- Case 1: Prostate artery embolization -- Case 2: IVC filters -- Case 3: Arterial gene transfer -- Step 3 -- Case 1: Prostate artery embolization -- Case 2: IVC filters -- Case 3: Arterial gene transfer -- Step 4 -- Case 1: Prostate artery embolization -- Case 2: IVC filters -- Case 3: Gene therapy -- Step 5 -- Case 1: Prostate artery embolization -- Case 2: IVC filters -- Case 3: Gene therapy -- Get started. , References -- 6 - Types of problems -- Key points -- Introduction (why it matters)? -- Intersection of interventional oncology and immuno-oncology -- Drug repurposing -- Technology and device development -- Get started -- References -- 7 - Types of interventions -- Key points -- Why it matters? -- Types of interventions -- Drugs -- Tools and devices -- Laboratory analysis and IR -- IR procedures -- Ablation-thermal ablation -- Ablation-cryoablation -- Angiogram/angiography -- Angioplasty and stent insertion -- Fluid drainage -- Chemoembolization -- Embolization -- Image-guided biopsy -- Inferior vena cava filters -- Shunt placement (TIPS) -- Thrombolysis -- Thrombectomy -- Percutaneous drainage -- Telehealth and telesurgery -- Behavioral change -- Palliative -- Real-world examples -- Potential pitfalls -- Get started -- Additional resources -- References -- 8 - Drug discovery -- References -- 9 - Drug safety in vitro, in vivo, harm, toxicity, dosing, good laboratory practices -- Introduction -- Preclinical studies: in vitro and in vivo -- Clinical studies: clinical trials -- Dosing -- Toxicity -- Medication harm -- Good laboratory practice -- Resources -- Characterization -- Rules -- Results -- Quality assurance -- Summary -- References -- 10 - Device discovery -- References -- 11 - Device prototyping: Iterative refinement, optimization process -- Why it matters? -- Customer requirements and technical benchmarking -- Types of prototypes -- Iterative design -- Prototype fidelity -- Real-world examples -- Get started -- References -- 12 - Device classification -- Key points -- Why it matters? -- Device classification: basics1-4 -- Regulatory basics1-5 -- Device classification: process1-3 -- Special device classifications23,25 -- Conclusion -- Get started -- References -- Further reading -- 13 - Device testing: Safety and efficacy -- Key points. , Why it matters? -- Get started -- Potential pitfalls -- Real-world examples -- Additional resources -- References -- 14 - Diagnostic testing -- Why it matters? -- Overview -- Sensitivity and specificity: measures of diagnostic accuracy -- Regulatory classification -- How are IVD products classified? -- Budgetary considerations and how to fund this stage -- References -- 15 - Regulatory process: Discussion of FDA history, organization, and regulatory purview and application process -- Background -- What does the FDA do? -- Combination products -- FDA approved: what does it mean and what is covered? -- FDA structure and review -- Drug approval process -- Orphan drug status -- Device approval process -- Premarket notification 510(k) -- Premarket approval -- Investigational device exemption -- Humanitarian device exemption -- De novo classification requests -- IR-related FDA regulated products -- References -- 16 - Procedural technique development -- Key points -- Why it matters? -- Overview -- Preclinical considerations -- Methodologies -- Live animal models (in vivo) -- Ex vivo models -- Simulation -- In vitro models -- Virtual animal models -- Stages of procedure technique development -- Stage 0: innovation-proof of principle -- Stage 1: development-refinement, definition, and early adoption -- Stage 2: exploration-dissemination -- Stage 3: assessment-comparison with existing treatments -- Stage 4: long term-surveillance, quality control, and improvement -- Get started -- Potential pitfalls -- Real-world examples -- Resources: additional reading -- References -- 17 - Behavioral interventions -- Summary -- Introduction -- Step 1: Define the problem and where it is happening -- Step 2: Understand the drivers of problem behavior -- Step 3: Design interventions with stakeholders in mind -- Step 4: Assess feasibility and effectiveness in the real world. , Conclusion -- Potential pitfalls -- References -- III - Clinical: fundamentals -- 18 - Introduction to clinical research: What is it? Why is it needed? -- Key points -- What is it and why it matters? -- Observational studies -- Interventional studies -- Who is involved in clinical research? -- Regulatory body -- Funding -- What are clinical trials? -- Get started -- References -- 19 - The question: Types of research questions and how to develop them -- Real-world example -- Get started -- Potential pitfalls -- Resources -- References -- 20 - Study population: Who and why them? -- Potential pitfall, real-world example: sample selection-the "how" and "why" of choosing the study population -- Real-world example: probabilistic sampling -- Potential pitfalls: nonprobabilistic sampling -- Get started -- Resources -- References -- 21 - Outcome measurements: What data is being collected and why? -- Potential pitfalls -- Real-world examples -- Potential pitfalls -- Real-world examples and potential pitfalls -- Get started -- Resources -- References -- 22 - Optimizing the question: Balancing significance and feasibility -- Key points -- Why it matters? -- Real-world examples: defining a value proposition to guide clinical strategy -- Real-world examples: constructing a clinical strategy -- Real-world examples: understanding the significance of clinical outcomes -- Feasibility considerations -- Potential pitfalls: less is more -- Get started and resources -- References -- IV - Statistical principles -- 23 - Common issues in analysis -- References -- Further reading -- 24 - Everyday statistics for the clinician -- What is significance? -- What is precision and what is accuracy? Why does this matter for my research? -- What are sensitivity and specificity? How can i use these properties to explain what a positive and negative test mean?. , How do incidence and prevalence change my positive predictive values and negative predictive values? -- How do I quantify risk? What formulas should I use? What pitfalls should I be aware of? -- References -- 25 - Distributions -- Key points -- Appendix of equations -- 26 - Hypotheses and types of error -- Key points -- Further reading -- 27 - Power -- Key points -- References -- 28 - Regression analysis: Applications to radiological research and recent examples -- Key points -- Introduction -- Linear and generalized linear models -- Regression analysis for time-to-event data -- Tree-based regression methods -- Unstructured data and analysis methods -- Association, causation, and prediction -- Examples of recent studies -- References -- Further reading -- 29 - t-test -- Key points -- Why it matters? -- Introduction -- Inferential statistics and T-distribution -- Assumptions for a t-test -- Key differences between a t-test and z-test -- One-sample t-test -- Independent sample t-test -- Paired t-test -- Conclusion -- Get started -- References -- 30 - Chi square -- Key points -- Why it matters? -- Introduction -- Nonparametric methods, chi-square distribution, and R×C tables -- Assumptions and limitations of a chi-square test -- Chi-square test for goodness of fit -- Chi-square test of independence -- Chi-square test for equality of proportions -- Conclusion -- Get started -- References -- 31 - Analysis of variance -- Key points -- Why it matters? -- Introduction -- Calculation and interpretation -- Examples in interventional radiology -- Post hoc analysis -- Alternatives -- Get started -- ANOVA pitfalls -- References -- 32 - Correlation -- Key points -- Introduction -- Correlation -- Correlation coefficient -- Coefficient of determination -- Regression model analysis -- Interventional radiology examples -- Get started -- References -- 33 - Biases. , Key points.

Additional Edition: Print version: Eltorai, Adam E. M. Translational Interventional Radiology San Diego : Elsevier Science & Technology,c2023 ISBN 9780128230268

Language: English

UID:

Format: 1 Online-Ressource (xxvii, 474 Seiten) : , Illustrationen, Diagramme, Karten (überwiegend farbig).

ISBN: 978-981-15-0565-2

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-15-0564-5

Language: English

DOI: 10.1007/978-981-15-0565-2

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 115 S.

ISBN: 9004089667

Series Statement: T'oung pao 16

Uniform Title: Sung-ch'ao ming-hua p'ing

Note: Text chines. in chines. Schrift u. engl. Übers., Einf. engl

Language: English

UID:

Format: 297 Seiten.

ISBN: 978-3-85409-785-3

Series Statement: Chinesische Gegenwartsliteratur 4

Uniform Title: Street wizards and other new folklore

Note: Die Originalausgabe ist in der Foreign Languages Press, Co., Ltd. Beijing unter dem Titel street wizards and other new folklore erschienen

Language: German

Subjects: Comparative Studies. Non-European Languages/Literatures

UID:

Format: 1 electronic resource (194 p.)

ISBN: 3-0365-5414-9

Content: This book mainly focuses on the processing and applications of polymer and its composites. With the fast development of the petroleum industry, polymer materials have been widely utilized in our daily lives. The various processing methods of polymers determine the final properties and performance of products. In addition, the introduction of different fillers, including inorganic fillers, metal oxide, natural fibers, and so on, can increase the physical and chemical properties of polymer composites, which will further broaden their practical applications. Special attention will be paid to the type of processing methods and the functional fillers on the performance of polymer composites.

Note: English

Additional Edition: ISBN 3-0365-5413-0

Language: English

UID:

Format: 1 Online-Ressource (XII, 495 p. 243 illus., 212 illus. in color)

Edition: 1st ed. 2021

ISBN: 9789811569906

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-156-989-0

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-156-991-3

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-156-992-0

Language: English

DOI: 10.1007/978-981-15-6990-6

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 Online-Ressource (194 p.)

ISBN: 9783036554136 , 9783036554143

Content: This book mainly focuses on the processing and applications of polymer and its composites. With the fast development of the petroleum industry, polymer materials have been widely utilized in our daily lives. The various processing methods of polymers determine the final properties and performance of products. In addition, the introduction of different fillers, including inorganic fillers, metal oxide, natural fibers, and so on, can increase the physical and chemical properties of polymer composites, which will further broaden their practical applications. Special attention will be paid to the type of processing methods and the functional fillers on the performance of polymer composites

Note: English

Language: Undetermined

URL: kostenfrei

UID:

Format: 1 Online-Ressource (154 p.)

ISBN: 9783036556710 , 9783036556727

Content: The book focuses on the diagnosis, evaluation, and assistance of gait disorders; all the papers have been contributed by research groups related to assistive robotics, instrumentations, and augmentative devices

Note: English

Language: Undetermined

URL: kostenfrei

UID:

Format: 1 online resource (310 p.)

Edition: 1st, New ed.

ISBN: 9783653052718

Series Statement: Europäische Hochschulschriften / European University Studies / Publications Universitaires Européennes 461

Content: Die Studie analysiert erstmals die Einführung einer gesetzlichen Unfallversicherung in China in den 2000er Jahren, basierend auf umfangreichen Feldforschungen. Mit der Unfallversicherung hat sich China für die Idee individueller sozialer Rechte geöffnet, die weder in der konfuzianischen noch der sino-kommunistischen Tradition verankert ist. Der Autor zeigt, dass dieser Durchbruch wesentlich auf Prozesse globaler Wissensdiffusion zurückzuführen ist, zu der internationale Organisationen und vor allem die Träger der deutschen gesetzlichen Unfallversicherung beigetragen haben. Ergänzend wird die weltweite Verbreitung unterschiedlicher Modelle der Unfallversicherung dargestellt. Theoretisch wird die Diffusion in den Zusammenhang einer emergierenden «Weltkultur» gestellt.

Note: Doctoral Thesis , Inhalt: Die gesetzliche Unfallversicherung in China – Globale Wissensdiffusion in der Sozialpolitik – Die Rolle internationaler Organisationen – Deutsch-chinesischer Politiktransfer – Modelle der Unfallversicherung weltweit – Die Emergenz einer «Weltkultur» – Diffusion und «Entkoppelung».

Additional Edition: ISBN 9783631658994

Language: German

DOI: 10.3726/978-3-653-05271-8

URL: https://www.peterlang.com/view/product/22564?format=EPDF

URL: Volltext

URL: Volltext  (lizenzpflichtig)

UID:

Format: 1 online resource (VII, 445 p.)

ISBN: 9783110721768 , 9783110766820

Series Statement: De Gruyter Contemporary Social Sciences Handbooks , 1

Content: Globalisation, regionalisation, new technology, demography, voters' expectations and re-structuring of societies are expected to influence welfare state development for years to come. This handbook analyses how different welfare state models and regimes will be able to cope with contemporary and future challenges, providing a variety of evidence based tools that make it essential reading for students, researchers and policy makers alike.

Note: Frontmatter -- , Contents -- , Part I Research methods -- , 1 Contemporary welfare states and their challenges -- , 2 Four families of theories to understand welfare state change -- , 3 Evidence-Based Policy-Making -- , Part II Welfare regimes -- , 4 Nordic welfare states: up to challenge? -- , 5 Continental European welfare states -- , 6 Liberal welfare states -- , 7 The Southern European welfare model -- , 8 Eastern European welfare states -- , 9 In search of a suitable path for welfare system development in China -- , 10 East Asia: welfare determinants and issues in the post-developmentalism era -- , Part III Issues and challenges -- , 11 Health policy in a comparative perspective -- , 12 COVID-19 and the welfare state: impacts, mechanisms, and responses -- , 13 Through the COVID-19 pandemic: perspectives for the welfare state -- , 14 Long-Term Care in ageing societies -- , 15 Pension -- , 16 The legitimacy of the welfare state in the age of migration -- , 17 Education and the welfare state: worlds of early school leaving in Europe -- , 18 Economic inequality - a growing issue? -- , 19 Poverty in the five welfare regimes of Europe -- , 20 Employment and unemployment -- , 21 Sustainability -- , 22 Populism -- , 23 Behavioural public policy -- , 24 North-South divide and global social policy -- , 25 Incentives-disincentives - the benefit side of the welfare states -- , Part IV Future research needs -- , 26 The future of welfare states? -- , Contributors to this volume , Issued also in print. , Mode of access: Internet via World Wide Web. , In English.

In: DG Plus DeG Package 2022 Part 1, De Gruyter, 9783110766820

In: EBOOK PACKAGE COMPLETE 2022 English, De Gruyter, 9783110993899

In: EBOOK PACKAGE COMPLETE 2022, De Gruyter, 9783110994810

In: EBOOK PACKAGE Political Science 2022 English, De Gruyter, 9783110994513

In: EBOOK PACKAGE Political Science 2022, De Gruyter, 9783110994407

Additional Edition: ISBN 9783110721829

Additional Edition: ISBN 9783110721249

Language: English

Subjects: Sociology

Keywords: Aufsatzsammlung

DOI: 10.1515/9783110721768

URL: https://doi.org/10.1515/9783110721768

URL: https://www.degruyter.com/isbn/9783110721768

URL: Cover

URL: Volltext  (lizenzpflichtig)

URL: Volltext  (lizenzpflichtig)

URL: Cover