UID:
almahu_9948025468802882
Format:
1 online resource (693 p.)
ISBN:
1-281-03726-5
,
9786611037260
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0-08-053620-4
Content:
Menopause: Biology and Pathobiology is a comprehensive volume covering all aspects of the biology, anatomy, physiology, pathobiology, and pharmacology of menopause, as well as its diagnosis and management.The book is divided into four sections: Basic Biology, Epidemiology, Menopausal Systems Pathophysiology, and Intervention. Basic Biology covers such fundamentals as ovarian anatomy and physiology, mechanisms of steroid hormone action, chronobiological effects, and premature menopause. Epidemiology includes, among others, chapters on methodology challenges in th
Note:
Description based upon print version of record.
,
Front Cover; Menopause: Biology and Pathobiology; Copyright Page; Contents; Contributors; Preface; Part I: Basic Biology; Chapter 1. Molecular Pharmacology of Estrogen and Progesterone Receptors; I. Introduction; II. Estrogen and Progesterone Receptors; III. Established Models of Estrogen and Progesterone Action; IV. Estrogen and Progesterone Receptor Isoforms and Subtypes; V. Regulation of Estrogen and Progesterone Receptor Function by Ligands; VI. Estrogen and Progesterone Receptor Associated Proteins; VII. An Updated Model of Estrogen and Progesterone Receptor Action; References
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Chapter 2. Ovarian Anatomy and PhysiologyI. Introduction; II. Statement of the Problem; III. The Primordial Follicle; IV. The Adult Ovary; V. Ovary Reserve; VI. Accelerated Loss in OR: Activin Hypothesis; VII. New Data on the Effects of Activin; VIII. Statement of Conclusion; References; Chapter 3. Regulation of the Hypothalamic-Pituitary-Gonadal Axis: Role of Gonadal Steroids and Implications for the Menopause; I. Introduction; II. Functional Organization of the Hypothalamic-Pituitary-Ovarian Axis
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III. Anatomical and Biochemical Correlates of Gonadal Steroid Hormone Action in the Central Nervous SystemIV. Ovarian Steroid Action in the Central Nervous System-Control of Reproduction; V. The Menopause: Consequences of Steroid Hormone Loss on the Central Nervous System; References; Chapter 4. Gonadotropins and Menopause: New Markers; I. Introduction; II. Gonadotropin Parameters of the Normal Menstrual Cycle; III. Structures of Gonadotropins and Their Fragments; IV. Assay of Gonadotropins; V. Changes in Gonadotropin Patterns in Menopause; VI. Gonadotropin Fragments as Urinary Analytes
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ReferencesChapter 5. Genetic Programming in Ovarian Development and Oogenesis; I. Ovarian Differentiation Requires Only One X (Constitutive); II. Polygenic and Stochastic Control over Oocyte Number; III. Monosomy X; IV. X Chromosomal Mosaicism: 45,X/46,XX and 45,X/47,XXX; V. Pitfalls in Localizing Ovarian Maintenance Genes to Specific Regions of the X; VI. Genes on the X Short Arm; VII. Genes on the X Long Arm; VIII. Nature of X Ovarian Maintenance Determinants; IX. Autosomal Chromosomal Abnormalities; X. Autosomal Genes (Mendelian); XI. To What Extent is Premature Ovarian Failure Genetic?
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ReferencesChapter 6. Neuroendocrine Regulation of the Perimenopause Transition; I. Definition of Perimenopause; II. Ovarian Determinants of Reproductive Aging; III. Dynamic Gonadotropin Secretion in Young Women; IV. Gonadotropin Changes during Perimenopause; V. The Neuroreproductive Axis in Postmenopause; VI. Brain Aging and Reproductive Senescence; VII. Future Studies; References; Chapter 7. Changes in Men as They Age: The Manopause; I. Introduction; II. Age-Related Changes in the Male Reproductive System; III. Age-Related Changes in Other Hormonal Systems
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IV. Other Changes with Aging Related to Hormonal Factors
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English
Additional Edition:
ISBN 0-12-453790-1
Language:
English
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