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  • 1
    Online Resource
    Online Resource
    Norfolk, England :Caister Academic Press,
    UID:
    almafu_9960963255002883
    Format: 1 online resource (256 pages) : , illustrations
    Edition: 1st ed.
    ISBN: 1-910190-72-1
    Content: Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. With an emphasis on cellular and molecular biology, areas covered include epigenetic regulation, cellular defence, manipulation of host macrophages, B lymphocyte response, adhesion and invasion of host tissues, immune evasion, immunotherapy, hemeproteins, phospholipids biosynthesis and DNA topoisomerases. A common theme throughout the book is the identification of new therapeutic targets for drug development. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites and will also be of interest to parasitologists, immunologists and drug development researchers. All parasitology laboratories should have a copy of this important reference volume.
    Note: Intro -- Contents -- Preface -- Current Books of Interest -- About the Editor -- 1. Genome-wide Profiling of Unique Domain Architectures Reveals Novel Epigenetic Regulators of Leishmania infantum -- Introduction -- Results and discussion -- Conclusion -- Materials and methods -- 2. Role of Hypoxia Inducible Factor-1 in Leishmania-Macrophage Interaction: -- Introduction -- Structure of HIF-1 -- Regulation of HIF-1α -- Regulation of HIF-1 activity -- Role of HIF-1 in physiology -- Role of HIF-1 in infection and innate immunity -- HIF-1 as possible drug target in visceral form of leishmaniasis -- 3. Response of B Lymphocytes During Leishmania Infection -- Leishmaniasis -- Immune system elements -- Host immune response -- B-cell development and functions of B-cells -- B-cell pathogenicity during Leishmania infection -- Developmental deregulation of B-cells during pathological condition -- Regulatory B-cells -- Secretion of IL-10 from B-lymphocytes during Leishmania infection -- 4. Cellular Defence of the Leishmania Parasite -- Introduction -- Distribution -- Life cycle -- Treatment -- Challenges in the field of treatment -- Parasite's defence arsenal -- Host manipulation by parasite -- Molecular Regulation of Macrophage Class Switching in Indian Post-kala-azar Dermal Leishmaniasis (PKDL) -- Introduction -- Historical background of PKDL -- Clinical features of PKDL -- Alternative activation of macrophages and disease etiopathogenesis of PKDL -- Status of cytokine milieu in dermal leishmaniasis -- Toll-like receptors in PKDL -- Status of reactive oxygen and nitrogen intermediates in PKDL -- Attenuated phosphorylation of p-38 and ERK in PKDL -- Role of host and parasite arginase 1 in PKDL -- Status of co-stimulatory molecules, CD80/CD 86 in PKDL -- Role of vitamin D in Indian PKDL -- Status of MRC 1 in Indian PKDL. , 6. Leishmania Exploits Host's Defence Machineries for Survival: A Tale of Immune Evasion -- Introduction -- Early stages of infection -- Mid stages of infection -- Late stages of infection -- Protecting own niche: prevention of host cell apoptosis -- Ceramide in the Establishment of Visceral Leishmaniasis, an Insight into Membrane Architecture and Pathogenicity -- Introduction -- Pathways of ceramide biosynthesis -- Ceramide an important component of inflammatory response -- Role of ceramide in infectious diseases -- Biphasic role of ceramide during visceral leishmaniasis -- Ceramide-mediated impairment in antigen presentation -- Ceramide mediated regulation of kinases and phosphatises -- Modulation of T-cell subsets through ceramide generation during visceral leishmaniasis -- 8. The Role of Haemproteins in Different Life Cycle Stages of Leishmania -- Introduction -- Haem and haem containing proteins -- Leishmania need haem for survival -- Source of haem and its acquisition systems in Leishmania -- Role of different types of haemproteins in eukaryotes and prokaryotes -- Conclusions -- Future trends -- 9. Pre-adaptation of Leishmania Promastigotes to Intracellular Life: Ensuring a Successful Infection -- Introduction -- Membrane and cytoskeleton-sensing the changes -- Parasite exoproteome-modulating the host -- Cytosolic proteins: a pool of stress busters -- The metabolic adaptations -- The global picture of parasite preadaptation -- Concluding remarks -- 10. DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives -- Introduction -- Different topoisomerases of kinetoplastid parasites -- Exploiting the topoisomerases of kinetoplastid parasites for therapeutic interventions -- Conclusion and future perspectives. , 11. Host-Kinetoplastid Parasite Interaction at the Immune System Interface: Immune Evasion and Immunotherapy -- Introduction -- Molecular host-parasite interaction and strategies of immune evasion by the parasite -- Morphological characterization of kinetoplastids -- Leishmania -- Trypanosoma -- Development of immunotherapeuetics -- Vaccination using parasite derived immunogenic components -- Conclusion -- 12. Extracellular Matrix Interacting Proteins of Trypanosomatids: Adhesion and Invasion of Host Tissues -- Introduction -- General overview of extracellular matrix components -- Mechanism of extracellular matrix interaction by the extracellular matrix interacting proteins -- Synopsis -- 13. Effects of Phospholipid Analogues on Trypanosomatids -- Introduction -- Phospholipids and their importance for the cell -- Phospholipids biosynthetic pathways in mammalian cells and in trypanosomatids -- Design and synthesis of phospholipid analogues -- Effect of phospholipid analogues on the growth and morphology of trypanosomatids -- Cell death processes and immunomodulatory effects induced by phospholipid analogues -- A critical view of the use of miltefosine for treatment of leishmaniasis -- Index.
    Additional Edition: ISBN 1-910190-71-3
    Language: English
    Keywords: Electronic books.
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  • 2
    Online Resource
    Online Resource
    New York, NY : Springer Science + Business Media | Austin, Tex. : Landes Bioscience
    UID:
    gbv_1647469503
    Format: Online-Ressource (digital)
    ISBN: 9780387775708
    Series Statement: Advances In Experimental Medicine And Biology 625
    Note: Includes bibliographical references and index
    Additional Edition: ISBN 9780387775692
    Additional Edition: Buchausg. u.d.T. Drug targets in kinetoplastid parasites New York, NY : Springer Science+Business Media LLC, 2008 ISBN 9780387775692
    Additional Edition: ISBN 0387775692
    Language: English
    Subjects: Chemistry/Pharmacy , Medicine
    RVK:
    RVK:
    Keywords: Leishmania ; Trypanosomen ; Kinetoplastida ; Kinetoplasten-DNS ; Pharmakotherapie ; Antiparasitäres Mittel ; Aufsatzsammlung
    URL: Cover
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  • 3
    Online Resource
    Online Resource
    New York, NY :Springer New York :
    UID:
    almahu_9949419093502882
    Format: XX, 158 p. 45 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2008.
    ISBN: 9780387775708
    Series Statement: Advances in Experimental Medicine and Biology, 625
    Content: If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas' disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.
    Note: Arsenite Resistance in Leishmania and Possible Drug Targets -- Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids -- Drugs and Transporters in Kinetoplastid Protozoa -- Selective Lead Compounds against Kinetoplastid Tubulin -- Fishing for Anti-Leishmania Drugs: Principles and Problems -- Sterol 14-Demethylase Inhibitors for Trypanosoma cruzi Infections -- Histone Deacetylases -- Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy -- DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy -- Antiparasitic Chemotherapy: -- Searching the Tritryp Genomes for Drug Targets -- Purine and Pyrimidine Metabolism in Leishmania.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9781441926562
    Additional Edition: Printed edition: ISBN 9780387569116
    Additional Edition: Printed edition: ISBN 9780387775692
    Language: English
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