Kooperativer Bibliotheksverbund

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Format: 1 online resource (516 p.)

ISBN: 9781641892636

Series Statement: CARMEN monographs and studies

Content: Memory was vital to the functioning of the medieval world. People in medieval societies shared an identity based on commonly held memories. Religions, rulers, and even cities and nations justified their existence and their status through stories that guaranteed their deep and unbroken historical roots. The studies in this interdisciplinary collection explore how manifestations of memory can be used by historians as a prism through which to illuminate European medieval thought and value systems. The contributors draw the link between memory and medieval science, management of power and remembrance of the dead ancestors through examples from southern Europe as a means of enriching and complicating our study of the Middle Ages; this is a region with a large amount of documentation but which to date has not been widely studied. Finally, the project has researched the role of memory as a means to sustain identity and ideology from the past to the present.[-][-]This book has two companion volumes, dealing with ideology and identity as part of a larger project that seeks to map and interrogate the significance of all three concepts in the Middle Ages in the West.

Content: Memory was vital to the functioning of the medieval world. People in medieval societies shared an identity based on commonly held memories. Religions, rulers, and even cities and nations justified their existence and their status through stories that guaranteed their deep and unbroken historical roots. The studies in this interdisciplinary collection explore how manifestations of memory can be used by historians as a prism through which to illuminate European medieval thought and value systems. The contributors draw the link between memory and medieval science, management of power, and remembrance of the dead ancestors through examples from southern Europe as a means of enriching and complicating our study of the Middle Ages; this is a region with a large amount of documentation but which to date has not been widely studied.

Note: Frontmatter -- , CONTENTS -- , List of Illustrations -- , Foreword -- , Introduction. Memory in the Middle Ages -- , PART ONE: MEMORY AND SCIENCE -- , Chapter 1. Memory and the Body in Medieval Medicine -- , Chapter 2. James I of Aragon, Vicent Ferrer, and Francesc Eiximenis: Natural Memory and Artificial Memory -- , PART TWO: MEMORY OF THE PAST AS IDENTITY -- , Chapter 3. History, Memory, and Ideas about the Past in the Early Middle Ages -- , Chapter 4. Charter Writing and Documentary Memory in the Origins of Catalan History -- , Chapter 5. The Memory of Saints in the Hispanic Translationes of the Eleventh and Twelfth Centuries -- , Chapter 6. Establishing a Memory in Medieval Spain -- , Chapter 7. The Legend of the Princess of Navarre: A Founding Myth in the Sardinian Conflict against the Kings of Aragon -- , PART THREE: MEMORY AND POWER -- , Chapter 8. Memory of the State or Memory of the Kingdom? A Comparative Approach to the Construction of Memory in France and England -- , Chapter 9. Art to Seal the Memory: Coronation Ceremonies and the Sword as Symbol of Power (Aragon, 1200–1400) -- , Chapter 10. Architecture and Legacy in Medieval Navarre -- , Chapter 11. Family Memory in Late Medieval Catalonia: The Marcs, Lords of Eramprunyà -- , PART FOUR: MEMORY AND COMMEMORATING THE DEAD -- , Chapter 12. The Tomb as Tool for Keeping Memory Alive: The Case of Late Medieval Zaragoza -- , Chapter 13. Wills, Tombs, and Preparation for a Good Death in Late Medieval Portugal -- , Chapter 14. Ceremonial Topography in the Consueta Antiga of the Cathedral of Mallorca -- , PART FIVE: REMEMBERING THE MIDDLE AGES -- , Chapter 15. Memory and Identity in Catalan-Aragonese Sardinia from 1323 to the Present -- , Chapter 16. Nineteenth-Century French Legal History and the Memory of the Middle Ages -- , Chapter 17. Spolia and Memory in Nineteenth-Century Venice -- , Chapter 18. Neo-Medievalism and the Anchoring of New Spatial Identities: Linking New Regional and Urban Identities with Medieval Memories -- , Chapter 19. The Hegemony of the Cult of Anniversaries and its Disadvantages for Historians , In English.

Language: English

Keywords: Aufsatzsammlung

DOI: 10.1515/9781641892636

URL: https://doi.org/10.1515/9781641892636

URL: https://www.degruyter.com/isbn/9781641892636

URL: https://doi.org/10.1515/9781641892636

URL: https://www.degruyter.com/isbn/9781641892636

URL: lizenzpflichtig

URL: Inhaltsverzeichnis

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Format: 1 Online-Ressource (25 Seiten)

Content: Human-relevant tests to predict developmental toxicity are urgently needed. A currently intensively studied approach makes use of differentiating human stem cells to measure chemically-induced deviations of the normal developmental program, as in a recent study based on cardiac differentiation (UKK2). Here, we (i) tested the performance of an assay modeling neuroepithelial differentiation (UKN1), and (ii) explored the benefit of combining assays (UKN1 and UKK2) that model different germ layers. Substance-induced cytotoxicity and genome-wide expression profiles of 23 teratogens and 16 non-teratogens at human-relevant concentrations were generated and used for statistical classification, resulting in accuracies of the UKN1 assay of 87–90%. A comparison to the UKK2 assay (accuracies of 90–92%) showed, in general, a high congruence in compound classification that may be explained by the fact that there was a high overlap of signaling pathways. Finally, the combination of both assays improved the prediction compared to each test alone, and reached accuracies of 92–95%. Although some compounds were misclassified by the individual tests, we conclude that UKN1 and UKK2 can be used for a reliable detection of teratogens in vitro, and that a combined analysis of tests that differentiate hiPSCs into different germ layers and cell types can even further improve the prediction of developmental toxicants.

Content: Peer Reviewed

In: Basel : MDPI, 11,21

Language: English

DOI: 10.3390/cells11213404

DOI: 10.18452/26457

URN: urn:nbn:de:kobv:11-110-18452/27136-7

URL: Volltext  (kostenfrei)