UID:
edoccha_9961427248002883
Format:
1 streaming video file (40 min., 33 sec.) :
,
sound, color.
,
004033
Series Statement:
Henry Stewart talks
Note:
Retrieved April 12, 2024, from https://hstalks.com/bs/269/.
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Introduction -- Objectives -- How do you define ADR? -- How common are ADRs? -- What are the costs of ADRs? -- Benefit-to-risk profile -- Classification of ADRs (1) -- Classification of ADRs (2) -- Pharmacokinetics and pharmacodynamics -- PK-PD Paradigm -- Route of oral medication -- Pharmacology -- Example of a type A ADR (1) -- Schizophrenia -- Dopamine hypothesis -- Correllation between dose-effect -- CNS dopamine pathway -- Dopamine receptors neuroanatomical distributions -- Example of a type A ADR -- Example of a type B ADR -- Mechanism of drug induced toxicity -- Carbamazepine-induced erythema multiforme -- Variability in drug response -- Summary -- Goal of pharmacogenetics -- Pharmacogenetics -- Genotype, phenotype - definitions -- How genotype and phenotype related to each other -- Gene, polymorphism, allele - definitions -- PK-PD paradigm in pharmacogenetics -- Route of psychotrophic drugs -- Polygenic drug response -- Comic relief -- Demographic and environmental factors in ADRs -- Examples of G-E interactions -- Functional polymorphisms in CYP1A2 -- PGX methods applied to ADRs -- Central hypotheses -- Genetic association strategy -- Alternative genetic association strategy -- Candidate gene polymorphisms -- Selected examples -- Example of PK polymorphism and ADR -- PGX as applied to debrisoquine -- PGX as applied to succinylcholine -- Example of PD polymorphism and ADR -- PGX as applied to beta-adrenergic agonists -- PGX as applied to quetiapine -- Long QT syndrome mechanism -- Limitations to current strategies -- What are endophenotypes? -- Genotype-endophenotype-phenotype -- Endophenotype of D1 receptor alleles -- Endophenotype of DRD1 Ddel polymorphism -- Other examples and references -- Phase 1 CYP450 polymorphisms and ADRs -- PD polymorphisms and ADRs -- Phase 2 enzyme polymorphisms and ADRs -- Target and transporter polymorphisms and ADRs -- HLA immunoregion polymorphism and ADR -- Possibilities for the furture -- Future directions -- More to come.
Language:
English
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