Format:
1 Online-Ressource (xvii, 449 Seiten)
Edition:
Ninth edition
ISBN:
9780128162835
Series Statement:
The handbooks of aging
Content:
Front Cover -- Handbook of the Biology of Aging -- Copyright Page -- Dedication -- References -- Contents -- List of contributors -- About the editors -- Foreword -- Preface -- I. Basic mechanisms, underlying physiological changes, model organisms and interventions -- 1 Longevity as a complex genetic trait -- Introduction -- Defining the aging gene-space -- Direct screens for genetic longevity determinants -- RNA interference screens in nematodes -- Knockout screens in budding yeast -- Overexpression and knockout screens in fruit flies -- Leveraging genetic diversity to identify aging loci -- Mapping longevity genes in human populations -- Mapping longevity genes in mouse populations -- Mouse-human concordance -- Age-associated gene expression studies -- Nongenetic sources of complexity -- Tissue-specific aging -- Tissue-specific age-related DNA methylation -- Tissue-specific responses of aging pathways -- Gene-environment interaction -- Genetic response to dietary restriction -- Dietary restriction: quantity, composition, and timing -- Other environmental factors that influence aging -- Emerging tools for studying complex genetic traits -- High-throughput life span assays in yeast and worms -- Genome-scale mouse knockout collection -- Collaborative cross and diversity outbred mice -- Expression QTLs -- Aging biomarkers -- Conclusions -- References -- 2 DNA damage and repair in aging -- Introduction -- Overview of the DNA damage response -- Endogenous DNA damage -- DNA damage induced by environmental exposures -- Linkage of DNA repair mechanisms to aging -- Nucleotide excision repair -- Base excision repair -- DNA double-strand break repair -- DNA damage theory of aging -- Aging disorders associated with DNA damage -- Diseases stemming from mutations in RecQ helicases -- Werner syndrome -- RECQL4 and premature aging syndromes.
Note:
Literaturangaben
,
Description based on publisher supplied metadata and other sources
Additional Edition:
ISBN 9780128159620
Additional Edition:
Erscheint auch als Druck-Ausgabe Handbook of the biology of aging London : Academic Press; an imprint of Elsevier, 2021 ISBN 9780128159620
Language:
English
Keywords:
Altern
;
Altersphysiologie
;
Entwicklungsbiologie
;
Aufsatzsammlung
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