Format:
Online-Ressource (VI, 136p. 40 illus., 20 illus. in color, digital)
ISBN:
9781441956385
Series Statement:
Advances in Experimental Medicine and Biology 710
Content:
Arturo Casadevall
Content:
Most studies of bacterial or fungal infectious diseases focus separately on the pathogenic microbe, the host response, or the characterization of therapeutic compounds. Compartmentalization of pathogenesis-related research into an analysis of the "pathogen", the "host," or the "antimicrobial compound" has largely been dictated by the lack of model systems in which all of these approaches can be used simultaneously, as well as by the traditional view that microbiology, immunology, and chemical biology and pharmacology are separate disciplines. An increasing number
Note:
Description based upon print version of record
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Recent Advances on Model Hosts; Contents; Chapter 1: Amoeba Provide Insight into the Origin of Virulence in Pathogenic Fungi; The Pathogenic Fungi; Endothermy and Susceptibility to Fungal Diseases; Origin of Fungal Infection; The Soil Environment; Amoeba and Fungi Coexist in Many Ecologic Sites; Amoebae as Model Hosts for the Study of Fungal Virulence; Other Single Celled Hosts for Fungi; Thoughts Towards a Synthesis on the Origin of Virulence; References
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Chapter 2: Of Model Hosts and Man: Using Caenorhabditis elegans , Drosophila melanogaster and Galleria mellonella as Model Hosts for Infectious Disease ResearchIntroduction; Caenorhabditis elegans; Drosophila melanogaster; Galleria mellonella; Conclusion; References; Chapter 3: Caenorhabditis elegans as an Alternative Model to Study Senescence of Host Defense and the Prevention by Immunonutrition; Introduction; C. elegans as a Model for Immunonutrition; C. elegans as a Model for Immunosenescence; Development of a Method for Oral Administration to Nematodes; Conclusion; References
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Chapter 4: Bacterial Effectors: Learning on the FlyIntroduction; Microbial Effectors; Using Drosophila to Study Bacterial Effectors that Regulate Rho GTPases: Filling in the GAPs; Effector-Triggered Immunity: PR1 and CNF1, Alerting the Host to the Presence of Pathogens; Using Drosophila to Study Effectors that Inhibit Innate Immune Responses: Yersinia pestis YopJ; Drosophila as a Tool to Decipher the Role of Effectors in Chronic Infection and Inflammation: Helicobacter pylori CagA; Future Directions; Finding the Bad Guys: Using Drosophila to Identify Bacterial Effectors
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Look and Learn: Intravital Imaging of Drosophila to Monitor the Consequences of Bacterial Effectors During In Vivo InfectionReferences; Chapter 5: A Drosophila Asthma Model - What the Fly Tells Us About Inflammatory Diseases of the Lung; Asthma and Other Chronic Inflammatory Diseases of the Lung; Drosophila as a Model in Biomedical Research; The Airway System of the Fly; Manipulation of the Airway Epithelium of the Fly; Drosophila in Asthma Research; Potential Roles of Asthma Susceptibility Genes in Drosophila; References
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Chapter 6: Elucidating the In Vivo Targets of Photorhabdus Toxins in Real-Time Using Drosophila EmbryosIntroduction; A New Perspective: The Drosophila Embryo; Using Drosophila Embryos to Study Bacterial Infection and Toxin-Induced Damage in Real-Time; Conclusions and Future Perspectives; References; Chapter 7: Ecological Niche Modeling as a Tool for Understanding Distributions and Interactions of Vectors, Hosts, and Etiologic Agents of Chagas Disease; Introduction; The Ecologic Niche Model (ENM) Concept; ENM and Chagas Disease; Pros, Cons and Conclusions; References
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Chapter 8: Where Simplicity Meets Complexity: Hydra , a Model for Host-Microbe Interactions
Additional Edition:
ISBN 9781441956378
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-441-95637-8
Language:
English
Keywords:
Congresses
DOI:
10.1007/978-1-4419-5638-5
URL:
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