Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (396 pages)

ISBN: 0-12-814937-X , 0-12-814936-1

Note: Front Cover -- NASOPHARYNGEAL CARCINOMA -- NASOPHARYNGEAL CARCINOMA: FROM ETIOLOGY TO CLINICAL PRACTICE -- Copyright -- Contents -- List of Contributors -- Preface -- Acknowledgments -- 1 - Nasopharyngeal Carcinoma: A History -- NASOPHARYNGEAL CARCINOMA: AN INTRODUCTION -- RECOGNITION OF THE TUMOR AND ITS UNIQUE EPIDEMIOLOGY -- ENVIRONMENTAL AND LIFESTYLE FACTORS -- DETERMINANTS OF GENETIC SUSCEPTIBILITY -- THE LINK TO EPSTEIN-BARR VIRUS -- THE IMPACT OF TUMOR GENOMICS -- TOWARD AN UNDERSTANDING OF NASOPHARYNGEAL CARCINOMA PATHOGENESIS -- DEVELOPMENT OF NASOPHARYNGEAL CARCINOMA THERAPIES -- NASOPHARYNGEAL CARCINOMA: A FUTURE PERSPECTIVE -- References -- 2 - Nasopharyngeal Carcinoma: Genetics and Genomics -- MOLECULAR BASIS FOR NASOPHARYNGEAL CARCINOMA: TUMOR SUPPRESSOR GENES AND ONCOGENES -- GENETIC PREDISPOSITION TO NASOPHARYNGEAL CARCINOMA -- Background, Approaches, and Findings From Early Studies -- Human Leukocyte Antigen Studies, Telomere Length Maintenance, and DNA Repair Genes -- Human Leukocyte Antigen Studies for Genetic Susceptibility -- Telomere Biology and Double-Strand Break Repair -- Whole-Exome Sequencing Identifies MST1R -- NASOPHARYNGEAL CARCINOMA LANDSCAPE GENOMICS STUDIES -- Methylation -- WNT/β-Catenin Signaling Pathway -- MAPK Signaling Pathway -- TGF-β Signaling Pathways -- Hedgehog Signaling Pathways -- Tumor Suppressor Genes -- Summary for Methylation Studies in Nasopharyngeal Carcinoma -- Whole-Exome Sequencing Studies -- NF-κB Pathway -- PI3K/AKT/mTOR Pathway -- Epigenetic Regulators -- SUMMARY AND ROUNDUP -- Acknowledgments -- References -- Commentary on Chapter 2: Nasopharyngeal Carcinoma: Genetics and Genomics -- References -- 3 - Pathogenesis of Nasopharyngeal Carcinoma: Histogenesis, Epstein-Barr Virus Infection, and Tumor Microenvironment -- Cell Type Origin of Nasopharyngeal Carcinoma. , Histopathology and Classification of Nasopharyngeal Carcinoma -- Altered Cell Signaling in Nasopharyngeal Carcinoma -- Aberrant Activation of NF-κB and STAT3 Inflammatory Pathways -- Altered PI3K-MAPK Signaling Pathway -- Aberrant NOTCH Pathways -- Activation of the Hedgehog Signaling Pathways -- Alterations in G1-S Cell Cycle Transition -- Epstein-Barr Virus Infection, BART-microRNAs, and Nasopharyngeal Carcinoma Pathogenesis -- The Contribution of Tumor Microenvironment to Nasopharyngeal Carcinoma Pathogenesis -- The Dynamic Interaction of Tumor Microenvironment Cells With Epstein-Barr Virus-Infected Nasopharyngeal Carcinoma Cells -- Macrophages in Nasopharyngeal Carcinoma -- Cancer Associated Fibroblasts in Nasopharyngeal Carcinoma -- Conclusion -- Acknowledgments -- References -- Commentary on Chapter 3: The Pathogenesis of Nasopharyngeal Carcinoma: What We Know and What We Don't Know -- Nasopharyngeal Carcinoma Pathogenesis -- Epstein-Barr Virus Strain Variation -- Tumor Microenvironment -- Conclusions and Future Perspectives -- Acknowledgment -- References -- 4 - Epidemiology and Population Screening -- Introduction -- Descriptive Epidemiology -- Geographic Distribution -- Secular Trends of Incidence and Mortality -- Family History of Cancer or Nasopharyngeal Carcinoma -- Environmental Factors (including Lifestyle Factors) -- Socioeconomic Status -- Consumption of Salted Fish -- Tobacco Smoking -- Consumption of Milk -- Ecological Study -- Calcium -- Milk Fat -- Milk Proteins and Folate -- Nasopharyngeal Carcinoma Multicenter Case-Control Study -- Vitamin D Deficiency -- Population Screening -- Methodological Considerations for Future Epidemiological Studies on Nasopharyngeal Carcinoma -- Knowledge Gaps -- Data Collection -- Hospital Versus Community Controls -- Individual Versus Frequency Matching. , Individual Participant Data Meta-Analysis of Nasopharyngeal Carcinoma Case-Control Study -- Conclusions -- Acknowledgments -- References -- Commentary on Chapter 4: Epidemiology and Population Screening -- References -- 5 - Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelia ... -- Establishment of in vitro Nasopharyngeal Carcinoma Cell Lines -- Overview of Nasopharyngeal Carcinoma Cell Lines Commonly Used in Investigation -- Epstein-Barr Virus Episomes Are Commonly Lost in Nasopharyngeal Carcinoma Cell Lines Upon Propagation in Culture -- Contamination With HeLa Genetic Components in Commonly Used Nasopharyngeal Carcinoma Cell Lines -- Suppression of Epithelial Differentiation and Lytic Epstein-Barr Virus Reactivation Support Establishment of Epstein-Barr V ... -- Establishment of Nasopharyngeal Carcinoma Patient-Derived Xenografts for Nasopharyngeal Carcinoma Research -- The Unique Tumor Microenvironment May Play an Essential Role to Support Establishment of Nasopharyngeal Carcinoma Patient-D ... -- Epstein-Barr Virus Episomes Are Stably Maintained in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- High Expression of BART microRNAs in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- Establishment and Immortalization of Nonmalignant Nasopharyngeal Epithelial Cell Lines and Their Applications in Nasopharyn ... -- Immortalization of Primary Nasopharyngeal Epithelial Cells by Viral Oncogenes -- Primary Nasopharyngeal Epithelial Cells Could Be Efficiently Immortalized by Telomerase in Combination with Common Genetic ... -- Overexpression of Cyclin D1 Supports Stable and Latent Infection of Epstein-Barr Virus -- Conclusion -- Acknowledgments -- References. , Commentary on Chapter 5: Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized ... -- Acknowledgments -- References -- 6 - Translational Studies: Drug Candidates and Preclinical Testing -- Introduction -- Genomic Landscape of Nasopharyngeal Carcinoma and Genome-Based Therapeutic Targets -- Therapeutic Targeting of Cancer Cell Signaling Pathways -- Cancer Stem Cell Signaling Pathways -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- NF-kB Signaling Pathways -- EBV LMP1 and NF-κB Signaling -- Roles of Various NF-κB Transcription Factors in Nasopharyngeal Carcinoma Pathogenesis -- Causative Agents for NF-κB Activation in Nasopharyngeal Carcinoma -- Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling -- Pathological Analysis and Activating Mechanisms for JAK/STAT3 in Nasopharyngeal Carcinoma -- JAK/STAT3 as a Nasopharyngeal Carcinoma Target -- Hsp90 -- Poly(ADP-Ribose) Polymerases -- Pathological Analysis of PARP in Nasopharyngeal Carcinoma -- PARP as a Target in Nasopharyngeal Carcinoma -- Targeting Epstein-Barr Virus Lytic Cycle in Nasopharyngeal Carcinoma Using Histone Deacetylase Inhibitors -- Therapeutic Targeting of Epstein-Barr Virus Viral Proteins -- Conclusion -- References -- Commentary on Chapter 6: Translational Studies: Drug Candidates and Preclinical Testing -- References -- 7 - Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Introduction -- Epstein-Barr Virus Serology -- Cell-Free Circulating Epstein-Barr Virus DNA -- Extracellular Epstein-Barr Virus microRNAs -- Methylation Biomarkers in Nasopharyngeal Carcinoma -- Telomere Lengths as a Prognostic Indicator for Nasopharyngeal Carcinoma -- Noninvasive Detection of Circulating Tumor Cells in Nasopharyngeal Carcinoma -- Summary and Roundup -- Acknowledgments. , References -- Commentary on Chapter 7: Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Background -- Epstein-Barr Virus Serology as a Biomarker for Nasopharyngeal Carcinoma Screening and Diagnosis -- Epstein-Barr Virus DNA Load as Biomarker for Nasopharyngeal Carcinoma Diagnosis and Monitoring -- Epstein-Barr Virus Encoded mRNA and microRNA -- Host Cell Markers in Nasopharyngeal Carcinoma Diagnosis -- Methylation Biomarkers -- Telomere Lengths as Biomarkers -- Circulating Tumor Cells as Biomarkers -- Summary -- References -- 8 - Imaging of Nasopharyngeal Carcinoma -- Introduction -- Initial Diagnostic Workup and Staging -- The Evaluation of the Primary Tumor -- The Evaluation of Cervical Nodal Metastasis -- Morphological Diagnostic Standard -- Metabolic Imaging of Nodal Metastasis -- False Positive Findings of Metabolic Imaging -- False Negative Findings of Metabolic Imaging -- Nodal Location Related Diagnostic Accuracy for Metabolic Imaging -- N-Staging -- Distant Metastasis -- Primary Treatment Evaluation -- Challenges and Diagnostic Pitfalls for Postradiotherapy Evaluation -- Disease Recurrence -- Local Recurrence -- Regional (Nodal) Recurrence -- Distant Metastasis -- Quantitative Imaging Biomarkers for Prognostication and Risk-Stratification: Potential Role and Challenges -- Morphologic MRI Parameters -- Novel Parameters From MRI -- PET Parameters -- Radiomic Parameters -- PET/MRI -- References -- Commentary on Chapter 8: Imaging of Nasopharyngeal Carcinoma -- References -- 9 - Staging of Nasopharyngeal Carcinoma Based on the 8th Edition of the AJCC/UICC Staging System -- Introduction -- Historical Development and Important Milestones in the Tumor, Node, Metastases Classification -- Comparison of 7th AJCC Staging, Chinese Staging, and 8th AJCC Staging -- Masticator Space Infiltration. , Prevertebral Muscle Involvement.

Language: English

UID:

Format: 1 online resource (396 pages)

ISBN: 0-12-814937-X , 0-12-814936-1

Note: Front Cover -- NASOPHARYNGEAL CARCINOMA -- NASOPHARYNGEAL CARCINOMA: FROM ETIOLOGY TO CLINICAL PRACTICE -- Copyright -- Contents -- List of Contributors -- Preface -- Acknowledgments -- 1 - Nasopharyngeal Carcinoma: A History -- NASOPHARYNGEAL CARCINOMA: AN INTRODUCTION -- RECOGNITION OF THE TUMOR AND ITS UNIQUE EPIDEMIOLOGY -- ENVIRONMENTAL AND LIFESTYLE FACTORS -- DETERMINANTS OF GENETIC SUSCEPTIBILITY -- THE LINK TO EPSTEIN-BARR VIRUS -- THE IMPACT OF TUMOR GENOMICS -- TOWARD AN UNDERSTANDING OF NASOPHARYNGEAL CARCINOMA PATHOGENESIS -- DEVELOPMENT OF NASOPHARYNGEAL CARCINOMA THERAPIES -- NASOPHARYNGEAL CARCINOMA: A FUTURE PERSPECTIVE -- References -- 2 - Nasopharyngeal Carcinoma: Genetics and Genomics -- MOLECULAR BASIS FOR NASOPHARYNGEAL CARCINOMA: TUMOR SUPPRESSOR GENES AND ONCOGENES -- GENETIC PREDISPOSITION TO NASOPHARYNGEAL CARCINOMA -- Background, Approaches, and Findings From Early Studies -- Human Leukocyte Antigen Studies, Telomere Length Maintenance, and DNA Repair Genes -- Human Leukocyte Antigen Studies for Genetic Susceptibility -- Telomere Biology and Double-Strand Break Repair -- Whole-Exome Sequencing Identifies MST1R -- NASOPHARYNGEAL CARCINOMA LANDSCAPE GENOMICS STUDIES -- Methylation -- WNT/β-Catenin Signaling Pathway -- MAPK Signaling Pathway -- TGF-β Signaling Pathways -- Hedgehog Signaling Pathways -- Tumor Suppressor Genes -- Summary for Methylation Studies in Nasopharyngeal Carcinoma -- Whole-Exome Sequencing Studies -- NF-κB Pathway -- PI3K/AKT/mTOR Pathway -- Epigenetic Regulators -- SUMMARY AND ROUNDUP -- Acknowledgments -- References -- Commentary on Chapter 2: Nasopharyngeal Carcinoma: Genetics and Genomics -- References -- 3 - Pathogenesis of Nasopharyngeal Carcinoma: Histogenesis, Epstein-Barr Virus Infection, and Tumor Microenvironment -- Cell Type Origin of Nasopharyngeal Carcinoma. , Histopathology and Classification of Nasopharyngeal Carcinoma -- Altered Cell Signaling in Nasopharyngeal Carcinoma -- Aberrant Activation of NF-κB and STAT3 Inflammatory Pathways -- Altered PI3K-MAPK Signaling Pathway -- Aberrant NOTCH Pathways -- Activation of the Hedgehog Signaling Pathways -- Alterations in G1-S Cell Cycle Transition -- Epstein-Barr Virus Infection, BART-microRNAs, and Nasopharyngeal Carcinoma Pathogenesis -- The Contribution of Tumor Microenvironment to Nasopharyngeal Carcinoma Pathogenesis -- The Dynamic Interaction of Tumor Microenvironment Cells With Epstein-Barr Virus-Infected Nasopharyngeal Carcinoma Cells -- Macrophages in Nasopharyngeal Carcinoma -- Cancer Associated Fibroblasts in Nasopharyngeal Carcinoma -- Conclusion -- Acknowledgments -- References -- Commentary on Chapter 3: The Pathogenesis of Nasopharyngeal Carcinoma: What We Know and What We Don't Know -- Nasopharyngeal Carcinoma Pathogenesis -- Epstein-Barr Virus Strain Variation -- Tumor Microenvironment -- Conclusions and Future Perspectives -- Acknowledgment -- References -- 4 - Epidemiology and Population Screening -- Introduction -- Descriptive Epidemiology -- Geographic Distribution -- Secular Trends of Incidence and Mortality -- Family History of Cancer or Nasopharyngeal Carcinoma -- Environmental Factors (including Lifestyle Factors) -- Socioeconomic Status -- Consumption of Salted Fish -- Tobacco Smoking -- Consumption of Milk -- Ecological Study -- Calcium -- Milk Fat -- Milk Proteins and Folate -- Nasopharyngeal Carcinoma Multicenter Case-Control Study -- Vitamin D Deficiency -- Population Screening -- Methodological Considerations for Future Epidemiological Studies on Nasopharyngeal Carcinoma -- Knowledge Gaps -- Data Collection -- Hospital Versus Community Controls -- Individual Versus Frequency Matching. , Individual Participant Data Meta-Analysis of Nasopharyngeal Carcinoma Case-Control Study -- Conclusions -- Acknowledgments -- References -- Commentary on Chapter 4: Epidemiology and Population Screening -- References -- 5 - Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelia ... -- Establishment of in vitro Nasopharyngeal Carcinoma Cell Lines -- Overview of Nasopharyngeal Carcinoma Cell Lines Commonly Used in Investigation -- Epstein-Barr Virus Episomes Are Commonly Lost in Nasopharyngeal Carcinoma Cell Lines Upon Propagation in Culture -- Contamination With HeLa Genetic Components in Commonly Used Nasopharyngeal Carcinoma Cell Lines -- Suppression of Epithelial Differentiation and Lytic Epstein-Barr Virus Reactivation Support Establishment of Epstein-Barr V ... -- Establishment of Nasopharyngeal Carcinoma Patient-Derived Xenografts for Nasopharyngeal Carcinoma Research -- The Unique Tumor Microenvironment May Play an Essential Role to Support Establishment of Nasopharyngeal Carcinoma Patient-D ... -- Epstein-Barr Virus Episomes Are Stably Maintained in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- High Expression of BART microRNAs in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- Establishment and Immortalization of Nonmalignant Nasopharyngeal Epithelial Cell Lines and Their Applications in Nasopharyn ... -- Immortalization of Primary Nasopharyngeal Epithelial Cells by Viral Oncogenes -- Primary Nasopharyngeal Epithelial Cells Could Be Efficiently Immortalized by Telomerase in Combination with Common Genetic ... -- Overexpression of Cyclin D1 Supports Stable and Latent Infection of Epstein-Barr Virus -- Conclusion -- Acknowledgments -- References. , Commentary on Chapter 5: Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized ... -- Acknowledgments -- References -- 6 - Translational Studies: Drug Candidates and Preclinical Testing -- Introduction -- Genomic Landscape of Nasopharyngeal Carcinoma and Genome-Based Therapeutic Targets -- Therapeutic Targeting of Cancer Cell Signaling Pathways -- Cancer Stem Cell Signaling Pathways -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- NF-kB Signaling Pathways -- EBV LMP1 and NF-κB Signaling -- Roles of Various NF-κB Transcription Factors in Nasopharyngeal Carcinoma Pathogenesis -- Causative Agents for NF-κB Activation in Nasopharyngeal Carcinoma -- Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling -- Pathological Analysis and Activating Mechanisms for JAK/STAT3 in Nasopharyngeal Carcinoma -- JAK/STAT3 as a Nasopharyngeal Carcinoma Target -- Hsp90 -- Poly(ADP-Ribose) Polymerases -- Pathological Analysis of PARP in Nasopharyngeal Carcinoma -- PARP as a Target in Nasopharyngeal Carcinoma -- Targeting Epstein-Barr Virus Lytic Cycle in Nasopharyngeal Carcinoma Using Histone Deacetylase Inhibitors -- Therapeutic Targeting of Epstein-Barr Virus Viral Proteins -- Conclusion -- References -- Commentary on Chapter 6: Translational Studies: Drug Candidates and Preclinical Testing -- References -- 7 - Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Introduction -- Epstein-Barr Virus Serology -- Cell-Free Circulating Epstein-Barr Virus DNA -- Extracellular Epstein-Barr Virus microRNAs -- Methylation Biomarkers in Nasopharyngeal Carcinoma -- Telomere Lengths as a Prognostic Indicator for Nasopharyngeal Carcinoma -- Noninvasive Detection of Circulating Tumor Cells in Nasopharyngeal Carcinoma -- Summary and Roundup -- Acknowledgments. , References -- Commentary on Chapter 7: Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Background -- Epstein-Barr Virus Serology as a Biomarker for Nasopharyngeal Carcinoma Screening and Diagnosis -- Epstein-Barr Virus DNA Load as Biomarker for Nasopharyngeal Carcinoma Diagnosis and Monitoring -- Epstein-Barr Virus Encoded mRNA and microRNA -- Host Cell Markers in Nasopharyngeal Carcinoma Diagnosis -- Methylation Biomarkers -- Telomere Lengths as Biomarkers -- Circulating Tumor Cells as Biomarkers -- Summary -- References -- 8 - Imaging of Nasopharyngeal Carcinoma -- Introduction -- Initial Diagnostic Workup and Staging -- The Evaluation of the Primary Tumor -- The Evaluation of Cervical Nodal Metastasis -- Morphological Diagnostic Standard -- Metabolic Imaging of Nodal Metastasis -- False Positive Findings of Metabolic Imaging -- False Negative Findings of Metabolic Imaging -- Nodal Location Related Diagnostic Accuracy for Metabolic Imaging -- N-Staging -- Distant Metastasis -- Primary Treatment Evaluation -- Challenges and Diagnostic Pitfalls for Postradiotherapy Evaluation -- Disease Recurrence -- Local Recurrence -- Regional (Nodal) Recurrence -- Distant Metastasis -- Quantitative Imaging Biomarkers for Prognostication and Risk-Stratification: Potential Role and Challenges -- Morphologic MRI Parameters -- Novel Parameters From MRI -- PET Parameters -- Radiomic Parameters -- PET/MRI -- References -- Commentary on Chapter 8: Imaging of Nasopharyngeal Carcinoma -- References -- 9 - Staging of Nasopharyngeal Carcinoma Based on the 8th Edition of the AJCC/UICC Staging System -- Introduction -- Historical Development and Important Milestones in the Tumor, Node, Metastases Classification -- Comparison of 7th AJCC Staging, Chinese Staging, and 8th AJCC Staging -- Masticator Space Infiltration. , Prevertebral Muscle Involvement.

Language: English

UID:

Format: 1 online resource (396 pages)

ISBN: 0-12-814937-X , 0-12-814936-1

Note: Front Cover -- NASOPHARYNGEAL CARCINOMA -- NASOPHARYNGEAL CARCINOMA: FROM ETIOLOGY TO CLINICAL PRACTICE -- Copyright -- Contents -- List of Contributors -- Preface -- Acknowledgments -- 1 - Nasopharyngeal Carcinoma: A History -- NASOPHARYNGEAL CARCINOMA: AN INTRODUCTION -- RECOGNITION OF THE TUMOR AND ITS UNIQUE EPIDEMIOLOGY -- ENVIRONMENTAL AND LIFESTYLE FACTORS -- DETERMINANTS OF GENETIC SUSCEPTIBILITY -- THE LINK TO EPSTEIN-BARR VIRUS -- THE IMPACT OF TUMOR GENOMICS -- TOWARD AN UNDERSTANDING OF NASOPHARYNGEAL CARCINOMA PATHOGENESIS -- DEVELOPMENT OF NASOPHARYNGEAL CARCINOMA THERAPIES -- NASOPHARYNGEAL CARCINOMA: A FUTURE PERSPECTIVE -- References -- 2 - Nasopharyngeal Carcinoma: Genetics and Genomics -- MOLECULAR BASIS FOR NASOPHARYNGEAL CARCINOMA: TUMOR SUPPRESSOR GENES AND ONCOGENES -- GENETIC PREDISPOSITION TO NASOPHARYNGEAL CARCINOMA -- Background, Approaches, and Findings From Early Studies -- Human Leukocyte Antigen Studies, Telomere Length Maintenance, and DNA Repair Genes -- Human Leukocyte Antigen Studies for Genetic Susceptibility -- Telomere Biology and Double-Strand Break Repair -- Whole-Exome Sequencing Identifies MST1R -- NASOPHARYNGEAL CARCINOMA LANDSCAPE GENOMICS STUDIES -- Methylation -- WNT/β-Catenin Signaling Pathway -- MAPK Signaling Pathway -- TGF-β Signaling Pathways -- Hedgehog Signaling Pathways -- Tumor Suppressor Genes -- Summary for Methylation Studies in Nasopharyngeal Carcinoma -- Whole-Exome Sequencing Studies -- NF-κB Pathway -- PI3K/AKT/mTOR Pathway -- Epigenetic Regulators -- SUMMARY AND ROUNDUP -- Acknowledgments -- References -- Commentary on Chapter 2: Nasopharyngeal Carcinoma: Genetics and Genomics -- References -- 3 - Pathogenesis of Nasopharyngeal Carcinoma: Histogenesis, Epstein-Barr Virus Infection, and Tumor Microenvironment -- Cell Type Origin of Nasopharyngeal Carcinoma. , Histopathology and Classification of Nasopharyngeal Carcinoma -- Altered Cell Signaling in Nasopharyngeal Carcinoma -- Aberrant Activation of NF-κB and STAT3 Inflammatory Pathways -- Altered PI3K-MAPK Signaling Pathway -- Aberrant NOTCH Pathways -- Activation of the Hedgehog Signaling Pathways -- Alterations in G1-S Cell Cycle Transition -- Epstein-Barr Virus Infection, BART-microRNAs, and Nasopharyngeal Carcinoma Pathogenesis -- The Contribution of Tumor Microenvironment to Nasopharyngeal Carcinoma Pathogenesis -- The Dynamic Interaction of Tumor Microenvironment Cells With Epstein-Barr Virus-Infected Nasopharyngeal Carcinoma Cells -- Macrophages in Nasopharyngeal Carcinoma -- Cancer Associated Fibroblasts in Nasopharyngeal Carcinoma -- Conclusion -- Acknowledgments -- References -- Commentary on Chapter 3: The Pathogenesis of Nasopharyngeal Carcinoma: What We Know and What We Don't Know -- Nasopharyngeal Carcinoma Pathogenesis -- Epstein-Barr Virus Strain Variation -- Tumor Microenvironment -- Conclusions and Future Perspectives -- Acknowledgment -- References -- 4 - Epidemiology and Population Screening -- Introduction -- Descriptive Epidemiology -- Geographic Distribution -- Secular Trends of Incidence and Mortality -- Family History of Cancer or Nasopharyngeal Carcinoma -- Environmental Factors (including Lifestyle Factors) -- Socioeconomic Status -- Consumption of Salted Fish -- Tobacco Smoking -- Consumption of Milk -- Ecological Study -- Calcium -- Milk Fat -- Milk Proteins and Folate -- Nasopharyngeal Carcinoma Multicenter Case-Control Study -- Vitamin D Deficiency -- Population Screening -- Methodological Considerations for Future Epidemiological Studies on Nasopharyngeal Carcinoma -- Knowledge Gaps -- Data Collection -- Hospital Versus Community Controls -- Individual Versus Frequency Matching. , Individual Participant Data Meta-Analysis of Nasopharyngeal Carcinoma Case-Control Study -- Conclusions -- Acknowledgments -- References -- Commentary on Chapter 4: Epidemiology and Population Screening -- References -- 5 - Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelia ... -- Establishment of in vitro Nasopharyngeal Carcinoma Cell Lines -- Overview of Nasopharyngeal Carcinoma Cell Lines Commonly Used in Investigation -- Epstein-Barr Virus Episomes Are Commonly Lost in Nasopharyngeal Carcinoma Cell Lines Upon Propagation in Culture -- Contamination With HeLa Genetic Components in Commonly Used Nasopharyngeal Carcinoma Cell Lines -- Suppression of Epithelial Differentiation and Lytic Epstein-Barr Virus Reactivation Support Establishment of Epstein-Barr V ... -- Establishment of Nasopharyngeal Carcinoma Patient-Derived Xenografts for Nasopharyngeal Carcinoma Research -- The Unique Tumor Microenvironment May Play an Essential Role to Support Establishment of Nasopharyngeal Carcinoma Patient-D ... -- Epstein-Barr Virus Episomes Are Stably Maintained in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- High Expression of BART microRNAs in Nasopharyngeal Carcinoma Patient-Derived Xenografts -- Establishment and Immortalization of Nonmalignant Nasopharyngeal Epithelial Cell Lines and Their Applications in Nasopharyn ... -- Immortalization of Primary Nasopharyngeal Epithelial Cells by Viral Oncogenes -- Primary Nasopharyngeal Epithelial Cells Could Be Efficiently Immortalized by Telomerase in Combination with Common Genetic ... -- Overexpression of Cyclin D1 Supports Stable and Latent Infection of Epstein-Barr Virus -- Conclusion -- Acknowledgments -- References. , Commentary on Chapter 5: Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized ... -- Acknowledgments -- References -- 6 - Translational Studies: Drug Candidates and Preclinical Testing -- Introduction -- Genomic Landscape of Nasopharyngeal Carcinoma and Genome-Based Therapeutic Targets -- Therapeutic Targeting of Cancer Cell Signaling Pathways -- Cancer Stem Cell Signaling Pathways -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- NF-kB Signaling Pathways -- EBV LMP1 and NF-κB Signaling -- Roles of Various NF-κB Transcription Factors in Nasopharyngeal Carcinoma Pathogenesis -- Causative Agents for NF-κB Activation in Nasopharyngeal Carcinoma -- Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling -- Pathological Analysis and Activating Mechanisms for JAK/STAT3 in Nasopharyngeal Carcinoma -- JAK/STAT3 as a Nasopharyngeal Carcinoma Target -- Hsp90 -- Poly(ADP-Ribose) Polymerases -- Pathological Analysis of PARP in Nasopharyngeal Carcinoma -- PARP as a Target in Nasopharyngeal Carcinoma -- Targeting Epstein-Barr Virus Lytic Cycle in Nasopharyngeal Carcinoma Using Histone Deacetylase Inhibitors -- Therapeutic Targeting of Epstein-Barr Virus Viral Proteins -- Conclusion -- References -- Commentary on Chapter 6: Translational Studies: Drug Candidates and Preclinical Testing -- References -- 7 - Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Introduction -- Epstein-Barr Virus Serology -- Cell-Free Circulating Epstein-Barr Virus DNA -- Extracellular Epstein-Barr Virus microRNAs -- Methylation Biomarkers in Nasopharyngeal Carcinoma -- Telomere Lengths as a Prognostic Indicator for Nasopharyngeal Carcinoma -- Noninvasive Detection of Circulating Tumor Cells in Nasopharyngeal Carcinoma -- Summary and Roundup -- Acknowledgments. , References -- Commentary on Chapter 7: Conventional and Novel Diagnostic Biomarkers and Approaches for Detection of Nasopharyngeal Carcinoma -- Background -- Epstein-Barr Virus Serology as a Biomarker for Nasopharyngeal Carcinoma Screening and Diagnosis -- Epstein-Barr Virus DNA Load as Biomarker for Nasopharyngeal Carcinoma Diagnosis and Monitoring -- Epstein-Barr Virus Encoded mRNA and microRNA -- Host Cell Markers in Nasopharyngeal Carcinoma Diagnosis -- Methylation Biomarkers -- Telomere Lengths as Biomarkers -- Circulating Tumor Cells as Biomarkers -- Summary -- References -- 8 - Imaging of Nasopharyngeal Carcinoma -- Introduction -- Initial Diagnostic Workup and Staging -- The Evaluation of the Primary Tumor -- The Evaluation of Cervical Nodal Metastasis -- Morphological Diagnostic Standard -- Metabolic Imaging of Nodal Metastasis -- False Positive Findings of Metabolic Imaging -- False Negative Findings of Metabolic Imaging -- Nodal Location Related Diagnostic Accuracy for Metabolic Imaging -- N-Staging -- Distant Metastasis -- Primary Treatment Evaluation -- Challenges and Diagnostic Pitfalls for Postradiotherapy Evaluation -- Disease Recurrence -- Local Recurrence -- Regional (Nodal) Recurrence -- Distant Metastasis -- Quantitative Imaging Biomarkers for Prognostication and Risk-Stratification: Potential Role and Challenges -- Morphologic MRI Parameters -- Novel Parameters From MRI -- PET Parameters -- Radiomic Parameters -- PET/MRI -- References -- Commentary on Chapter 8: Imaging of Nasopharyngeal Carcinoma -- References -- 9 - Staging of Nasopharyngeal Carcinoma Based on the 8th Edition of the AJCC/UICC Staging System -- Introduction -- Historical Development and Important Milestones in the Tumor, Node, Metastases Classification -- Comparison of 7th AJCC Staging, Chinese Staging, and 8th AJCC Staging -- Masticator Space Infiltration. , Prevertebral Muscle Involvement.

Language: English