Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (XIII, 416 p. 123 illus., 86 illus. in color.)

Edition: 2nd ed. 2014.

ISBN: 1-62703-721-7

Series Statement: Methods in Molecular Biology, 1101

Content: The determination of protein function has been a major goal of molecular biology since the founding of the discipline. However, as we learn more about gene function, we discover that the context within which a gene is expressed controls the specific function of that gene. It has become critical to establish the background in which gene function is determined and to perform experiments in multiple applicable backgrounds.  In Gene Function Analysis, Second Edition, a number of computational and experimental techniques are presented for identifying not only the function of an individual gene, but also the partners that work with that gene.  The theme of data integration runs strongly through the computational techniques, with many focusing on gathering data from different sources and different biomolecular types. Experimental techniques have evolved to determine function in specific tissues and at specific times during development. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, Gene Function Analysis, Second Edition seeks to serve both professionals and novices with a growing understanding of the complexity of gene function.

Note: Bibliographic Level Mode of Issuance: Monograph , The Present State and Future Direction of Integrated Gene Function Analysis -- Performing Integrative Functional Genomics Analysis in GeneWeaver.org -- Functional Annotation of Differentially Regulated Geneset Using WebGestalt: A Geneset Predictive of Response to Ipilimumab in Tumor Biopsies -- ­Integrative Data-Mining Tools to Link Fene and Function -- Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large Scale Transcriptome-Interactome Integration -- Pattern Identification in Time Course Gene Expression Data with the CoGAPS Matrix Factorization -- Statistical Tools and R Software for Cancer Driver Probabilities -- Predicting the Functional Consequences of Somatic Missense Mutations Found in Tumors -- Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells -- Reverse Engineering Transcriptional Gene Network -- Integrating In Silico Resources to Map a Signaling Network -- A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using Pogostick -- Construction and Application of Site-specific Artificial Nucleases for Targeted Gene Editing -- Selection of Recombinant Antibodies from Antibody Gene Libraries -- Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Sequences from Mammalian Genes -- Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination -- In Ovo Electroporation of miRNA-Based Plasmids to Investigate Gene Function in the Developing Neural Tube -- Proteomic Strategies: SILAC and 2D-DIGE - Powerful Tool to Investigate Cellular Alterations -- Conditional Gene-Trap Mutagenesis in Zebrafish. , English

Additional Edition: ISBN 1-62703-720-9

Language: English

Keywords: Laboratory Manuals. ; Laboratory Manuals. ; Laboratory Manuals. ; Laboratory Manuals.

DOI: 10.1007/978-1-62703-721-1

UID:

Format: 573 Seiten , Illustrationen , 21 cm

ISBN: 9783836550581 , 383655058X

Series Statement: Bibliotheca universalis

Content: "Record covers are a sign of our life and times. Like the music on the discs, they address such issues as love, life, death, fashion, and rebellion. For music fans the covers are the expression of a period, of a particular time in their lives. Many are works of art and have become as famous as the music they stand for--Andy Warhol's covers, for example, including the banana he designed for The Velvet Underground. This edition of Record covers presents a selection of the best '60s to '90s rock album covers from music archivist, disc jockey, journalist, and former record-publicity executive Michael Ochs's enormous private collection. Both a trip down memory lane and a study in the evolution of cover art, this is a sweeping look at an underappreciated art form." --Publisher description

Note: Hier auch später erschienene, unveränderte Nachdrucke , "Original edition: ©1996 Benedikt Taschen Verlag GmbH", Title page verso. - This volume does not have covers after 1995 , Includes index , Text in English, German and French

Language: English

Keywords: Cover ; Geschichte 1958-1995 ; Schallplattensammlung Michael Ochs ; Cover ; Schallplatte ; Rock 'n' Roll ; Geschichte 1950-1995 ; Sammlung ; Cover ; Schallplatte ; Rockmusik ; Geschichte 1950-1995 ; Sammlung ; Ochs, Michael 1943- ; Schallplatte ; Cover ; Geschichte 1950-1995 ; Sammlung ; Cover ; Schallplatte ; Geschichte 1950-2000

Author information: Ochs, Michael 1943-

UID:

Format: 1 online resource (360 p.)

Edition: 1st ed. 2007.

ISBN: 1-280-97179-7 , 9786610971794 , 1-59745-547-4

Series Statement: Methods in Molecular Biology, 408

Content: With the advent of high-throughput technologies, the number of genes of interest has expanded and the traditional methods for gene function analysis cannot achieve the throughput necessary for large-scale exploration. In Gene Function Analysis, a select team of experts bring together a number of recently developed techniques for studying gene function. The volume begins with a variety of computational techniques, which provide an excellent point of departure for the cutting-edge experimental methods that follow. Written in the highly successful Methods in Molecular Biology™ series format, each chapter surveys its subject with readily reproducible laboratory protocols, a list of the necessary materials, and the popular Notes section, which contains tips for troubleshooting and avoiding known pitfalls. Comprehensive and timely, Gene Function Analysis offers researchers a clear guide and the important tools they need to further study the intricate human genome.

Note: Description based upon print version of record. , Computational Methods I -- Gene Function Inference From Gene Expression of Deletion Mutants -- Association Analysis for Large-Scale Gene Set Data -- Estimating Gene Function With Least Squares Nonnegative Matrix Factorization -- From Promoter Analysis to Transcriptional Regulatory Network Prediction Using PAINT -- Prediction of Intrinsic Disorder and Its Use in Functional Proteomics -- Computational Methods II -- Sybil: Methods and Software for Multiple Genome Comparison and Visualization -- Estimating Protein Function Using Protein-Protein Relationships -- Bioinformatics Tools for Modeling Transcription Factor Target Genes and Epigenetic Changes -- Mining Biomedical Data Using MetaMap Transfer (MMTx) and the Unified Medical Language System (UMLS) -- Statistical Methods for Identifying Differentially Expressed Gene Combinations -- Experimental Methods -- Gene Function Analysis Using the Chicken B-Cell Line DT40 -- Design and Application of a shRNA-Based Gene Replacement Retrovirus -- Construction of Simple and Efficient DNA Vector-Based Short Hairpin RNA Expression Systems for Specific Gene Silencing in Mammalian Cells -- Selection of Recombinant Antibodies From Antibody Gene Libraries -- A Bacterial/Yeast Merged Two-Hybrid System -- A Bacterial/Yeast Merged Two-Hybrid System -- Engineering Cys2His2 Zinc Finger Domains Using a Bacterial Cell-Based Two-Hybrid Selection System. , English

Additional Edition: ISBN 1-58829-734-9

Language: English

DOI: 10.1007/978-1-59745-547-3

UID:

Format: 574 S. : , überw. Ill.

Edition: Taschen's 25. anniversary special ed.

ISBN: 3-8228-4085-8 , 978-3-8228-4085-6

Note: Text dt., engl. und franz.

Language: German

Subjects: Musicology

Keywords: Cover ; Schallplatte ; Rockmusik ; Sammlung ; 1943- Ochs, Michael ; Schallplatte ; Cover ; Sammlung ; Cover ; Schallplatte ; Rock 'n' Roll ; Sammlung ; Cover ; Schallplatte ; Cover ; Schallplattensammlung Michael Ochs ; Bildband ; Bildband

Author information: Ochs, Michael 1943-

UID:

Format: 144 S , Ill

Series Statement: Harvard Library bulletin N.S.,2,1

Language: Undetermined

UID:

Format: Partitur (X, 87 Seiten) , Illustrationen

ISBN: 9780960082735

Note: Liedtexte überwiegend englisch, teilweise hebräisch; hebräisch in hebräischer Schrift und lateinischer Umschrift

Language: Hebrew

UID:

Format: 573 pages , chiefly illustrations (chiefly colour) , 20.5 x 15 cm

Edition: [Reprint]

ISBN: 9783836550581 , 383655058X

Series Statement: Bibliotheca universalis / Taschen

Content: "Record covers are a sign of our life and times. Like the music on the discs, they address such issues as love, life, death, fashion, and rebellion. For music fans the covers are the expression of a period, of a particular time in their lives. Many are works of art and have become as famous as the music they stand for-Andy Warhol's covers, for example, including the banana he designed for The Velvet Underground. This edition of Record Covers presents a selection of the best rock album covers of the 60s to 90s from music archivist, disc jockey, journalist, and former record-publicity executive Michael Ochs's enormous private collection. Both a trip down memory lane and a study in the evolution of cover art, this is a sweeping look at an underappreciated art form."

Note: EDITORIAL NOTE: original edition: ©1996 as paperback edition (ISBN: 9783822885956, 3822885959), Benedikt Taschen Verlag , INDEX NOTE: includes index. , LANGUAGE NOTE: text in English, German, and French.

Language: Multiple languages

UID:

Format: 41 S. , Lit.Hinw.

Language: English

UID:

Format: 153 S. , Kt.

Series Statement: Seminar Series 1996-1997, Vol. 2

Content: Gorgiladze, R.: Georgian politics and the conflicts in Abkhazia and South Ossetia. - S. 4-19. Kvarchelia, L.: Georgia-Abkhazia conflict. View from Abkhazia. - S. 20-40. Libardian, J.: Conflicts and prospects for peace in the Caucasus. - S. 41-57. Ochs, M.: The Armenian presidential elections of 1996. - S. 58-80. Young, S.: US interests in the Caucasus. - S. 81-82. Retondo, C.: A groundhog's view of Baku. - S. 83-108. Sobhani, S. R.: US, Iran, Russia and Turkey. - S. 109-128. Goltz, T.: Samashki: belief and betrayal in a Chechen town at war. - S. 129-153

Note: Gorgiladze, R.: Georgian politics and the conflicts in Abkhazia and South Ossetia. - S. 4-19. Kvarchelia, L.: Georgia-Abkhazia conflict. View from Abkhazia. - S. 20-40. Libardian, J.: Conflicts and prospects for peace in the Caucasus. - S. 41-57. Ochs, M.: The Armenian presidential elections of 1996. - S. 58-80. Young, S.: US interests in the Caucasus. - S. 81-82. Retondo, C.: A groundhog's view of Baku. - S. 83-108. Sobhani, S. R.: US, Iran, Russia and Turkey. - S. 109-128. Goltz, T.: Samashki: belief and betrayal in a Chechen town at war. - S. 129-153.

Language: English

UID:

Format: 144 S , Ill., Notenbeisp

Note: Auch als: Harvard Library bulletin ; N.S. 2, Nr. 1

Language: Undetermined

Keywords: Konferenzschrift