ISSN:
1619-3997
,
1619-3997
Content:
Objectives: To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely supplement endogenous pulmonary surfactants (enPS) by looking at sequential changes in the surfactant proteins (SP) SP-A and SP-D in alveolar pools. Methods: Fourteen preterm infants with RDS treated with an artificial surfactant were compared to five normal-term infants without RDS who were treated with artificial ventilation at birth. Results: Immediately after birth, SP-A and SP-D were essentially absent in the alveolar pools of the RDS group, but were present at normal levels in the controls. Treatment with exPS apparently stimulated enPS production. Conclusions: In infants who responded well to exPS therapy, the SP concentration reached essentially normal levels within 48–72 h after birth.
Content:
Peer Reviewed
In:
Journal of Perinatal Medicine, : de Gruyter, 2009, 37,2009,5, Seiten 561-564, 1619-3997
Language:
Undetermined
DOI:
10.1515/JPM.2009.100
URN:
urn:nbn:de:kobv:11-100160616
URL:
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