UID:
almahu_9949413656802882
Format:
1 online resource (800 pages)
ISBN:
9780323884631
Content:
Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.
Note:
Intro -- Mitochondrial Intoxication -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Acknowledgments -- Chapter 1: Mitochondrial physiology: An overview -- 1. Introduction -- 2. TCA cycle and oxidative phosphorylation system activity -- 3. Mitochondrial dynamics: Fusion and fission -- 3.1. Mitochondrial fusion -- 3.2. Mitochondrial fission -- 4. Mitochondrial biogenesis and mitophagy -- 4.1. Regulation of mitochondrial biogenesis -- 4.2. Mitophagy: Molecular mechanisms -- 4.3. Mitochondrial homeostasis: Coordination of mitochondrial biogenesis and mitophagy -- 4.4. Physiological functions of biogenesis and mitophagy -- 5. Mitochondria-related cell death -- 5.1. Mitochondrial role in apoptosis -- 5.2. Mitochondria in pyroptosis, necroptosis, and ferroptosis -- 6. Mitochondrial redox biology -- 6.1. Superoxide dismutase -- 6.2. Mitochondrial catalase and oxidative injury -- 6.3. Mitochondrial NADPH and redox homeostasis -- 6.4. Mitochondrial glutathione -- 7. Concluding remarks -- References -- Chapter 2: Molecular markers of mitochondrial intoxication -- 1. Mechanisms of interaction leading to mitochondrial injury -- 2. Markers of mitochondrial damage -- 2.1. ROS/RNS production by mitochondria -- 2.2. Protein nitration -- 2.3. Protein carbonylation -- 2.4. Lipid peroxidation -- 2.5. MMP loss -- 2.6. Opening of the MPT and apoptosis -- 2.7. Calcium metabolism dyshomeostasis -- 2.8. Damage to mitochondrial DNA -- 2.9. Bioenergetics failure -- 3. Chemical-induced mitochondrial damage: Case examples -- 3.1. Interference in membrane structure and functions -- 3.2. Inhibition and uncoupling of oxidative phosphorylation -- 3.3. Alteration of the calcium homeostasis -- 3.4. Complexation with biomolecules -- 4. Conclusions -- References -- Chapter 3: Drug-induced mitochondrial impairment: Mechanisms and testing systems.
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1. Introduction -- 2. Mechanisms of drug-induced mitochondrial impairment -- 2.1. Changes in mitochondrial membrane composition and integrity -- 2.2. The inhibition of mitochondrial respiratory chain components -- 2.3. Mitochondrial permeabilization -- 2.4. Mitochondrial DNA damage -- 2.5. Effects of drugs on the uptake of molecules required for mitochondrial function -- 2.6. Drugs with protonophoretic and oxidative phosphorylation uncoupling activity -- 3. Testing systems for evaluating drug-induced mitochondrial impairment -- 4. Biomarkers of drug-induced mitochondrial injury in clinical settings -- 5. Protective strategies against drug-induced mitochondrial dysfunction -- 6. Outlook -- Conflicts of interest -- References -- Chapter 4: Clinical consequences of drug-induced mitochondrial dysfunction -- Abbreviations -- 1. Introduction -- 2. Clinical manifestations of drug-induced mitochondrial dysfunction -- 2.1. Hepatotoxicity -- 2.1.1. Steatosis -- 2.1.1.1. Mitochondrial involvement -- 2.1.1.2. Clinical examples -- 2.1.2. Acute liver failure -- 2.1.2.1. Mitochondrial involvement -- 2.1.2.2. Clinical examples -- 2.2. Skeletal muscle toxicity -- 2.2.1. Mitochondrial involvement -- 2.2.2. Clinical examples -- 2.3. Cardiotoxicity -- 2.3.1. Mitochondrial involvement -- 2.3.2. Clinical examples -- 2.4. Neuropathy -- 2.4.1. Mitochondrial involvement -- 2.4.2. Clinical examples -- 2.5. Nephrotoxicity -- 2.5.1. Mitochondrial involvement -- 2.5.2. Clinical examples -- 2.6. Ototoxicity -- 2.6.1. Mitochondrial involvement -- 2.6.2. Clinical examples -- 3. Interindividual variation -- 4. Concluding remarks -- References -- Chapter 5: Challenges in mitochondrial profiling during pre-clinical studies -- Abbreviations and formulae -- 1. Introduction -- 1.1. Introduction to mitochondrial toxicology -- 1.2. Main roles of mitochondria.
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1.3. Examples of mitochondrial toxicity -- 2. Experimental models and conditions -- 3. Mitochondrial microscopy, concerns and pitfalls -- 3.1. Mitochondria under the microscope-Chemical dyes vs genetically encoded sensors -- 3.2. Caveats in mitochondrial microscopy studies -- 4. Studying mitochondrial biology using machine learning methodologies -- 4.1. Machine learning, friend or foe? -- 4.2. Machine learning approaches crucial role in mitochondrial biology and toxicology -- 5. Conclusion -- Acknowledgments -- References -- Chapter 6: Mitochondrial dysfunction and underlying molecular mechanisms in acrylamide-induced toxicity -- 1. Introduction -- 2. AA induces the destruction and dysfunction of mitochondria -- 3. AA induces DNA damage and influences cell cycle and growth -- 4. AA induces extensive oxidative stress in mitochondria -- 5. Signaling pathways involved in mitochondrial dysfunction induced by AA -- 5.1. Collapse of antioxidant system's nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway -- 5.2. AA could damage mitochondria via mitogen-activated protein kinase (MAPK) signaling pathway -- 5.3. AA regulates nuclear factor (NF)-κB signaling pathway to initiate inflammation and damage mitochondria -- 5.4. AA could damage mitochondria via PI3K/AKT/mTOR signaling pathway -- 6. Conclusion -- References -- Chapter 7: The effects of air pollution toxicants on the mitochondria -- 1. Introduction -- 2. Mitochondria structure and function -- 3. Mitochondrial dynamics -- 4. Oxidative stress and the mitochondria -- 5. Major types of hazardous air pollutants -- 6. Major organs affected by air pollutants and disease exacerbations -- 7. Air pollutants as a source of ROS in the mitochondria -- 8. Conclusion -- 9. Future direction -- Acknowledgments -- References -- Chapter 8: Mitochondrial toxicity of aflatoxin B1 -- 1. Introduction.
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2. Biotransformation of AFB1 -- 3. AFB1 toxicity of the mitochondria -- 3.1. AFB1 toxicity in the mitochondria: Lipids -- 3.2. AFB1 toxicity in the mitochondria: Membrane potential and permeability -- 3.3. AFB1 toxicity in the mitochondria: Oxidative stress and apoptosis -- 3.4. AFB1 toxicity in the mitochondria: Respiratory chain enzymes -- 4. Conclusion -- References -- Chapter 9: The effects of alcohol abuse against the mitochondria: Functional consequences for liver, muscle, and the brain -- 1. Introduction -- 2. Alcohol toxicity -- 2.1. Alcohol consumption in our current society -- 2.2. Types of alcohol consumption -- 3. Alcohol consumption affects mitochondrial function -- 3.1. Alcohol impairs mitochondria in the liver -- 3.2. Alcohol impairs mitochondrial health in muscle cells -- 3.3. Association of alcohol consumption with brain abnormalities -- 4. Strategies to reduce mitochondrial injury induced by alcohol -- 4.1. Enhancing mitochondrial function to reduce alcohol-induced liver disease -- 4.2. Reversing mitochondria injury to reduce muscle disease induced by alcohol -- 4.3. Activation of melanocortin system and Nrf2 antioxidant pathway to reduce brain mitochondrial dysfunction induced by ... -- 5. Conclusions -- Acknowledgments -- References -- Further reading -- Chapter 10: The effect of aluminum on mitochondrial dysfunctions -- 1. Introduction -- 2. Aluminum and human exposure -- 3. Aluminum toxicokinetic -- 4. Basic mechanism of action of aluminum -- 5. Mitochondrion as a target organelle for Al toxicity -- 5.1. Production of aluminum-superoxide anion complexes in the mitochondrial matrix -- 5.2. Oxidative environment leads to lipid peroxidation of mitochondrial membranes -- 5.3. Disturbance in the activity of antioxidant enzymes after aluminum exposure -- 5.4. Disruption of mitochondrial energy metabolism mediated by aluminum.
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5.5. Effects of aluminum and the elevated concentrations of mitochondrial α-ketoglutarate -- 5.6. Aluminum exposure and oxidation of mtDNA -- 5.7. Aluminum toxicity and impairment of the mitochondrial quality control -- 6. Aluminum toxicity and the consequences to high energy-requiring tissues -- 6.1. Aluminum toxicity and mitochondrial dysfunction in neurological disorders -- 6.2. Hepatic damages and metabolic shift in lipogenesis after aluminum exposure -- 6.3. Cardiac tissue and mitochondrial dysfunction caused by aluminum -- 7. Conclusion -- Acknowledgments -- References -- Chapter 11: Discovery of amiodarone mitochondrial toxicity in liver and beyond -- 1. Introduction -- 2. Amiodarone-induced hepatotoxicity -- 3. Drug-induced microvesicular steatosis and mitochondrial dysfunction -- 4. First evidence that amiodarone could inhibit mitochondrial FAO -- 5. Amiodarone-induced inhibition of the mitochondrial respiratory chain -- 6. Amiodarone-induced uncoupling of oxidative phosphorylation -- 7. Amiodarone accumulates within the mitochondria -- 8. Amiodarone-induced mitochondrial dysfunction: A schematic overview -- 9. Subsequent confirmation that amiodarone can impair mitochondrial functions -- 10. From mitochondrial dysfunction to hepatic steatosis and steatohepatitis -- 11. Amiodarone-induced mitochondrial dysfunction in other tissues -- 12. Concluding remarks -- Acknowledgment -- References -- Chapter 12: Ammonia -- 1. Introduction: Ammonia metabolism, hyperammonemia, and hepatic encephalopathy -- 2. Mitochondria: The main subcellular target of ammonia toxicity -- 3. Effects of ammonia on organs other than CNS -- 4. Therapeutic approaches and future perspectives -- Conflicts of interest -- References -- Chapter 13: Mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines -- 1. Introduction.
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2. The tricarboxylic acid cycle as a target of amphetamines.
Additional Edition:
Print version: Oliveira, Marcos Roberto de Mitochondrial Intoxication San Diego : Elsevier Science & Technology,c2022 ISBN 9780323884624
Language:
English
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